One of the most powerful tools in science is the analytic method, whereby we seek to understand complex systems by studying simpler sub-systems from which the complex is composed. If this method is to be successful, something about the sub-systems must remain invariant as we move from the relatively isolated conditions in which we study them, to the complex conditions in which we want to put our knowledge to use. This paper asks what this invariant could be. The paper shows (...) that the kinds of thing that a Humean might point to – behaviour, laws, and dispositions – cannot play the role required of the invariant in question. Nor, indeed, can non-Humean causal powers of the kind advocated by contemporary metaphysicians such as Ellis and Lierse. The paper suggests that the analytic method presupposes a kind of entity that does not appear in standard ontologies – a metaphysically substantial notion of causal influence. This notion of causal influence is one that Cartwright has also seen the need for, though she does not seem to take the notion as seriously as she should. (shrink)

Concerns about the risks of unmitigated greenhouse gas emissions are growing. At the same time, confidence that international policy agreements will succeed in considerably lowering anthropogenic greenhouse gas emissions is declining. Perhaps as a result, various geoengineering solutions are gaining attention and credibility as a way to manage climate change. Serious consideration is currently being given to proposals to cool the planet through solar-radiation management. Here we analyze how the unique and nontrivial risks of geoengineering strategies pose fundamental questions at (...) the interface between science and ethics. To illustrate the importance of integrated ethical and scientific analysis, we define key open questions and outline a coupled scientific-ethical research agenda to analyze solar-radiation management geoengineering proposals. We identify nine key fields of coupled research including whether solar-radiation management can be tested, how quickly learning could occur, normative decisions embedded in how different climate trajectories are valued, and justice issues regarding distribution of the harms and benefits of geoengineering. To ensure that ethical analyses are coupled with scientific analyses of this form of geoengineering, we advocate that funding agencies recognize the essential nature of this coupled research by establishing an Ethical, Legal, and Social Implications program for solar-radiation management. (shrink)

As Buddhism spread into China, the Mahayana (Dacheng) and Hinayana (Xiaocheng) schools, as well as the kong 空 (empty) or you 有 (being) schools, each developed separately, with all sorts of competing theories emerging. While Chinese Buddhism saw a revival in modern times, Western science also gained ground all over the country, and many scholars, technologists and monks sought to interpret the meaning of kong according the achievements and method of the natural sciences. They used science to interpret the content (...) and methods of Buddhist teachings, ontology, and outlook on life. Of the scholars who did so, Wang Jitong (王季同) and You Zhibiao (尤智表) are the most excellent. (shrink)

Vision + Value Series. Gyorgy Kepes. Education of Vision. New York: Geo. Braziller, Inc., 1965, pp. 233 + vii. Structure in Art and Science. New York: Geo. Braziller, Inc., 1965, pp. 189 + vii. The Nature of Art and Motion.

This paper introduces the thought of Pierre Teilhard de Chardin from a perspective neglected until now: a view that builds on the analysis of his scientific papers. His scientific work formed part of the “modern synthesis” which laid the foundation of contemporary Darwinism. His main contributions in the field were the definition of a new branch of evolutionary sciences, geobiology; the redefinition of the term orthogenesis; and the proposal of the “scale” phyletic tree. Using these new research (...) concepts, Teilhard de Chardin attempted to solve, within a scientific framework, a problem fundamental for his philosophical synthesis: that of evolutionary directionality. (shrink)

The unified theory of dose and effect, as indicated by the median-effect equation for single and multiple entities and for the first and higher order kinetic/dynamic, has been established by T.C. Chou and it is based on the physical/chemical principle of the massaction law (J. Theor. Biol. 59: 253-276, 1976 (質量作用中效定理) and Pharmacological Rev. 58: 621-681, 2006) (普世中效指數定理). The theory was developed by the principle of mathematical induction and deduction (數學演繹歸納法). Rearrangements of the median-effect equation lead to Michaelis-Menten, Hill, Scatchard, (...) and Henderson-Hasselbalch equations. The “median” serves as the universal reference point and the “common link” for the relationship of all entities and is also the “harmonic mean” of kinetic dissociation constants. Over 300 mechanism-specific equations have been derived and published using the mathematical induction-deduction process. These equations can be deduced into several general equations, including the median-mediated whole/part equation, combination index theorem, isobologram equation, and polygonogram. It is proven that “dose” and “effect” are interchangeable, thus, “substance” and “function” are interchangeable, which leads to “the unity theory” (劑效、心物、知行一元論) in quantitative mathematical philosophy (數學的定量哲學) in functional context. Therefore, a general theory centered on the “median” and based on equilibrium dynamics has evolved. In other words: [「中」的宇宙觀： 以「中」爲基凖的動力學生態平衡]. Based on the median-effect equation of the mass-action law, the fundamental claim is that we can draw “a specific cure” for only two data points, if they are determined accurately. This claim has far reaching consequences since it defies the general held belief that two points can dray only a straight line. Remarkably, the unity theory (一元論) providesscientific/mathematical interpretation in equations and in graphics of Chinese ancient philosophy, including Fu-Si Ba Gua (伏羲八卦), Dao’s Harmony (和諧), the Confucian doctrine of the mean (儒家中庸之道), Chou Dun-Yi’s (周敦頤, 1017-1073) From Wu-ji to Tai-ji and Taiji Tu Sho (無極而太極及太極圖說). The moderntopological analysis for trinity yields an exact correspondence to the Ba-Gua, which was introduced over 4,000 years ago. Furthermore, the median-centered algorithm, promotes modern ecological content (生態學) in the equilibral dynamic state of harmony. It is concluded that Western science and Eastern philosophy are directly linked and complementary to each other. Since the truth in mathematical quantitative philosophy (數學的定量哲學) has no boundaries, East and West philosophies can flourish together for the common goal and ideal in science and in humanity (世界大同). (shrink)

Abstract.There is ample evidence that humans (and other primates) possess a knowledge instinct—a biologically driven impulse to make coherent sense of the world at the highest level possible. Yet behavioral decision‐making data suggest a contrary biological drive to minimize cognitive effort by solving problems using simplifying heuristics. Individuals differ, and the same person varies over time, in the strength of the knowledge instinct. Neuroimaging studies suggest which brain regions might mediate the balance between knowledge expansion and heuristic simplification. One region (...) implicated in primary emotional experience is more activated in individuals who use primitive heuristics, whereas two areas of the cortex are more activated in individuals with a strong knowledge drive: one region implicated in detecting risk or conflict and another implicated in generating creative ideas. Knowledge maximization and effort minimization are both evolutionary adaptations, and both are valuable in different contexts. Effort minimization helps us make minor and routine decisions efficiently, whereas knowledge maximization connects us to the beautiful, to the sublime, and to our highest aspirations. We relate the opposition between the knowledge instinct and heuristics to the biblical story of the fall, and argue that the causal scientific worldview is mathematically equivalent to teleological arguments from final causes. Elements of a scientific program are formulated to address unresolved issues. (shrink)

This paper argues that Gadamer's hermeneutics offers a methodological perspective for social and political theory that overcomes the impasse created by the dichotomy between the positivist and humanist approaches to social action. Both the positivists’attempt to replace the actors’subjective concepts with the objective concepts of the social scientist and the humanists’attempt to describe meaningful action strictly in the social actors’terms have been called into question in contemporary discussions. Gadamer's approach, which is based on the hermeneutical method of textual interpretation, offers (...) an alternative to both the positivist and humanist perspectives. Gadamer argues that understanding a text involves the fusing of the conceptual schemes of author and interpreter. Relying on Ricoeur's analysis of the parallels between actions and texts, it is argued that this understanding of the process of textual interpretation can be profitably applied to the analysis of social action. This application, furthermore, provides a means of analyzing social action that transcends the dichotomy between the positivist and humanist approaches. Gadamer's approach legitimizes the imposition of the observer's conceptual scheme without denying the constitutive role of the social actors’concepts. (shrink)

The present paper is concerned with the question of whether scientific conceptual analysis provides better justification than armchair conceptual analysis. In order to address this question, I provide exact definitions of armchair conceptual analysis and scientific conceptual analysis. Furthermore, I use a certain criticism of armchair conceptual analysis, raised by experimental philosophers, as a basis for an argument to the conclusion that scientific conceptual analysis provides better justification than armchair conceptual (...) class='Hi'>analysis, and consider the expertise defence as a possible response to this argument. The argument is based on the idea that the concept of a common usage implies a certain degree of uniformity among different speakers, and can be called ‘argument from uniformity of agreement’. The expertise defence can be understood as an attack of one of the premises of this argument. Finally, I present and discuss the results from an empirical study in which scientific conceptual analysis was used in order to gather evidence as regards the soundness of the argument from uniformity of agreement and the expertise defence. (shrink)

Although science was once seen as the product of individual great men working in isolation, we now realize that, like any other creative activity, science is a highly social enterprise, influenced in subtle as well as obvious ways by the wider culture and values of its time. Scientific Knowledge is the first introduction to social studies of scientific knowledge. The authors, all noted for their contributions to science studies, have organized this book so that each chapter examines a (...) key step in the process of doing science. Using case studies from cognitive science, physics, and biology to illustrate their descriptions and applications of the social study of science, they show how this approach provides a crucial perspective on how science is actually done. Scientific Knowledge will be of interest not only to those engaged in science studies, but also to anyone interested in the practice of science. (shrink)

There is ample evidence that humans (and other primates) possess a knowledge instinct—a biologically driven impulse to make coherent sense of the world at the highest level possible. Yet behavioral decision-making data suggest a contrary biological drive to minimize cognitive effort by solving problems using simplifying heuristics. Individuals differ, and the same person varies over time, in the strength of the knowledge instinct. Neuroimaging studies suggest which brain regions might mediate the balance between knowledge expansion and heuristic simplification. One region (...) implicated in primary emotional experience is more activated in individuals who use primitive heuristics, whereas two areas of the cortex are more activated in individuals with a strong knowledge drive: one region implicated in detecting risk or conflict and another implicated in generating creative ideas. Knowledge maximization and effort minimization are both evolutionary adaptations, and both are valuable in different contexts. Effort minimization helps us make minor and routine decisions efficiently, whereas knowledge maximization connects us to the beautiful, to the sublime, and to our highest aspirations. We relate the opposition between the knowledge instinct and heuristics to the biblical story of the fall, and argue that the causal scientific worldview is mathematically equivalent to teleological arguments from final causes. Elements of a scientific program are formulated to address unresolved issues. (shrink)

Scientists use a variety of modes of representation in their work, but philosophers have studied mainly sentences expressing propositions. I ask whether diagrams are mere conveniences in expressing propositions or whether they are a distinct, ineliminable mode of representation in scientific texts. The case of path analysis, a statistical method for quantitatively assessing the relative degree of causal determination of variation as expressed in a causal path diagram, is discussed. Path analysis presents a worst case for arguments (...) against eliminability since path diagrams are usually presumed to be mathematically or logically “equivalent” in an important sense to sets of linear path equations. I argue that path diagrams are strongly generative, i.e., that they add analytical power to path analysis beyond what is supplied by linear equations, and therefore that they are ineliminable in a strong scientific sense. (shrink)

First published in 2000. Routledge is an imprint of Taylor & Francis, an informa company.

We describe the ongoing citations to biomedical articles affected by scientific misconduct, and characterize the papers that cite these affected articles. The citations to 102 articles named in official findings of scientific misconduct during the period of 1993 and 2001 were identified through the Institute for Scientific Information Web of Science database. Using a stratified random sampling strategy, we performed a content analysis of 603 of the 5,393 citing papers to identify indications of awareness that the (...) cited articles affected by scientific misconduct had validity issues, and to examine how the citing papers referred to the affected articles. Fewer than 5% of citing papers indicated any awareness that the cited article was retracted or named in a finding of misconduct. We also tested the hypothesis that affected articles would have fewer citations than a comparison sample; this was not supported. Most articles affected by misconduct were published in basic science journals, and we found little cause for concern that such articles may have affected clinical equipoise or clinical care. (shrink)

First published in 2000. Routledge is an imprint of Taylor & Francis, an informa company.

First published in 2000. Routledge is an imprint of Taylor & Francis, an informa company.

Ethical debate about the use of animals in science is argued within different ethical frameworks; mainly utilitarianism, deontology, relativism or emotional ethics, with some debaters preferring particular frameworks. Stakeholders to the debate are veterinarians, scientists using animals, animal welfare groups and the general public. To estimate the balance of ethical frameworks used, we ran a discourse analysis of written texts by each stakeholder . The discourse analysis targeted the description of animals, instances of emotional language and language associated (...) with utilitarianism, deontology and relativism. Frequencies were compared using ANOVAs and Tukey tests. All stakeholders used words associated with all frameworks but emotional language was the most used followed by utilitarian , relativist and deontological language. Emotional language was used in texts from the general public more than in texts from veterinarians and scientists and animal welfare representatives . Animals were mainly described in a utilitarian way , more frequently by scientists than the general public . All stakeholders preferentially used negative emotional language when referring to animals than positive , and all stakeholders prioritised human interests over animals . Not surprisingly, a mixture of ethical frameworks were used to assess the ethics of animal experimentation. However, the language used in texts from animal welfare groups and the general public suggest that those two groups preferentially build arguments with emotion rather than utilitarianism, a framework that is privileged by veterinarians and scientists since they primarily use animals. (shrink)

The benzodiazepines can produce a wide variety of abnormal mental responses and hazardous behavioral abnormalities, including rebound anxiety and insomnia, mania and other forms of psychosis, paranoia, violence, antisocial acts, depression, and suicide. These drugs can impair cognition, especially memory, and can result in confusion. They can induce dependence and addiction. Severe withdrawal syndromes with psychosis, seizures, and death can develop. The short-acting benzodiazepines, alprazolam and triazolam , are especially prone to cause psychological and behavioral abnormalities. The sources of data (...) to support these observations and conclusions are discussed in regard to the scientific method. These adverse drug effects can wreck havoc in the lives of individuals and their families. (shrink)

Wakefield's (2000) responses to our paper herein (Murphy and Woolfolk 2000) are not only unsuccessful, they force him into a position that leaves him unable to preserve any distinction between disorders and other problems. They also conflate distinct scientific concepts of function. Further, Wakefield fails to show that ascriptions of human dysfunction do not ineliminably involve values. -/- We suggest Wakefield is analyzing a concept that plays a role in commonsense thought and arguing that the task of science is (...) to identify the natural processes that accord with that commonsense concept. We argue that this represents an attempt to use conceptual analysis to legislate what should be acceptable science. We conclude that this constraint on science is unacceptable and that therefore Wakefield's overall position should be rejected. (shrink)

Loop analysis is a method of qualitative modeling anticipated by Sewall Wright and systematically developed by Richard Levins. In Levins’ (1966) distinctions between modeling strategies, loop analysis sacrifices precision for generality and realism. Besides criticizing the clarity of these distinctions, Orzack and Sober (1993) argued qualitative modeling is conceptually and methodologically problematic. Loop analysis of the stability of ecological communities shows this criticism is unjustified. It presupposes an overly narrow view of qualitative modeling and underestimates the broad (...) role models play in scientific research, especially in helping scientists represent and understand complex systems. (shrink)

This paper uses Pierre Bourdieu’s field theory to develop tools for analyzing interdisciplinary scientific fields. Interdisciplinary fields are scientific spaces where no single form of scientific capital has a monopoly and therefore multiple forms of scientific capital constitute the structures and stakes of scientific competition. Scientists compete to accumulate and define forms of scientific capital and also to set the rates of exchange between them. The paper illustrates this framework by applying it to the (...) interdisciplinary field of behavior genetics. Most behavior geneticists envision their participation in the field as a means to compete for scientific capital in other fields. However, the scientific capital of behavior genetics has different values for scientists attempting to deploy it in different neighboring fields. These values depend on situations in each field and the ways behavior genetics mediates relationships among them. The pattern of relationships of exchange helps explain the social hierarchy and several features of knowledge production within behavior genetics. (shrink)

The author contends that analysis is dependent on the criteria of "the scientific world-View." otherwise, There would be "no basis for excluding analyses which were simply precise formulations of unverifiable realms of being.".

Developing World Bioethics, Volume 22, Issue 3, Page 126-139, September 2022.

Representation of scientific knowledge in ontologies suffers so often from the lack of computational knowledge required for inference. This article aims to perform quantitative analysis on physical systems, that is, to answer questions about values of quantitative state variables of a physical system with known structure. For this objective, we incorporate procedural knowledge on two distinct levels. At the domain-specific level, we propose a representation model for scientific knowledge, i.e. variables, theories, and laws of nature. At the (...) domain-independent level, we provide an algorithm which, given a system S with known structure and a relevant scientific theory T, extracts a constraint network, whose variables are state variables of S defined by T, and whose constraints raise from relevant laws in T. The constraint network is then solved, to build a system of equations whose unknowns are the output variables of S. The proposed representation model and reasoning algorithm are evaluated by applying them to classic analysis examples. (shrink)

Ethics in research became a central theme regarding globalization of the scientific development, particularly when related to the socioeconomic conditions of the countries involved as partners in research protocols, production of inputs and of knowledge. The objective of this paper is to analyze the sources of information about ethics in research present at Scientific Electronic Library Online. Methodologically, this is an exploratory study was carried out by the systematic analysis of the literature available. The search engines retrieved (...) 885 summaries, from which 170 were analyzed. The first publication was dated from 1996 and it could be identified the mention to international documents about research in humans. Since 2002 there has been an increase of publications related to the gain of legitimacy of the topic in academy. As a conclusion, although the amount is not huge, the manuscripts presented great impact as they stimulated debates and produced scientific knowledge on the topic. It can be observed that ethics in research has outcome the biomedical field, being inserted in other fields of knowledge. (shrink)

ArgumentIn the United States, scientific knowledge is brought before the courts by way of testimony – the testimony of scientific experts. We argue that this expertise is best understoodfirstas related to the quality of the underlying scienceand thenin terms of who delivers it. Bloodstain pattern analysis (BPA), a contemporary forensic science, serves as the vaulting point for our exploration of objectivity as a metric for the quality of a science in judicial contexts. We argue that BPA fails (...) to meet the minimal standard set by Helen Longino’s social-procedural account of objectivity (1990, 2002). In light of some pressing issues for social-procedural accounts, we offer an infrastructural account of objectivity. This account offers what amounts to a friendly amendment to Longino’s account and adds to the ways in which we might analyze social-procedural objectivity. Finally, we address an issue that is pressing in the legal context: given that scientific knowledge is delivered by individuals, not communities, at least in U.S. courts, we (may) need a way to evaluate individual scientific and epistemic agents. We suggest a means for making this evaluation that is derived from our infrastructural account of objectivity. (shrink)

Papers on nanotechnology in the Scientific Electronic Library Online database were studied bibliometrically. The terms ‘nanotechnology’, ‘nanoparticle’, ‘graphene’, ‘fullerene’, ‘nanotube’ and ‘quantum dot’ were used for the search in their singular and plural forms in three languages, and a total of 1205 papers were selected for the study to assess the frequency rates of the study variables. The results of the study are presented in this article focusing on gender differences.

In this paper, we examine how a research institution’s social structure and academic opinion leaders’ presence shaped the early adoption of a scientific innovation. Our case considers the early engagement of mathematical economists at the Cowles Commission with John von Neumann and Oskar Morgenstern’s Theory of Games and Economic Behavior. We argue that scholars with administrative leadership functions who were not only scientifically but also organizationally central – in our case the director of research Jacob Marschak – played a (...) crucial role in promoting the adoption of the Theory of Games. We support our argument with a scientometric analysis of all acknowledgments made in 488 papers published from 1944 to 1955 in the two main paper series at Cowles. We apply blockmodeling techniques to the acknowledgments network to reconstruct the formal and informal social structure at Cowles at the time. Our findings suggest that studies of the early adoption of scientific theories benefit from complementary perspectives on the role of academic leaders and scientists. Our study reveals the importance of formal and informal social structures and the agenda of administrative leaders in these structures to explain their adoption. (shrink)