In The Conditions for Ethical Chemical Restraint, Crutchfield and Redinger (2024) propose ethical standards for the use of chemical restraints, which they consider normatively distinct from physica...

In this article, the insertion of a two-staged highly interesting question in an online, survey-based field experiment is shown to produce better survey completion rate (i.e., decreases completion refusal by 8%) and sample representativeness (increases the number of moderate answer patterns by 12%) than a typical (same) highly interesting question at the beginning of a survey only. Using nonparametric tests and subgroup probability analysis, measured effects include survey completion rates, response bias and reported demographic differences. In regards to sample representativeness, (...) the results also raise questions about the sensitivity of the conventional practice of comparing early to late respondent means scores as a method of investigating nonresponse bias in marketing research. Alternative approaches to measuring potential non-response bias are compared with the tradition of comparing early-wave verses late-wave mean respondent differences. The results indicate that the conventional mean test fails to identify differences in nonresponse bias; the scores of highly interested or opposed respondents in the first waves produce equivalent means to the scores of the less interested or opposed respondents in the latter wave between the surveys (e.g., 1's and 5's vs. 2's and 4's, both averaging to 3's) that are identifiable through kurtosis and probability analysis. (shrink)

BackgroundDeep brain stimulation is approved for treating refractory obsessive-compulsive disorder in adults under the US Food and Drug Administration Humanitarian Device Exemption, and studies hav...

In ‘Reification and Assent in Research Involving Those Who Lack Capacity’, Smajdor argues that adults with impaired capacity to grant informed consent (AWIC) are often excluded from participating in biomedical research because they cannot provide informed consent, leading to decreased chances AWIC will benefit from such research. Smajdor uses Honneth’s concept of reification to propose that securing assent (rather than consent) in cases involving AWIC offers patients moral recognition that is not tied to their capacities. Assent provides this recognition by (...) including the patient in a shared moral sphere, highlighting her agency and worth without reducing her to her incapacity or a thing-to-be-managed. Assent also avoids grounding in, or a reliance on, the future development of autonomy (pp.5–6).1 Our recent research on patient and caregiver perspectives of potential paediatric deep brain stimulation (pDBS) for refractory obsessive–compulsive disorder (OCD) and dystonia demonstrates that paediatric neurosurgery patients desire the kind of recognition Smajdor associates with assent, and their caregivers largely agree.2 3 Since (generally) paediatric patients in the USA are unable to grant informed consent, their caregivers must provide it instead. This raises the question of how to properly integrate paediatric patients into the DBS decision-making process. One dimension along which this is evident is that …. (shrink)

In ‘Patients, doctors and risk attitudes,’ Makins argues that, when physicians must decide for, or act on behalf of, their patients they should defer to patient risk attitudes for many of the same reasons they defer to patient values, although with a caveat: physicians should defer to the higher-order desires of patients when considering their risk attitudes. This modification of what Makins terms the ‘deference principle’ is primarily driven by potential counterexamples in which a patient has a first-order desire with (...) one risk attitude (either risk-seeking or averse) and a second-order desire that this risk attitude not be effective in guiding their choices.1 There are two reasons we might think people with obsessive–compulsive disorder (OCD) are particularly relevant patients for evaluating Makins’ proposal. Not only might their first-order risk attitudes be irrational, but many people with OCD also judge their own OCD behaviours to be excessive or unwarranted making them structurally similar to the counterexamples outlined above. Yet, I argue that recent research about risk and decision-making under uncertainty for those with OCD complicates Makins’ proposal by raising questions of whether and to what degree their risk attitudes are irrational such that they should not play a part in the surrogate decisions made by physicians. This places more …. (shrink)

The ongoing debate within neuroethics concerning the degree to which neuromodulation such as deep brain stimulation (DBS) changes the personality, identity, and agency (PIA) of patients has paid relatively little attention to the perspectives of prospective patients. Even less attention has been given to pediatric populations. To understand patients’ views about identity changes due to DBS in obsessive-compulsive disorder (OCD), the authors conducted and analyzed semistructured interviews with adolescent patients with OCD and their parents/caregivers. Patients were asked about projected impacts (...) to PIA generally due to DBS. All patient respondents and half of caregivers reported that DBS would impact patient self-identity in significant ways. For example, many patients expressed how DBS could positively impact identity by allowing them to explore their identities free from OCD. Others voiced concerns that DBS-related resolution of OCD might negatively impact patient agency and authenticity. Half of patients expressed that DBS may positively facilitate social access through relieving symptoms, while half indicated that DBS could increase social stigma. These views give insights into how to approach decision-making and informed consent if DBS for OCD becomes available for adolescents. They also offer insights into adolescent experiences of disability identity and “normalcy” in the context of OCD. (shrink)

Political corruption imposes substantial costs on shareholders in the U.S. Yet, we understand little about the basic factors that exacerbate or mitigate the value consequences of political corruption. Using federal corruption convictions data, we find that firm-level economic rents and monitoring mechanisms moderate the negative relation between corruption and firm value. The value consequences of political corruption are exacerbated for firms operating in low-rent product markets and mitigated for firms subject to external monitoring by state governments or monitoring induced by (...) disclosure transparency. Our results should inform managers and policymakers of the tradeoffs imposed on firms operating in politically corrupt districts. (shrink)

In “Revive and Refuse: Capacity, Autonomy, and Refusal of Care After Opioid Overdose”, Marshall, Derse, Weiner, and Joseph contend that patients who may appear to satisfy the standard criteria for...

Rapid advancements in artificial intelligence and machine learning (AI/ML) in healthcare raise pressing questions about how much users should trust AI/ML systems, particularly for high stakes clinical decision-making. Ensuring that user trust is properly calibrated to a tool’s computational capacities and limitations has both practical and ethical implications, given that overtrust or undertrust can influence over-reliance or under-reliance on algorithmic tools, with significant implications for patient safety and health outcomes. It is, thus, important to better understand how variability in trust (...) criteria across stakeholders, settings, tools and use cases may influence approaches to using AI/ML tools in real settings. As part of a 5-year, multi-institutional Agency for Health Care Research and Quality-funded study, we identify trust criteria for a survival prediction algorithm intended to support clinical decision-making for left ventricular assist device therapy, using semistructured interviews (n=40) with patients and physicians, analysed via thematic analysis. Findings suggest that physicians and patients share similar empirical considerations for trust, which were primarilyepistemicin nature, focused on accuracy and validity of AI/ML estimates. Trust evaluations considered the nature, integrity and relevance of training data rather than the computational nature of algorithms themselves, suggesting a need to distinguish ‘source’ from ‘functional’ explainability. To a lesser extent, trust criteria were also relational (endorsement from others) and sometimes based on personal beliefs and experience. We discuss implications for promoting appropriate and responsible trust calibration for clinical decision-making use AI/ML. (shrink)

In their paper, “Conversational Artificial Intelligence in Psychotherapy: A New Therapeutic Tool or Agent?” Sedlakova and Trachsel (2023) claim that therapeutic insights and therapeutic changes are...

The paper presents a comprehensive solution to the new riddle of induction. Gruesome induction is blocked because “grue” is not independent of our sampling and observation methods. Before presenting my theory, I critically survey previous versions of what I call the “independence strategy”, tracing the strategy to three different papers from the 1970s by (respectively) Wilkerson, Moreland, and Jackson. Next I critically examine recent approaches by Okasha, Godfrey-Smith, Schramm, and Freitag. All of these approaches have their virtues, but none (...) of them rules out every problem case. Nor do any of them alone explain exactly what goes wrong in all types of gruesome reasoning. My account aims to do both. Learning lessons from my criticisms of previous theories, I argue that there are several crucial types of independence. All of them are needed to rule out every problem case. I close by suggesting that the independence solution can also be adopted by proponents of other approaches—Bayesians, fans of natural kinds, and pragmatists. (shrink)

The legacy of deconstruction continues to loom large, not least in the field of continental philosophy of religion.

Distinguishing “business” concerns from “ethical” values is not only an unfruitful and meaningless task, it is also an impossible endeavor. Nevertheless, fruitless attempts to separate facts from values produce detrimental second-order effects, both for theory and practice, and should therefore be abandoned. We highlight examples of exemplary research that integrate economic and moral considerations, and point the way to a business ethics discipline that breaks new ground by putting ideas and narratives about businesstogetherwith ideas and narratives about ethics.

Abstract:Ecofeminism refers to a broad range philosophical and political movements that call attention to the link between social oppression and environmental destruction. Despite their relevance and potential theoretical and practical utility, ecofeminisms are largely absent from extant approaches to environmental governance (E-Governance). In addition to calling attention to the absence of ecofeminist voices in this arena, this paper explores the consequences of said exclusion and assesses the potential for ecofeminism to inform and ultimately improve E-Governance initiatives. I find that E-Governance (...) research often disregards or fails to explicitly acknowledge and incorporate the inseparable and mutually reinforcing nature of social and environmental forms of domination and oppression. The consequences of this are twofold. First, many extant approaches forgo any opportunity to leverage the resolution of social inequities as a potential mechanism for reducing environmental harm. Second, initiatives that appear to be equity-driven often emerge as paternalistic and perpetuate the marginalization of oppressed groups. Accordingly, I develop and apply a novel collection of ecofeminist-informed design principles for evaluating, informing, and improving existing E-Governance initiatives. Ultimately, this paper yields fresh insight into the way ecofeminist voices can help researchers, communities, and societies transform how they think about societal interactions with the environment and equips E-Governance with the capacity to challenge social and environmental exploitation simultaneously. (shrink)

Conceptual engineers have recently turned to the notion of conceptual functions to do a variety of explanatory work. Functions are supposed to explain what speakers are debating about in metalinguistic negotiations, to capture when two concepts are about the same thing, and to help guide our normative inquiries into which concepts we should use. In this paper, I argue that this recent “functional turn” should be deflated. Contra most interpreters, we should not try to use a substantive notion of conceptual (...) functions to handle various problems for conceptual engineering. The primary accounts of function appealed to by conceptual engineers, namely etiological and system functions, are not suited to handle many of the problems functions are supposed to handle, and it’s dubious whether any other account of function would do better. Instead of trying to use substantive functions to solve theoretical problems, we should deflate those problems themselves by focusing only on what matters to us, as speakers or theorists, in a given inquiry. (shrink)

Conceptual engineers sometimes say they want to change what our words mean. If a certain kind of externalism is true, it might be nearly impossible to do that. For some of the external factors that determine meaning, like metaphysical naturalness or past usage, are not within our power to change. And if we can’t change what determines meaning, then we can’t change meaning. I argue that, if this sort of externalism is true, then conceptual engineers didn’t want to change what (...) our words mean anyway. And if they did, they could always engineer externalism out of the language, or engineer a new sense of ‘meaning’ which could be changed. So the truth of externalism does not pose a threat to the possibility of conceptual engineering. (shrink)

Putting feelings into words, or “affect labeling,” can attenuate our emotional experiences. However, unlike explicit emotion regulation techniques, affect labeling may not even feel like a regulatory process as it occurs. Nevertheless, research investigating affect labeling has found it produces a pattern of effects like those seen during explicit emotion regulation, suggesting affect labeling is a form of implicit emotion regulation. In this review, we will outline research on affect labeling, comparing it to reappraisal, a form of explicit emotion regulation, (...) along four major domains of effects—experiential, autonomic, neural, and behavioral—that establish it as a form of implicit emotion regulation. This review will then speculate on possible mechanisms driving affect labeling effects and other remaining unanswered questions. (shrink)

Once upon a time, logical conventionalism was the most popular philosophical theory of logic. It was heavily favored by empiricists, logical positivists, and naturalists. According to logical conventionalism, linguistic conventions explain logical truth, validity, and modality. And conventions themselves are merely syntactic rules of language use, including inference rules. Logical conventionalism promised to eliminate mystery from the philosophy of logic by showing that both the metaphysics and epistemology of logic fit into a scientific picture of reality. For naturalists of all (...) stripes, this was paradise. Alas, paradise was lost. By the end of the twentieth century, logical conventionalism had been almost universally abandoned. But more recently, it has been revitalized. This chapter provides an overview of logical conventionalism and its history, clears away misunderstandings, and briefly responds to both the canonical objections to conventionalism (from Quine, Dummett, Boghossian, and many others) as well as new objections (from Field and Golan). From paradise lost, to paradise regained: logical conventionalism is back. (shrink)

In recent years, direct brain interventions have shown increased success in manipulating neurobiological processes often associated with moral reasoning and decision-making. As current DBIs are refined, and new technologies are developed, the state will have an interest in administering DBIs to criminal offenders for rehabilitative purposes. However, it is generally assumed that the state is not justified in directly intruding in an offender’s brain without valid consent. Thomas Douglas challenges this view. The state already forces criminal offenders to go to (...) jail without their consent. This represents a serious interference with an offender’s rights. If criminal offenders are already morally liable to incarceration, why is the state not also entitled to administer DBIs without consent for the purposes of rehabilitation? Douglas argument focuses on the right to ‘bodily integrity’. He argues that there is no compelling reason to believe that bodily rights that protect an offender from non-consensual DBIs are stronger than rights that protect an offender from incarceration. This paper will extend Douglas’ analysis. It will consider the more fundamental right to ‘mental integrity’. The right to mental integrity defends an inner sphere of liberty. It protects critical capacities necessary for the exercise of autonomous human agency—without which a vast majority of moral rights could not exist. Thus, the right to mental integrity is ultimately more important for a moral assessment of DBIs. The right strongly suggests that both presently, and in the future, there may be many cases in which the state is not entitled to administer DBIs to criminal offenders without valid consent. (shrink)

Søren Kierkegaard is well-known as an original philosophical thinker, but less known is his reliance upon and development of the Christian tradition of the Seven Deadly Sins, in particular the vice of acedia, or sloth. As acedia has enjoyed renewed interest in the past century or so, commentators have attempted to pin down one or another Kierkegaardian concept (e.g., despair, heavy-mindedness, boredom, etc.) as the embodiment of the vice, but these attempts have yet to achieve any consensus. In our estimation, (...) the complicated reality is that, in using slightly different but related concepts, Kierkegaard is providing a unique look at acedia as it manifests differently at different stages on life’s way. Thus, on this “perspectival account”, acedia will manifest differently according to whether an individual inhabits the aesthetic, ethical, or religious sphere. We propose two axes for this perspectival account. Such descriptions of how acedia manifests make up the first, phenomenal axis, while the second, evaluative axis, accounts for the various bits of advice and wisdom we read in the diagnoses of acedia from one Kierkegaardian pseudonym to another. Our aim is to show that Kierkegaard was not only familiar with the concept of acedia, but his contributions helped to develop and extend the tradition. (shrink)

How (Not) to Be Secular is what Jamie Smith calls "your hitchhiker's guide to the present" -- it is both a reading guide to Charles Taylor's monumental work A Secular Age and philosophical guidance on how we might learn to live in our times. Taylor's landmark book A Secular Age (2007) provides a monumental, incisive analysis of what it means to live in the post-Christian present -- a pluralist world of competing beliefs and growing unbelief. Jamie Smith's book (...) is a compact field guide to Taylor's insightful study of the secular, making that very significant but daunting work accessible to a wide array of readers. Even more, though, Smith's How (Not) to Be Secular is a practical philosophical guidebook, a kind of how-to manual on how to live in our secular age. It ultimately offers us an adventure in self-understanding and maps out a way to get our bearings in today's secular culture, no matter who "we" are -- whether believers or skeptics, devout or doubting, self-assured or puzzled and confused. This is a book for any thinking person to chew on. (shrink)

The author discusses some difficulties involved in the application of "degree of confirmation" to the confirmation of lawlike-statements. An alternative analysis is proposed, which is based on interval estimation. It is argued that this analysis is superior to the criticized method, in that it is better able to show how instantial confirmations are inductively relevant to a law, and in that it requires fewer undesirable extra-logical assumptions.

Este ensayo examina la relacionalidad y representación del pueblo nicaragüense y la naturaleza a través de los marcos de la precariedad y la ecocrítica. El documental Palabras mágicas (para romper un encantamiento) (2012) de Mercedes Moncada presenta la tierra como una extensión del yo, primero, como una alegoría del país, de la revolución y del individuo y, segundo, por la contingencia y la vulnerabilidad del medio ambiente y el pueblo nicaragüense. Tanto los nicaragüenses como la naturaleza son víctimas de un (...) sistema político que se repite a lo largo de los siglos XX y XXI. A partir de la corporalidad o la materialidad, el documental establece un vínculo entre la tierra y el sujeto nicaragüense a través de la discursividad, ambos como sitios de inscripciones que se someten a relaciones de poder, un hecho que precariza a los dos. Palabras mágicas (2012) propone que el pueblo y el medio ambiente nicaragüense son víctimas del somocismo del siglo XX y el neosandismo de Ortega en el siglo XXI. Por último, a partir del vínculo metafórico entre la naturaleza y el pueblo nicaragüense, uno de los resultados es encuadrar el medio ambiente dentro de un marco de precariedad y vulnerabilidad, destacando la dependencia y contingencia entre seres humanos y él. (shrink)

Prologue, invitation to thinking about God In the Hebrew Bible? -- Part I, questions about God? -- Why does God in the Bible have a body? -- What do God's body parts in the Bible mean? -- Why is God angry in the Bible? -- Does God in the Bible have gender or sexuality? -- Part II, questions about God in the world? -- What can creation tell us about God? -- Who-or what-is the Satan? -- Why do people suffer (...) according to the Hebrew Bible? -- Epilogue, God in the Bible and beyond. (shrink)

The Descartes Dictionary is an accessible guide to the world of the seventeenth-century philosopher René Descartes. Meticulously researched and extensively cross-referenced, this unique book covers all his major works, ideas and influences, and provides a firm grounding in the central themes of Descartes' thought. The introduction provides a biographical sketch, a brief account of Descartes' philosophical works, and a summary of the current state of Cartesian studies, discussing trends in research over the past four decades. The A-Z entries include clear (...) definitions of the key terms used in Descartes' writings and detailed synopses of his works. Also included are entries noting philosophical influences, of both figures that influenced Descartes and those that he in turn influenced. For anyone reading or studying Descartes, rationalism, or modern philosophy more generally, this original resource provides a wealth of useful information, analysis, and criticism. Including clear explanations of often complex terminology, The Descartes Dictionary covers everything that is essential to a sound understanding of Descartes' philosophy. (shrink)

What is the source of logical and mathematical truth? This book revitalizes conventionalism as an answer to this question. Conventionalism takes logical and mathematical truth to have their source in linguistic conventions. This was an extremely popular view in the early 20th century, but it was never worked out in detail and is now almost universally rejected in mainstream philosophical circles. Shadows of Syntax is the first book-length treatment and defense of a combined conventionalist theory of logic and mathematics. It (...) argues that our conventions, in the form of syntactic rules of language use, are perfectly suited to explain the truth, necessity, and a priority of logical and mathematical claims, as well as our logical and mathematical knowledge. (shrink)

The study of defeasible reasoning unites epistemologists with those working in AI, in part, because both are interested in epistemic rationality. While it is traditionally thought to govern the formation and (with)holding of beliefs, epistemic rationality may also apply to the interrogative attitudes associated with our core epistemic practice of inquiry, such as wondering, investigating, and curiosity. Since generally intelligent systems should be capable of rational inquiry, AI researchers have a natural interest in the norms that govern interrogative attitudes. Following (...) its recent coinage, we use the term ``zetetic'' to refer to the properties and norms associated with the capacity to inquire. In this paper, we argue that zetetic norms can be modeled via defeasible inferences to and from questions---a.k.a erotetic inferences---in a manner similar to the way norms of epistemic rationality are represented by defeasible inference rules. We offer a sequent calculus that accommodates the unique features of ``erotetic defeat" and that exhibits the computational properties needed to inform the design of zetetic agents. The calculus presented here is an improved version of the one presented in Millson (2019), extended to cover a new class of defeasible erotetic inferences. (shrink)

This title presents a comprehensive guide to interpretative phenomenological analysis (IPA) which is an increasingly popular approach to qualitative inquiry taught to undergraduate and postgraduate students today.

In recent years, the e ffort to formalize erotetic inferences (i.e., inferences to and from questions) has become a central concern for those working in erotetic logic. However, few have sought to formulate a proof theory for these inferences. To fill this lacuna, we construct a calculus for (classes of) sequents that are sound and complete for two species of erotetic inferences studied by Inferential Erotetic Logic (IEL): erotetic evocation and regular erotetic implication. While an attempt has been made to (...) axiomatize the former in a sequent system, there is currently no proof theory for the latter. Moreover, the extant axiomatization of erotetic evocation fails to capture its defeasible character and provides no rules for introducing or eliminating question-forming operators. In contrast, our calculus encodes defeasibility conditions on sequents and provides rules governing the introduction and elimination of erotetic formulas. We demonstrate that an elimination theorem holds for a version of the cut rule that applies to both declarative and erotetic formulas and that the rules for the axiomatic account of question evocation in IEL are admissible in our system. (shrink)

This article suggests evidence for and reasons why prior acquisition may either facilitate or inhibit acquisition of a new construction. It investigates acquisition of the German passive and future constructions which contain a lexical verb with either the auxiliary sein “to be” or werden “to become”, and are related through these to potential supporting constructions. We predicted that a supported construction should be acquired earlier, faster, and unusually rapidly. An inhibited construction should show an extended depressed usage. We analyzed a (...) dense corpus of a German boy between 2;0 and 5;0. He acquired the sein- before the werden-passive. The former was supported by his prior acquisition of the sein copula, whereas the werden-passive itself supported one werden copula construction. He acquired the werden-future extremely slowly due to the hindrance of a semantically identical construction. These results fit with an emergentist approach in which apparently “sudden” acquisition is still due to gradual learning mechanisms. (shrink)

This paper explores the relationship between Toni Morrison’s 1987 novel, Beloved, and F. W. J. Schelling’s 1813 draft of Ages of the World (Die Weltalter). It shows that Die Weltalter, contrary to much recent scholarship, which often stresses the many ways Schelling anticipated the antimetaphysical trends of post-Hegelian thought, should be first approached as a genuine attempt tobe faithful to the event of first creation and time’s “indivisible remainders”. The paper will show that Schelling’s “indivisible remainders”, the forgotten and “disremembered” (...) of history, force his thought to the limits of Romantic and idealist reflection and toward the traumatic encounters of Beloved. Morrison’s depiction of the irrepressible longing for life and recognition amid the pain and ugliness of American slavery parallels Schelling’s efforts to understand the tremendous need for life and fellowship that first urged god toward creation, when primordial longing was overcome in a child and a god entered time. (shrink)

This paper explores the relationship between Toni Morrison’s 1987 novel, Beloved, and F. W. J. Schelling’s 1813 draft of Ages of the World (Die Weltalter). It shows that Die Weltalter, contrary to much recent scholarship, which often stresses the many ways Schelling anticipated the antimetaphysical trends of post-Hegelian thought, should be first approached as a genuine attempt tobe faithful to the event of first creation and time’s “indivisible remainders”. The paper will show that Schelling’s “indivisible remainders”, the forgotten and “disremembered” (...) of history, force his thought to the limits of Romantic and idealist reflection and toward the traumatic encounters of Beloved. Morrison’s depiction of the irrepressible longing for life and recognition amid the pain and ugliness of American slavery parallels Schelling’s efforts to understand the tremendous need for life and fellowship that first urged god toward creation, when primordial longing was overcome in a child and a god entered time. (shrink)

"This book integrates a thinking about dilemmas faced in the context of the clinical practice of psychoanalysis today, with contemporary social and political concerns specific to the age of the global consumer marketplace. Beginning with an analysis of the fate of the concept of sublimation in Freud’s work, and its relationship to the elaboration of the concept of the superego in 1923, the book examines how these concepts provide a lever for integrating psychoanalytic thinking with topics of urgent social concern, (...) beyond the critique of ideology. Taking up topics such as the experience of time, addiction to consumption, and the general consequences of the insinuation of digital technologies at increasingly earlier stages in human development-and thinking these through the lens of what the clinical practice of psychoanalysis teaches us about intimate human relatedness-the book addresses how a philosophically oriented approach to psychoanalysis can illuminate our response to the problems of everyday life under conditions of late capitalism. Drawing on a diverse range of authors such as Freud, Heidegger, Hans Loewald, Christopher Bollas, Lacan, Deleuze and Bernard Stiegler, it is argued that the concepts of sublimation and of the superego must be reinvented with regard to both clinical and critical discourse today if psychoanalysis is to remain relevant to the major issues we face, both individually and collectively, in the twenty-first century. The book stages a unique encounter between philosophy, critical theory and clinical practice that will be of interest to psychoanalysts, scholars of twentieth century Continental philosophy, critical social theorists and mental health practitioners"–. (shrink)

How should an acknowledgement of contingency affect our understanding of moral identity? The book considers various ways of thinking about this question in contemporary moral and political theory. Drawing on the work of Gadamer, Ricoeur, Taylor and others, it defends a realist but pluralist 'strong hermeneutic' view.

Motivation: There is an ongoing search for definitive and reliable biomarkers to forecast or predict imminent seizure onset, but to date most research has been limited to EEG with sampling rates <1,000 Hz. High-frequency oscillations have gained acceptance as an indicator of epileptic tissue, but few have investigated the temporal properties of HFOs or their potential role as a predictor in seizure prediction. Here we evaluate time-varying trends in preictal HFO rates as a potential biomarker of seizure prediction.Methods: HFOs were (...) identified for all interictal and preictal periods with a validated automated detector in 27 patients who underwent intracranial EEG monitoring. We used LASSO logistic regression with several features of the HFO rate to distinguish preictal from interictal periods in each individual. We then tested these models with held-out data and evaluated their performance with the area-under-the-curve of their receiver-operating curve. Finally, we assessed the significance of these results using non-parametric statistical tests.Results: There was variability in the ability of HFOs to discern preictal from interictal states across our cohort. We identified a subset of 10 patients in whom the presence of the preictal state could be successfully predicted better than chance. For some of these individuals, average AUC in the held-out data reached higher than 0.80, which suggests that HFO rates can significantly differentiate preictal and interictal periods for certain patients.Significance: These findings show that temporal trends in HFO rate can predict the preictal state better than random chance in some individuals. Such promising results indicate that future prediction efforts would benefit from the inclusion of high-frequency information in their predictive models and technological architecture. (shrink)

One argument for reductive physicalism, the explanatory argument, rests on its ability to explain the vast and growing body of acknowledged psychophysical correlations. Jaegwon Kim has recently levelled four objections against the explanatory argument. I assess all of Kim's objections, showing that none is successful. The result is a defence of the explanatory argument for physicalism.

I broadly explore the question by examining several common criticisms of CEO pay through both philosophical and empirical lenses. While some criticisms appear to be unfounded, the analysis shows not only that current compensation practices are problematic both from the standpoint of distributive justice and fairness, but also that incentive pay ultimately exacerbates the very agency problem it is purported to solve.