To show how the case of Mary Shelley’s Victor Frankenstein brings light to the ethical and moral issues raised in Institutional Review Board protocols, we nest an imaginary IRB proposal dated August 1790 by Victor Frankenstein within a discussion of the importance and function of the IRB. Considering the world of science as would have appeared in 1790 when Victor was a student at Ingolstadt, we offer a schematic overview of a fecund moment when advances in comparative anatomy, medical experimentation (...) and theories of life involving animalcules and animal electricity sparked intensive debates about the basic principles of life and the relationship between body and soul. Constructing an IRB application based upon myriad speculations circulating up to 1790, we imagine how Victor would have drawn upon his contemporaries’ scientific work to justify the feasibility of his project, as well as how he might have outlined the ethical implications of his plan to animate life from “dead” tissues. In Mary Shelley’s Frankenstein, Victor failed to consider his creature’s autonomy, vulnerability, and welfare. In this IRB proposal, we show Victor facing those issues of justice and emphasize how the novel can be an important component in courses or workshops on research ethics. Had Victor Frankenstein had to submit an IRB proposal tragedy may have been averted, for he would have been compelled to consider the consequences of his experiment and acknowledge, if not fulfill, his concomitant responsibilities to the creature that he abandoned and left to fend for itself. (shrink)

Therapists and their patients must deal with the negative sequelae of short term mating strategies. Implications for therapy of Gangestad & Simpson's strategic pluralism theory are compared with those of Buss's sexual strategies theory and Eagly's social role theory. Naive theories held by therapists and patients, as well as prevailing societal views, are posited as influential in determining the course and outcome of therapy.

Lev Vygotsky's research presented individual men tal processes as being determined by one's historically developed activity, both on a physical level (through labor) and on a mental level (through the use of psychological tools). In this study, the author reviews the translated research of Vygotsky and compares his use of the term psychological tools with research in the areas of metaphors and semiotics. Could these semiotic psychological tools be included in media sound bites and computer software to facilitate and enhance (...) learning? Because the author's research interests are in the area of instructional technology, the intention is to explore psychological theories, such as those of Vygotsky, to see how instructional technologists might use these theories. The ideal would be to incorporate theories into their design and create innovative technology programs that affect learning positively both in the United States and in other countries and cultures. (shrink)

This article takes a fresh look at the Ardeners' muted group theory, originally applied in social anthropology and later taken up by the women's movement. The theory has wider applicability in aiding understanding of the communication processes between females and males but there is a need for a combination of disparate types of research extending the focus beyond mutedness as a structural product to the processes by which women are rendered mute, involving a broader analysis of the political, economic and (...) organizational context. The communications research arena is envisaged as one in which further work could be carried out. (shrink)

Women’s embodied memories of “Dangerous Breasts”, generated as part of a wider collective memory project on women’s breasts, Iconstruct women as always at risk of our bodies turning against us. We trace through memory stories how we inscribe our bodies as “dangerous” through practices involving silence, fear, surveillance and diagnosis. We examine how regimes directed at the prevention and treatment of breast cancer serve, in our memories, to increase anxiety and distance us from our bodies and any sense of agency.

We read with interest the extended essay published from Riisfeldt and are encouraged by an empirical ethics article which attempts to ground theory and its claims in the real world. However, such attempts also have real-world consequences. We are concerned to read the paper’s conclusion that clinical evidence weakens the distinction between euthanasia and normal palliative care prescribing. This is important. Globally, the most significant barrier to adequate symptom control in people with life-limiting illness is poor access to opioid analgesia. (...) Opiophobia makes clinicians reluctant to prescribe and their patients reluctant to take opioids that might provide significant improvements in quality of life. We argue that the evidence base for the safety of opioid prescribing is broader than that presented, restricting the search to palliative care literature produces significant bias as safety experience and literature for opioids and sedatives exists in many fields. This is not acknowledged in the synthesis presented. By considering additional evidence, we reject the need for agnosticism and reaffirm that palliative opioid prescribing is safe. Second, palliative sedation in a clinical context is a poorly defined concept covering multiple interventions and treatment intentions. We detail these and show that continuous deep palliative sedation is a specific practice that remains controversial globally and is not considered routine practice. Rejecting agnosticism towards opioids and excluding CDPS from the definition of routine care allows the rejection of Riisfeldt’s headline conclusion. On these grounds, we reaffirm the important distinction between palliative care prescribing and euthanasia in practice. (shrink)

Clinical Ethics, Ahead of Print. This paper is a response to a recent BMJ Blog: ‘The duty to treat: where do the limits lie?’ Members of the Surrey Heartlands Integrated Care Service Clinical Ethics Group reflected on arguments in the Blog in relation to resuscitation during the COVID-19 pandemic.Clinicians have had to contend with ever-changing and conflicting guidance from the Resuscitation Council UK and Public Health England regarding personal protective equipment requirements in resuscitation situations. St John Ambulance had different guidance (...) for first responders.The situation regarding resuscitation led the CEG to consider ethical aspects of health care professionals’ responses to the need for resuscitation during COVID-19. Members agreed that professionals should, ideally, have the level of PPE required for an aerosol generating procedure. However, there was no consensus regarding professionals’ duty to care when this is not available. On the one hand, it was agreed that the casualty/patient’s interests regarding resuscitation should be prioritised due to professionals’ contract with the public and professional privilege. On the other hand, risk thresholds were considered relevant to individual decision-making and professionals’ duty to care. All agreed that decision-making should not be influenced by rewards or reprimands. It was agreed also that decisions to resuscitate should not be considered as moral heroism or supererogatory - regardless of PPE availability - but rather as ‘minimally decent’. We agreed that it may be acceptable for professionals, with good reasons, to opt out of resuscitation attempts and these should be reflected on and discussed before the event. (shrink)

A request to admit a hospital inpatient with motor neurone disease to the hospice generated unusual unease. Significantly, withdrawal of ventilation had already been planned. The presumption that ventilation would be withdrawn after transfer presented a dilemma. Should the hospice accept the admission? If so, should the hospice staff stop the ventilation, and then when and how? Debate centred on the continuity of best interests and the logistics of withdrawing ventilation. The factors making the request contentious identified competing interests within (...) hospice admission decision making that could detrimentally impact on patient care. (shrink)

Introduction Bronwyn Davies We began this book at a collective biography workshop that Susanne and I convened in a house at Bombo on the south coast of New ...

In NIP theories, generically stable Keisler measures can be characterized in several ways. We analyze these various forms of “generic stability” in arbitrary theories. Among other things, we show that the standard definition of generic stability for types coincides with the notion of a frequency interpretation measure. We also give combinatorial examples of types in NSOP theories that are finitely approximated but not generically stable, as well as ϕ-types in simple theories that are definable and finitely satisfiable in a small (...) model, but not finitely approximated. Our proofs demonstrate interesting connections to classical results from Ramsey theory for finite graphs and hypergraphs. (shrink)

Research ethics education has taken many forms since federal funding agencies issued regulatory guidance directing those supported by these agencies to complete required training. In the absence of a standard training approach among institutions such as universities, the design and content of courses, workshops, and seminars varies widely. Here we describe a southwestern United States research university program that employed six teaching strategies to assist students in deep learning of ethical principles and behavior. Our purpose was to determine how these (...) strategies impact understanding and empowerment among an interdisciplinary group of graduate students. Results suggested that deep learning design can result in learning that requires students not only to remember and understand key ethics concepts but also to analyze and apply them in a broader ethical domain. Key findings inform design and delivery of future research ethics courses for instructional designers and instructors in higher education. (shrink)

This volume gathers together for the first time are all the key texts in a crucial debate in modern philosophy, centered on Leibniz's famous 1695 essay, the "New System of the Nature of Substances and their Communication," in which he introduced his strikingly original theory of metaphysics. His "system" became increasingly famous and drew him into discussion and development of these ideas, both in public and in private, with a variety of thinkers, most notably the great French philosopher Pierre Bayle. (...) Woolhouse's and Francks's new English edition gives the only full representation of this debate, and will therefore be essential reading for anyone who wishes to gain a proper understanding of Leibniz's philosophy and its intelletual context. All the texts are newly translated and extensively annotated; many appear in English for the first time. (shrink)

Social, legal and health-care changes have created an increasing need for ethical review within end-of-life care. Multiprofessional clinical ethics committees (CECs) are increasingly supporting decision-making in hospitals and hospices. This paper reports findings from an analysis of formal summaries from CEC meetings, of one UK hospice, spanning four years. Using qualitative content analysis, five themes were identified: timeliness of decision-making, holistic care, contextual openness, values diversity and consensual understanding. The elements of an engaged clinical ethics in a hospice context is (...) not generally acknowledged nor its elements articulated. Findings from this study have the potential to explain some of the most challenging ethical problems and to contribute to their resolution. It may also guide future deliberation and raise CEC members' awareness of the recurrent issues and values of their CEC practice. (shrink)

Photographs and interviews document the history of deaf culture in the United States.

The importance of nitrogen fixation, in assimilation of atmospheric dinitrogen for eventual storage in plant proteins, has resulted in extensive study of both plant and bacterial genes involved in this process. To date, the major plant genes analysed are the leghaemoglobins. These are closely related to the animal globins, allowing us to compare their gene organization, expression and evolution. We review here the progress and results of leghaemoglobin analysis and the comparisons with the related animal globins.

This chapter offers a proceduralist argument against capital punishment. More specifically, it contends that the possibility of irrevocable mistakes precludes the just administration of the death penalty. At stake is a principle of political morality: legal institutions must strive to remedy their mistakes and to compensate those who suffer from wrongful sanctions. The incompatibility of remedy and execution is the crux of the irrevocability argument: because the wrongly executed cannot enjoy the morally required compensation, execution is impermissible. Along with defending (...) his key premises, Yost explains the complicated role that sentencing uncertainty plays in the argument. He concludes by noting some of the flaws in substantive consequentialist and retributivist justifications of capital punishment. (shrink)

In light of a gap found by Krupiński, we give a new proof of associativity for the Morley product of invariant measures in NIP theories.

Plato's dialogues frequently criticize traditional Greek myth, yet Plato also integrates myth with his writing. Daniel S. Werner confronts this paradox through an in-depth analysis of the Phaedrus, Plato's most mythical dialogue. Werner argues that the myths of the Phaedrus serve several complex functions: they bring nonphilosophers into the philosophical life; they offer a starting point for philosophical inquiry; they unify the dialogue as a literary and dramatic whole; they draw attention to the limits of language and the limits of (...) knowledge; and they allow Plato to co-opt cultural authority as a way of defining and legitimating the practice of philosophy. Platonic myth, as a species of traditional tale, is thus both distinct from philosophical dialectic and similar to it. Ultimately, the most powerful effect of Platonic myth is the way in which it leads readers to participate in Plato's dialogues and to engage in a process of self-examination. (shrink)

About the extent of the trouble and the suitability of the remedies that have been advanced, there have been some differences of opinion; everyone, however, has recognized that there is something amiss in the lines 984–6. At the very least few would deny these difficulties: ξυνεμβ⋯λοιс is suspect. ψαμμ⋯αс must be regarded as seriously corrupt. χρ⋯νοс … παρ⋯βηсεν must be emended as a whole so that either the indispensable constituents of two complete clauses appear or ⋯πε⋯ disappears. ψαμμ⋯αс ⋯κ⋯τα παρ⋯ (...) and εὔχομαι δ᾽ ⋯ξ ⋯μ⋯с must be brought into metrical correspondence. (shrink)

Aeschylus' constant metrical practice shows that either Ag. 404/5 in the strophe, or 421/2 , correspondingly in the antistrophe, is corrupt in the manuscript tradition.

Motivated by the theory of domination for types, we introduce a notion of domination for Keisler measures called extension domination. We argue that this variant of domination behaves similarly to its typesetting counterpart. We prove that extension domination extends domination for types and that it forms a preorder on the space of global Keisler measures. We then explore some basic properties related to this notion (e.g., approximations by formulas, closure under localizations, convex combinations). We also prove a few preservation theorems (...) and provide some explicit examples. (shrink)

n the first of his three magisterial articles on the Agamemnon H. L. Ahrens showed that all the evidence then available best fitted the conclusion that τται derived from τνω and not from τω. Subsequently Ed. Fraenkel in his own note on the word reviewed and supplemented the evidence gathered by Ahrens, and expressed the view that Ahrens' ‘discussion, details apart, is final’; and there seems to be widespread agreement that on the linguistic side at least Ahrens' argument cannot be (...) refuted. If this means anything, it means that the sense of the word cannot be ‘unhonoured’ or ‘dishonoured’. Yet Denniston–Page in their commentary say that ‘”unhonoured” seems the only possible sense here’, and R. Fagles' recent translation, which generally rests on sound scholarship as well as poetic gifts, has ‘dishonored’. The principal reason for this persistent disagreement seems to be that the sense proposed by Ahrens for τται has been thought to have rather less plausibility than the linguistic considerations that appear to lead to it. (shrink)

Aeschylus' constant metrical practice shows that either Ag. 404/5 in the strophe, or 421/2, correspondingly in the antistrophe, is corrupt in the manuscript tradition..

A human document of historic interest concerning a good-will mission to wartime England filled with trenchant and witty observation of its brave and stoical people.

This educators’ introduction to semiotics describes a communications phenomenon that has permeated and influenced learner attitudes, behaviors and cognition in any learning environment but especially formal mediated learning environments. Relevant semiotic theory is meaningfully integrated into each chapter.

We study generically stable measures in the local, NIP context. We show that in this setting, a measure is generically stable if and only if it admits a natural finite approximation.

This book provides seminal data on what has been found to best motivate faculty to teach online. This information is critical to most universities because, in order to stay competitive, many will increase their online course offerings. Faculty will be needed to design and teach these programs.

Many books explain what is known about the universe. This book investigates what cannot be known. Rather than exploring the amazing facts that science, mathematics, and reason have revealed to us, this work studies what science, mathematics, and reason tell us cannot be revealed. In The Outer Limits of Reason, Noson Yanofsky considers what cannot be predicted, described, or known, and what will never be understood. He discusses the limitations of computers, physics, logic, and our own thought processes. Yanofsky describes (...) simple tasks that would take computers trillions of centuries to complete and other problems that computers can never solve; perfectly formed English sentences that make no sense; different levels of infinity; the bizarre world of the quantum; the relevance of relativity theory; the causes of chaos theory; math problems that cannot be solved by normal means; and statements that are true but cannot be proven. He explains the limitations of our intuitions about the world -- our ideas about space, time, and motion, and the complex relationship between the knower and the known. Moving from the concrete to the abstract, from problems of everyday language to straightforward philosophical questions to the formalities of physics and mathematics, Yanofsky demonstrates a myriad of unsolvable problems and paradoxes. Exploring the various limitations of our knowledge, he shows that many of these limitations have a similar pattern and that by investigating these patterns, we can better understand the structure and limitations of reason itself. Yanofsky even attempts to look beyond the borders of reason to see what, if anything, is out there. (shrink)