Genome editing enables very accurate alterations to DNA. It promises profound and potentially disruptive changes in healthcare, agriculture, industry, and the environment. This paper presents a multidisciplinary analysis of the contemporary development of genome editing and the tension between continuity and change. It draws on the idea that actors involved in innovation are guided by “sociotechnical regimes” composed of practices, institutions, norms, and cultural beliefs. The analysis focuses on how genome editing is emerging in different domains and whether this marks (...) continuity or disruption of the established biotechnology regime. In conclusion, it will be argued that genome editing is best understood as a technology platform that is being powerfully shaped by this existing regime but is starting to disrupt the governance of biotechnology. In the longer term is it set to converge with other powerful technology platforms, which together will fundamentally transform the capacity to engineer life. (shrink)

This article adds to earlier research revealing that the American news media did not discharge their responsibility as a watchdog press in the post-9/11 years by failing to scrutinize extreme and unlawful government policies and actions, most of all the decision to invade Iraq based on false information about Saddam Hussein’s alleged weapons of mass destruction arsenal. The content analyses presented here demonstrate that leading US news organizations, both television and print, did not expressly refer to human rights violations when (...) they reported on the torturing of foreign detainees during “enhanced interrogations” in US-run prison facilities abroad and the killing of civilians, including children, in US drone strikes overseas and outside theaters of war. Moreover, by framing torture and the “collateral damage” caused by drone-launched missile attacks episodically rather than in the context of human rights, the news media failed to alert the American public to the grave humanitarian violations in the so-called war on terrorism during the George W. Bush and Barack Obama administrations. (shrink)

Taxonomy Based modeling was applied to describe drivers’ mental models of variable message signs (VMS’s) displayed on expressways. Progress in road telematics has made it possible to introduce variable message signs (VMS’s). Sensors embedded in the carriageway every 500m record certain variables (speed, flow rate, etc.) that are transformed in real time into “driving times” to a given destination if road conditions do not change.VMS systems are auto-regulative Man-Machine (AMMI) systems which incorporate a model of the user: if the traffic (...) flow is too high, then drivers should choose alternative routes. In so doing, the traffic flow should decrease. The model of the user is based on suppositions such as: people do not like to waste time, they fully understand the displayed messages, they trust the displayed values, they know of alternative routes. However, people also have a model of the way the system functions. And if they do not believe the contents of the message, they will not act as expected.We collected data through interviews with drivers using the critical incidents technique (Flanagan, 1985). Results show that the mental models that drivers have of the way the VMS system works are various but not numerous and that most of them differ from the“ideal expert” mental model. It is clear that users don’t have an adequate model of how the VMS system works and that VMS planners have a model of user behaviour that does not correspond to the behaviour of the drivers we interviewed. Finally, Taxonomy Based Modeling is discussed as a tool for mental model remediation. (shrink)

Walter Benjamin, der Traum und das Bild des Weiblichen Geschichtsphilosophie aus gendertheoretischer Perspektive. 0Karin Stögner: 0Beschädigtes Leben und antisemitische „Schiefheilung". Freud und Adorno revisited.0Ljiljana Radonic: 0Autonomie versus Engagement? Über Adorno und Brecht. 0Gerhard Scheit: 0„Une promesse de bonheur". Herbert Marcuses „Über den affirmativen Charakter der Kultur".0Daniela Berner und Florian Wagner: 0Gebrochene Geschichte, Bedrängte Gegenwart. Möglichkeiten und Grenzen eines fremdgestellten Blicks 0auf die nationalsozialistische Vergangenheit im Film. 0Tobias Ebbrecht-Hartmann: 0Das drastische Medium. Über Adornos Kritik des Films. 0Christoph Hesse: 0Träumerinnen im Wachen. (...) Die „Kollektivträume" der Comics und die Kritische Theorie. 0Barbara Eder : 0Verehrte Unsichtbare!"0Über die Kunst des Hörens bei Walter Benjamin und Theodor W. Adorno 0Christine Ehardt: 0Exkursion 0Shopping Mall, mit Walter Benjamin u.a. 0Anette Baldauf : 0Zum Einbruch des.Realen' in die Gegenwart 0Eingedenken, Erinnern, Katharsis 0Sara Vorwalder und Veronika Zangl : 0„Alles wirklich Brauchbare besteht in Aushilfen". Zwei Lektüren zu Oskar Negt und Alexander Kluges Geschichte und Eigensinn 0Valentin Mertes und Michael Paninski : 0„Die Nord-West-Passage der Revolution" 0Herrschaftsverhältnisse und die situationistische Kartographierung 0der Stadtlandschaft 0Brigitte Marschall: 0. (shrink)

The physics of condensed matter, in contrast to quantum physics or cosmology, is not traditionally associated with deep philosophical questions. However, as science - largely thanks to more powerful computers - becomes capable of analysing and modelling ever more complex many-body systems, basic questions of philosophical relevance arise. Questions about the emergence of structure, the nature of cooperative behaviour, the implications of the second law, the quantum-classical transition and many other issues. This book is a collection of essays by leading (...) physicists and philosophers. Each investigates one or more of these issues, making use of examples from modern condensed matter research. Physicists and philosophers alike will find surprising and stimulating ideas in these pages. (shrink)

This article applies some ofthe insights from framing studies in policyresearch, metaphor analysis, and the history ofmedicine to a cultural understanding ofagriculture, using the 2001 outbreak of footand mouth disease in the UK as a case study.The article will show how metaphors of war wereused as a “rhetorical frame” by the media andas an implicit “action frame” by policy makers.It will be argued that although the war framemight initially have been useful in rallyingsupport for the slaughter policy, the metaphorlater backfired, (...) when a metaphorical war turnedinto a literal holocaust. This might haveencouraged the public to perceive the policy asmedieval, brutal, and misguided, thuspotentially undermining the willingness ofsections of the public to support the slaughterpolicy in future outbreaks. If, on the otherhand, a vaccination policy were adopted in thefuture, care would need to be taken to avoidmetaphorical linkages with other controversiesover vaccination in other domains. (shrink)

After the UN Guiding Principles on Business and Human Rights were adopted in 2011, an international treaty has been being negotiated since 2014. The two instruments reveal similarities and also conflicts regarding the adequate organization of the global economy based on human rights. The focus in this article will be on the processes leading to these instruments, because they themselves mirror different understandings of governance in the field of business and human rights as well as the struggle over the power (...) of definition and legitimacy. The UNGPs were developed on the basis of global multi-stakeholder consultations, underlining legitimacy through broad inclusion. There are varying judgements as to the success of this approach. The process towards the treaty follows the traditional path of negotiations at UN level. These negotiations reveal a struggle for recognition of the legitimacy of the process itself. Both procedures have shortcomings with regard to legitimacy and show the need for a revision concerning the inclusion of stakeholders. The complementarity of a soft and hard law instrument may enhance the creation of a level playing field in the global economy, thereby strengthening human rights. (shrink)

Different types of consent are used to obtain human biospecimens for future research. This variation has resulted in confusion regarding what research is permitted, inadvertent constraints on future research, and research proceeding without consent. The National Institutes of Health Clinical Center's Department of Bioethics held a workshop to consider the ethical acceptability of addressing these concerns by using broad consent for future research on stored biospecimens. Multiple bioethics scholars, who have written on these issues, discussed the reasons for consent, the (...) range of consent strategies, and gaps in our understanding, and concluded with a proposal for broad initial consent coupled with oversight and, when feasible, ongoing provision of information to donors. This article describes areas of agreement and areas that need more research and dialogue. Given recent proposed changes to the Common Rule, and new guidance regarding storing and sharing data and samples, this is an important and tim.. (shrink)

Currently, affect and emotions are a widely discussed political topic. At least since the early 1990s, different disciplines—from the social sciences and humanities to science and technoscience—have increasingly engaged in studying and conceptualizing affect, emotion, feeling, and sensation, evoking yet another turn that is frequently framed as the “affective turn.” Within queer feminist affect theory, two positions have emerged: following Eve Kosofsky Sedgwick's well-known critique, there are either more “paranoid” or more “reparative” approaches toward affect. Whereas the latter emphasize the (...) potentialities of affect, the former argue that one should question the mere idea of affect as liberation and promise. Here, I suggest moving beyond a critique or celebration of affect by embracing the political ambivalence of affect. For this queer feminist theorizing of affective politics, I adapt Jacques Rancière's theory of the political and particularly his understanding of emancipation. Rancière takes emancipation into account without, however, uncritically endorsing or celebrating a politics of liberation. I draw on his famous idea of the “distribution of the sensible” and reframe it as the “distribution of emotions,” by which I develop a multilayered approach toward a nonidentitarian, nondichotomous, and emancipatory queer feminist theory of affective politics. (shrink)

Grace de Laguna was a philosopher working in the first part of the twentieth century on analytic and speculative philosophy, as well as on the psychology and philosophy of language, especially the social function of language. Joel Katzav’s lead essay focuses mainly on the former part of her work, while my commentary focuses mostly on the latter. Katzav shows how her work played a role in the development of analytic philosophy, I try to show how her work played a role (...) in the development of pragmatic linguistics, whose development overlapped with some aspects of analytic philosophy. I situate it in the context of an emerging ‘pragmatic Weltanschauung’ that was embraced by many working in linguistics, philology, philosophy, psychology, anthropology and what would later be called linguistic pragmatics. (shrink)

Brigitte Bourgeois and Philippe Jockey Gold and Marble: the Gilded Hellenistic Sculptures of Delos p. 331-349 The investigation we are conducting on the polychromy of the Hellenistic sculptures of Delos has enabled us to add to the corpus of gilded marble works and to refine the typology. A visual examination of the sculptures through a video-microscope, combined with an analysis of the remains isolated by this means under X-fluorescence, has revealed the existence of three large types of gold leaf (...) gilding on marble at Delos in around 100 BC: totally gilded statues, works on which the gilding forms only an added colouring to the general polychromy, and works that we propose to call "chrysochromes", which present a singularity not hitherto recognised of a very bright polychromy on the clothed parts associated with gold on the nude parts. Among the number of important results of this enquiry may be counted the revelation of the overall gilding on the Delian copy in the National Museum at Athens of the Polyclitus Diadumenus, carved and gilded in imitation of a gilt bronze or even a gold statue. Such a use of gold leaf gilding on the Delos marbles calls in any case for a reconsideration of the question of the reception in antiquity of such works, as well as of such a success of gold at Delos and no doubt elsewhere in the Greek world in the same period. (shrink)

This book analyzes--in terms of branching--the pervasive reorganization of Latin syntactic and morphological structures: in the development from Latin to French, a shift can be observed from the archaic, left-branching structures (which Latin inherited from Proto-Indo-European) to modern right-branching equivalents. Brigitte Bauer presents a detailed analysis of this development based on the theoretical discussion and definition of "branching" and "head." Subsequently she relates the diachronic shift to psycholinguistic evidence, arguing that the difficuly of LB complex structures as reflected in (...) their painstaking and delayed acquisition accounts for the extensive typological shift from left to right branching that took place in Latin/French and the other Indo-European languages. (shrink)

Entrepreneurs who start a business to serve both self-interests and collective interests by addressing unmet social and environmental needs are usually referred to as sustainable entrepreneurs. Compared with regular entrepreneurs, we argue that sustainable entrepreneurs face specific challenges when establishing their businesses owing to the discrepancy between the creation and appropriation of private value and social value. We hypothesize that when starting a business, sustainable entrepreneurs feel more hampered by perceived barriers, such as the institutional environment and have a different (...) risk attitude and perception than regular entrepreneurs. We use two waves of the Flash Eurobarometer survey on entrepreneurship, which contains information on start-up motivations, start-up barriers, and risk perceptions of approximately 3000 business owners across 33 countries. We find that sustainable entrepreneurs indeed perceive more institutional barriers in terms of a lack of financial, administrative, and informational support at business start-up than regular entrepreneurs. Further, no significant differences between sustainable and regular entrepreneurs are found in terms of their risk attitudes or perceived financial risks. However, sustainable entrepreneurs are more likely to fear personal failure than regular entrepreneurs, which is explained by their varied and complex stakeholder relations. These insights may serve as an important signal for both governments and private capital providers in enhancing the institutional climate. (shrink)

On 14 July 2021, the western states of Germany, Rheinland Palatinate and North-Rhein-Westphalia experienced major flash floods and about two hundred people died. This article explores how those affected and journalists they spoke to created meaning from the mayhem of an unprecedented disaster and how social representations of flooding emerged in which language, politics and values were intimately intertwined. Combining thematic analysis with elements of social representations theory, and analysing a sample of articles from a national news magazine, we show (...) how social representations of the floods were shaped by the objectification of the floods through metonymy (mud and debris) and the anchoring of the floods through personification and metaphors (natural and mechanical forces), thus adding a new dimension to the existing body of work on flood and metaphors. We claim that the immediate focus on the extreme force of the 2021 floods, on the one hand, and the weakness of political response, on the other, may entrench feelings of helplessness and divert attention away from more systematic and long-term engagement with flood dangers in the context of climate change, including extreme weather events. (shrink)

The interdependence between compliance with norms and economic behavior can be highlighted by the effects of corporate governance codes. Their underlying comply or explain mechanism is first compared with the economic theory of corporate law. Diverging empirical studies on the effect of capital market pressure on compliance with codes leave room for different compliance mechanisms, which can be compared with the discussion on corporate social responsibility and its underlying business cases. The emerging common ground between economic motivation and social interests (...) shows limits of the traditional rational actor model which can be further explored on the basis of fairness norms. Similar parallels and overlaps between market-driven self-interest and intrinsic motivation can be shown at the example of incentive effects of executive compensation. Its regulation in the German Stock Corporation Act is lacking any empirical foundation which is also true for the yet empirically unexplored compliance patterns in corporate governance. (shrink)

The paper presents a logical treatment of actions based on dynamic logic. This approach makes it possible to reflect clearly the differences between static and dynamic elements of the world, a distinction which seems crucial to us for a representation of actions.Starting from propositional dynamic logic a formal system (DLA) is developed, the programs of which are used to model action types. Some special features of this system are: Basic aspects of time are incorporated in DLA as far as they (...) are needed for our purpose. Names for states and for instants are simulated by formulas. It is possible to express formally that a formula is satisfiable or valid. A special program is introduced to reflect developments which are not caused by an official agent but by external influences. (shrink)

Die Arbeit untersucht die auflagenstärkste und international bekannteste deutsche Zeitung des 18. Jahrhunderts, die "Staats- und Gelehrte Zeitung des Hamburgischen unpartheyischen Correspondenten", mit dem Ziel, ihre Rolle als Instrument der Aufklärung zu analysieren. Basis der Studie sind als regelmäßige Stichprobe die Jahrgänge 1731, 1741,..., 1781. Auf einen ersten Teil, der sich mit der Unternehmensgeschichte der Zeitung, ihrer Konzeption sowie den Prinzipien der 'unpartheylichen' Nachrichtenmeldung in der politischen Berichterstattung und der 'unpartheylichen' Kritik in den Rezensionen des "Hamburgischen Correspondenten" beschäftigt, folgt ein (...) zweiter inhaltsanalytischer Teil. Dort liegt das Interesse nicht primär auf der Rezeption bestimmter Ereignisse oder Schriften, die von der Forschung als 'Meilensteine' der Aufklärungsbewegung ausgemacht wurden. Vielmehr werden in fünf zentralen Themenbereichen (Wissenschaftsverständnis, Literaturkritik, Rezeption staatswissenschaftlicher und ökonomischer Theorieelemente, bürgerliches Selbstverständnis, Frauenbild) für die Aufklärung typische Argumentationsmuster und Werte nachgewiesen, die den Zeitungslesern durch wiederholte Lektüre so vertraut werden mußten, daß sie ihre Weltanschauung im Sinne der Aufklärung beeinflussen konnten. (shrink)

This book, first published in 2000, offers translations of the initial critical reactions to Kant's philosophy. Also included is a selection of writings by Kant's contemporaries who took on the task of defending the critical philosophy against early attacks. The first aim of this collection is to show in detail how Kant was understood and misunderstood by his contemporaries. The second aim is to reveal the sorts of arguments that Kant and his first disciples mounted in their defense of the (...) theoretical philosophy. The third aim of the book is to contribute to an understanding of the development of Kant's critical philosophy after its initial formulation in the Critique of Pure Reason, and in particular why Kant made the changes he did in the second edition of the work in 1787. This collection, which includes a glossary of key terms and biographical sketches of the critics on both sides of the debate, is a major addition to Kant scholarship and should be seen as a companion volume to the Cambridge Edition of the Works of Immanuel Kant. (shrink)

This paper deals with some structural properties of the sequent calculus and describes strong symmetries between cut-free derivations and derivations, which do not make use of identity axioms. Both of them are discussed from a semantic and syntactic point of view. Identity axioms and cuts are closely related to the treatment of negation in the sequent calculus, so the results of this article explain some nice symmetries of negation.

Le travail avec les familles ayant une histoire en lien avec la migration nécessite une réflexion et une écoute adaptées. Dans ce contexte a été pensé un dispositif thérapeutique au sein d’un centre médico-psychopédagogique pour accueillir et prendre en compte l’origine culturelle ainsi que la situation transculturelle de ces familles. Cet article relate l’expérience clinique d’une mère et de son enfant autour de contes issus de la tradition orale du Maghreb dans le cadre d’un atelier rassemblant des dyades mères-enfants. Le (...) dispositif a pu restaurer le lien symbolique et dyadique, activer une autorisation à apprendre. La remobilisation des représentations culturelles au travers du conte a joué un rôle essentiel dans la renarcissisation à un niveau individuel pour une (re)construction identitaire. (shrink)

The concept of self is imbedded in the psychoanalytic theory of object relations. The theory of object relations poses the question of the constitution of the person’s inner life or ‘representational world’. It will be discussed, in what respect the concept of self serves the description of dependency relations, in which the psychic relations of the person to the social and cultural reality are expressed. The significance of the concept of self lies in the explicative role it takes in the (...) portrayal of the individual’s developing participation in human community. (shrink)

This article explores a German philosophy of metaphor, which proposed a close link between the body and the mind as the basis for metaphor, debunked the view that metaphor is just a decorative rhetorical device and questioned the distinction between the literal and the figurative. This philosophy of metaphor developed at the intersection between a reflection on language and thought and a reflection on the nature of beauty in aesthetics. Thinkers such as Giambattista Vico, Johann Wolfgang von Goethe, Jean Paul (...) and others laid the foundations for this philosophy and it was successively refined by Gustav Gerber, Alfred Biese and Friedrich Nietzsche. It influenced in its turn in various ways the linguistic study of metaphor and the psychology of metaphor as elaborated, for instance, by a lesser-known American scholar, Gertrude Buck. All these thinkers contributed to a philosophy and psychology of the metaphoric according to which metaphors are not only nice, but necessary for the structure and growth of human thought and language. Obvious parallels between this 19th-century philosophy of metaphor and the 20th-century theory of metaphor developed by Lakoff and his followers are examined throughout. (shrink)

Despite the scientific revolutions of the twentieth century, mechanistic explanations show a striking methodological continuity from early modern science to current scientific practice. They are rooted in the traditional method of analysis and synthesis, which was the background of Galileo’s resolutive-compositive method and Newton’s method of deduction from the phenomena. In early modern science as well as in current scientific practice, analysis aims at tracking back from the phenomena to the principles, i.e., from wholes to parts, and from effects to (...) causes. Vice versa, synthesis aims at explaining the phenomena from the parts and their interactions. Today, mechanistic explanations are atomistic in a generalized sense. They have in common to explain higher-level phenomena in terms of lower-level components and their causal actions or activities. In quantum physics, the lower-level components are subatomic particles, and the causes are their quantum interactions. After the quantum revolution, the approach continues to work in terms of the sum rules which hold for conserved properties of the parts and the whole. My paper focuses on the successes and limitations of this approach, with a side glance at the recent generalization of mechanistic explanations in cognitive neuroscience. (shrink)

Welche Erkenntnisse bietet Michel Foucaults Ansatz der Gouvernementalität für eine politische Theorie, die Geschlecht als zentrale Kategorie setzt? In diesem Band werden Grundbegriffe aus Foucaults Spätwerk aus feministischer Sicht beleuchtet, z.B. Gouvernementalität, Macht, Staat, Subjekt, Sicherheit, Wissen und Kritik. Diese Re-Lektüre möchte zum einen Foucaults Ansatz geschlechtertheoretisch weiterentwickeln und vertiefen, zum anderen Anstöße für eine politische Theoretisierung von Geschlecht geben.