Estudio bibliográfico y crítico de / A bibliographical and critical study of: Marcello Montanari, Vico e la politica dei Moderni, prefazione di Biagio De Giovanni, Palomar, Bari, 1995, pp. 266.

Este artigo tem por objetivo apresentar o desenvolvimento do conceito de “vontade” na obra O mundo como vontade e representação (1818-9) do filósofo alemão Arthur Schopenhauer. Pretende-se apresentar o conceito perpassando inicialmente pela dicotomia kantiana da Crítica da razão pura entre “coisa em si” e “fenômeno”. Depois, seguiremos as observações feitas por Schopenhauer a essa categorização da realidade e suas ressalvas, para, então, explicitarmos a sua respectiva filosofia fundamentada na oposição entre “vontade” e “representação”. Por último, a influência desse pensamento (...) na denominada “segunda tópica” (pós 1920) na obra do pai da Psicanálise, Sigmund Freud. (shrink)

Esse artigo visa demonstrar como o psicanalista francês Jacques Lacan delineou e reformulou o conceito freudiano de pulsão de morte no interior dos três registros da experiência humana. Dito isso, iremos inicialmente compreender de forma geral como o conceito de pulsão de morte aparece na obra lacaniana, de maneira a demonstrarmos como ela é reformulada pelo autor francês. Depois, iremos delinear como esse conceito aparece no interior dos registros do Imaginário, Simbólico e Real; desse modo, estaremos envoltos com o Estágio (...) do Espelho desenvolvido por Lacan no decorrer dos anos 1930 e 1940, a teoria do significante fundada por nosso autor mais atentamente nos anos 1950 e por último o registro do Real, o qual foi introduzido com mais atenção a partir dos anos 1960 em diante. (shrink)

This collection addresses two different audiences: 1) historians and philosophers of the life sciences reflecting on collaborations across disciplines, especially as regards defining and addressing Grand Challenges; 2) researchers and other stakeholders involved in cross-disciplinary collaborations aimed at tackling Grand Challenges in the life and medical sciences. The essays collected here offer ideas and resources both for the study and for the practice of goal-driven cross-disciplinary research in the life and medical sciences. We organise this introduction in three sections. The (...) first section provides some background and context. The second motivates our take on this topic and then outlines the central ideas of each paper. The third section highlights the specificity and significance of this approach by considering: a) how this collection departs from existing literature on inter- and trans-disciplinarity, b) what is characteristic about this approach, and c) what role this suggests for the history and philosophy of the life sciences in addressing Grand Challenges. (shrink)

The idea of personalised medicine (PM) has gathered momentum recently, attracting funding and generating hopes as well as scepticism. As PM gives rise to differing interpretations, there have been several attempts to clarify the concept. In an influential paper published in this journal, Schleidgen and colleagues have proposed a precise and narrow definition of PM on the basis of a systematic literature review. Given that their conclusion is at odds with those of other recent attempts to understand PM, we consider (...) whether their systematic review gives them an edge over competing interpretations. We have found some methodological weaknesses and questionable assumptions in Schleidgen and colleagues’ attempt to provide a more specific definition of PM. Our perplexities concern the lack of criteria for assessing the epistemic strength of the definitions that they consider, as well as the logical principles used to extract a more precise definition, the narrowness of the pool from which they have drawn their empirical data, and finally their overlooking the fact that definitions depend on the context of use. We are also worried that their ethical assumption that only patients’ interests are legitimate is too simplistic and drives all other stakeholders’ interests—including those that are justifiable—underground, thus compromising any hope of a transparent and fair negotiation among a plurality of actors and interests. As an alternative to the shortcomings of attempting a semantic disciplining of the concept we propose a pragmatic approach. Rather than considering PM to be a scientific concept in need of precise demarcation, we look at it as an open and negotiable concept used in a variety of contexts including at the level of orienting research goals and policy objectives. We believe that since PM is still more an ideal than an achieved reality, a plurality of visions is to be expected and we need to pay attention to the people, reasons and interests behind these alternative conceptions. In other words, the logic and politics of PM cannot be disentangled and disagreements need to be tackled addressing the normative and strategic conflicts behind them. (shrink)

This paper has two main objectives. The first one is to reflect on the validity of data in analysis and projections that underpin the engineering asset management of organizations, considering, on the one hand, a certain resistance or even inadequate use of data and information of a subjective nature and; on the other hand, a consolidated reliance on quantitative approaches and decisions based on data series. The second objective is to contextualize the applicability of combining qualitative data based on experts’ (...) experience and on the tacit knowledge built in organizations, with approaches based essentially on quantitative data, according to the data availability and the decision scenario over the asset life cycle. We present two application of an approach combining quali and quanti data. One example interrelates Statistics with Psychology and the other combines elicitated data about asset indicators with parameters deterministically calculated. Both applications aiming at providing more realistic indicators and supporting the Asset Management process to make more assertive decisions. (shrink)

Initially identified as a key phosphoinositide that controls membrane trafficking at the Golgi complex, phosphatidylinositol‐4‐phosphate (PI4P) has emerged as a key molecule in the regulation of a diverse array of cellular functions. In this review we will discuss selected examples of the findings that in the last few years have significantly increased our awareness of the regulation and roles of PI4P in the Golgi complex and beyond. We will also highlight the role of PI4P in infection and cancer. We believe (...) that, with the increasing number of regulators and effectors of PI4P identified, the time is ripe for a more integrated approach of study. A first step in this direction is the delineation of PI4P‐centered molecular networks that we provide using data from low and high throughput studies in yeast and mammals. (shrink)

How can the discoveries made in the biological sciences play a role in a discussion on the foundation of ethics? This book responds to this question by examining how evolutionism can explain and justify the existence of ethical normativity and the emergence of particular moral systems. Written by a team of philosophers and scientists, the essays collected in this volume deal with the limits of evolutionary explanations, the justifications of ethics, and methodological issues concerning evolutionary accounts of ethics, among other (...) topics. They offer deep insights into the origin and purpose of human moral capacities and of moral systems. (shrink)

In this paper, the ontological, terminological, epistemological, and ethical aspects of omission are considered in a coherent and balanced framework, based on the idea that there are omissions which are actions and omissions which are non-actions. In particular, we suggest that the approach to causation which best deals with omission is Mackie's INUS conditional proposal. We argue that omissions are determined partly by the ontological conditional structure of reality, and partly by the interests, beliefs, and values of observers. The final (...) upshot is that moral judgments involved in cases of omissions cannot be grounded on, but are the ground for judgments about what INUS conditions count as omissions. (shrink)

Esse artigo visa apresentar como foi forjado o conceito de pulsão de morte pelo pai da Psicanálise, Sigmund Freud. Nesse sentido, estaremos envoltos com as respectivas modificações do conceito inicial de pulsão principalmente no decorrer no período da Primeira Guerra Mundial até o final da década em questão. Esse momento é chave na teoria da pulsão almejada por Freud nos anos de 1914 até a dualismo pulsional - de pulsões de vida e pulsões de morte - em 1920 com a (...) publicação de Além do Princípio do Prazer, e é esse período que pretendemos desenvolver no presente artigo que antecede o início da Segunda Tópica. (shrink)

The paper uses two historical examples, public health (1840-1880) and town planning (1945-1975) in Britain, to analyse the challenges faced by goal-driven research, an increasingly important trend in science policy, as exemplified by the prominence of calls for addressing Grand Challenges. Two key points are argued. (1) Given that the aim of research addressing social or global problems is to contribute to improving things, this research should include all the steps necessary to bring science and technology to fruition. This need (...) is captured by the idea of practical integration, which brings this type of research under the umbrella of collective practical reason rather than under the aegis of science. Achieving practical integration is difficult for many reasons: the complexity of social needs, the plurality of values at stake, the limitation of our knowledge, the elusive nature of the skills needed to deal with uncertainty, incomplete information and asymmetries of power. Nevertheless, drawing from the lessons of the case studies, it is argued that (2) practical integration needs a proper balance between values, institutions and knowledge: i.e. a combination of mutual support and mutual limitation. Pursuing such a balance provides a flexible strategy for approximating practical integration. (shrink)

The paper discusses the possibility that the benefits of pharmacogenomics will not be distributed equally and will create orphan populations. I argue that since these inequalities are not substantially different from those produced by ‘traditional’ drugs and are not generated with the intention to discriminate, their production needs not be unethical. Still, the final result is going against deep-seated moral feelings and intuitions, as well as broadly accepted principles of just distribution of health outcomes and healthcare. I thus propose two (...) provisos that would prevent the most offensive outcomes and moderate the scope of the produced inequalities. The first proviso rejects pharmacogenomics innovations that worsen existing group inequalities and aggravate the disadvantage of communities with a history of discrimination. The second proviso requires that there is a strategy in place to even out as much as possible the distribution of benefits in the future and that a system of compensations is in place for pharmacogenomic orphans. Given that only one moral problem generated by pharmacogenomics has been tackled, the list of provisos might be expanded when other issues are considered. (shrink)

The background paper provides an introduction to the concept of pandemics and to the ethical and political issues related with pandemic preparedness.

In this article we raise a problem, and we offer two practical contributions to its solution. The problem is that academic communities interested in digital publishing do not have adequate tools to help them in choosing a publishing model that suits their needs. We believe that excessive focus on Open Access (OA) has obscured some important issues; moreover exclusive emphasis on increasing openness has contributed to an agenda and to policies that show clear practical shortcomings. We believe that academic communities (...) have different needs and priorities; therefore there cannot be a ranking of publishing models that fits all and is based on only one criterion or value. We thus believe that two things are needed. First, communities need help in working out what they want from their digital publications. Their needs and desiderata should be made explicit and their relative importance estimated. This exercise leads to the formulation and ordering of their objectives. Second, available publishing models should be assessed on the basis of these objectives, so as to choose one that satisfies them well. Accordingly we have developed a framework that assists communities in going through these two steps. The framework can be used informally, as a guide to the collection and systematic organization of the information needed to make an informed choice of publishing model. In order to do so it maps the values that should be weighed and the technical features that embed them. Building on our framework, we also offer a method to produce ordinal and cardinal scores of publishing models. When these techniques are applied the framework becomes a formal decision–making tool. Finally, the framework stresses that, while the OA movement tackles important issues in digital publishing, it cannot incorporate the whole range of values and interests that are at the core of academic publishing. Therefore the framework suggests a broader agenda that is relevant in making better policy decisions around academic publishing and OA. (shrink)

O presente artigo coloca em evidência uma proposta sobre educação e os respectivos pressupostos para que ela aconteça no sujeito, tendo como referência a pedagogia da hospitalidade com base na filosofia da alteridade em Levinas. Nesse caso, a educação não é vista a partir do movimento do Eu em direção do Outro, mas sim, o contrário. Precisamente o Outro assume o protagonismo pedagógico já que o Eu se abre à possibilidade de acolhida do Outro sem nenhum critério preestabelecido, de forma (...) assimétrica. A partir disso, o texto apresenta a possibilidade de uma hospitalidade a partir da alteridade, tendo o Outro como base de uma relação ética em que o Eu é convidado a participar do convívio do Outro. Essa pedagogia rompe as barreiras de uma educação centrada tão-somente na capacidade do eu egoísta, mas se abre ao infinito das possibilidades da relação onde o Outro se revela com sua história, cultura, e o Eu se adequa às necessidades daquilo que se apresenta como diferente. O rosto do Outro revela ao sujeito o infinito e o valor dele como superação do próprio preconceito por meio da pedagogia da hospitalidade. (shrink)

The paper points out three serious problems in Ruud ter Meulen’s view of solidarity and of its role in healthcare ethics. First, it is not clear whether and to what extent ter Meulen expects normative concepts to be rooted in existing social practices: his criticism of liberal theories of justice seems to imply a different view on this issue than his implicit assumption that normative concepts are independent from social and historical trends. Second, it is not clear at which level (...) his notion of solidarity is meant to be applied: does it provide principles for individuals or for institutions? Nor is it clear at what level of generality it should work: is it meant for healthcare institutions or for states, for citizens or for healthcare practitioners? Third, it is not at all clear how the communitarian and the universalist aspirations in his conception of solidarity can be reconciled. In light of such difficulties it is argued that within philosophical discourse solidarity can be a useful notion only if it can be clearly distinguished from existing and commonly used ethical concepts. Three examples of such narrow and specific uses of solidarity are presented. Finally, a sceptical view of confining the work of applied philosophers to articulating normative concepts is put forward and an alternative view of blending empirical and philosophical analysis is proposed. This vision of field philosophy requires serious attention and careful understanding of the circumstances and constraints within which normative recommendations operate. It is suggested that such a modest and empirically grounded understanding of normative work is a better way of honouring the belief that philosophy is rooted in social institutions and in complex webs of relations. (shrink)

The status of wild capture fisheries has induced many fisheries and conservation scientists to express concerns about the concept of using forage fish after reduction to fishmeal and fish oil, as feed for farmed animals, particularly in aquaculture. However, a very large quantity of forage fish is being also used untransformed (fresh or frozen) globally for other purposes, such as the pet food industry. So far, no attempts have been made to estimate this quantum, and have been omitted in previous (...) fishmeal and fish oil exploitation surveys. On the basis of recently released data on the Australian importation of fresh or frozen fish for the canned cat food industry, here we show that the estimated amount of raw fishery products directly utilized by the cat food industry equates to 2.48 million metric tonnes per year. This estimate, plus the previously reported global fishmeal consumption for the production of dry pet food suggest that 13.5% of the total 39.0 million tonnes of wild caught forage fish is used for purposes other than human food production. This study attempts to bring forth information on the direct use of fresh or frozen forage fish in the pet food sector that appears to have received little attention to this date and that needs to be considered in the global debate on the ethical nature of current practices on the use of forage fish, a limited biological resource. (shrink)

The primary aim of this interpretive essay is to reconstruct some of the most important features of Rawls’s theory of justice, and to offer a hypothesis about how its assumptions and arguments are tied together in a highly structured construction. An almost philological approach is adopted to highlight Rawlsian ideas. First, I consider in what sense Rawls is an individualist and in what sense he is not. Fromthis I conclude that he ought not be charged of psychological egoism or atomism. (...) Then I consider the role of rational choice, the contract and the relation of the latter to the criterion of reflective equilibrium. Here, pride of place is given to the reflexive method, while the role of contract and rational choice, though not denied, is downgraded. Finally, I enquire whether Rawls can be considered a universalist, and suggest that this category, owing to the theory’s practical aim and pragmatic method, is of little use. If successful, my reconstruction should offer a better insight into the theory and dispel some possible misunderstandings. But my presentation should not be read as either an assessment or a defense. (shrink)

Both a significant body of literature and the case study presented here show that digital knowledge repositories struggle to attract the needed level of data and knowledge contribution that they need to be successful. This happens also to high profile and prestigious initiatives. The paper argues that the reluctance of researchers to contribute can only be understood in light of the highly competitive context in which research careers need to be built nowadays and how this affects researchers’ quality of life. (...) Competition and managerialism limit the discretion of researchers in sharing their results and in donating their working time. A growing corpus of research shows that academic researchers are increasingly overworked and highly stressed. This corroborates the point that the room for undertaking additional tasks with future and uncertain benefits is very limited. The paper thus recommends that promoters of digital knowledge repositories focus on the needs of the researchers who are expected to contribute their knowledge. In order to treat them fairly and to ensure the success of the repositories, knowledge sharing needs to be rewarded so as to improve the working conditions of contributors. In order to help implementing this researcher-centred approach, the paper proposes the idea of expediential trust: rewards for contributing should be such that rational, self-interested researchers would freely decide to contribute their knowledge and effort trusting that this would make them better off. (shrink)

Com este trabalho, pretendemos trazer à luz a poesia amorosa de um dos mais célebres poetas neolatinos. Nascido em Cerreto di Spoleto, na Úmbria e educado em Perúgia, Giovanni Pontano (1429-1503) trabalhou na chancelaria real da Casa de Aragão, vindo a se tornar primeiro ministro, durante o governo do rei Fernando I. Embora na tenha se dedicado apenas à poesia amorosa, é sobre esta, por ora, que nossos comentários versarão. Estes comentários se baseiam em poemas endereçados às suas três (...) musas inspiradoras: Fannia, Adriana e Stella. A primeira é o amor da juventude; a segunda, com quem se casou, o amor da fase madura e, a última, o amor de sua velhice. Seus versos são graciosos, fluentes e intensamente sensuais, cheios de paixão e afeto, principalmente aqueles dirigidos à sua esposa. (shrink)

The need to better balance the promotion of scientific and technological innovation with risk management for consumer protection has inspired several recent reforms attempting to make regulations more flexible and adaptive. The pharmaceutical sector has a long, established regulatory tradition, as well as a long history of controversies around how to balance incentives for needed therapeutic innovations and protecting patient safety. The emergence of disruptive biotechnologies has provided the occasion for regulatory innovation in this sector. This article investigates the regulation (...) of advanced biotherapeutics in the European Union and shows that it presents several defining features of an adaptive regulation regime, notably institutionalized processes of planned adaptation that allow regulators to gather, generate, and mobilize new scientific and risk evidence about innovative products. However, our in-depth case analysis highlights that more attention needs to be paid to the consequences of the introduction of adaptive regulations, especially for critical stakeholders involved in this new regulatory ecosystem, the capacity and resource requirements placed on them to adapt, and the new tradeoffs they face. In addition, our analysis highlights a deficit in how we currently evaluate the performance and public value proposition of adaptive regulations vis-à-vis their stated goals and objectives. (shrink)

This paper discusses the role of attention in the phenomenological analysis of intentional experience in light of the problem of the relation between consciousness, intentionality, and transcendental subjectivity. Are these concepts equivalent? Or should we rather say that there is more to intentionality (and subjectivity) than consciousness? Does subjectivity embrace an unconscious domain? And, if so, how does this unconscious, yet intentional, life of subjectivity operate and how is it related to consciousness? In order to answer these questions, the paper (...) tracks the development of Husserl’s conception of attention from the Logical Investigations to genetic phenomenology, by focusing on his analyses of temporality in the Bernau Manuscripts, on the relation between activity and passivity in the Analyses Concerning Active and Passive Synthesis, and on the issue of the self-constitution of subjectivity. (shrink)

The paper defends the theoretical strength and consistency of Rawls's constructivism, showing its ability to articulate and convincingly weave together several key ethical ideas; yet it questions the political relevance of this admirable normative architecture. After having illustrated Rawls's conception of moral agency and practical reason, the paper tackles two criticisms raised by Scheffler. First the allegation of naturalism based on Rawls's disdain of common sense ideas on desert is rebutted. It is then shown that, contrary to Scheffler's contention, Rawls (...) takes proper account of our moral sentiments in the process of constructing his normative theory. Finally, the second criticism is assessed, namely the inability of Rawls's theory to increase consent around liberal policies. Despite disagreement with details of Scheffler's argument, it is suggested that the failure of recent normative liberal theories to have a political impact belies their inability to take into proper consideration the reality of politics. A more realistic appraisal of political life and of historical events and developments are called for if political philosophy wants to be something more than an academic exercise. (shrink)

El transhumanismo como filosofía e ideología tecnologicista tiene cada vez más adeptos y se coloca en los ámbitos académicos como una posición positiva, posible y deseable. Su implementación aparece solapada en una vida cotidiana que depende, como nunca antes, de los avances tecnológicos. La posición que manejaremos es que esta ideología, que sobredimensiona el papel de la tecnología en la sociedad, tiene una visión limitada respecto con los conflictos éticos, económicos y sociales que dimanan de sus presupuestos. El problema no (...) es negar la tecnología sino qué rol juega en la construcción de la sociedad. El transhumanismo puede estar vendiendo un falso sueño de libertad, donde la uniformidad, la ausencia de crítica, la discriminación y la separación radical entre pobres y ricos definan ese mundo paradisíaco que propone. (shrink)