Deep brain stimulation (DBS) to different sites allows interfering with dysfunctional network function implicated in major depression. Because a prominent clinical feature of depression is anhedonia--the inability to experience pleasure from previously pleasurable activities--and because there is clear evidence of dysfunctions of the reward system in depression, DBS to the nucleus accumbens might offer a new possibility to target depressive symptomatology in otherwise treatment-resistant depression. Three patients suffering from extremely resistant forms of depression, who did not respond to pharmacotherapy, psychotherapy, (...) and electroconvulsive therapy, were implanted with bilateral DBS electrodes in the nucleus accumbens. Stimulation parameters were modified in a double-blind manner, and clinical ratings were assessed at each modification. Additionally, brain metabolism was assessed 1 week before and 1 week after stimulation onset. Clinical ratings improved in all three patients when the stimulator was on, and worsened in all three patients when the stimulator was turned off. Effects were observable immediately, and no side effects occurred in any of the patients. Using FDG-PET, significant changes in brain metabolism as a function of the stimulation in fronto-striatal networks were observed. No unwanted effects of DBS other than those directly related to the surgical procedure (eg pain at sites of implantation) were observed. Dysfunctions of the reward system--in which the nucleus accumbens is a key structure--are implicated in the neurobiology of major depression and might be responsible for impaired reward processing, as evidenced by the symptom of anhedonia. These preliminary findings suggest that DBS to the nucleus accumbens might be a hypothesis-guided approach for refractory major depression. (shrink)

In theCompanion to Heidegger's Contributions to Philosophyan international group of fourteen Heidegger scholars shares strategies for reading and understanding this challenging work.

ZusammenfassungDie finanziellen Ressourcen im deutschen Gesundheitssystem sind begrenzt. Diese Mittelknappheit führt im Rahmen der ärztlichen Tätigkeit zu medizinischen, ökonomischen, juristischen und ethischen Problemen, welche sich in den kommenden Jahren weiter verschärfen dürften. Aus ethischer Perspektive sind die Probleme einer gerechten Verteilung knapper Ressourcen sowie mögliche Rollen- oder Gewissenskonflikte der ärztlichen Profession besonders relevant. Mit Hilfe von qualitativen Interviewstudien lässt sich der aktuelle ärztliche Umgang mit der Mittelknappheit in der klinischen Versorgung in seiner Komplexität und seinen ethisch relevanten Aspekten untersuchen. An (...) fünf Kliniken mit unterschiedlichem Versorgungsauftrag wurden Tiefeninterviews mit fünfzehn leitenden Ärzten in den Bereichen Intensivmedizin und Kardiologie durchgeführt. Die auf Tonband aufgezeichneten Interviews wurden nach dem Verfahren der Grounded Theory ausgewertet. Die Ärzte berichten ein heterogenes Spektrum von Einflussfaktoren, Konsequenzen und Reaktionen im Zusammenhang mit ihrem Handeln bei Mittelknappheit. Zuteilungskriterien wie der medizinische Nutzen oder die Kosteneffektivität werden von den befragten Ärzten sehr unterschiedlich interpretiert und führen damit möglicherweise zu inkonsistenten Allokationsentscheidungen. Gleichzeitig bestätigen die Untersuchungen aber auch, dass die Ärzte nicht leichtfertig mit den Allokationsentscheidungen umgehen, im Gegenteil: Die Mittelknappheit und die dadurch hervorgerufenen Verteilungsprobleme können zu Gewissenskonflikten, emotionalem Stress und Gefühlen der Überforderung führen. Um Lösungskonzepte für ethische Probleme im Umgang mit der Mittelknappheit in der klinischen Praxis entwickeln und erfolgreich implementieren zu können, müssen die in dieser Arbeit systematisch zusammengestellten Verständnisweisen, Einflussfaktoren und Konsequenzen im Zusammenhang mit dem Kostendruck berücksichtigt werden. (shrink)

Conley and colleagues (2023) explore how calls for broad public engagement (PE) in the case of heritable human genome editing are being put into action, reviewing the activities of five different i...

El presente artículo pone en diálogo dos teorías sobre la justicia frente al fenómeno migratorio, específicamente, aquel que corresponde a la movilización masiva de ciudadanos venezolanos a Colombia desde el caso particular de la ciudad de Bucaramanga. Lo anterior tiene por objetivo proponer alternativas frente a los principales conflictos que han surgido con el choque cultural, político y económico que conlleva una movilización de esta envergadura en un país poco capacitado. Para conseguir esta meta, se proponen tres momentos; primero, se (...) exponen en conjunto tanto la teoría de Jürgen Habermas como la de Jacques Derrida, el primero de estos al respecto de la relación justicia-tolerancia, mientras que el segundo lo hace desde la dupla justicia-hospitalidad. Seguidamente, se exponen algunos puntos principales para ser analizados sobre la ola migratoria en Colombia, de modo que, finalmente, se pueda hacer una lectura desde el aparato conceptual de ambos autores a la problemática migratoria en la ciudad de Bucaramanga. (shrink)

A discussão por mudanças na educação brasileira é tema recorrente desde a “descoberta” do Brasil. Com o advento da pandemia do novo Coronavírus, percebeu-se, por exemplo, a intensificação da tentativa de regulamentar o homeschooling no Brasil como um modal educacional, justificando, assim, a necessidade de discussão a respeito de uma propositiva de educação escolar domiciliar. Nesse viés, o presente estudo teve por objetivo compreender os elementos constitutivos do homeschooling no Brasil. Com base em pressupostos críticos e fazendo uso de estudo (...) bibliográfico e análise documental, o corpus teórico utilizado foi de Lubienski (2007), Roldão (2007), Saviani (2003; 2008), entre outros, tendo como referência o levantamento nas bases de dados ANPEd, CAPES e BDTD. Como recorte temporal no período 2019-2021, concluiu-se que o ensino domiciliar seria um retrocesso para a educação brasileira, aumentando a desigualdade social outrora existente, além de acarretar perdas irreparáveis para os estudantes. (shrink)

It is widely believed that we ought not to criticize others for wrongs that we ourselves have committed. The author draws out and challenges some of the background assumptions about the practice of criticism that underlie our attraction to this claim, such as the tendency to think of criticism either as a social sanction or as a didactic intervention. The author goes on to offer a taxonomy of cases in which the moral legitimacy of criticism is challenged on the grounds (...) that the critic him- or herself engages in the behavior that he or she criticizes in others. The author argues that, in each type of case, the would-be critics should not constrain their participation in moral discourse on the grounds that they are not themselves innocent of the wrongdoing they criticize in others. (shrink)

Individuals who deviate from social norms by committing crimes may have reduced facial emotion recognition abilities. Nevertheless, a specific category of offenders – i.e. organised crime (OC) members – is characterised by hierarchically organised social networks and a tendency to manipulate others to reach their illicit goals. Since recognising emotions is crucial to building social networks, OC members may be more skilled in recognising the facial emotion expressions of others to use this information for their criminal purposes. Evidence of a (...) difference between OC and non-organised crime (NOC) offenders in terms of facial emotion recognition is still lacking. To fill this gap in the literature, we tested 50 OC, 50 NOC offenders, and 50 non-offender controls for their ability to identify six basic emotions (happiness, sadness, fear, anger, disgust, and surprise). All participants underwent a cognitive and psychological evaluation to avoid alternative explanations. Results show that OC members were more able to detect the expression of fear in others as compared to NOC. We interpreted this finding in light of the social context and the behavioural criminal attitude of OC members. (shrink)

It is thought that just as hunger itself, the expectancy to eat impacts attention and cognitive control toward food stimuli, but this theory has not been extensively explored at a behavioral level. In order to study the effect of expectancy to eat on attentional and cognitive control mechanisms, 63 healthy fasting participants were presented with an affective priming spatial compatibility Simon task that included both food and object distracters. The participants were randomly assigned to two groups: an “immediate expectancy” group (...) made up of participants who expected to eat immediately after the task and a “delayed expectancy” cohort made up of individuals who expected to eat a few hours later. Slower reaction times toward the food and non-food distracters and a more pronounced effect on the RTs in the incompatible condition [i.e., the Simon effect ] were noted in both groups. The effect of the food and non-food distracters on the RTs was more pronounced in the immediate with respect to the delayed expectancy group. The magnitude of the SE for the food and the non-food distracters was also greater in the immediate with respect to the delayed expectancy group. These results seem to indicate that when the expectancy to eat is short, the RTs are delayed, and the SE is more pronounced when food and non-food distracters are presented. Instead, when the expectancy to eat is more distant, the distracters have less of an effect on the RTs and the correspondence effect is smaller. Our results suggest that the expectancy to eat can modulate both attention orienting and cognitive control mechanisms in healthy fasting individuals when distracting details are competing with information processing during goal directed behavior. (shrink)

When there are two lines of argument that contradict each other but still end up with the same conclusion, this conclusion is called a floating conclusion. It is an open topic in skeptical defeasible reasoning if floating conclusions ought to be accepted. Inter- estingly, the answer seems to be changing for different examples. In this paper, we propose a solution for explaining the different treatments of the floating conclusion in the various examples from the literature. We collect the examples from (...) the literature, extend them with additional examples and test various hypotheses for explaining the difference by means of the examples. We will argue for a framework that accepts a floating conclusion by default but allows for reasons to deviate from the default in order to reject it. These reasons nicely explain the different underlying patterns of our intuitions. (shrink)

IntroductionThe assessments of the motor symptoms in Parkinson’s disease are usually limited to clinical rating scales, and it depends on the clinician’s experience. This study aims to propose a machine learning technique algorithm using the variables from upper and lower limbs, to classify people with PD from healthy people, using data from a portable low-cost device. And can be used to support the diagnosis and follow-up of patients in developing countries and remote areas.MethodsWe used Kinect®eMotion system to capture the spatiotemporal (...) gait data from 30 patients with PD and 30 healthy age-matched controls in three walking trials. First, a correlation matrix was made using the variables of upper and lower limbs. After this, we applied a backward feature selection model using R and Python to determine the most relevant variables. Three further analyses were done using variables selected from backward feature selection model, movement disorders specialist, and all the variables from the dataset. We ran seven machine learning models for each model. Dataset was divided 80% for algorithm training and 20% for evaluation. Finally, a causal inference model using the DoWhy library was performed on Dataset B due to its accuracy and simplicity.ResultsThe Random Forest model is the most accurate for all three variable Datasets followed by the support vector machine. The CIM shows a relation between leg variables and the arms swing asymmetry and a proportional relationship between ASA and the diagnosis of PD with a robust estimator.ConclusionsMachine learning techniques based on objective measures using portable low-cost devices are useful and accurate to classify patients with Parkinson’s disease. This method can be used to evaluate patients remotely and help clinicians make decisions regarding follow-up and treatment. (shrink)

In this volume, renowned experts in psychoanalysis reflect on the relationship between psychoanalysis and religion, in particular presenting various controversial interpretations of the question if and to what extent monotheism semantically and structurally fits psychoanalytic insights. Some essays augment traditional religious critiques of Freudianism with later religio-philosophical theories on, for example, femininity. Others explore the relation between psychopathology and morality from the Freudian premise that psychopathology shows in an excessive way aspects or mechanisms of the human psyche that constitute our (...) subjectivity, moral capacities, and behavior.Contributors: Andreas De Block, KU Leuven-University of Leuven; Fethi Benslama, University of Paris Diderot; Sergio Benvenuto, ISTC, Rome; Gohar Homayounpour, Shahid Beheshti University, Tehran; Felix de Mendelssohn, Sigmund Freud University, Vienna; Julia Kristeva, University of Paris Diderot; Lode Lauwaert, KU Leuven-University of Leuven; Siamak Movahedi, University of Massachusetts; Wolfgang Muller-Funk, University of Vienna; Gilles Ribault, University of Paris Diderot; Céline Surprenant, University of Sussex; Inge Scholz-Strasser, Sigmund Freud Foundation; Herman Westerink, University of Vienna; Joel Whitebook, Columbia University; Moshe Zuckermann, Tel Aviv University. (shrink)

Der Sammelband geht den Fragen nach, was eigentlich studierendenzentrierte Lehre ist, welche konkreten Herausforderungen bei der Umsetzung einer studierendenzentrierten Lehre auftreten und wie eine solche Lehre angesichts dieser Herausforderungen umgesetzt werden kann. Aber auch: Welche Hürden haben sich bisher als unüberwindbar erwiesen, und wie können Lehrende damit umgehen?

In a hospital UFNs, an outbreak of food poisoning can have disastrous consequences and aggregate risk of death for patients. Thus, the training of food handlers is critical to ensuring the quality of the food that is produced. The aim of this study was to implement the SOPs related to sanitation and disinfection of equipment and utensils, by means of a training, containing illustrative figures and everyday issues on the subject; and evaluate the daily practice of sanitation and disinfection activities (...) before and after the intervention with employees of UFN. We developed and implemented a guidefor inspection of best practices in sanitation of equipment and utensils at two different times, before and after the intervention with the food handlers. The results showed a significant improvement in the situation of this unit in terms of practice, frequency and fulfillment of stages related to sanitation and disinfection of equipment and utensils. We concluded that the implementation of SOPs for sanitation and disinfection was carried out successfully, and that empowering employees with dynamic and interactive training allows them a greater understanding of the importance of hygiene practices in the daily routine of UFN. (shrink)

I-Language introduces the uninitiated to linguistics as cognitive science. In an engaging, down-to-earth style Daniela Isac and Charles Reiss give a crystal-clear demonstration of the application of the scientific method in linguistic theory. Their presentation of the research programme inspired and led by Noam Chomsky shows how the focus of theory and research in linguistics shifted from treating language as a disembodied, human-external entity to cognitive biolinguistics - the study of language as a human cognitive system embedded within the (...) mind/brain of each individual. The recurring theme of equivalence classes in linguistic computation ties together the presentation of material from phonology, morphology, syntax, and semantics. The same theme is used to help students understand the place of linguistics in the broader context of the cognitive sciences, by drawing on examples from vision, audition, and even animal cognition.This textbook is unique in its integration of empirical issues of linguistic analysis, engagement with philosophical questions that arise in the study of language, and treatment of the history of the field. Topics ranging from allophony to reduplication, ergativity, and negative polarity are invoked to show the implications of findings in cognitive biolinguistics for philosophical issues like reference, the mind-body problem, and nature-nurture debates.This textbook contains numerous exercises and guides for further reading as well as ideas for student projects. A companion website with guidance for instructors and answers to the exercises features a series of pdf slide presentations to accompany the teaching of each topic. (shrink)

El presente artículo aborda la estrategia escritural de Daniela Catrileo. Se propone revisar la elaboración del concepto de piñen examinando la relación entre lenguaje y colonialidad, para, de ese modo, subrayar el potencial político y reivindicativo que comporta en la novela del mismo nombre, Piñen (2019). Dicha hipótesis articulará el ejercicio de lectura aquí propuesto, atendiendo principalmente las estrategias narrativas empleadas –servirse de un polilingüismo que rompe estructuras gramaticales– para descentrar el lenguaje de su determinismo colonial. Así, interpretamos dicha (...) estrategia escritural en consonancia con las potencias micropolíticas y descolonizadoras del arte descritas por Suely Rolnik y, en consecuencia, apostando por la posibilidad de diagramar un devenir minoritario que dispute los imaginarios del inconsciente colonial-capital. (shrink)

O objetivo deste estudo foi analisar o bem-estar dos trabalhadores da saúde de um centro de reabilitação e readaptação, relacionando-o com a crença no mundo justo e com o lócus de controle. Participaram 146 profissionais que responderam a um questionário formado por perguntas sobre dados sócio-demog..

En el marco de los debates sobre cómo alojar los testimonios de lesa humanidad del terrorismo de Estado argentino, que tensan modelos habituales de análisis y demandan escucha y respuestas respetuosas, se indaga lo que puede la vergüenza, afecto/emoción de particular presencia en las denuncias de la violencia sexual concentracionaria. Por un lado, esta vergüenza ha impedido o demorado la posibilidad de denunciar este crimen y/o de resignificar su sentido; por otro lado, su exposición en las instancias públicas de narración (...) de violaciones o abusos articula una agencia de las víctimas que desestabiliza normas de género en los límites de lo decible/audible. Preguntarse lo que puede la vergüenza como ruta a transitar procura reconocer modos de agencia de las sobrevivientes testigos que aportan significativamente a la construcción política de las memorias y a los archivos feministas de las violencias de género. Considerando las resistencias a estos testimonios y analizando el rol de la vergüenza en ellos desde claves interpretativas del “giro afectivo” se sigue la imbricación entre dinámicos mecanismos de legitimación de la opresión de género y la lógica contingente de atribución de afectos. Se abren así posibilidades de reconfigurar lo que merece ser recordado y constituirse en un legado. (shrink)

Placing the analyses in an interdisciplinary manner, the present paper fallows to catch and value, form a moral-formative perspective, the interpretations of the ethical theories regarding the evolutions in a moral plan, in order to build a structural model of the morality development levels, with all the complex and dynamiccomponents that this one transmits. We have proposed that this should have as final purpose the transfer and focalization of this data over the significant space of forming the human being as (...) a moral, autonomous and responsible personality, by offering, we hope, in the terms in of efficiency, a rich space, a more complete and operational form about the levels of morality and moral education. The education in mostly very responsible for the step that defines the educated morality, of the community, of the society and a re-thinking, a restructuring and direction of the moral education on different levels is, we think, a way of responding to the challenges of today and tomorrow’s world. (shrink)

Unter den Institutionen des Sendens stellt das Fernsehen mit Sicherheit die über lange Jahrzehnte erfolgreichste dar. Gleichwohl wird angesichts der mit der Digitalisierung einhergehenden, das Senden und die Sendungen weitreichend betreffenden Veränderungen, die das Medium unterläuft, vielerorts und nicht völlig grundlos die Post-Broadcast-Ära ausgerufen. Anhand der Lektüre verschiedener Serien werden diese Veränderungen hier nachvollzogen und untersucht. Das Sendungsformat der Serie erscheint für ein solches Unterfangen besonders geeignet, weil das Senden des Fernsehens zutiefst mit der Serialität und dem Seriellen als Prinzip (...) verknüpft scheint. An den Formen und Veränderungen des Seriellen lassen sich auch die Veränderungen des Fernsehsendens ablesen. Among the many institutions of sending, television certainly represents the most successful one over long decades. Nevertheless, given the changes that the medium incurs in terms of broadcasting and broadcasts as a consequence of digitalisation, many proclaim – and not entirely without reason – the post-broadcast era. This paper studies these changes by way of a reading of different television series. The format of the series seems particularly suitable to this end, since the broadcasting of television seems deeply linked to seriality and the serial as a principle. The changes in television broadcasting can be gleaned from the forms and changes of the serial. (shrink)

An extensive literature has focused on the impact of new public management oriented structural changes on academics’ practice and identity. These critical studies have been resolute in concluding that NPM inevitably leads to a degeneration of academics’ ethos and values. Drawing from the moral philosophy of Alasdair MacIntyre, we argue that these previous analyses have overlooked the moral agency of the academics and their role in ‘moralizing’ and consequently shaping the ethical nature of their practices. The paper provides a new (...) theoretical understanding of NPM-oriented reforms in light of the virtue ethics approach, thereby directing the attention to the moral character and moral agency of academics. Our analysis of interviews collected in the business department of a Danish university provides an example of how individuals have divergent ethical understandings of these structural changes and enact/resist pre-defined social roles in different ways. While in some cases the NPM agenda of the institutions has triggered internal moral conflict and a crisis of moral character, in other cases the new logic resonates with academics’ values and evaluative standards. Partially departing from the theoretical ground of MacIntyre, we conclude that academics can play a crucial role in shaping the morality of NPM-oriented institutions and in transforming these settings into suitable contexts for the cultivation of virtues. (shrink)

Drawing on Deleuze's early works of the 1960s, this article investigates the ways in which Deleuze challenges our traditional linguistic notion of sense and notion of truth. Using Frege's account of sense and truth, this article presents our common understanding of sense and truth as two separate dimensions of the proposition where sense subsists only in a formal relation to the other. It then goes on to examine the Kantian account, which makes sense the superior transcendental condition of possibility of (...) truth. Although both accounts define sense as merely the form of possibility of truth, a huge divide cuts across a simple formal logic of sense and a transcendental logic: transcendental logic discovered a certain genetic productivity of sense, such that a proposition always has the kind of truth that it merits according to its sense. In pursuit of this genetic productivity of sense, Deleuze applies different models of explanation: a Nietzschean genealogical model of the genetic power of sense, and in The Logic of Sense a structural model combined with elements of Stoic philosophy. This article follows Deleuze in setting up a new and very complex notion of sense, which he radically distinguishes from what he terms ‘signification’, that is, an extrinsic, linguistic or logical, condition of possibility. Rather, sense has to be conceived as both the effect and the intrinsic genetic element of an extra-propositional sense-producing machine. (shrink)

Architecture has always been a magnificent and much debated platform to express the spirit of the times, world views, everyday life, and aesthetics. It is a daring materialisation of private and public visions, of applied art and the avant-garde alike.

In this book, Gobetti combines political theory with the history of political thought to question the conceptual conventions and tacit assumptions which surround the concepts of private and public. In seeking the foundations of the modern liberal conception of private and public, she traces it to modern Natural Law thinkers, in particular Locke and Hutcheson. By developing a revised interpretation of 17th century natural jurisprudence, which recognizes that every adult controls an individual or private domain, as well as engaging in (...) political, community or public interaction, Gobetti raises interesting questions about the politics of participation in modern society. (shrink)

There are few doubts about the significance of science and technology for modern human culture and society. But as historians, we are still struggling to find appropriate descriptive terms to capture the broad processes of transformation brought about by “techno-science,” the merging of technical production and modern institutionalized science. This dissertation argues that the term “experience” may serve as such an analytic lens in the specific historical setting of German aviation research from the 1920s through 1945. I reconstruct, on the (...) one hand, the theorization of experience as a concept by the technical physicist Paul von Handel, influenced by the British astronomer Sir Arthur Eddington’s distinction between "scientific" and "everyday" experience. On the other hand, I use the term as a historian’s analytic concept to investigate practices in the context of flight experiments that I take to be constitutive of my historical actors’ experiences. These are recordings of experimental pilots’ cognitive judgements and bodily actions, some of them—such as in-flight note taking—continuous with older cultural technologies. On both of these levels of analysis, I explore the different resonances of “experience” as a term with a legacy as a central epistemological concept in the modern sciences, and as capturing the changing everyday reality in an increasingly technicized environment. My analysis of the textual theorization and simultaneous practical constitution of "techno-scientific experience" serves to read in a new light the story of the pilot and physicist Melitta Schiller-Stauffenberg. Of Jewish descent, Schiller chose to work for the Luftwaffe, the German air force, until her death in 1945 on a flight searching for her husband, Count Alexander Stauffenberg, who was imprisoned after his brother’s failed attempt to assassinate Hitler. The concept and practical reality of “experience” are key to understanding the two striking choices Schiller made as intrinsically connected: the professional choice of working simultaneously as a pilot and a physicist, and the political choice of supporting the Reich’s war effort. Schiller’s story may be understood as exemplifying the fragile identity of the experiencing and the knowing self in 20th-century techno-scientific modernity. (shrink)