IntroductionParkinson’s disease patients have a significantly higher risk of developing dementia in later disease stages, leading to severe impairments in quality of life and self-functioning. Questions remain on how deep brain stimulation affects cognition, and whether we can individualize therapy and reduce the risk for adverse cognitive effects. Our aim in this systematic review is to assess the current knowledge in the field and determine if the findings could influence clinical practice.MethodsWe have conducted a systematic review according to PRISMA guidelines (...) through MEDLINE and Embase databases, with studies being selected for inclusion via a set inclusion and exclusion criteria.ResultsSixty-seven studies were included in this systematic review according to the selected criteria. This includes 6 meta-analyses, 18 randomized controlled trials, 17 controlled clinical trials, and 26 observational studies with no control arms. The total number of PD patients encompassed in the studies cited in this review is 3677, not including the meta-analyses.ConclusionCognitive function in PD patients can deteriorate, in most cases mildly, but still impactful to the quality of life. The strongest evidence is present for deterioration in verbal fluency, while inconclusive evidence is still present for executive function, memory, attention and processing speed. Global cognition does not appear to be significantly impacted by DBS, especially if cognitive screening is performed prior to the procedure, as lower baseline cognitive function is connected to poor outcomes. Further randomized controlled studies are required to increase the level of evidence, especially in the case of globus pallidus internus DBS, pedunculopontine nucleus DBS, and the ventral intermediate nucleus of thalamus DBS, and more long-term studies are required for all respective targets. (shrink)

Predictivists use the no miracle argument to argue that “novel” predictions are decisive evidence for theories, while mere accommodation of “old” data cannot confirm to a significant degree. But deductivists claim that since confirmation is a logical theory-data relationship, predicted data cannot confirm more than merely deduced data, and cite historical cases in which known data confirmed theories quite strongly. On the other hand, the advantage of prediction over accommodation is needed by scientific realists to resist Laudan’s criticisms of the (...) no miracle argument. So, if the deductivists are right, the most powerful argument for realism collapses. There seems to be an inescapable contradiction between these prima facie plausible arguments of predictivists and deductivists; but this puzzle can be solved by understanding what exactly counts as novelty, if novel predictions must support the no miracle argument, i.e., if they must be explainable only by the truth of theories. Taking my cues from the use-novelty tradition, I argue that (1) the predicted data must not be used essentially in building the theory or choosing the auxiliary assumptions. This is possible if the theory and its auxiliary assumptions are plausible independently of the predicted data, and I analyze the consequences of this requirement in terms of best explanation of diverse bodies of data. Moreover, the predicted data must be (2) a priori improbable, and (3) heterogeneous to the essentially used data. My proposed notion of novelty, therefore, is not historical, but functional. Hence, deductivists are right that confirmation is independent of time and of historical contingencies such as if the theorist knew a datum, used it, or intended to accommodate it. Predictivists, however, are right that not all consequences confirm equally, and confirmation is not purely a logical theory-data relation, as it crucially involves background epistemic conditions and the notion of best explanation. Conditions (1)–(3) make the difference between prediction and accommodation, and account for the confirming power of theoretical virtues such as non ad-hocness, non-fudging, non-overfitting, independence and consilience. I thus show that functional novelty (a) avoids the deductivist objections to predictivism, (b) is a gradual notion, in accordance with the common intuition that confirmation comes in degrees, and (c) supports the no miracle argument, so vindicating scientific realism. (shrink)

How does a Muslim jurist think the law and how, accordingly, he judges a fact? Using Alice in Wonderland as hermeneutical device to explore the logic of fiqh, this article identifies a divergence between Western and Islamic legal thinking in the application of abduction as key form of inference in the law of Islam. In particular, looking at the fact/law relation in symbolic terms, the article highlights how, while a dichotomy between fact and law characterizes Western legal thinking, fiqh upholds (...) a connection between the “real” and the “right”, where the effort in understanding sharī‘ah postulates the actualization of the “rule” in God’s creation. Thus, if sharī‘ahpre-scribes the Law, not only is the rule discovered through the sources, but the right has to be justified through a verdict de-scribing the fact, for the law to be validly stated for the given situation. In this sense, abduction as explanatory “hypothesis” and “inference to the best explanation” of sharī‘ah provides an account for the probabilistic nature of fiqh, its ramification through verdicts, as well as for the epistemic and narrative function of the tradition as core aspects of the logic of Islamic law. At the same time, doubts can be raised about the compatibility between this logic and the deductive logic of modern state law, as a sub-product of Western legal thinking. (shrink)

Cómo es posible la historia? -- Giambattista Vico : Una nueva ciencia, la historia (1725) -- Carta de Heidelberg.

Starting from macroscopic and microscopic facts of cerebellar histology, we propose a new functional interpretation that may elucidate the role of the cerebellum in movement control. The idea is that the cerebellum is a large collection of individual lines (Eccles's : Eccles et al. 1967a) that respond specifically to certain sequences of events in the input and in turn produce sequences of signals in the output. We believe that the sequence-in/sequence-out mode of operation is as typical for the cerebellar cortex (...) as the transformation of sets into sets of active neurons is typical for the cerebral cortex, and that both the histological differences between the two and their reciprocal functional interactions become understandable in the light of this dichotomy. The response of Purkinje cells to sequences of stimuli in the mossy fiber system was shown experimentally by Heck on surviving slices of rat and guinea pig cerebellum. Sequential activation of a row of eleven stimulating electrodes in the granular layer, imitating a of the stimuli along the folium, produces a powerful volley in the parallel fibers that strongly excites Purkinje cells, as evidenced by intracellular recording. The volley, or has maximal amplitude when the stimulus moves toward the recording site at the speed of conduction in parallel fibers, and much smaller amplitudes for lower or higher The succession of stimuli has no effect when they in the opposite direction. Synchronous activation of the stimulus electrodes also had hardly any effect. We believe that the sequences of mossy fiber activation that normally produce this effect in the intact cerebellum are a combination of motor planning relayed to the cerebellum by the cerebral cortex, and information about ongoing movement, reaching the cerebellum from the spinal cord. The output elicited by the specific sequence to which a is tuned may well be a succession of well timed inhibitory volleys the motor sequences so as to adapt them to the complicated requirements of the physics of a multijointed system. (shrink)

Un’originale interpretazione di Lettera a una professoressa che, a mezzo secolo dalla sua uscita, si presta a una rilettura in chiave sociologica. Concetti come “capitale culturale”, “ideologia delle doti”, “violenza simbolica”, “habitus”, “codici linguistici”, ne costituiscono di fatto la cornice teorica.Depurando il priore di Barbiana dalle incrostazioni ideologiche che si sono andate sommando nel tempo, fino a falsarlo sublimandolo in una icona buona per tutti gli utilizzi, anche politici, sottolineandone l’eccezionale statura ma anche i, sia pur pochi, limiti, se ne (...) ottiene una rappresentazione più vicina alla realtà, inquadrata nell’ambito della Chiesa fiorentina del suo tempo. (shrink)

L'autore parte dall'analisi dei problemi etici espressi nei linguaggi della poesia, della tragedia e della storiografia, per passare poi alla lettura delle maggiori opere del pensiero antico, fornendo di ognuna puntuali introduzioni. Un'attenzione particolare, alla fine di ogni capitolo, è dedicata all'eredità moderna e al significato attuale dei problemi dell'etica antica, proponendo in modo esplicito un collegamento fra ricostruzione storica e discussione teorica contemporanea.

The original evidence advanced to support the Tensed S Condition (TSC) and the Specified Subject Condition (SSC) in Chomsky's Conditions on Transformations is reconsidered and viable alternatives to these constraints are provided. It is shown that TSC and SSC, in some instances, lead to a loss of linguistically significant generalization. Satisfactory alternatives can account for the relevant range of data and provide a more general account of additional data. Finally, counterevidence to Subjacency and Superiority is adduced, but explicit alternatives to (...) these conditions are not offered. (shrink)

Although our idea of sequential input being a key to cerebellar function was taken seriously by most commentators, there were also objections, based in part on experimental evidence that seems to contradict our intuitions and in part on commentators' preferences for different schemes. Several were suspicious of experiments (performed on slices of cerebellar tissue) that may have severed some of the synaptic connections, particularly the inhibitory ones. It is our feeling that a modi-fication of our theory that could satisfy most (...) critics would not have to be very radical. (shrink)

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)‐based “active genetic” elements developed in 2015 bypassed the fundamental rules of traditional genetics. Inherited in a super‐Mendelian fashion, such selfish genetic entities offered a variety of potential applications including: gene‐drives to disseminate gene cassettes carrying desired traits throughout insect populations to control disease vectors or pest species, allelic drives biasing inheritance of preferred allelic variants, neutralizing genetic elements to delete and replace or to halt the spread of gene‐drives, split‐drives with the core constituent (...) Cas9 endonuclease and guide RNA (gRNA) components inserted at separate genomic locations to accelerate assembly of complex arrays of genetic traits or to gain genetic entry into novel organisms (vertebrates, plants, bacteria), and interhomolog based copying systems in somatic cells to develop tools for treating inherited or infectious diseases. Here, we summarize the substantial advances that have been made on all of these fronts and look forward to the next phase of this rapidly expanding and impactful field. (shrink)

On December 18, 2014, a yellow female fly quietly emerged from her pupal case. What made her unique was that she had only one parent carrying a mutant allele of this classic recessive locus. Then, one generation later, after mating with a wild‐type male, all her offspring displayed the same recessive yellow phenotype. Further analysis of other such yellow females revealed that the construct causing the mutation was converting the opposing chromosome with 95% efficiency. These simple results, seen also in (...) mosquitoes and yeast, open the door to a new era of genetics wherein the laws of traditional Mendelian inheritance can be bypassed for a broad variety of purposes. Here, we consider the implications of this fundamentally new form of “active genetics,” its applications for gene drives, reversal and amplification strategies, its potential for contributing to cell and gene therapy strategies, and ethical/biosafety considerations associated with such active genetic elements. (shrink)

Most social scientists and philosophers claim that sociology and philosophy are disjoint fields of inquiry. Some have wondered how to trace the precise boundary between them. Mario Bunge argues that the two fields are so entangled with one another that no demarcation is possible or, indeed, desirable. In fact, sociological research has demonstrably philosophical pre-suppositions. In turn, some findings of sociology are bound to correct or enrich the philosophical theories that deal with the world, our knowledge of it, or (...) the ways of acting upon it. While Bunge's thesis would hardly have shocked Mill, Marx, Durkheim, or Weber, it is alien to the current sociological mainstream and dominant philosophical schools. Bunge demonstrates that philosophical problematics arise in social science research. A fertile philosophy of social science unearths critical presuppositions, analyzes key concepts, refines effective research strategies, crafts coherent and realistic syntheses, and identifies important new problems. Bunge examines Marx's and Durkheim's thesis that social facts are as objective as physical facts; the so-called Thomas theorem that refutes the behaviorist thesis that social agents react to social stimuli rather than to the way we perceive them; and Merton's thesis on the ethos of basic science which shows that science and morality are intertwined. He considers selected philosophical problems raised by contemporary social studies and argues forcefully against tolerance of shabby work in academic social science and philosophy alike. (shrink)

Philosophies and phobosophies -- The philosophical matrix of scientific progress -- Systemics and materialism -- Technoscience? -- Climate and logic -- Informatics : one or multiple? -- Wealth and well-being, economic growth and integral development -- Can standard economic theory account for crises? -- Marxist philosophy : promise and reality -- Rules of law : just and unjust -- Subjective probabilities : admissible in science? -- Does inductive logic work? -- Bridging theories to data -- Matter and energy : physical (...) or metaphysical concepts? -- Does quantum physics refute realism, materialism and determinism? -- Parallel universes? Digital physics? -- Can functionalist psychology explain anything? -- Knowledge pyramids or rosettes? -- Existence : single or double? -- Conclusion : valuation criterion. (shrink)

The papers that follow were read and discussed at the first Symposium on Exact Philosophy. This conference was held at Montreal on November 4th and 5th, 1971, to celebrate the sesquicentennial of McGill University and establish the Society for Exact Philosophy. The expression 'exact philosophy' is taken to signify mathematical phi losophy, i.e., philosophy done with the explicit help of mathematical logic and mathematics. So far the expression denotes an attitude rather than a fully blown discipline: it intends to convey (...) the intention to try and pro ceed in as exact a manner as we can in formulating and discussing phi losophical problems and theories. The kind of philosophy we wish to practice and promote is disciplined rather than wild, systematic rather than disconnected, and capable of being argued over rather than oracular. We believe that even metaphysics, notoriously riotous, can be subjected to the control of logic and mathematics. Even the history of philosophy, notoriously unsystematic, can benefit from an exact reconstruction of some classical ideas. (shrink)

A re-evaluation of the notion of vacuum in quantum electrodynamics is presented, focusing on the vacuum of the quantized electromagnetic field. In contrast to the ‘nothingness’ associated to the idea of classical vacuum, subtle aspects are found in relation to the vacuum of the quantized electromagnetic field both at theoretical and experimental levels. These are not the usually called vacuum effects. The view defended here is that the so-called vacuum effects are not due to the ground state of the quantized (...) electromagnetic field. Nevertheless it is possible to maintain an empirically demonstrable notion of vacuum state that is consistent with the interpretation of the formalism of the theory. (shrink)

This fascinating exploration of the great discoveries of history's most important mathematicians seeks an answer to the eternal question: Does mathematics hold the key to understanding the mysteries of the physical world?

It is generally argued that if the wave-function in the de Broglie–Bohm theory is a physical field, it must be a field in configuration space. Nevertheless, it is possible to interpret the wave-function as a multi-field in three-dimensional space. This approach hasn’t received the attention yet it really deserves. The aim of this paper is threefold: first, we show that the wave-function is naturally and straightforwardly construed as a multi-field; second, we show why this interpretation is superior to other interpretations (...) discussed in the literature; third, we clarify common misconceptions. (shrink)

Machine generated contents note: I. METAPHYSICS -- 1. How Do Realism, Materialism, and Dialectics Fare in Contemporary Science? -- 2. New Dialogues between Hylas and Philonous -- 3. Energy: Between Physics and Metaphysics -- 4. The Revival of Causality -- 5. Emergence and the Mind -- 6 SCIENTIFIC REALISM -- 6. The Status of Concepts -- 7. Popper's Unworldly World 3 --II. METHODOLOGY AND PHILOSOPHY OF SCIENCE -- 8. On Method in the Philosophy of Science -- 9. Induction in Science (...) -- 10. The GST Challenge to the Classical Philosophies of Science -- 11. The Power and Limits of Reduction -- 12. Thinking in Metaphors --III. PHILOSOPHY OF MATHEMATICS -- 13. Moderate Mathematical Fictionism -- 14. The Gap between Mathematics and Reality -- 15. Two Faces and Three Masks of Probability --IV. PHILOSOPHY OF PHYSICS -- 16. Physical Relativity and Philosophy -- 17. Hidden Variables, Separability, and Realism -- 18. Schrodinger's Cat Is Dead --V. PHILOSOPHY OF PSYCHOLOGY -- 19. From Mindless Neuroscience and Brainless Psychology to Neuropsychology -- 20. Explaining Creativity -- VI. PHILOSOPHY OF SOCIAL SCIENCE -- 21. Analytic Philosophy of Society and Social Science: -- The Systemic Approach as an Alternative to Holism and Individualism -- 22. Rational Choice Theory: A Critical Look at Its Foundations -- 23. Realism and Antirealism in Social Science --VII. PHILOSOPHY OF TECHNOLOGY -- 24. The Nature of Applied Science and Technology -- 25. The Technology-Science-Philosophy Triangle in Its Social Context -- 26. The Technologies in Philosophy --VIII. MORAL PHILOSOPHY -- 27. A New Look at Moral Realism -- 28. Rights Imply Duties --IX. SOCIAL AND POLITICAL PHILOSOPHY -- 29. Morality Is the Basis of Legal and Political Legitimacy -- 30. Technoholodemocracy: An Alternative to -- Capitalism and Socialism -- Bibliography -- Index of Names -- Index of Subjects. (shrink)

Wer bin ich, wenn nicht mein Gehirn? Das menschliche Gehirn ist eine besonders eindrucksvolle Blüte am Baum der biologischen Vielfalt. Dieser Stammbaum hat seine Äste in der Welt entwickelt und ist mit seinen Wurzeln tief in der Natur verankert. Wer aber erkennt die Gesetze der Natur und beobachtet die wundersame Entwicklung des Lebendigen, wenn nicht das Gehirn selbst? Bei dieser Spiegelung des Gehirns in der Welt und der Welt im Gehirn schließt sich ein Kreis, in dem Geist und Stoff nicht (...) mehr als unvereinbare Elemente erscheinen. Im Mittelpunkt der philosophisch-naturwissenschaftlichen Gedanken von Valentin Braitenberg steht der Begriff der Information, der in der Form der Lebewesen als ein Wissen über die Welt aufscheint. Ein geistreicher Fundus für alle, die Lust haben, unsere Existenz in dieser Welt zu verstehen, wie Forscher, Mediziner, Philosophen... Die italienische Ausgabe dieses Buches, "L'immagine del mondo nella testa", wurde mit dem renommierten italienischen Medienpreis "Premio Galileo 2000"L'immagine del mondo nella testa", wurde mit dem renommierten italienischen Medienpreis "Premio Galileo 2000" für das Jahr 2009 ausgezeichnet. Prof. Dr. Dr. h.c. Valentin Braitenberg, Hirnforscher, war u.a. Direktor am Max-Planck-Institut für biologische Kybernetik in Tübingen und Honorarprofessor an den Universitäten Tübingen und Freiburg. Braitenberg bringt das Kunststück fertig, kurzweilig viele Fragen auf amüsante und ebenso intelligente Weise anzureißen und damit den Leser selbst zu befähigen, darüber zu meditieren, wie das Bild der Welt in dessen eigenen Kopf kommt. Gerade in einer Zeit, in der Meditation gerne als gedankenloses Singen von Mantras missverstanden wird, gereichen die cartesianischen Meditationen à la Braitenberg jedem denkenden Menschen zu einem ganz privaten Vergnügen der besonderen Art. (shrink)

This essay concerns Constant’s classic text The Liberty of the Ancients Compared with that of the Moderns. Although this is a frequently quoted text, what makes reading it still something of an effort is that it contains a baffling shift from the complete exaltation of modern liberty in its first part to the recognition of the significance of political participation in safeguarding modern liberty in its final part. The text is also replete with additional treasures, including Constant’s famous distinction between (...) the liberty of the ancients and that of the moderns and his turn to the basic human capacity of self-development to support his stubborn insistence on the irreducibility of political participation. With regard to the aforementioned shift in the 1819 text, some have argued that in order to reveal the richness of the text we must be aware that its two parts were written under different historical circumstances. Accepting this claim, I argue that the basic tone of the text is Constant’s attempt to combine modern liberty and political participation and that deciphering the argumentative thrust inherent in the text helps reveal its richness. I focus on the centrality of the representative system, which, I argue, plays an important role in Constant’s endeavour to unify the liberty of the moderns and political liberty throughout the text. To see how he defends both the enjoyment of individual interests and the practice of political liberty, it is necessary to recognize the nature of representative assemblies in Constant’s constitutionalism and to characterize his appeal to self-development as a justification of the practice of political liberty. (shrink)