Using masking techniques combined with electrophysiological recordings is a promising way to study neural correlates of visual awareness, as shown in recent studies. Here I comment on the following puzzling aspects typical for this endeavour that have made obstacles for a potentially even more impressive progress. First, the continuing practice of confounds between objective stimulus variables and subjective dependent measures. Second, complexity of timing the emergence of subjective conscious percept which is partly due to complex interactivity between target and (...) mask. Third, the ambiguity of the concept of neural correlates of awareness. (shrink)

The title of this book echoes a phrase used by the Washington Post to describethe American attempt to kill Saddam Hussein at the start of the war againstIraq. Its theme is the notion of targeting (skopos) as the name of an intentionalstructure in which the subject tries to confirm its invulnerability by aiming todestroy a target. At the center of the first chapter is Odysseus’s killing of the suitors;the second concerns Carl Schmitt’s Roman Catholicism and Political Form; thethird (...) and fourth treat Freud’s “Thoughts for the Times on War and Death” and“The Man Moses and Monotheistic Religion.” Weber then traces the emergenceof an alternative to targeting, first within military and strategic thinking itself(“Network Centered Warfare”), and then in Walter Benjamin’s readings of“Capitalism as Religion” and “Two Poems of Friedrich Hölderlin.”. (shrink)

Geron recently announced that it had begun enrolling patients in the world's first-in-human clinical trial involving cells derived from human embryonic stem cells (hESCs). This trial raises important questions regarding the future of hESC-based therapies, especially in spinal cord injury (SCI) patients. We address some safety and efficacy concerns with this research, as well as the ethics of fair subject selection. We consider other populations that might be better for this research: chronic complete SCI patients for a safety trial, (...) subacute incomplete SCI patients for an efficacy trial, and perhaps primary progressive multiple sclerosis (MS) patients for a combined safety and efficacy trial. (shrink)

As Nelson Goodman highlighted, there are two main senses of “abstract” that can be found in discussions about abstract art. On the one hand, a representation is abstract if it leaves out certain features of its target. On the other hand, something can be abstract to the extent that it does not represent a concrete subject. The first sense of “abstract” is well-known in philosophy of science. For example, philosophers discuss mathematical models of physical, biological, and economic systems (...) as being abstract in this sense. However, it is the second sense that dominates discussions of abstract art in aesthetics. For example, abstract art was (and is) considered revolutionary precisely for being non-figurative. Through an analysis of artists including Kandinsky, Malevich, and Mondrian, we develop a reading of this second sense, which we call “generative abstraction,” as opposed to “subtractive” abstraction. Generative abstraction is a process in which a new artifact is created which does not represent the initial concrete target system that inspired it (if there was one), where the artifact’s features are explored for their own sake, and where the “language” of the new artifact is in some way more “universal.” Focusing on this sense of abstraction is helpful in revealing the complexity of the process of crafting an abstract artifact, in problematizing the notion that abstraction can always be un-done (or concretized), as well as revealing new ways for abstractions to be epistemically (un)successful. (shrink)

Rapid actions to persons holding weapons were simulated using desktop virtual reality. Subjects responded to simulated (a) criminals, by pointing the computerÕs mouse at them and left-clicking (simulated shooting), (b) fellow police officers, by pressing the spacebar (safety signal), and (c) citizens, by inaction. In one of two tasks Black males holding guns were police officers while White males holding guns were criminals. In the other, Whites with guns were police and Blacks with guns were criminals. In both tasks Blacks (...) or Whites holding harmless objects were citizens. Signal detection analyses revealed two race effects that led to Blacks being incorrectly shot at more than Whites: a perceptual sensitivity effect (when held by Blacks guns were less distinguishable from harmless objects) and a response bias effect (objects held by Blacks were more likely to be treated as guns). Ó 2003 Elsevier Science (USA). All rights reserved. (shrink)

Much progress has been made in recent years regarding the mechanisms of targeting of secretory proteins to, and across, the endoplasmic reticulum (ER) membrane. Many of the cellular components involved in mediating translocation across this bilayer have been identified and characterized. Polypeptide domains of secretory proteins, termed signal peptides, have been shown to be necessary, and in most cases sufficient, for entry of preproteins into the lumen of the ER. These NH2‐ terminal segments appear to serve multiple roles in targeting (...) and translocation. The structural features which mediate their multiple functions are currently the subject of intense study. (shrink)

Conscious visual perception can fail in many circumstances. However, little is known about the causes and processes leading to failures of visual awareness. In this study, we introduce a new signal detection measure termed subjective discriminability of invisibility that allows one to distinguish between subjective blindness due to reduction of sensory signals or to lack of attentional access to sensory signals. The SDI is computed based upon subjective confidence in reporting the absence of a target . Using this new (...) measure, we found that target misses were subjectively indistinguishable from physical absence when contrast reduction, backward masking and flash suppression were used, whereas confidence was appropriately modulated when dual task, attentional blink and spatial uncertainty methods were employed. These results show that failure of visual perception can be identified as either a result of perceptual or attentional blindness depending on the circumstances under which visual awareness was impaired. (shrink)

Before one can even begin to model consciousness and what exactly it means that it is a subjective phenomenon one needs a theory about what a first-person perspective really is. This theory has to be conceptually convincing, empirically plausible and, most of all, open to new developments. The chosen conceptual framework must be able to accommodate scientific progress. Its ba- sic assumptions have to be plastic as it were, so that new details and empirical data can continuously be fed into (...) the theoretical model as it grows and becomes more refined. This paper makes an attempt at sketching the outlines of such a theory, offering a representationalist analysis of the phenomenal first-person perspective. Three phenomenal target properties are centrally relevant. (shrink)

Context: The integration of data measured in first- and third-person frameworks is a challenge that becomes more prominent as we attempt to refine the ties between the dimensions we assume to be objective and our experience itself. As a result, cognitive science has been a target for criticism from the epistemological and methodological point of view, which has resulted in the emergence of new approaches. Neurophenomenology has been proposed as a means to address these limitations. The methodological application of (...) this discipline, even in its mildest form, enriches the methodology typically used in cognitive sciences. Problem: Nowadays psychological studies are difficult to replicate. As a way to achieve replication of results published in a previous study in order to develop a methodological adaptation suitable for electroencephalographic measurements in a subsequent experiment, first-person accounts from the participants in our pilot study were included in the experiment construction. This study’s objective is to show the benefit of including a mild-neurophenomenology-inspired approach in the adaptation from an original paradigm, which requires, foremost, the ability to replicate the original results. Method: Interviews with open and semi-structured questions were carried out at the end of an Approach-Avoidance Task (AAT. The first-person reports, together with the behavioral outcomes of each pilot, were taken into account for the development of the next piloting phase until replication of the original results was achieved, and the final experimental design was elaborated. Results: A sequence of four pilots, where the integration of third- and first-person information derived from subjects’ behavior and reported experiences while carrying them out rendered the behavioral replication we sought to achieve, providing support for a first-person enriched cognitive science paradigm. Implications: Including first-person accounts systematically during the development and performance of classic cognitive paradigms ensures that those paradigms are measuring what they claim to measure. This is the next logical step to improve replication rates, to refine the explanation of the results and avoid confounding third-person data interpretation. Constructivist content: Including first-person experiences and acknowledging the active role that participants’ experiences regarding the paradigm had in the modeling of its final version is in concordance with a constructivist standing. (shrink)

Is the “act itself” of separating a pregnant woman and her previable child neither good nor bad morally, considered in the abstract? Recently, Maureen Condic and Donna Harrison have argued that such separation is justified to protect the mother’s life and that it does not constitute an abortion as the aim is not to kill the child. In our article on maternal–fetal conflicts, we agree there need be no such aim to kill (supplementing aims such as to remove). However, we (...) argue that to understand “abortion” as performed only where the death of the child is intended is to define the term too narrowly. Respect for the mother, the fetus, and the bond between them goes well beyond avoiding any such aim. We distinguish between legitimate maternal treatments simply aimed at treating or removing a damaged part of the woman and illegitimate treatments that focus harmfully on the fetal body and its presence within the mother’s body. In obstetrics as elsewhere, not all side effects for one subject of intervention can be outweighed by intended benefits for another. Certain side effects of certain intended interventions are morally conclusive. (shrink)

‘Subject of one’s acts’: Lacanian reflections on a Foucauldian art of living In Les aveux de la chair, the fourth volume of his Histoire de la sexualité, Foucault explains how the still dominant idea that man is ‘subject of desire’ – and thus subjected to the law of desire – has its origin in the libido theory of Augustine. With this genealogical analysis Foucault targets, among other things, the libido theory of his contemporary, the psychoanalyst Jacques Lacan. This (...) essay briefly discusses what makes Lacan and Foucault theoretically opposed to each other. I zoom in on how both conceive the modern ‘subject’. Opposite to the subject as ‘subject to desire’, Foucault puts forward the ‘subject of one’s own actions’, the subject that is itself the ground/base of its own ‘care for oneself’ (epimileia heautou). This essay presents a critical reflection on the possibility of such a subject. It is here that Lacan’s theory of the subject can shed a light on Foucault’s understanding of a modern ‘care of oneself’ or ‘art of living’. Lacanian psychoanalysis can provide a ‘critical theory’, indispensable for what is at stake in a Foucauldian ‘art of living’. (shrink)

Instances in which we cannot retrieve information immediately but know that the information might be retrieved later are subjective states that accompany retrieval failure. These are expressed in feeling-of-knowing and Tip-of-the-tongue experiences. In Experiment 1, participants with Parkinson’s disease and older adult controls were given general questions and asked to report when they experienced a TOT state and to give related information about the missing word. The PD group experienced similar levels of TOTs but provided less correct peripheral information related (...) to the target when in a TOT state. In Experiment 2, participants were given a Semantic and an Episodic FOK task. PD patients failed to accurately predict their future memory performance in response to both episodic and semantic cues. Results are interpreted in the context of recent frameworks of memory and metacognition. (shrink)

The notion that visual attention can operate over visual objects in addition to spatial locations has recently received much empirical support, but there has been relatively little empirical consideration of what can count as an `object' in the ®rst place. We have investi- gated this question in the context of the multiple object tracking paradigm, in which subjects must track a number of independently and unpredictably moving identical items in a ®eld of identical distractors. What types of feature clusters can (...) be tracked in this manner? In other words, what counts as an `object' in this task? We investigated this question with a technique we call target merging: we alter tracking displays so that distinct target and distractor loca- tions appear perceptually to be parts of the same object by merging pairs of items (one target with one distractor) in various ways ± for example, by connecting item locations with a simple line segment, by drawing the convex hull of the two items, and so forth. The data show that target merging makes the tracking task far more dif®cult to varying degrees depending on exactly how the items are merged. The effect is perceptually salient, involving in some conditions a total destruction of subjects' capacity to track multiple items. These studies provide strong evidence for the object-based nature of tracking, con®rming that in some contexts attention must be allocated to objects rather than arbitrary collections of features. In addition, the results begin to reveal the types of spatially organized scene components that can be independently attended as a function of properties such as connectedness, part struc- ture, and other types of perceptual grouping. q 2001 Elsevier Science B.V. All rights reserved. (shrink)

Against the background of degeneration and the perceived threat to the nation’s health and stock, family politics came to constitute an important site for eugenic discourses and interventions. Eugenic regulation of reproductive sexuality and marriage was not only pursued through ‘negative’ eugenics but also through educational policies targeted at young adults and youth. Switzerland serves as a useful case to explore a general idea, namely the limitations for eugenicists of exploiting the concept of a rational subject in order to (...) achieve their ends. Practices of ‘positive eugenics’ crucially hinged on the utilitarian principle of rationality underpinning positive eugenics which this paper seeks to elaborate. Eugenicists devised tools to deal efficiently with social problems on a collective as well as an individual basis by deploying technologies of government which conceived individuals to be members of a population who were each held responsible for the generation of healthy future generations. As a form of ‘sustaining, multiplying and ordering life’ eugenics thus relied on the premise that its ideas would be adopted through an appeal to rationality and, where this was insufficient, through a series of coercive measures. Relying on conviction and education about the merits of eugenics, however, posed particular problems to positive eugenic thinking and practice. (shrink)

Hong Kong is undergoing two overlapping crises: social unrest over anti-government protests, and COVID-19. The media has linked these events in both objective and subjective ways. While some liken the social unrest to COVID-19, others do the opposite. This is an intriguing real-world instance of source-target reversibility with interchangeable source and target resulting in two apt variants. This paper reports a survey study of the links between crisis perceptions and the aptness of metaphor variants. Participants (N = 93) (...) rated 30 matched items on the effects of both crises on trust in governance, interpersonal relations, the economy, physical/mental health, and Hong Kong’s future. This determined, for each participant, a correlation coefficient reflecting perceived structural similarity, and absolute/raw difference scores reflecting perceived substantive similarity of the crises. They then explained which (or neither) of two constructed headlines depicting the SOCIAL UNREST as COVID-19 or COVID-19 as the SOCIAL UNRESTwas more apt. Logistic regression analyses showed that i) metaphor aptness was predictable from structural but not substantive similarity, and ii) the worse crisis was preferred as source domain, but only for its more experientially concrete aspects. The study exemplifies socio-culturally situated’ theoretical investigation and how metaphor research can shed light on crisis perceptions. (shrink)

A widely accepted tenet of evolutionary biology is that spontaneous mutations occur randomly with regard to their fitness effect. However, since the mutation rate varies along a genome and this variation can be subject to selection, organisms might evolve lower mutation rates at loci where mutations are most deleterious or increased rates where mutations are most needed. In fact, mechanisms of targeted hypermutation are known in organisms ranging from bacteria to humans. Here we review the main forces driving the (...) evolution of local mutation rates and identify the main limiting factors. Both targeted hyper‐ and hypomutation can evolve, although the former is restricted to loci under very frequent positive selection and the latter is severely limited by genetic drift. Nevertheless, we show how an association of repair with transcription or chromatin‐associated proteins could overcome the drift limit and lead to non‐random hypomutation along the genome in most organisms.Editor's suggested further reading in BioEssays Stress‐induced mutation via DNA breaks in Escherichia coli: A molecular mechanism with implications for evolution and medicine Abstract. (shrink)

The aim of this study, which is a field reseach, is to determine the level of religiosity and subjective well-being (SWB) of patients with chronic renal failure who are receiving hemodialysis treatment with a descriptive approach and by using socio-psychological methods and to try to determine the relationship between their religiosity and subjective well-being. The sample of the study consists of 205 individuals who were determined by stratified random sampling method from the patients treated in Turkish Ministry of Health, Hitit (...) University Çorum Erol Olçok Training and Research Hospital and Çorum District Dialysis Units. 54.1% (n=111) of the participants are males and 45.9% (n=94) are females. Data was collected via a “Religiosity Inventory”, developed by Kula, and “Subjective Well-Being Scale”, developed by Dost, to determine participants’ religiosity and subjective well-being as well as a personal information form to determine demographic characteristics. Statistical analysis of the data showed significant differences and relationships between demographic variables, religiosity, and subjective well-being. Moreover, a statistically significant relationship between the levels of religiousness and subjective well-being of the participants was found and that religiosity accounts for 31.9% of subjective well-being variance. The findings of the study show that the major hypotheses and sub-hypotheses have statistically been validated and that religiosity is a significant and important predictor of subjective well-being.Summary: Throughout history, existential questions and the answers sought for these questions have remained important for human beings. Human beings have always wondered about life, meaning of life, death, after death and pursued meaning systems that will satisfy this curiosity. While various thinkers and philosophers put forward opinions about the secrets of life; religion has presented the transcendent dimension to the individual as a source of meaning. Thus, the individual has found the definitive answer to many of his questions about existence in religion, and this sense of certainty has contributed positively to his psychological well-being. However, human beings may also face disasters, diseases or adversities in the natural flow of life and sometimes unexpectedly, such situations make them desperate. Desperation creates a feeling of loneliness in the person and this can trigger a sense of meaninglessness for him. The feeling of vacuum in the inner world of the individual who struggles with difficulty or the sense of meaninglessness somehow affects his subjective well-being.From this perspective the subject of the study is the effect of religiosity levels on subjective well-being of individuals who are struggling with chronic renal failure and have experienced a compelling treatment process such as hemodialysis. The aim of this study is to determine the level of religiosity and subjective well-being of these patients. The sample of the study consists of 205 individuals who were determined by stratified random sampling method from the patients treated in Turkish Ministry of Health, Hitit University Çorum Erol Olçok Training and Research Hospital and Çorum District Dialysis Units.The major hypothesis of the study is “The religiosity levels of hemodialysis patients have a significant effect on their subjective well-being.” Further sub-hypotheses are as follows: 1. Women’s religiosity is higher than men’s. 2. There is a significant relationship between the perception of subjective happiness and religiosity levels of the participants. The subjective happiness perception levels of the individuals with high religiosity scores are also high. 3. There is no significant difference between the SWB levels of the participants according to gender variable. 4. There is a significant relationship between the perception of subjective religiosity and SWB levels of participants. According to this; subjective well-being increases as the person’s self-religious perception levels increase.5. There is a significant positive relationship between the religiosity scores of the participants and SWB scores. 6. Religiosity is a significant predictor of subjective well-being. Thus; the SWB level is expected to increase as the religiosity scores increase.The data of the study was obtained by using Personal Information Form prepared by the researcher, Kula’s Religiosity Inventory and Dost’s Subjective Well-Being Scale. The study was conducted in hospitals. After getting the necessary legal permissions and consent of the patients, the patients were informed about the study and the study was conducted on a voluntary basis. The questionnaires were applied by the researcher in person through face-to-face interviews with patients in hospitals, sometimes on weekdays and sometimes on Saturdays. Together with the physician of the hemodialysis unit, district hospitals were visited to reach the target group receiving treatment in these districts.In accordance with the relational screening model, the data of the study was analyzed with SPSS 16.0 package program. The mean (x̄) and standard deviation (ss) scores of the Religiosity Inventory and Subjective Well-Being Scale were calculated according to independent variables and tables were created. The significance of the difference between the two means obtained from two independent sample groups was determined by independent samples t-test for independent samples. One-way Varayns analysis (ANOVA) was used to test hypotheses about whether there was a difference between the means of more than two sample groups. In case of significant differences between means, LSD test and Tamhane’s T2 test from post-hoc multiple comparison tests were usedand the direction of the differences were determined as such. To determine the relationship between two continuous variables, religiosity and subjective well-being, Pearson Moments Correlation Analysis technique was used, and Simple Linear Regression analysis was performed to determine how much religiosity explains the changes observed in the dependent variable. The significance of the obtained statistics was tested at 0.05 level and bidirectional and the analysis values were presented in sequential tables in accordance with the purpose of the research. It is possible to summarize the findings of the study as follows:• 45.9% (n=94) of the sample are women and 54.1% (n=111) are men. According to subjective evaluations, 55.6% of the sample considers themselves as happy and very happy and 79.5% defines themselves as religious and very religious. According to the findings, subjective religiosity perception is higher in patients than subjective happiness perception. • The sample group has a high level of religiosity ( x̄ =4,3713).• There is a significant difference between gender and general religiosity (t=2,933; p=,004; p 0.05). However there is a difference in the SWB averages of male and female participants, women scored higher (x̄=3,8309) in SWB than men (x̄=3,7135). • A significant relationship has been found between subjective religiosity perception and SWB level of the sample (F=12,345; p=,000, p<0.05). SWB levels increased with increasing subjective religiosity. Further, there is a significant relationship between “slightly religious” (x̄=3,3439), “religious” (x̄=3,7737) and “very religious” (x̄=4,1363) groups and SWB level. There is also a steady increase in the mean scores of SWB from “not at all religious” to “very religious”. • A positive and moderately significant relationship has been found between general religiosity and general SWB (r=,565, p<0.01). • According to the results of regression analysis to determine whether total religiosity in HD patients is a significant predictor of subjective well-being; religiosity explaines 31.9% of the variance in subjective well-being. This result shows that one of the important determinants of SWB in HD patients is religiousness. Religiosity is a significant and important predictor of subjective well-being, and increased religiosity directly affects the SWB levels of HD patients. In addition, the basic hypothesis and sub-hypotheses were validated statistically at the end of the study. (shrink)

One of the most challenging questions surrounding subjective animal welfare is whether these states are measurable: that is, is subjective welfare an appropriately quantifiable target for scientific enquiry and ethical and deliberative calculation? The availability of several different types of measurement scale raises important questions regarding whether subjective experience has the right properties to be meaningfully represented on the types of scale required for different applications. This methodological question has so far received scant attention in the animal welfare literature. (...) In this paper, I address this omission by examining the types of measurement scale we can reasonably expect to apply to animal welfare measurements, and which we will actually need for our applications. I argue that our different applications will require variously ordinal, interval, and ratio scales, and that we have sufficient reason to believe that subjective welfare is a target with the appropriate characteristics to justify the practice of representing it using each of these types of scales. (shrink)

The EU General Data Protection Regulation recognizes the data subject’s consent as one of the legal grounds for data processing. Targeted advertising, based on personal data processing, is a central source of revenue for data controllers such as Google and Facebook. At present, the implementation of consent mechanisms for such advertisements are often not well developed in practice and their compliance with the GDPR requirements can be questioned. The absence of consent may mean an unlawful data processing and a (...) lack of control of the user on his personal data. However, consent mechanisms that do not fully satisfy GDPR requirements can give users a false sense of control, encouraging them to allow the processing of more personal data than they would have otherwise. In this paper, we identify the features, originating from GDPR requirements, of consent mechanisms. For example, the GDPR specifies that a consent must be informed and freely given, among other requirements. We then examine the Ad Consent Mechanism of Facebook that is based on processing of user activity data off Facebook Company Products provided by third parties with respect to these features. We discuss to what extent this consent mechanism respects these features. To the best of our knowledge, our evaluation of Facebook’s Ad Consent Mechanism is the first of its kind. (shrink)

This article aims to present a Žižekian reading of the British author David Herbert Lawrence. The contemporary continental philosopher has tackled each of the British author’s reoccurring themes individually and thus may be used as a keystone for a valid literary interpretatio n. The paper begins by shedding light on the representation of Western ideology, moves further into the comprehension of the impacts of modern cultural capital and the limitations of industrialization. While at the same time the dissertation targets another (...) component of the romantic poet’s many writings which are characterized by the regeneration of the subject’s carnal presence as a defense mechanism against the prevalent culture of de-humanization. The argument at hand is that the reconstruction of the bodily image rendered through Lawrence’s erotic literature is not one that portrays promiscuity, but rather demonstrates a transgression of the Lacanian symbolic and the attainment of a partial rendition of a Hegelian totality. Lawrence’s six novels and set of poems are thoroughly analyzed from a strictly Žižekian p erspective to demonstrate that th e two authors share thematic representations, a common worldview and propose a manifestation of how literary analyses may be conveyed using Žižek as a philosophical lens for literary interpretation. (shrink)

Animal welfare is a concept that plays a role within both our moral deliberations and the relevant areas of science. The study of animal welfare has impacts on decisions made by legislators, producers and consumers with regards to housing and treatment of animals. Our ethical deliberations in these domains need to consider our impact on animals, and the study of animal welfare provides the information that allows us to make informed decisions. This thesis focusses on taking a philosophical perspective to (...) answer the question of how we can measure the welfare of animals. Animal welfare science is an applied area of biology, aimed at measuring animal welfare. Although philosophy of animal ethics is common, philosophy focussing on animal welfare science is rare. Despite this lack, there are definitely many ways in which philosophical methods can be used to analyse the methodologies and concepts used in this science. One of the aims of the work in this thesis is to remedy this lack of attention in animal welfare. Animal welfare science is a strong emerging discipline, but there is the need for conceptual and methodological clarity and sophistication in this science if it is to play the relevant informative role for our practical and ethical decision-making. There is thus is a strong role here for philosophical analysis for this purpose. The central aim of this thesis is to provide an account of how we can measure subjective animal welfare, addressing some of the potential problems that may arise in this particular scientific endeavour. The two questions I will be answering are: what is animal welfare, and how do we measure it? Part One of the thesis looks at the subjective concept of animal welfare and its applications. In it, I argue for a subjective welfare view - that animal welfare should be understood as the subjective experience of individuals over their lifetimes - and look at how the subjective welfare concept informs our ethical decision-making in two different cases in applied animal ethics. Part Two of the thesis looks more closely at the scientific role of welfare. Understanding welfare subjectively creates unique measurement problems, due to the necessarily private nature of mental states and here I address a few of these problems, including whether subjective experience is measurable, how we might validate indicators of hidden target variables such as welfare, how we can make welfare comparisons between individual animals and how we might compare or integrate the different types of experience that make up welfare. I end with a discussion of the implications of all these problems and solutions for the practice of welfare science, and indicate useful future directions for research. (shrink)

On one understanding of ideal theory, the optimally just social world is specified at the outset to serve as the target for nonideal theory to strive to realize subject to the constraints of implementation imposed by a world of nonideal actors. In the spirit of recent work by Gerald Gaus and Keith Hankins, I argue that certain models of the path to the target prove inadequate because they are too simplistic. Figuring out both what the target (...) is and how to get there is a much more difficult task than defenders of the target view suggest. Contra Gaus and Hankins, I believe the problem disagreement poses to ideal targets is uniquely epistemic. (shrink)

Transcranial direct current stimulation over the contralateral primary motor cortex of the target muscle has been described to enhance corticospinal excitability, as measured with transcranial magnetic stimulation. Recently, tDCS targeting the brain regions functionally connected to the contralateral primary motor cortex was reported to enhance corticospinal excitability more than conventional tDCS. We compared the effects of motor network tDCS, 2 mA conventional tDCS, and sham tDCS on corticospinal excitability in 21 healthy participants in a randomized, single-blind within-subject study (...) design. We applied tDCS for 12 min and measured corticospinal excitability with TMS before tDCS and at 0, 15, 30, 45, and 60 min after tDCS. Statistical analysis showed that neither motor network tDCS nor conventional tDCS significantly increased corticospinal excitability relative to sham stimulation. Furthermore, the results did not provide evidence for superiority of motor network tDCS over conventional tDCS. Motor network tDCS seems equally susceptible to the sources of intersubject and intrasubject variability previously observed in response to conventional tDCS. (shrink)

Grant Gillett's (2009) welcome and extremely thought-provoking target article addresses many complex issues of such far-ranging consequence that it seems impossible to provide a commentary worthy o...

In three experiments, each of a set colour-unrelated distracting words was presented most often in a particular target print colour . In Experiment 1, half of the participants were told the word-colour contingencies in advance and half were not . The instructed group showed a larger learning effect. This instruction effect was fully explained by increases in subjective awareness with instruction. In Experiment 2, contingency instructions were again given, but no contingencies were actually present. Although many participants claimed to (...) be aware of these contingencies, they did not produce an instructed contingency effect. In Experiment 3, half of the participants were given contingency instructions that did not correspond to the correct contingencies. Participants with these false instructions learned the actual contingencies worse than controls. Collectively, our results suggest that conscious contingency knowledge might play a moderating role in the strength of implicit learning. (shrink)

This paper considers the nature of a curriculum as presented in formal curriculum documents, and the inherent difficulties of representing formal disciplinary knowledge in a prescription for teaching and learning. The general points are illustrated by examining aspects of a specific example, taken from the chemistry subject content included in the science programmes of study that are part of the National Curriculum in England. In particular, it is suggested that some statements in the official curriculum document are problematic if (...) we expect a curriculum to represent canonical disciplinary knowledge in an unambiguous and authentic manner. The paper examines the example of the requirement for English school children to be taught that chemical reactions take place in only three different ways and considers how this might be interpreted in terms of canonical chemistry and within the wider context of other curriculum statements, in order to make sense of neutralisation and precipitation reactions. It is argued that although target knowledge that is set out as the focus of teaching and learning cannot be identical to disciplinary knowledge, the English National Curriculum offers a representation of chemistry which distorts and confuses canonical ideas. It is suggested that the process of representing the disciplinary knowledge of chemistry as curriculum specifications is worthy of more scholarly attention. (shrink)

Our study examines the expression and position of subjects in L2 acquisition, two phenomena that are studied within the framework of the Interface Hypothesis. The first version of the IH predicts that interface properties involving syntax and another cognitive domain may not be fully acquirable in a second language. The second version of the IH predicts that formal properties involving the syntax-semantics interface are unproblematic to acquire in L2 grammars compared to the vulnerable properties integrating syntax with the higher level (...) of pragmatics. We test these IH versions in L2 Spanish as acquired by L1 Greek speakers, a language combination understudied in the literature. Both languages share the null subject parameter, but still the IHs predict incomplete command at the syntax-pragmatics interface. Two acceptability judgment tasks were designed for Spanish: the first task tested null/overt subjects in referential contexts and the second task tested preverbal/postverbal subjects in informational contexts. Participants were L1 Greek intermediate and advanced learners of Spanish and native speakers of Spanish. In the first task, both experimental groups showed target-like distribution of null/overt subjects in most non-contrastive and contrastive contexts, except for the advanced group in unambiguous referential contexts. In the second task, the respective groups accepted felicitous preverbal subjects with unergative verbs, but diverged from native-like distribution of postverbal subjects with unaccusative verbs in neutral contexts. The L2 groups showed a high preference for unfelicitous preverbal subjects with both intransitive verbs in informational contexts, contrary to the subject inversion patterns of the control group. The results obtained were not consistent with the IH predictions, and other factors such as the type of subject, verb class and context played a role in L2 performance. (shrink)

Open peer commentary on the target article “How and Why the Brain Lays the Foundations for a Conscious Self” by Martin V. Butz. Excerpt: Being impressed by Butz’s psychological account for the process of objectification of the subjective self, I would like to postulate, from my expertise in synthetic neuro-robotics studies, possible neuro-dynamic mechanisms that account for his psychological theorem.

At the heart of Seth Lazar’s arguments in support of what he calls Moral Distinction – ‘In war, with rare exceptions, killing noncombatants is worse than killing combatants’ – is his treatment of eliminative and opportunistic killing. He adopts the standard line, that eliminative killing is easier to justify than opportunistic killing. And he acknowledges that there are various circumstances in which one might be able to justify killing noncombatants on eliminative grounds. Nonetheless, he relies on the notion of a (...) mixed kind of agency to argue that intentionally killing civilians is normally ‘more opportunistic than intentionally killing soldiers’, and is therefore normally more wrongful. I argue that his argument in favor of this claim fails. If we distinguish objectively available reasons from subjectively motivating ones, and pay attention to the limited relevance of subjectively motivating reasons, then it becomes clear that mixed agency cannot do the sort of work for just war theory that Lazar wants it to do. This failure need not impugn other parts of his defense of Moral Distinction. But it takes the heart out of his defense of it, putting a greater burden on the other parts of his argument. (shrink)

Measurement of subjective animal welfare creates a special problem in validating the measurement indicators used. Validation is required to ensure indicators are measuring the intended target state, and not some other object. While indicators can usually be validated through looking for correlation between target and indicator under controlled manipulations, this is not possible when the target state is not directly accessible. In this paper, I outline a four-step approach using the concept of robustness, that can help with (...) validating indicators of subjective animal welfare. (shrink)

One of the mathematical programming techniques is data envelopment analysis, which is used for evaluating the efficiency of a set of similar decision-making units. Fixed resource allocation and target setting with the help of DEA is a subject that has gained much attention from researchers. A new model was proposed by determining a common set of weights. All DMUs were involved with the aim of achieving higher efficiency in every DMU after the procedure. The minimum resources and targets (...) allocated to each DMU were commensurate to the efficiency of that DMU and the share of DMU in the input resources and the output productions. To examine the proposed method, other methods in the DEA literature were examined as well, and then, the efficiency of the method was demonstrated through a numerical example. (shrink)

In a September 2004 interview, Donald Trump agreed with Howard Stern’s statement that his daughter Ivanka is “a piece of ass.” This utterance is a synecdochical utterance targeting women, by which I mean that its form is such that a term for an anatomical part is predicated of, or could be used by a speaker to refer to, a woman. I propound a theory of what SUTW speakers do in undertaking an SUTW on which the SUTW speaker prompts the hearer (...) to engage in a certain derogatory pattern of associational thinking—that is, taking a “perspective” in Elisabeth Camp’s sense—on the female subject. This perspective is one that reduces her to the bodily part in question—that is, fragments her and biologizes her. Essentially, the hearer thinks of the woman as a “piece of meat.”. (shrink)

This article analyzes the construction of female subjectivity in the specific context of audiovisual cyberspaces in Spain dedicated to the struggle against violence against women. Looking at the YouTube channels of two virtual feminist communities that deal with violence against women, the authors analyze how the victim-subject is configured in terms of agency and activism. The authors adopt a multimodal model of studying the sign complexes of the videos as semiotic artifacts that produce meaning. Sign complexes are always engaged (...) because representation is never neutral because what is represented in sign is meant to realize the values and positions of those who make the sign. In this article, the authors understand feminist activism in the fight against violence targeting women as constructing in its discourse not only the activist process, but also the subject of this activism: the victim-subject of gender-based violence. The analysis engages in the discussion about the various ways in which this subject is interpellated by the audiovisual texts in terms of agency. As a result, this study proposes the necessity to devise new ways of articulating this subject as a political and agential one. (shrink)

In 2001, the U.S. House of Representatives passed the "Human Cloning Prohibition Act" and President Bush announced his decision to allow only limited research on existing stem cell lines but not on "embryos." In contrast, the U.K. has explicitly authorized "therapeutic cloning." Much more will be said about bioethical, legal, and social implications, but subtleties of the science and careful definitions of terms have received much less consideration. Legislators and reporters struggle to discuss "cloning," "pluripotency," "stem cells," and "embryos," and (...) whether "adult" are preferable to "embryonic" stem cells as research subjects. They profess to abhor "copying humans" or "killing embryos." Do they know what they are talking about? Do we? This paper explores the historical, philosophical, and scientific contexts that inform this heated discussion. (shrink)

Foucault rejects the subject as a center, that is to say, as a transparent self-conscious being who gives meaning to his actions. However, ideas about subjects that are thinking and willing autonomously are still functioning within modern culture. Discourses on subjectivity thus call for an archeological and genealogical explanation. This compels Foucault to view subjectivity increasingly not only as a product and a target of power, but also as a source of resistance and as an agent; for Foucault (...) defines power as “actions about actions.” In his latest writings, Foucault starts to define the teleology of his philosophical ethos as the production of new forms of subjectivity, in terms of freedom and autonomy. I argue that Foucault was always particularly concerned with circling (around) transgression, apprehending subjectivity as an aimless self-negation, rather than with a “return of the subject.”. (shrink)

In 2001, the U.S. House of Representatives passed the "Human Cloning Prohibition Act" and President Bush announced his decision to allow only limited research on existing stem cell lines but not on "embryos." In contrast, the U.K. has explicitly authorized "therapeutic cloning." Much more will be said about bioethical, legal, and social implications, but subtleties of the science and careful definitions of terms have received much less consideration. Legislators and reporters struggle to discuss "cloning," "pluripotency," "stem cells," and "embryos," and (...) whether "adult" are preferable to "embryonic" stem cells as research subjects. They profess to abhor "copying humans" or "killing embryos." Do they know what they are talking about? Do we? This paper explores the historical, philosophical, and scientific contexts that inform this heated discussion. (shrink)

The present study was designed to explore the performance costs of negative emotional stimuli in a vigilance task. Forty participants performed a vigilance task in two conditions: one with task-irrelevant negative-arousing pictures and one with task-irrelevant neutral pictures. In addition to performance, we measured subjective state and frontal cerebral activity with near infrared spectroscopy. Overall performance in the negative picture condition was lower than in the neutral picture condition and the negative picture condition had elevated levels of energetic arousal, tense (...) arousal and task-related thoughts. Moreover, there was a significant relationship between the impact of the negative pictures on tense arousal and task-related thoughts and the impact of the negative pictures on performance . These results provide support for indirect cost models of negative emotional stimuli on target detection performance. (shrink)

In this paper, we use PCR5 in order to fusion the information of two sources providing subjective probabilities of an event A to occur in the following form: chance that A occurs, indeterminate chance of occurrence of A, chance that A does not occur. -/- .

The gaze cueing effect is characterized by faster attentional orienting to a gazed-at than a non-gazed-at target. This effect is often enhanced when the gazing face bears an emotional expression, though this finding is modulated by a number of factors. Here, we tested whether the type of task performed might be one such modulating factor. Target localization and target discrimination tasks are the two most commonly used gaze cueing tasks, and they arguably differ in cognitive resources, which (...) could impact how emotional expression and gaze cues are integrated to orient attention. In a within-subjects design, participants performed both target localization and discrimination gaze cueing tasks with neutral, happy, and fearful faces. The gaze cueing effect for neutral faces was greatly reduced in the discrimination task relative to the localization task, and the emotional enhancement of the gaze cueing effect was only present in the localization task and only when this task was performed first. These results suggest that cognitive resources are needed for gaze cueing and for the integration of emotional expressions and gaze cues. We propose that a shift toward local processing may be the mechanism by which the discrimination task interferes with the emotional modulation of gaze cueing. The results support the idea that gaze cueing can be greatly modulated by top-down influences and cognitive resources and thus taps into endogenous attention. Results are discussed within the context of the recently proposed EyeTune model of social attention. (shrink)

The detection of moving targets is to detect the change area in a sequence of images and extract the moving targets from the background image. It is the basis. Whether the moving targets can be correctly detected and segmented has a huge impact on the subsequent work. Aiming at the problem of high failure rate in the detection of sports targets under complex backgrounds, this paper proposes a research on the design of an intelligent background differential model for training (...) class='Hi'>target monitoring. This paper proposes a background difference method based on RGB colour separation. The colour image is separated into independent RGB three-channel images, and the corresponding channels are subjected to the background difference operation to obtain the foreground image of each channel. In order to retain the difference of each channel, the information of the foreground images of the three channels is fused to obtain a complete foreground image. The feature of the edge detection is not affected by light; the foreground image is corrected. From the experimental results, the ordinary background difference method uses grey value processing, and some parts of the target with different colours but similar grey levels to the background cannot be extracted. However, the method in this paper can better solve the defect of misdetection. At the same time, compared with traditional methods, it also has a higher detection efficiency. (shrink)

Answering important public health questions often requires collection of sensitive information about individuals. For example, our understanding of how HIV is transmitted and how to prevent it only came about with people's willingness to share information about their sexual and drug-using behaviors. Given the scientific need for sensitive, personal information, researchers have a corresponding ethical and legal obligation to maintain the confidentiality of data they collect and typically promise in consent forms to restrict access to it and not to publish (...) identifying data.The interests of others, however, can threaten researchers' promises of confidentiality when legal demands are made to access research data. In some cases, the subject of the litigation is tightly connected to the research questions, and litigants' interest in the data is not surprising. Researchers conducting studies on tobacco or occupational or other chemical exposures, for example, are relatively frequent targets of subpoenas. (shrink)

Since the publication of The Man-Not in July of 2017, the wealth of empirical information challenging the conclusions of intersectionality and Black masculinity studies has gained the public’s attention. The Man-Not argues that in western patriarchal societies Black males and other racialized men and boys are targeted for extermination and social ostracization. Following the work of social dominance theorists and Global South Masculinities, Black Male Studies argues that patriarchy places outgroup-racialized men at the bottom of the social hierarchy.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Paradox of Subjectivity: The Self in the Transcendental TraditionJeffrey EdwardsDavid Carr. The Paradox of Subjectivity: The Self in the Transcendental Tradition. New York/Oxford: Oxford University Press, 1999. Pp. xii + 150. Cloth, $35.00.This book presents a response to contemporary attacks on the concept of the subject. Carr investigates the historical background to the criticisms of the "Metaphysics of the Subject" that are found in French (...) post-structuralist thought and in critical theories descended from the Frankfurt School. In explaining this background, he targets the widely held assumption that the history of modern philosophy can best be understood in terms of a fundamentally unified conception of the subject and subjectivity that unfolds inevitably from Descartes and culminates in twentieth-century phenomenology and existentialism. Those who share this assumption fail to recognize the significance of what Husserl (in the Crisis of European Sciences) called the "paradox of subjectivity," which derives from the necessity of understanding the knowing subject both as a subject for the world and as an object in the world.The origins of contemporary interpretations of the metaphysics of the subject are found primarily in Heidegger's thought. Carr thus devotes the first chapter of this study to the critical assessment of Heidegger's view of modern metaphysics starting with Descartes. For Heidegger, Descartes took over the dominant concept of substance from traditional ontology and transferred it to the human subject. The Cartesian subject, then, was revealed as an underlying hypokeimenon that absorbs or overpowers the world by reducing it to the representational contents of the thinking thing. Moreover, Heidegger maintained that modern thinkers did not go beyond the reductive conception of subjectivity intrinsic to the Cartesian metaphysics of substance. This Heideggerian judgment applies to the major modern thinkers. Even Kant and Husserl figure as representatives of a tradition in which "the knowing subject takes the role of substance; everything is reduced to first properties, whether as immanent in consciousness, object for the subject, or, as in transcendental philosophy, construct and product of subjective activity" (Carr, 31).In chapters 2-4, Carr argues that the Heideggerian interpretation is inadequate with respect to Kant and Husserl. In supporting this position, Carr emphasizes the close affinities between Kant's and Husserl's conceptions of objectivity for consciousness and between their portrayals of subject and self. Specifically, Carr argues (1) that both thinkers were committed to the representationalist view of cognition that is typical of other major modern philosophers; and (2) that both presented parallel, and indeed unifiable, accounts of the relationship between the transcendental and the empirical self.The key to explaining the fundamental agreement between Kant's and Husserl's transcendental theories lies in the concept of intentionality. There are, of course, significant differences between Husserl's phenomenological method and the procedure of inquiry into the possibility conditions of objective experience that Kant follows in the Critique of Pure Reason. Still, Husserl's portrayal of the intentional character of consciousness provides the basis for understanding how Kant's account of transcendental apperception and the original synthetic unity of self-consciousness grounds a non-representationalist theory of the subject's relation to a world of objects. Husserl's portrayal of intentionality also enables us to see how Kant's concept of transcendental [End Page 609] apperception allows for a description of the empirical self as something that is part of the objective world. Conversely, the Kantian distinction between the transcendental and the empirical self, or subject, sheds light on the sense of the distinction that Husserl draws between transcendental and natural reflection. In natural reflection, I "appear to myself as an empirical subject within a world to which I relate in causal-bodily and intentional [i.e., purposive]-motivational ways" (89). On the other hand, the consciousness of self at issue in transcendental reflection involves my awareness of the meaning-constituting cognitive accomplishments by which I am consciousness of the world as the horizon of possible objects and, at the same time, as something transcendent to consciousness.It is Husserl's conception of intentionality, combined with Kant's understanding of the transcendental-empirical distinction, that allows us to grasp the full significance of the paradox... (shrink)

The article by MacKay and Saylor (2020) claims that the principle of fair subject selection yields conflicting imperatives (e.g. in the case of pregnant women) and should be understood as “a bundle of four distinct sub-principles” (i.e. fair inclusion, burden sharing, opportunity, distribution of third-party risks), each having conflicting normative recommendations (MacKay and Saylor 2020). The authors also offer guidance as to how we should navigate between subprinciples that may conflict with each other. The problem is a crucial one (...) since fair subject selection is one of the principles regulating clinical research that produces generalizable knowledge with the potential of improving people’s health. Therefore, there may be cases where the way in which participants are selected directly influences the generalizability (or its lack) of the clinically relevant knowledge and its value (if any) to different groups. In my commentary article, written from the philosophical perspective, I notice a number of interrelated problems which I believe have not been discussed thoroughly in the target article: (1) the precise way in which health care priority setting should influence the content of health research priority setting and fair inclusion principles; (2) the distinction between group and individual benefits and burdens from clinical research; (3) the reference class problem in medical research. (shrink)

BackgroundHigh frequency repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex has shown significant efficiency in the treatment of resistant depression. However in healthy subjects, the effects of rTMS remain unclear.ObjectiveOur aim was to determine the impact of 10 sessions of rTMS applied to the DLPFC on mood and emotion recognition in healthy subjects.DesignIn a randomised double-blind study, 20 subjects received 10 daily sessions of active or sham rTMS. The TMS coil was positioned on the left DLPFC through neuronavigation. (...) Several dimensions of mood and emotion processing were assessed at baseline and after rTMS with clinical scales, visual analogue scales, and the Ekman 60 faces test.ResultsThe 10 rTMS sessions targeting the DLPFC were well tolerated. No significant difference was found between the active group and the control group for clinical scales and the Ekman 60 faces test. Compared to the control group, the active rTM... (shrink)

Positive psychology has recently seen unprecedented rise and has reached vast achievements in the area of quality of life improvement. The purpose of this study is to show that there are different aspects of well-being that make healthy older people motivated to learn a foreign language at a later age. The research was conducted in the Czech Republic and Poland in two groups of learners aged 55 years and more. The experimental group consisted of 105 Czech respondents who were targeted (...) with an online questionnaire with the aim to determine the level of FLL outcomes connected to QoL in healthy older adults in their L2 acquisition. The second experimental group was established of Polish seniors who attended similar language courses. The findings of the research clearly show that FLL has an irreplaceable role as one of several non-pharmacological strategies utilized to improve the aging process and reduce drawbacks of aging. The results indicate that seniors' overall satisfaction and subjective feelings of well-being are enormously high when attending foreign language classes at older age. FLL, therefore, creates an environment that can enhance QoL of older adults that can be supplemented by other means such as well-balanced diet, other social activities, sport and physical activity, music, or computer games. All these intervention methods can significantly improve QoL of older adults and the parties engaged and/or responsible for taking care of older generation should take it into serious consideration. (shrink)

Michel Henry wishes to salvage Descartes’s first principle ‘I think, I am’ by claiming that there is no need to appeal to the world or others to make sense of the self. One of his main targets is Edmund Husserl, who claims that thought is necessarily intentional and thus necessarily about something that is other to thought. To show that this is not so, Henry draws on passages from Descartes’s texts which emphasize that we should not equate the cogito with (...) thinking but with sensation and imagination. This allows Henry to explore the notion that the self has its own form of manifestation. This paper questions Henry’s reading of Descartes and his critique of Husserl on two fronts. First, the passages Henry draws upon, if anything only confirm, rather than question Husserl’s claim that consciousness is intentional. Second, Henry believes that he can show that the life of the self is infinitely rich without having to appeal to other persons or, indeed, to the world. Yet, I wish to contend that Henry is mistaken: as Husserl has shown convincingly, a life without others and the world is not only impoverished and bereft of meaning, but remains entirely indeterminate. The self only manifests itself with respect to others and the world. (shrink)