Geron recently announced that it had begun enrolling patients in the world's first-in-human clinical trial involving cells derived from human embryonic stem cells (hESCs). This trial raises important questions regarding the future of hESC-based therapies, especially in spinal cord injury (SCI) patients. We address some safety and efficacy concerns with this research, as well as the ethics of fair subject selection. We consider other populations that might be better for this research: chronic complete SCI patients for a safety trial, subacute (...) incomplete SCI patients for an efficacy trial, and perhaps primary progressive multiple sclerosis (MS) patients for a combined safety and efficacy trial. (shrink)

The idea that deep brain stimulation (DBS) induces changes to personality, identity, agency, authenticity, autonomy and self (PIAAAS) is so deeply entrenched within neuroethics discourses that it has become an unchallenged narrative. In this article, we critically assess evidence about putative effects of DBS on PIAAAS. We conducted a literature review of more than 1535 articles to investigate the prevalence of scientific evidence regarding these potential DBS-induced changes. While we observed an increase in the number of publications in theoretical neuroethics (...) that mention putative DBS-induced changes to patients’ postoperative PIAAAS, we found a critical lack of primary empirical studies corroborating these claims. Our findings strongly suggest that the theoretical neuroethics debate on putative effects of DBS relies on very limited empirical evidence and is, instead, reliant on unsubstantiated speculative assumptions probablyin lieuof robust evidence. As such, this may reflect the likelihood of a speculative neuroethics bubble that may need to be deflated. Nevertheless, despite the low number of first-hand primary studies and large number of marginal and single case reports, potential postoperative DBS changes experienced by patients remain a critical ethical concern. We recommend further empirical research in order to enhance theoretical neuroethics work in the area. In particular, we call for the development of better instruments capable of capturing potential postoperative variations of PIAAAS. (shrink)

The phenomenological effects of deep brain stimulation (DBS) on the self of the patient remains poorly understood and under described in the literature, despite growing evidence that a significant number of patients experience postoperative neuropsychiatric changes. To address this lack of phenomenological evidence, we conducted in-depth, semistructured interviews with 17 patients with Parkinson's disease who had undergone DBS. Exploring the subjective character specific to patients' experience of being implanted gives empirical and conceptual understanding of the potential phenomenon of DBS-induced self-estrangement. (...) Our study concluded that (1) the more patients preoperatively felt alienated by their illness, the more they experienced postoperative self-estrangement, and (2) the notion of self-estrangement seems to exist in association with certain common qualitative characters, namely, loss of control, which reflects a deteriorative estrangement, and distorted perception of capacities, which reveals a restorative estrangement. These findings indicate that subjective self-reports help us to understand some aspects of the potential phenomenon of DBS-induced self-estrangement. (shrink)

Optogenetics is being optimistically presented in contemporary media for its unprecedented capacity to control cell behavior through the application of light to genetically modified target cells. As such, optogenetics holds obvious potential for application in a new generation of invasive medical devices by which to potentially provide treatment for neurological and psychiatric conditions such as Parkinson's disease, addiction, schizophrenia, autism and depression. Design of a first-in-human optogenetics experimental trial has already begun for the treatment of blindness. Optogenetics trials involve a (...) combination of highly invasive genetic and electronic interventions that results in irreversible and permanent modifications of an individual's nervous system. Given its novelty, its uncertain benefit to patients, and its unique risk profile of irreversible physiological alteration, optogenetics requires a reassessment of the ethical challenges for protecting human participants in clinical trials, particularly at formative stages of clinical evaluation. This study explores the evolving ethical issues surrounding optogenetics’ potential harm to participants within trial design, especially focusing on whether Phase 1 trials should incorporate efficacy as well as safety endpoints in ways that are fair and respectful to research trial participants. (shrink)

Cet article s’intéresse au problème de la maintenance, c’est-à-dire au moment où les membres d’un collectif social tentent d’assurer dans le temps l’existence de leur collectif en instituant des règles pour réguler leurs comportements. Ce problème se pose avec acuité lorsque certains membres ne respectent pas ces règles communes. Pour maintenir la coopération sociale, les membres peuvent décider d’instituer des règles secondaires visant à sanctionner les transgressions des règles primaires déjà établies. La maintenance d’un collectif peut ainsi reposer sur l’émergence (...) de pouvoirs déontiques qui donnent aux membres l’autorité de légitimement punir et expulser les transgresseurs. Mais d’où viennent ces règles ? On peut penser qu’elles émergent des émotions éprouvées par les membres envers les transgresseurs. Je le démontre à l’aide d’une étude de cas qui établit que, dans le collectif Occupy Geneva, l’institutionnalisation de normes pour punir, exclure et réintégrer les déviants s’ancraient respectivement dans l’indignation, le mépris et le pardon. -/- This article focuses on the problem of maintenance; that is the moment when the members of a social collective attempt to ensure the existence of their collective over time by instituting rules to regulate their behavior. This problem becomes critical when certain members do not respect the common rules. To maintain social cooperation, members can decide to institute secondary rules aimed at sanctioning the transgressions of the already established primary rules. The maintenance of a collective can thus rely on the emergence of deontic powers that give members the authority to legitimately punish and expel transgressors. But where do these rules come from? The hypothesis is that they emerge from the emotions felt by the members towards the transgressors. I show this with the help of a case study, which establishes that the institutionalization of norms allowing the punishment, the exclusion, and the reintegration of deviants within the “Occupy Geneva” collective, was grounded in indignation, contempt, and forgiveness respectively. (shrink)

Comme tout hommage posthume réussi, le livre que nous recensons souffre de ce douloureux paradoxe : celui dont on honore la mémoire aurait adoré le lire. Il s’agit également de l’un des très rares hommages posthumes dont la liste des contributeurs comprend le nom du défunt lui-même. Joli pied de nez qu’aurait sans aucun doute apprécié l’apparemment très austère Angel d’Ors (1951-2012). Les quelque treize contributions réunies par Paloma Pérez-Ilzarbe et María Cerezo sont parfaitement représen...

In response to the many changes currently going on in health care, this book offers the combined insight and wisdom of a stellar group of scholars and professionals with extensive experience in the health care field. The book opens with a look at people's actual experience of health care today, from four different perspectives. It then addresses foundational questions, including the nature of medicine, nursing, and justice. Surveyed next are the changing economics of health care as well as the impact (...) of these changes on such areas as mental health care, long-term care, health care for minorities, and legal malpractice. The closing section of the book assesses from a Christian perspective available constructive alternatives, including creative funding strategies with special attention to the needs of poor persons, physician unions, and the use of "alternative medicine" therapies. (shrink)

In Quebec, dropout of university studies is a scarcely studied phenomenon, particularly in the 120-credit Bachelor’s degree programs in Vocational Education. More than 10 years after the implementation of these programs, the secondary analysis of existing data from two sources reveals that almost one in two students abandoned their studies. A look at the specific context these students are in, along with a discussion on theoretical and methodological issues related to these dropout statistics, are used to examine the complex and (...) troubling dropout phenomenon in this particular university program. (shrink)

L’œuvre de Marcel Duchamp pose à nouveaux frais la question classique du génie de l’artiste, de sa puissance de création. Voulant échapper à l’impératif de l’œuvre, Duchamp emprunte la voie du ready-made, du tout fait. Or, ce tout fait, fût-il choisi dans l’indifférence, n’en recèle pas moins le procès industriel de sa production. Si bien qu’en ces lieux singuliers de la réplique, de la série, exemplairement obtenues par moulage ou emboutissage, se rejoueront dans l’opéra de Duchamp de surprenants imaginaires tant (...) de la création que de la procréation. Feuille de vigne femelle ou Coin de chasteté, exemplifiant les ressources matricielles de la reproduction par moulage, donneront à voir les figures, si nécessaires au processus créatif de Duchamp, du pli, de la fissure, de la section. (shrink)

The twentieth century Russian philosopher Nikolai Lossky was one of the earliest and most important proponents—but also critics—of Bergson’s philosophy in Russia at a time when many Russian philosophers were preoccupied with the same complex of philosophical questions and answers that Bergson was addressing. Thus, if only from the standpoint of intellectual history, Lossky is central to the study of the reception of Bergson in Russia. In this article, I present the principal historical links, points of agreement between Bergson and (...) Lossky, such as their respective anti-Kantianism, intuitivism, ontological realism, vitalism, organicism, Neo-Platonism, as well as their points of disagreement, including some of Lossky’s key criticisms of Bergson, with special emphasis on the issues of intuition, ideal being, substance and change, time, and sensible qualities. This paper is meant as an introduction to the translations of Lossky’s “Heдocтaтки гнoceoлoгiи Бepгcoнa и влiянie иxъ нa eгo мeтaфизикy” (The Defects of Bergson’s Epistemology and Their Consequences on His Metaphysics) (1913) and his review of Bergson’s, Les deux sources de la morale et de la religion (1932), which are published in the present issue of Studies in East European Thought. (shrink)

The prominent Russian philosopher Nikolai Lossky and his ex-student Nicolai Hartmann shared many metaphysical and epistemological views, and Lossky is likely to have influenced Hartmann in adopting several of them. But, in the case of axiological issues, it appears that Lossky also borrowed from the axiologies of Hartmann and the latter's Cologne colleague, Max Scheler. The links between the theories of values of Scheler and Hartmann have been studied abundantly, but never in relation to Lossky. In this paper, I examine (...) the manifold relationships – similarities, differences, borrowings, criticisms, and possible influences – between Lossky's axiology and those of Scheler and Hartmann on four key interweaving issues: (1) their ontological realism with regards to the objectivity of values, (2) their epistemological theories of the intuition of values, (3) their ontological definitions of "value", i.e., whether values are relations, qualities, essences, powers, meanings, etc., and (4) their theories of the stratification of values. (shrink)

According to Thagard and Stewart :1–33, 2011), creativity results from the combination of neural representations, and combination results from convolution, an operation on vectors defined in the holographic reduced representation framework. They use these ideas to understand creativity as it occurs in many domains, and in particular in science. We argue that, because of its algebraic properties, convolution alone is ill-suited to the role proposed by Thagard and Stewart. The semantic pointer concept allows us to see how we can apply (...) the full range of HRR operations while keeping the modal representations so central to Thagard and Stewart’s theory. By adding another combination operation and using semantic pointers as the combinatorial basis, this modified version overcomes the limitations of the original theory and perhaps helps us explain aspects of creativity not covered by the original theory. While a priori reasons cast doubts on the use of HRR operations with modal representations :5039–5054, 1987) such as semantic pointers, recent models point in the other direction, allowing us to be optimistic about the success of the revised version. (shrink)

Schizophrenia is a disturbance of the self, of which the attribution of agency is a major component. In this article, we review current theories of the Sense of Agency, their relevance to schizophrenia, and propose a novel framework for future research. We explore some of the models of agency, in which both bottom-up and top-down processes are implicated in the genesis of agency. We further this line of inquiry by suggesting that ongoing neurological activity (the brain’s resting state) in self-referential (...) regions of the brain can provide a deeper level of influence beyond what the current models capture. Based on neuroimaging studies, we suggest that aberrant activity in regions such as the default mode network of individuals with schizophrenia can lead to a misattribution of internally/externally generated stimuli. This can result in symptoms such as thought insertion and delusions of control. Consequently, neuroimaging can contribute to a more comprehensive conceptualization and measurement of agency and potential treatment implications. (shrink)

Cognition is not, and could not possibly be, entirely representational in character. There is also a phenomenal form of cognitive expression that registers the intrinsic properties of mental states themselves. Arguments against the reality of this intrinsic phenomenal dimension to mental experience have focused either on its supposed impossibility, or secondly, the non-appearance of any such qualities to introspection. This paper argues to the contrary, that the registration of cognitive state properties does take place independently of representational content; and necessarily (...) so, since it supports an independent function—self-management. Given the fact that unlike a computer, the brain must, of necessity, operate itself, it needs to be in touch with itself to do so. Intrinsic phenomenal forms of cognitive expression allow the brain to do just that by registering characteristics of the cognitive states themselves. Self-management might well prove to constitute the prime reason for the emergence of subjectivity itself. (shrink)

Qu’est-ce que l’indignation ? Cette émotion est souvent conçue comme une émotion morale qu’une tierce-partie éprouve vis-à-vis des injustices qu’un agent inflige à un patient. L’indignation aurait ainsi trait aux injustices et serait éprouvée par des individus qui n’en seraient eux-mêmes pas victimes. Cette émotion motiverait la tierce-partie indignée à tenter de réguler l’injustice en l’annulant et en punissant son auteur. Cet article entreprend de montrer que cette conception de l’indignation n’est que partielle. En effet, l’indignation ne porte pas que (...) sur les injustices, mais plus généralement sur les torts injustifiés. Ce faisant, l’indignation peut être une émotion morale, mais aussi une émotion conventionnelle ou esthétique. De plus, elle peut être éprouvée par les individus victime des torts : elle n’est pas uniquement éprouvée par des tierces-parties. De la sorte, les individus indignés qui subissent les torts peuvent eux-mêmes chercher à les annuler et à punir leurs auteurs. Puisqu’elle peut être éprouvée tant par des spectateurs que par les personnes qui subissent les torts et qu’elle incline ceux qui l’éprouvent à faire appel à d’autres personnes pour réguler ces torts, l’indignation vécue individuellement est partageable : elle peut devenir une émotion collective jouant un rôle fondamental dans la régulation sociale en contribuant au renforcement de normes sociales existantes ou à l’émergence de nouvelles normes sociales associées aux idées du juste prévalant dans la société considérée. (shrink)

Résumé Les auteurs distinguent classiquement topologie et ontologie temporelles et entreprennent de montrer que le choix d’une ontologie temporelle, mais aussi d’une ontologie générale, a des conséquences sur les propriétés de la topologie temporelle. Ils choisissent comme point de départ de cette démonstration l’application du principe d’indépendance d’Armstrong à l’ontologie temporelle et plus spécialement à la transitivité. Leur conclusion est que le choix de ce principe pose des problèmes très difficiles pour l’ontologie temporelle, autant que pour la topologie temporelle.

We are not only threatened by the Sixth Extinction, but also haunted. Coming back from the future, the Ghosts of History — some para-Benjaminian creatures—try to tell us how serious the threat is....

Cet article s’intéresse aux émotions dans l’internalisation et l’émergence des normes sociales. Nous y montrons comment les normes sociales ont un impact sur les émotions et comment les émotions ont un impact sur les normes sociales. Pour le faire, trois approches complémentaires mais souvent traitées indépendamment les unes des autres dans la littérature scientifique sont discutées. La première a trait à la façon dont les normes sociales (les normes émotionnelles) régulent les émotions. Cette régulation se comprend comme l’internalisation de la (...) normativité sociale dans les membres d’une société : les normes émotionnelles contribuent à la fabrique des dispositions émotionnelles des membres qui s’ajustent aux normes et aux valeurs valant dans leur société. La deuxième approche a trait au rôle des émotions dans le soutien aux normes sociales. Une fois que l’internalisation des normes et des valeurs est opérée et que les membres ont développé une sensibilité affective aux normes et aux valeurs de leur collectif, les émotions peuvent opérer comme des régulateurs des comportements : les émotions font que les membres se conforment aux normes et aux valeurs. Les normes internalisées suscitent des réactions émotionnelles qui contribuent au maintien de l’ordre normatif. La troisième approche affirme que les émotions contribuent à l’émergence des normes sociales et des valeurs dans une société donnée. En ce sens, les émotions peuvent contribuer à la transformation de l’ordre normatif. Il s’agit donc de la fabrique de la société. (shrink)

On conçoit souvent la jalousie comme une émotion ayant pour objet les relations de proximité (amour, amitié, fratrie, etc.). Elle a généralement mauvaise presse et est typiquement envisagée comme une émotion moralement condamnable, voire comme un vice. Or, la jalousie ne porte pas uniquement sur les relations de proximité : elle peut également porter sur divers biens (prestige, richesses, biens matériels, privilèges, etc.). Par ailleurs, certains auteurs soutiennent que des cas de jalousie pourraient être moralement justifiés, voire que la jalousie (...) pourrait être une vertu. La jalousie paraît également jouer un rôle dans l’institution et le maintien d’institutions visant à perpétuer des inégalités entre les individus jaloux de leurs avantages et ceux qu’ils envisagent comme des concurrents cherchant à les déposséder de leurs biens. De fait, la jalousie paraît utile pour la théorie politique de par les liens qu’elle entretient avec la justice distributive. Cet article propose, dans la première section, une discussion portant sur la nature de la jalousie où elle est contrastée avec l’envie et l’indignation. Dans la seconde section, on se demandera si la jalousie est un vice, ou si elle peut être parfois moralement justifiée, ou même être une vertu. La troisième section traitera les rôles joués par la jalousie collective dans la justice distributive et la fondation et le maintien d’institutions sociales visant à protéger les intérêts des jaloux. Pour le faire, le cas de la jalousie économique, telle que David Hume et Adam Smith la concevaient dans les relations commerciales entre États européens au XVIIIème siècle, est considéré. (shrink)

This devastating polemical critique of the existentialist philosophy of Martin Heidegger is a monumental study in Adorno's effort to apply qualitative analysis to the content and impact of cultural phenomena.

Individual identity and the multiplicity of cultural factors that “influence” the individual obviously raise the question of who we are as persons. But it is equally obvious that such individual reality is temporal, thereby constituting individual history. The latter seems to be like a Heraclitean flux where change is the only constant. In other words, since we never cease to change—even imperceptibly—shouldn’t we conclude that we never remain identical to ourselves in such a process of becoming? To use a concept (...) put forward by Ricœur, Idem-Identity, as stable and substantial sameness, appears to be an illusion, as we are the history of our actions and experiences, a history that continues to shape... (shrink)

Les penseurs occidentaux du politique affirment volontiers que la démocratie a été inventée par la Grèce antique et redécouverte par l’Europe moderne. Mais cette conception ne participe-t-elle pas d’un vol de l’histoire dont l’Occident se serait rendu coupable en imposant le récit de son passé au reste du monde? Telle est la thèse forte défendue par l’anthropologue britannique Jack Goody. Il y a insisté dans des développements consacrés à l’individualisme, dont la démocratie représente « l’aspect politique » : l’individualisme n’est (...) pas une invention exclusivement européenne ; en d’autres lieux et à d’autres époques, les hommes se sont pensés comme des individus. (shrink)

By engaging the incredible medical technologies available today from a biblical and theological perspective, this book equips students, church and lay leaders, and health care professionals to help foster a world in which medical expertise informs our bioethical decisions and human beings are shown respect as people created in the image of God.

For John Wyclif, the fundamental belief that Scripture is true de virtute sermonis is grounded in the fact that the meanings of the words therein are equivocal. A word can have several different meanings depending on whether it is outside or inside Scripture as well as on its location in Scripture. This principle allows each and every word in Scripture to be endowed with its own meaning — however figurative, i.e., metaphorical, allegorical etc. it may be —, tailored for the (...) very context in which it is used. Scripture cannot then fail to be true in virtue of the syntactic-semantic properties of language, which are precisely set up in accordance with the message to be delivered. All in all, Scripture as the matrix of all logics and semantics is a holistic system that may serve as master key for deciphering any possible meaning of a word. (shrink)