Hypoxia hampers ATP production and threatens cell survival. Since cellular energetics tightly controls cell responses and fate, ATP levels and dynamics are of utmost importance. An integrated mathematical model of ATP synthesis by the mitochondrial oxidative phosphorylation/electron transfer chain system has been recently published :e36, 2005). This model was validated under static conditions. To evaluate its performance under dynamical situations, we implemented and simulated it . Inner membrane potential and [NADH] were used as indicators of mitochondrial function. (...) Root mean squared error was used to compare simulations and experiments :39155–39165, 2003). Steady-state experimental data were reproduced within 2–6%. Model dynamics were evaluated under: baseline, activation of NADH production, addition of ADP, addition of inorganic phosphate, oxygen exhaustion. In all phases, except the last one, ΔΨ and [NADH] as well as oxygen consumption, were reproduced . Under anoxia, simulated ΔΨ markedly depolarized . In conclusion, the model reproduces dynamic data as long as oxygen is present. Anticipated improvement by the inclusion of ATP consumption and explicit Krebs cycle are under evaluation. (shrink)

Mitochondrial function is key for maintaining cellular health, while mitochondrial failure is associated with various pathologies, including inherited metabolic disorders and age‐related diseases. In order to maintain mitochondrial quality, several pathways of mitochondrial quality control have evolved. These systems monitor mitochondrial integrity through antioxidants, DNA repair systems, and chaperones and proteases involved in the mitochondrial unfolded protein response. Additional regulation of mitochondrial function involves dynamic exchange of components through mitochondrial fusion and fission. (...) Sustained stress induces a selective autophagy – termed mitophagy – and ultimately leads to apoptosis. Together, these systems form a network that acts on the molecular, organellar, and cellular level. In this review, we highlight how these systems are regulated in an integrated context‐ and time‐dependent network of mitochondrial quality control that is implicated in healthy aging. (shrink)

The pore‐forming BCL‐2 family proteins are effectors of mitochondrial poration in apoptosis initiation. Two atypical effectors—BOK and truncated BID (tBID)—join the canonical effectors BAK and BAX. Gene knockout revealed developmental phenotypes in the absence the effectors, supporting their roles in vivo. During apoptosis effectors are activated and change shape from dormant monomers to dynamic oligomers that associate with and permeabilize mitochondria. BID is activated by proteolysis, BOK accumulates on inhibition of its degradation by the E3 ligase gp78, while BAK (...) and BAX undergo direct activation by BH3‐only initiators, autoactivation, and crossactivation. Except tBID, effector oligomers on the mitochondria appear as arcs and rings in super‐resolution microscopy images. The BH3‐in‐groove dimers of BAK and BAX, the tBID monomers, and uncharacterized BOK species are the putative building blocks of apoptotic pores. Effectors interact with lipids and bilayers but the mechanism of membrane poration remains elusive. I discuss effector‐mediated mitochondrial poration. (shrink)

Mitochondria can change their shape from discrete isolated organelles to a large continuous reticulum. The cellular advantages underlying these fused networks are still incompletely understood. In this paper, we describe and compare hypotheses regarding the function of mitochondrial networks. We use mathematical and physical tools both to investigate existing hypotheses and to generate new ones, and we suggest experimental and modelling strategies. Among the novel insights we underline from this work are the possibilities that (i) selective mitophagy is not (...) required for quality control because selective fusion is sufficient; (ii) increased connectivity may have non‐linear effects on the diffusion rate of proteins; and (iii) fused networks can act to dampen biochemical fluctuations. We hope to convey to the reader that quantitative approaches can drive advances in the understanding of the physiological advantage of these morphological changes. (shrink)

Mitochondria have been fundamental to the eco‐physiological success of eukaryotes since the last eukaryotic common ancestor (LECA). They contribute essential functions to eukaryotic cells, above and beyond classical respiration. Mitochondria interact with, and complement, metabolic pathways occurring in other organelles, notably diversifying the chloroplast metabolism of photosynthetic organisms. Here, we integrate existing literature to investigate how mitochondrial metabolism varies across the landscape of eukaryotic evolution. We illustrate the mitochondrial remodelling and proteomic changes undergone in conjunction with major evolutionary (...) transitions. We explore how the mitochondrial complexity of the LECA has been remodelled in specific groups to support subsequent evolutionary transitions, such as the acquisition of chloroplasts in photosynthetic species and the emergence of multicellularity. We highlight the versatile and crucial roles played by mitochondria during eukaryotic evolution, extending from its huge contribution to the development of the LECA itself to the dynamic evolution of individual eukaryote groups, reflecting both their current ecologies and evolutionary histories. (shrink)

The evolution of sex in eukaryotes represents a paradox, given the “twofold” fitness cost it incurs. We hypothesize that the mutational dynamics of the mitochondrial genome would have favored the evolution of sexual reproduction. Mitochondrial DNA (mtDNA) exhibits a high‐mutation rate across most eukaryote taxa, and several lines of evidence suggest that this high rate is an ancestral character. This seems inexplicable given that mtDNA‐encoded genes underlie the expression of life's most salient functions, including energy conversion. We (...) propose that negative metabolic effects linked to mitochondrial mutation accumulation would have invoked selection for sexual recombination between divergent host nuclear genomes in early eukaryote lineages. This would provide a mechanism by which recombinant host genotypes could be rapidly shuffled and screened for the presence of compensatory modifiers that offset mtDNA‐induced harm. Under this hypothesis, recombination provides the genetic variation necessary for compensatory nuclear coadaptation to keep pace with mitochondrial mutation accumulation. (shrink)

As endosymbionts, the mitochondria are unique among organelles. This review provides insights into mitochondrial behavior and introduces the idea of a unified collective, an interconnected reticulum reminiscent of the Borg, a fictional humanoid species from the Star Trek television series whereby decisions are made within their network (or “hive”), linked to signaling cascades that coordinate the cross‐talk between mitochondrial and cellular processes (“subspace domain”). Similarly, mitochondrial dynamics are determined by two distinct processes, namely the local regulation (...) of fission/fusion and the global control of their behavior through cellular signaling pathways. Indeed, decisions within the hive provide each mitochondrial unit with autonomous control of their own degradation, whereby mitochondrial fusion is inactivated and they become substrates for autophagy. Decisions within the subspace domain couple signaling pathways involved in the functional integration of mitochondria with complex cellular transitions, including developmental cues, mitosis, and apoptosis. (shrink)

We propose a signaling pathway in which cell‐extracellular matrix (ECM) adhesion components PINCH‐1 and kindlin‐2 sense mechanical signals from ECM and link them to proline biosynthesis, a vital metabolic pathway for macromolecule synthesis, redox balance, and ECM remodeling. ECM stiffening promotes PINCH‐1 expression via integrin signaling, which suppresses dynamin‐related protein 1 (DRP1) expression and mitochondrial fission, resulting in increased kindlin‐2 translocation into mitochondria and interaction with Δ1‐pyrroline‐5‐carboxylate (P5C) reductase 1 (PYCR1). Kindlin‐2 interaction with PYCR1 protects the latter from proteolytic (...) degradation, leading to elevated PYCR1 level. Additionally, PINCH‐1 promotes P5C synthase (P5CS) expression and P5C synthesis, which, together with increased PYCR1 level, support augmented proline biosynthesis. This signaling pathway is frequently activated in fibrosis and cancer, resulting in increased proline biosynthesis and excessive collagen matrix production, which in turn further promotes ECM stiffening. Targeting this signaling pathway, therefore, may provide an effective strategy for alleviating fibrosis and cancer progression. (shrink)

Both RalA and RalB interact with the ubiquitous calcium sensor, calmodulin (CaM). New structural and biophysical characterisation of these interactions strongly suggests that, in the native membrane‐associated state, only RalA can be extracted from the membrane by CaM and this non‐canonical interaction could underpin the divergent signalling roles of these closely related GTPases. The isoform specificity for RalA exhibited by CaM is hypothesised to contribute to the disparate signalling roles of RalA and RalB in mitochondrial dynamics. This would (...) lead to CaM shuttling RalA to the mitochondrial membrane but leaving RalB localisation unperturbed, and in doing so triggering mitochondrial fission pathways rather than mitophagy. (shrink)

Several features of the yeast mitochondrial genome, including high mutation rate, dynamic genomic structure, small effective population size, and dispensability for cellular viability, make it a promising candidate for generating hybrid incompatibility and driving speciation. Cytonuclear incompatibility, a specific type of Dobzhansky‐Muller genetic incompatibility caused by improper interactions between mitochondrial and nuclear genomes, has previously been observed in a variety of organisms, yet its role in speciation remains obscure. Recent studies in Saccharomyces yeast species provide a new insight, (...) with experimental evidence that cytonuclear incompatibility and DNA sequence divergence are both causes of the reproductive isolation of different yeast species. Interestingly, these two mechanisms seem to be perfectly complementary to each other in terms of their effects and evolutionary trajectories. Direct molecular analyses of the incompatible genes in yeasts have started to shed light on the evolutionary forces driving speciation. Editor's suggested further reading in BioEssaysThe cytoplasmic structure hypothesis for ribosome assembly, vertical inheritance, and phylogeny AbstractMitochondrial bioenergetics as a major motive force of speciation Abstract. (shrink)

Phase separation underlies the formation of biomolecular condensates. We hypothesize the cellular processes that occur within condensates shape their structural features. We use the example of transcription to discuss structure–function relationships in condensates. Various types of transcriptional condensates have been reported across the evolutionary spectrum in the cell nucleus as well as in mitochondrial and bacterial nucleoids. In vitro and in vivo observations suggest that transcriptional activity of condensates influences their supramolecular structure, which in turn affects their function. Condensate (...) organization thus becomes driven by differences in miscibility among the DNA and proteins of the transcription machinery and the RNA transcripts they generate. These considerations are in line with the notion that cellular processes shape the structural properties of condensates, leading to a dynamic, mutual interplay between structure and function in the cell. (shrink)

Many conserved eukaryotic traits, including apoptosis, two sexes, speciation and ageing, can be causally linked to a bioenergetic requirement for mitochondrial genes. Mitochondrial genes encode proteins involved in cell respiration, which interact closely with proteins encoded by nuclear genes. Functional respiration requires the coadaptation of mitochondrial and nuclear genes, despite divergent tempi and modes of evolution. Free‐radical signals emerge directly from the biophysics of mosaic respiratory chains encoded by two genomes prone to mismatch, with apoptosis being the (...) default penalty for compromised respiration. Selection for genomic matching is facilitated by two sexes, and optimizes fitness, adaptability and fertility in youth. Mismatches cause infertility, low fitness, hybrid breakdown, and potentially speciation. The dynamics of selection for mitonuclear function optimize fitness over generations, but the same selective processes also operate within generations, driving ageing and age‐related diseases. This coherent view of eukaryotic energetics offers striking insights into infertility and age‐related diseases. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:preface Sometimes, even those of us who have organized our entire lives around the transformative possibilities of Black feminist thought can sit back in wonder at the expansiveness of this intergenerational transnational practice.Thisspecialissuetakesamomenttoimbibewhere we have been, where we are, and where we have yet to journey. The contributors to this special issue on, or more precisely, of Black feminist thought find Black feminist thinking in a wide range of (...) times, places, and forms. Each of the contributors invites us to bear witness in a distinct way to the pushes and pulls of critical engagement with Black feminist thought. Biomythic origin point “mitochondrial eve” brainstorms the archive and admonishes those of us looking back to “be a forest of your own / dreams.” Gladys Bentley sends unrequited texts to... Gladys Bentley. Everything is possible here, even what should never have happened. In If You Can’t Be Free, Be a Mystery: In Search of Billie Holiday, Farah Jasmine Griffin, one of the most dedicated and prolific stewards of Black feminist thought as a liberatory practice, cites Rita Dove’s poem “Canary” to evoke the protective strategies Black women employ to hold something (ourselves, each other) sacred in an unfree world.1 The lineage we participate in through our Black 1. Farah Jasmine Griffin, If You Can’t Be Free, Be a Mystery: In Search of Billie Holiday (New York: Ballantine Books, 2001), 155–56. “Be a Mystery”: (The Infinity of) Black Feminist Thought 8Preface feminist intellectual labor is sacred to us. For generations, even before the name “Black Feminist,” it has existed as a form of love, communion, protest, and prophecy, often far from the spotlight. Nurtured by the warmth of imagination, practices became praxis. Griffin and others have ensured a tradition wherein, to invoke Griffin’s paraphrase of Toni Morrison in her tribute to Nellie McKay, “the mothers may soar and the daughters may know their names.”2 We are some of the daughters. But we are living in times that neither we nor our mothers would hardly recognize. Abolitionist queer Black feminists are topping the New York Times bestseller lists. Our scholars and experts speak on the nightly news. Some of what were once our most marginalized proposals have become policies, funding keywords, and even memes. The Movement for Black Lives, one of the largest and most visible social movements of our time, or any time, explicitly connects its vision to the foundational Combahee River Collective statement. We do this work now in the light of recognition. Masses of people think they know what Black feminism is, and yet, this is not the world that we dreamed. We, the current generation of practicing Black feminist thinkers, are faced with the consequences of Black feminist practice feeling like less of a mystery. We celebrate the legacy our foremothers have made possible, and we must also think creatively, lovingly, and sometimes even cryptically about what this moment can and must mother—or bring into being. It has to bring into being something we cannot describe from here, something we have not yet known. It is exhilaratingly beautiful to look upon what’s been made possible, but we know there is so much more than recognition. Undaunted by a world still hellbent on not caring for or loving us, even as it consumes our insights, theories, and modes of organizing, we create worlds filled with an abundance of joy, affirmation, and ingenuity. It is from this robust, ancestral practice of world-making that this special issue emerges. The pieces found here provide insight into one of the most dynamic aspects of Black feminist thought: its generative power. The range of topics included in this special issue encapsulates the breadth of this interdisciplinary, transnational, multimodal, and 2. Farah Jasmine Griffin, “That the Mothers May Soar and the Daughters May Know Their Names: A Retrospective of Black Feminist Literary Criticism,” Signs 32, no. 2 (Winter 2007): 483–507. Preface 9 intergenerational practice. Given the seemingly infinite nodes and entry points of Black feminist thought, it is befitting that this issue coheres because of an unboundedness and porousness among the pieces. The art essays, articles, field reviews, and conversations converse, dance, and harmonize with... (shrink)

Recent research into human origins has largely focused on deducing past events and processes from current patterns of genetic variation. Some human genes possess unexpectedly low diversity, seemingly resulting from events of the late Pleistocene. Such anomalies have previously been ascribed to population bottlenecks or selection on genes. For four species of matrilineal whale, evidence suggests that cultural evolution may have reduced the diversity of genes which have similar transmission characteristics to selective cultural traits, through a process called cultural hitchhiking. (...) Cultural evolution is characteristic of human societies and so should be considered as a potential determinant of human genetic diversity. A stochastic simulation of gene and cultural dynamics in an array of hunter-gatherer tribes shows that cultural selection has the potential to severely reduce genetic diversity if: inter-tribe gene flows are reasonably low (<~0.6-15 genes/tribe/generation); cultural evolution changes fitness by >~0.3-3%/generation; and fitness is changed more by cultural innovation within a tribe than cultural assimilation from neighboring tribes. Thus cultural hitchhiking may explain low diversity and short coalescence times in mitochondrial and, especially, Y-linked human genes. (shrink)

There is a debate regarding the function of Drp1, a GTPase involved in mitochondrial fission, during the elimination of mitochondria by autophagy. A number of experiments indicate that Drp1 is needed to eliminate mitochondria during mitophagy, either by reducing the mitochondrial size or by providing a noncanonical mitophagy function. Yet, other convincing experimental results support the conclusion that Drp1 is not necessary. Here, we review the possible functions for Drp1 in mitophagy and autophagy, depending on tissues, organisms and (...) stresses, and discuss these apparent discrepancies. In this regard, it appears that the reduction of mitochondria size is often required for mitophagy but not always in a Drp1‐dependent manner. Finally, we speculate on Drp1‐independent mitochondrial fission mechanism that may take place during mitophagy and on noncanonical roles, which Drp1 may play such as modulating organelle contact sites dynamic during the autophagosome formation. (shrink)

In non‐literal uses of language, the content an utterance communicates differs from its literal truth conditions. Loose talk is one example of non‐literal language use (amongst many others). For example, what a loose utterance of (1) communicates differs from what it literally expresses: (1) Lena arrived at 9 o'clock. Loose talk is interesting (or so I will argue). It has certain distinctive features which raise important questions about the connection between literal and non‐literal language use. This paper aims to (i.) (...) introduce a range of novel data demonstrating certain overlooked features of loose talk, and (ii.) develop a new theory of the phenomenon which accounts for these data. In particular, this theory is motivated by the need to explain minimal pairs such as (2)-(3): (2) Lena arrived at 9 o'clock, but she did not arrive at 9 o'clock exactly. (3) ?? Lena did not arrive at 9 o'clock exactly, but she arrived at 9 o'clock. (2) and (3) agree in their truth conditions. Yet they differ in felicity. As such, they constitute a problem for any account which hopes to predict the acceptability of the loose use of a sentence from its truth conditions and the context of utterance alone. Instead, it will be argued, to explain loose talk phenomena we must posit an additional layer of meaning outstripping truth conditions. This layer of meaning is shown to exhibit a range of properties, all of which point to its being semantically encoded. Thus, if correct, the theory provides a new example of how semantic meaning must extend beyond literal, truth‐conditional content. (shrink)

Introduction: Chinese philosophy and the translation of disciplines -- The faces of masters literature until the Eastern Han -- Scenes of instruction and master bodies in the Analects -- From scenes of instruction to scenes of construction: Mozi -- Interiority, human nature, and exegesis in Mencius -- Authorship, human nature, and persuasion in Xunzi -- The race for precedence: polemics and the vacuum of traditions in Laozi -- Zhuangzi and the art of negation -- The self-regulating state, paranoia, and rhetoric (...) in Han Feizi -- Epilogue: a future for masters literature and Chinese philosophy. (shrink)

This paper develops a media theoretical extension of the communicative view on corporate social responsibility by elaborating on the characteristics of network societies, arguing that new media increase the speed and connectivity, and lead to higher plurality and the potential polarization of reality constructions. We discuss the implications for corporate social responsibility of becoming more polyphonic and sketch the contours of “communicative legitimacy.” Finally, we present this special issue and develop some questions for future research.

The thesis that scientists give greater weight to novel predictions than to explanations of known facts is tested against historical cases in physical science. Several theories were accepted after successful novel predictions but there is little evidence that extra credit was given for novelty. Other theories were rejected despite, or accepted without, making successful novel predictions. No examples were found of theories that were accepted primarily because of successful novel predictions and would not have been accepted if those facts had (...) been previously known. (shrink)

This paper examines three accounts of the sleeping beauty case: an account proposed by Adam Elga, an account proposed by David Lewis, and a third account defended in this paper. It provides two reasons for preferring the third account. First, this account does a good job of capturing the temporal continuity of our beliefs, while the accounts favored by Elga and Lewis do not. Second, Elga’s and Lewis’ treatments of the sleeping beauty case lead to highly counterintuitive consequences. The proposed (...) account also leads to counterintuitive consequences, but they’re not as bad as those of Elga’s account, and no worse than those of Lewis’ account. (shrink)

What I call the dynamics of reason is a post-Kuhnian approach to the history and philosophy of science articulating a relativized and historicized version of the Kantian conception of the rationality and objectivity of the modern physical sciences. I here discuss two extensions of this approach. I argue that, although the relativized standards of rationality in question change over time, the particular way in which they do this still preserves the trans-historical rationality of the entire process. I also make (...) a beginning in extending my historical narrative from purely intellectual history (both philosophical and scientific) to the wider cultural context. (shrink)

I have two main aims. The first is general, and more philosophical. The second is specific, and more closely related to physics. The first aim is to state my general views about laws and causation at different ”levels’. The main task is to understand how the higher levels sustain notions of law and causation that ”ride free’ of reductions to the lower level or levels. I endeavour to relate my views to those of other symposiasts. The second aim is to (...) give a framework for describing dynamics at different levels, emphasizing how the various levels’ dynamics can mesh or fail to mesh. This framework is essentially that of elementary dynamical systems theory. The main idea will be, for simplicity, to work with just two levels, dubbed ”micro’ and ”macro’, which are related by coarse-graining. I use this framework to describe, in part, the first four of Ellis’ five types of top-down causation. (shrink)

In this paper, I consider how, given mutual knowledge of the information codified in a compositional semantic theory, an assertion of a sentence serves to update the shared information in a conversation. There is a standard account, due to Stalnaker, of how such conversational updating occurs. While this account has much to recommend it, in this paper I argue that it needs to be revised in light of certain patterns of updating that result from certain natural discourses. Having argued for (...) this, I present a new account of conversational updating that can be seen as a natural generalization of the standard account, and show how it can predict these patterns in a simple and principled manner. (shrink)

I show why Michael Friedman’s idea that we should view new constitutive frameworks introduced in paradigm change as members of a convergent series introduces an uncomfortable tension in his views. It cannot be justified on realist grounds, as this would compromise his Kantian perspective, but his own appeal to a Kantian regulative ideal of reason cannot do the job either. I then explain a way to make better sense of the rationality of paradigm change on what I take to be (...) Friedman’s own terms. (shrink)

Essays on a wide range of areas and topics in Asian studies for scholars looking to incorporate Asia into their worldview and teaching. Contributors give contemporary presence to Asian studies through a variety of themes and topics in this multidisciplined and interdisciplinary volume. In an era of globalization, scholars trained in Western traditions increasingly see the need to add materials and perspectives that have been lacking in the past. Accessibly written and void of jargon, this work provides an adaptable entrée (...) to Asia for the integration of topics into courses in the humanities, social sciences, cultural studies, and global studies. Guiding principles, developed at the East-West Center, include noting uncommon differences, the interplay among Asian societies and traditions, the erosion of authenticity and cultural tradition as an Asian phenomenon as well as a Western one, and the possibilities Asian concepts offer for conceiving culture outside Asian contexts. The work ranges from South to Southeast to East Asia. Essays deal with art, aesthetics, popular culture, religion, geopolitical realities, geography, history, and contemporary times. “This volume truly lies at the intersection of scholarship and teaching. Each essay has the potential to help rethink approaches to scholarly issues, and there is a great deal of material for classroom discussion and examples. The book’s breadth—covering India, China, Korea, the Sea of Malay, Bhutan, and other locations—is impressive.” — Robert André LaFleur, Beloit College. (shrink)

Global dynamics and the integrity of life -- Pluralism in creation -- Reconsidering greed -- Timing moral cosmologies -- Love in the end times -- From toleration to political forgiveness -- Sacred texts and the social imaginary -- Comparing religions, comparing lives -- On moral madness -- Presenting theological humanism.

Honorable Mention, 2007 Book Prize competition sponsored by the Canadian Philosophical Association.In Onflow, Ralph Pred supplies an account of the nature of ...

Language is coordination. Pursuing this, the present Special Issue of Pragmatics & Cognition challenges two widely held positions. First, the papers reject the claim that language is essentially ‘symbolic’. Second, they deny that minds represent verbal patterns. Rather, language is social, individual, and contributes the feeling of thinking. Simply, it is distributed. Elucidating this claim, the opening papers report empirically-based work on the anticipatory dynamics of reading, their cognitive consequences, Shakespearean theatre, what images evoke, and insight problem-solving. Having given (...) reasons for rejecting linguistic autonomy, the papers turn to theory building. Initially, attention is given to a possible origin for semiotic cognition. Then, it is claimed that language functions by realizing values. Next, it is argued that human dynamics are co-regulated by cultural and biological symbols. Finally, in a review article, the distributed view of language is used to contrast Clark’s organism-centered cognition with what is here called ecologically extended cognition. (shrink)

Two examples demonstrate the possibility of extremely complicated non-convergent behavior in evolutionary game dynamics. For the Taylor-Jonker flow, the stable orbits for three strategies were investigated by Zeeman. Chaos does not occur with three strategies. This papers presents numerical evidence that chaotic dynamics on a strange attractor does occur with four strategies. Thus phenomenon is closely related to known examples of complicated behavior in Lotka-Volterra ecological models.

Every statement represents a certain state of affairs as holding in a certain situation, which the statement concerns. The situation which a statement concerns is indicated by the context. It must be distinguished from whichever situation may be explicitly mentioned in the statement. In this framework, two cognitive processes are analysed: projection and reflection. Both involve two representations: one which concerns a situation s, and another one which explicitly mentions that situation. Through reflection we go from the representation concerning s (...) to the representation mentioning s. Through projection we go from the representation mentioning s to the representation concerning s. (shrink)

Several tasks in artificial intelligence require the ability to find models about knowledge dynamics. They include belief revision, fusion and belief merging, and abduction. In this paper, we exploit the algebraic framework of mathematical morphology in the context of propositional logic and define operations such as dilation or erosion of a set of formulas. We derive concrete operators, based on a semantic approach, that have an intuitive interpretation and that are formally well behaved, to perform revision, fusion and abduction. (...) Computation and tractability are addressed, and simple examples illustrate the main results. (shrink)

Inferences from clinical research results to estimates of therapeutic effectiveness suffer due to various biases. I argue that predictions of medical effectiveness are prone to failure because current medical research overlooks the impacts of a particularly detrimental set of biases: meta-biases. Meta-biases are linked to higher-level characteristics of medical research and their effects are only observed when comparing sets of studies that share certain meta-level properties. I offer a model for correcting research results based on meta-research evidence, the bias (...) class='Hi'>dynamics model, which employs regularly updated empirical bias coefficients to attenuate estimates of therapeutic effectiveness. (shrink)

Extracting the regularities of our environment is one of our core cognitive abilities. To study the fine-grained dynamics of the extraction of embedded regularities, a method combining the advantages of the artificial language paradigm and the serial response time task was used with a group of Guinea baboons in a new automatic experimental device. After a series of random trials, monkeys were exposed to language-like patterns. We found that the extraction of embedded patterns positioned at the end of larger (...) patterns was faster than the extraction of initial embedded patterns. This result suggests that there is a learning advantage for the final element of a sequence that benefits from the contextual information provided by previous elements. (shrink)