We propose a signaling pathway in which cell‐extracellular matrix (ECM) adhesion components PINCH‐1 and kindlin‐2 sense mechanical signals from ECM and link them to proline biosynthesis, a vital metabolic pathway for macromolecule synthesis, redox balance, and ECM remodeling. ECM stiffening promotes PINCH‐1 expression via integrin signaling, which suppresses dynamin‐related protein 1 (DRP1) expression and mitochondrial fission, resulting in increased kindlin‐2 translocation into mitochondria and interaction with Δ1‐pyrroline‐5‐carboxylate (P5C) reductase 1 (PYCR1). Kindlin‐2 interaction with PYCR1 protects the latter from proteolytic degradation, (...) leading to elevated PYCR1 level. Additionally, PINCH‐1 promotes P5C synthase (P5CS) expression and P5C synthesis, which, together with increased PYCR1 level, support augmented proline biosynthesis. This signaling pathway is frequently activated in fibrosis and cancer, resulting in increased proline biosynthesis and excessive collagen matrix production, which in turn further promotes ECM stiffening. Targeting this signaling pathway, therefore, may provide an effective strategy for alleviating fibrosis and cancer progression. (shrink)

In the past few decades, a lot of optimization methods have been applied in estimating the parameter of photovoltaic models and obtained better results, but these methods still have some deficiencies, such as higher time complexity and poor stability. To tackle these problems, an enhanced success history adaptive DE with greedy mutation strategy is employed to optimize parameters of PV models to propose a parameter optimization method in this paper. In the EBLSHADE, the linear population size reduction strategy is used (...) to gradually reduce population to improve the search capabilities and balance the exploitation and exploration capabilities. The less and more greedy mutation strategy is used to enhance the exploitation capability and the exploration capability. Finally, a parameter optimization method based on EBLSHADE is proposed to optimize parameters of PV models. The different PV models are selected to prove the effectiveness of the proposed method. Comparison results demonstrate that the EBLSHADE is an effective and efficient method and the parameter optimization method is beneficial to design, control, and optimize the PV systems. (shrink)

Eye-tracking technology has become a powerful tool for biomedical-related applications due to its simplicity of operation and low requirements on patient language skills. This study aims to use the machine-learning models and deep-learning networks to identify key features of eye movements in Alzheimer's Disease (AD) under specific visual tasks, thereby facilitating computer-aided diagnosis of AD. Firstly, a three-dimensional (3D) visuospatial memory task is designed to provide participants with visual stimuli while their eye-movement data are recorded and used to build an (...) eye-tracking dataset. Then, we propose a novel deep-learning-based model for identifying patients with Alzheimer's Disease (PwAD) and healthy controls (HCs) based on the collected eye-movement data. The proposed model utilizes a nested autoencoder network to extract the eye-movement features from the generated fixation heatmaps and a weight adaptive network layer for the feature fusion, which can preserve as much useful information as possible for the final binary classification. To fully verify the performance of the proposed model, we also design two types of models based on traditional machine-learning and typical deep-learning for comparison. Furthermore, we have also done ablation experiments to verify the effectiveness of each module of the proposed network. Finally, these models are evaluated by four-fold cross-validation on the built eye-tracking dataset. The proposed model shows 85% average accuracy in AD recognition, outperforming machine-learning methods and other typical deep-learning networks. (shrink)

The race among global firms to launch its respective products and services into the market sooner than the competitors puts pressure to equip its employees with job-related skills at the pace of business. Today’s global and dynamic business requires employees to develop highly complex cognitive skills such as decision-making, problem-solving, troubleshooting to perform their jobs proficiently. Traditional training models used by some organizations lead to a very slow speed at which employees gain an acceptable level of proficiency in the targeted (...) job skills. Also, these models have long and regimented instructional development cycle. Thus, traditional models are inherently counter-productive to the business and do not enable employees and organizations for today’s business needs. Therefore, business organizations need to explore new training models and strategies that could reduce the time an employee takes to reach target proficiency in complex skills without compromising the effectiveness or outcome. A comprehensive review of the literature shows a very limited amount of academic or practitioner research on this topic. This doctorate research study aims to find various training strategies that have proven successful in organizations for accelerating proficiency of employees in complex job skills. The researcher collected data primarily through 74 in-depth interviews with 86 training experts with known work experience of reducing time-to-proficiency in various settings. A total of 105 project cases have been collected across 42 industries to date. A grounded theory approach with constant comparison method is used to guide the theoretical saturation, analyze the data and to develop a theoretical model of training strategies. This unique study revealed a range of training strategies from non-training solutions to classroom instructions to workplace training to accelerate proficiency of employees in acquiring complex skills. This paper will specifically report the preliminary findings and conceptual model of major classroom-based instructional strategies only that has been found to hold the potential to shorten time-to-proficiency of employees at the workplace. This paper will also discuss the implications of the findings for the practitioners. Results in this study confirmed that classroom-based instructional strategies need to be designed and delivered the way the work is being performed in reality by the learners. Research findings suggest a pattern of five classroom-based instructional strategies that are more successful in reducing time-to-proficiency - 1) Contextualized learning 2) Performance analysis of star performer 3) Active processing and emotional involvement 4) Access to self-guided learning resources 5) Social interconnectivity and informal learning. (shrink)

With the rapid development of renewable generators such as distributed photovoltaic and profound changes of the power structure, this paper analyzes the frequency characteristics of the power system with high penetration of renewable generations in the process of low-frequency load shedding and discusses the influence of the distributed renewable generator frequency endurance capabilities on the implementation effect of low-frequency load shedding in detail. Finally, the influences of the distributed renewable generator frequency endurance capability and the capacities of the distributed renewable (...) generator on frequency response characteristics of an actual Hunan power grid are simulated. The simulation results show that more distributed photovoltaic capacity without frequency endurance capability leads to deeper frequency drops after the disturbance and requires more basic rounds of load shedding. When the penetration rate of distributed photovoltaic is too high, it may cause load shedding, resulting in power grid load losses and, at the same time, leading to an overshoot phenomenon in the process of frequency recovery. Therefore, the influence of distributed photovoltaic on the control of low-frequency load shedding should be considered when designing low-frequency load shedding schemes for the power grid with high penetration of distributed photovoltaic. (shrink)

Attention has been theorized as a system comprising three networks that can be estimated reliably by the attention network test ; the three networks are defined as alerting, orienting, and conflict control. The present study aims to identify the attention networks that are crucial for elite shooting and archery athletes and to examine whether mindfulness training can improve elite athletes' attention networks. We compared the performances in ANT between 62 elite athletes from the Chinese national team of shooting and archery (...) and 49 athletes from a provincial team in China. The results indicate three well-functioned attention networks in both groups, but elite athletes in the national team responded faster overall than athletes in the provincial team. The 62 elite athletes in the national team then received mindfulness training with varied periods ranging from 5 to 8 weeks, after which the ANT was re-administered. After mindfulness training, the elite athletes improved in orienting and conflict control networks compared with their pre-training performances. These results suggest that elite shooting and archery athletes in the national team are more efficient in all three attention networks, which means that they are able to reach the alerting state faster, make better use of environmental information, and suppress interference from distractors more efficiently. Moreover, the orienting and conflict control networks of the elite shooting and archery athletes can be improved by mindfulness training. We conclude that mindfulness practice should be considered as a useful addition to daily training for shooting and archery athletes. (shrink)

Developing World Bioethics, Volume 22, Issue 3, Page 170-178, September 2022.

With the rapid and unbalanced development of industry, a large amount of cultivated land is converted into industrial land with lower efficiency. The existing research is extensively concerned with industrial land use and industrial development in isolation, but little attention has been paid to the relationship between them. To help address this gap, the paper creates a new efficiency measure method for industrial land use combining Subvector Data Envelope Analysis with spatial analysis approach. The proposed model has been verified by (...) using the industrial land use data of 30 Chinese provinces from 2001 to 2013. The spatial autocorrelation relationship between industrial development and industrial land use efficiency is explored. Furthermore, this paper examines the effects of industrial development on industrial land use efficiency by spatial panel data model. The results indicate that the industrial land use efficiency and the industrial development level in the provinces of eastern region are higher than those of the western region. The spatial distribution of industrial land use efficiency shows remarkable positive spatial autocorrelation. However, the level of industrial development has obvious negative spatial autocorrelation since 2009. The improvement of industrial development has a significant positive impact on the industrial land use efficiency. (shrink)

本书对自组织理论进行综合性研究,并探讨了关于自然界自组织演化的自然图景和自然观,关于自然科学自组织演化的科学图景和科学观。.

Background Performance evaluation is vital for IRB operations. As the number of IRBs and their responsibilities in reviewing and supervising clinical research grow in China, there is a significant need to evaluate their performances. To date, little research has examined IRB performance within China. The aim of this study was to ascertain the perspectives and experiences of IRB employees and researchers to understand the current status of IRBs; compare collected results with those of other countries; and identify shortcomings to improve (...) IRB performance. Methods This study was conducted in China from October 2020 to September 2021, using an online survey with the IRB-researcher assessment tool-Chinese version. Results 757 respondents were included in the analysis and classified into IRB employees, researchers, or those who are both IRB employees and researchers. Overall, the score for an ideal IRB was significantly higher than that of an actual IRB. Compared to the US National Validation study, Chinese participants and American participants both agree and differ in their perspectives on the most and least important ideal items. Conclusion This investigation provides a benchmark of the perceived performance of actual IRBs in China. IRBs in China can be precisely adjusted by targeting identified areas of weakness to improve their performances. (shrink)

Drawing on the perspective of causal reasoning and the social cognitive theory of moral thought and action, this study explores the mechanisms underlying the association between exposure to exploitative leadership and employee workplace deviance. The results of a time-lagged survey conducted in China reveal that exposure to exploitative leadership can evoke a moral justification process that leads to increased employee organizational and interpersonal deviance. A tendency toward hostile attribution bias reinforces the direct link between exploitative leadership and moral justification and (...) the indirect effects of exploitative leadership on employee organizational and interpersonal deviance, via moral justification. The theoretical and practical implications of this study are discussed and potential directions for future studies are proposed. (shrink)

Erratum to: Found Sci DOI 10.1007/s10699-014-9364-0The author, Kun Wu’s name, affiliation and biography have been incorrectly published in the original article. The correct affiliation and biography are provided below.

The masked priming paradigm has been extensively used to investigate the indirect impacts of unconscious stimuli on conscious behaviors, and the congruency effect of priming on free choices has gained increasing attention. Free choices allow participants to voluntarily choose a response from multiple options during each trial. While repeated practice is known to increase priming effects in subliminal visual tasks, whether practice increases the priming effect of free choices in the masked priming paradigm is unclear. And it is also not (...) clear how the proportions of free choice and forced choice trials in one block will affect the free choice masked priming effect. The present study applied repeated practice in the masked priming paradigm and found that after training, the participants were more likely to be influenced by masked primes during free choice, but this training process did not alter the visibility of masked stimuli. In addition, this study revealed that when the proportions of free choice and forced choice trials were equal during the training stage, this enhanced effect by practice was the strongest. These results indicated that practice could enhance masked stimulus processing in free-choice, and that the learning effect may mainly be derived from the early selection and integrated processing of masked stimuli. (shrink)

Neural markers, such as the mismatch negativity, have been used to examine the phonological underspecification of English feature contrasts using the Featurally Underspecified Lexicon model. However, neural indices have not been examined within the approximant phoneme class, even though there is evidence suggesting processing asymmetries between liquid and glide phonemes. The goal of this study was to determine whether glide phonemes elicit electrophysiological asymmetries related to [consonantal] underspecification when contrasted with liquid phonemes in adult English speakers. Specifically, /ɹɑ/ is categorized (...) as [+consonantal] while /wɑ/ is not specified [i.e., ]. Following the FUL framework, if /w/ is less specified than /ɹ/, the former phoneme should elicit a larger MMN response than the latter phoneme. Fifteen English-speaking adults were presented with two syllables, /ɹɑ/ and /wɑ/, in an event-related potential oddball paradigm in which both syllables served as the standard and deviant stimulus in opposite stimulus sets. Three types of analyses were used: traditional mean amplitude measurements; cluster-based permutation analyses; and event-related spectral perturbation analyses. The less specified /wɑ/ elicited a large MMN, while a much smaller MMN was elicited by the more specified /ɹɑ/. In the standard and deviant ERP waveforms, /wɑ/ elicited a significantly larger negative response than did /ɹɑ/. Theta activity elicited by /ɹɑ/ was significantly greater than that elicited by /wɑ/ in the 100–300 ms time window. Also, low gamma activation was significantly lower for /ɹɑ/ vs. /wɑ/ deviants over the left hemisphere, as compared to the right, in the 100–150 ms window. These outcomes suggest that the [consonantal] feature follows the underspecification predictions of FUL previously tested with the place of articulation and voicing features. Thus, this study provides new evidence for phonological underspecification. Moreover, as neural oscillation patterns have not previously been discussed in the underspecification literature, the ERSP analyses identified potential new indices of phonological underspecification. (shrink)

Given the colexification of perception and cognition, Georgakopoulos et al. (2022. Universal and macro-areal patterns in the lexicon: A case-study in the perception-cognition domain. Linguistic Typology 26(2). 439–487) claim that uncontrolled experience rather than controlled activity has a direct linkage to cognition. To test whether this is a universal tendency, this study conducts a contrastive behavioral profile analysis of two basic vision verbs in Mandarin: kàn, a controlled activity verb, and jiàn, an uncontrolled experience verb. The results show that (i) (...) both kàn and jiàn colexify visual activity and cognitive senses; (ii) kàn is able to express a wider range of cognitive meanings, i.e., know, understand, and think, whereas jiàn only extends into know; and (iii) visual and cognitive meanings have more proximal relationships in the colexification pattern of kàn than that of jiàn. The study confirms the universality of the colexification between vision and cognition while providing counterexamples to the above-mentioned large data-based findings. Accordingly, a dichotomy of controlled activity versus uncontrolled experience is proposed for the colexification of vision and cognition in cognitive typology. (shrink)

On 19 October 2013, the Chinese government issued the Opinions on Further Regulation on Party and Political Leaders and Cadres Working Part-Time in Enterprises, also known as the 18th Decree, to regulate government officials’ employment with businesses. The 18th Decree is widely perceived as having had a significant impact on the use of independent directors with political backgrounds by firms, given the prevalence of this business practice. This paper examines the market reaction to the 18th Decree to ascertain the value (...) effect of political connections in China. We note a negative relationship between the political connections of independent directors and market reaction. We also note that the negative relationship between political connections and market reaction is moderated by ownership type and state of regional development. Specifically, we find that the negative relationship holds only for private firms in less developed regions. These results support our prediction that political connections add value to Chinese firms and that the value effect of political connection is contingent on institutional factors. (shrink)

Lachlan observed that any nonzero d.c.e. degree bounds a nonzero c.e. degree. In this paper, we study the c.e. predecessors of d.c.e. degrees, and prove that given a nonzero d.c.e. degree , there is a c.e. degree below and a high d.c.e. degree such that bounds all the c.e. degrees below . This result gives a unified approach to some seemingly unrelated results. In particular, it has the following two known theorems as corollaries: there is a low c.e. degree isolating (...) a high d.c.e. degree [S. Ishmukhametov, G. Wu, Isolation and the high/low hierarchy, Arch. Math. Logic 41 259–266]; there is a high d.c.e. degree bounding no minimal pairs [C.T. Chong, A. Li, Y. Yang, The existence of high nonbounding degrees in the difference hierarchy, Ann. Pure Appl. Logic 138 31–51]. (shrink)

Scientific papers written as dialogues evoke Platonist philosophical discourses and are foreseen as elementary forms of expression in neoclassical scientific renaissance. Here we report on a study of the Brazil nut effect in a series of macroscopic and microscopic systems in the form of a play in three acts. The nut effect predicting the segregation of smaller grains at the bottom of the mixture and larger ones at the top was observed in a polydisperse mix of manually shaken playground pebbles, (...) albeit following different kinetics than in an agitated pile of chess pieces. Common sense predicts that vertical, gravity-driven segregation in colloidal dispersions with heterogeneous particle size distributions is such that larger particles would settle toward the bottom and the lighter ones cream at the top. Here we refute this expectation and demonstrate that segregation of colloidal particles in the vertical direction conforms to the Brazil nut effect when the agitation is delivered in the forms of vortex mixing or audio vibration, but not when the colloids are manually shaken. The effect is demonstrated on aqueous dispersions of hydroxyapatite and iron oxide nanoparticles. Kinetic experiments showed that segregation increases with the agitation time in mixtures of pebbles and with the post-agitation aging time in fine particle colloids. The particle size gradient established due to agitation-induced segregation led to a corresponding gradient in optoelectronic properties—band gap, conductivity, lattice acoustics—in the vertical direction of the colloidal column for both types of nanoparticles. Such morphological gradients induced by the Brazil nut effect can be harnessed as affordable and facile templates for the synthesis of functionally gradient materials. Discussion of the mechanism and the application potential of the observed effect in colloidal and coarse systems is enriched with a literature review of this curious effect and entwined with the literary elements of the dramaturgical narrative involving a family of scientist in exile from mainstream scientific institutions: the mother, the father, an elementary school boy and a kindergarten girl. The narrative conforms in its structure to the shape of a Brazil nut and presents the first research study whose findings are enacted through a dream. The play questions the humaneness and creative prospects of modern science and celebrates children’s science projects performed with meager resources and a plentiful of imagination, showing that they could be gateways to important scientific discoveries. (shrink)

E-commerce conceivable future trade, consumption, and service is a new digital employer mode. Therefore, in order to decorate the customary natural environment of operation, it is quintessential to get rid of the preferred desktop in the true field, create a social logistics and transportation administration computing device with commodity agents and distributors as the key features, and mix freight logistics, business enterprise approach waft and data waft advertising and marketing, and advertising and marketing organically. The notion of e-commerce logistics looks (...) alongside the enchantment vogue of neighborhood technological knowledge and social demand. It is an integral part of ending e-commerce authentic economic value. All kinds of cell networks clear up the problem of data flow communication; in the technological know-how of telephone network, digital cost solves the bother of capital flow; at present, logistics is however a long-standing problem of e-commerce. Logistics has grown to be the last and entirely bottleneck of e-commerce. If logistics cannot adapt to the enchantment of e-commerce, it may also additionally lead to the slow enchantment of e-commerce. The purpose of this paper is to supply an Internet of things e-commerce logistics cloud provider platform based totally absolutely on cell communication, which can be combined with e-commerce and beautify the transport tempo of e-commerce. This paper moreover optimizes the e-commerce logistics system, so that it can combine with e-commerce to increase out the distribution of goods, the distribution tempo of e-commerce is doubled, and e-commerce can in a similar fashion develop rapidly. (shrink)

Differential leadership as a localized leadership style gradually developed on the basis of the Pattern of Differential Sequence. It plays a dual role in stimulating “insider subordinates” and “outsider subordinates” through the dynamic transformation of the roles. Using the process of game reasoning, the study identifies the differing principles used by insider subordinates and outsider subordinates in implementing deviant innovative behaviors. The simulation graph presents the perceived benefits of employees performing or not performing deviant innovative behaviors as clues during the (...) reasoning process, and implements deviant innovative behaviors for the high risk-taking trait of insider subordinates and the high internal control personality of outsider subordinates who implement deviant innovation. The theoretical derivation of behavior provides relevant references, and provides counter measures for effectively promoting employees’ deviant innovative behavior in the context of differential leadership. (shrink)

Laws in China relating to HIV disclosure are inconsistent. After a patient has tested HIV‐positive, service providers struggle to decide who should be informed first: patients, family members, or both. To understand service providers' attitudes and practices regarding the HIV notification process in China, 1101 service providers from a southwestern province of China were surveyed. Opinions were gathered from providers at five different levels of health care facilities (provincial, city, county, township and village). A mixed methods approach was used to (...) analyze perceptions of informing family members of a patient's HIV status. Quantitative analysis was used to examine whether providers held a favorable attitude toward notifying family members first and qualitative analysis was used to explore the reasons and consequences of notifying family members first. Nearly half of service providers felt family members should be informed of a patient's HIV status first. Providers who were older, had contact with HIV patients, or had less medical education were more likely to agree with a family‐first notification practice. Psychological pressure, concern about protecting family members, the need for family support, and consideration for local regulations were cited as the main reasons for this practice. There is an immediate need to re‐examine HIV notification policies so that there are consistent guidelines and procedures for providers throughout China. (shrink)

This paper studies the adaptive event-triggered finite-time tracking of output-constrained high-order nonlinear systems with time-varying powers. Due to the presence of multiple unknown powers and the consideration of event-triggered control, all the existing control methods of output-constrained nonlinear systems are inapplicable. By introducing nonlinear mappings, finite-time performance functions, and low-power and high-power terms into adding a power integrator technique and the relative threshold strategy, an adaptive state-feedback controller is designed to eliminate the effects caused by the output constraint and time-varying (...) powers. It is proved that all the closed-loop signals are bounded, the asymmetric time-varying output constraint is not violated, and the tracking error converges to a prescribed arbitrarily small region around zero in a preassigned finite time. Furthermore, the Zeno phenomenon can be avoided. Two simulation examples demonstrate the effectiveness of this control scheme. (shrink)