To preserve postoperative brain function, it is important for neurosurgeons to fully understand the brain's structure, vasculature, and function. Intraoperative high-frequency electrical stimulation during awake craniotomy is the gold standard for mapping the function of the cortices and white matter; however, this method can only map the “focal” functions and cannot monitor large-scale cortical networks in real-time. Recently, an in vivo electrophysiological method using cortico-cortical evoked potentials induced by single-pulse electrical cortical stimulation has been developed in an extraoperative setting. By (...) using the CCEP connectivity pattern intraoperatively, mapping and real-time monitoring of the dorsal language pathway is available. This intraoperative CCEP method also allows for mapping of the frontal aslant tract, another language pathway, and detection of connectivity between the primary and supplementary motor areas in the frontal lobe network. Intraoperative CCEP mapping has also demonstrated connectivity between the frontal and temporal lobes, likely via the ventral language pathway. Establishing intraoperative electrophysiological monitoring is clinically useful for preserving brain function, even under general anesthesia. This CCEP technique demonstrates potential clinical applications for mapping and monitoring large-scale cortical networks. (shrink)

Exploring Renaissance humanists’ debates on matter, life and the soul, this volume addresses the contribution of humanist culture to the evolution of early modern natural philosophy so as to shed light on the medical context of the ...

The treatise On Formative Power of Ferrara's emblematic medical humanist, Nicolò Leoniceno, is the one of the first embryological monographs of the Renaissance. It shows, at the same time, the continuity of medieval Arabo-Latin tradition and the new elements brought by Renaissance medical humanism, namely through the use of the ancient Greek commentators of Aristotle like Simplicius. Thus this treatise stands at the crossroad of these two currents. The present study analyses the range of Leoniceno's philosophical discussion, determines its exact (...) sources and brings to light premises for the early modern development of the concept of formative force, which will end up in the theory of "plastic nature" at the heart of the Scientific Revolution. (shrink)

Summary The famous Jesuit father Athanasius Kircher (1602?1680) tried to interpret the Creation of the world and to explain the origin of life in the last book of his geocosmic encyclopedia, Mundus subterraneus (Amsterdam, 1664?1665). His interpretation largely depended on the ?concept of seeds? which was derived from the tradition of Renaissance ?chymical? (chemical and alchemical) philosophy. The impact of Paracelsianism on his vision of the world is also undeniable. Through this undertaking, Kircher namely developed a corpuscular theory for the (...) spontaneous generation of living beings. The present study examines this theory and its relationship with Kircher's chymical interpretation of the Creation in order to place it in its own intellectual and historical context and will uncover one of its most important sources. (shrink)

Dans le cadre des recherches sur les sources allemandes de la pensée de M. Henry, Yukihiro Hattori livre une étude tentant d’analyser la place que tient le concept d’action dans une phénoménologie de la vie. Pour ce faire l’auteur examine notamment l’analyse par M. Henry de la conception kantienne du respect dans L’essence de la manifestation, ainsi que ses prolongements selon l’analyse du « commandement de la Vie » dans C’est moi la vérité.

Inspired by Christian Platonism as developed in the late fifteenth-century Florentine milieu, the French physician Jean Fernel proposed a particular interpretation of Galen in a medico-philosophical work entitled On the Hidden Causes of Things . With this interpretation, he responded to the serious and urgent need for a reconciliation of the newly reconstituted Galen of Renaissance humanism with Christian faith. The present study examines Fernel's strategy and method in constructing this singular Galenic body of doctrine, special attention being given to (...) the roles attributed to the Creator, the formative force, and the soul. Subsequently, an analysis of the notions of spirit and of its innate heat as indispensable instruments of Fernel's physiology will uncover the very target of his criticism of materialism. (shrink)

In his embryological treatise De plastica seminis facultate , Jacob Schegk , professor of philosophy and medicine at the University of Tübingen, developed, through a unique interpretation of the Aristotelian embryology, a theory of the "plastic faculty" , whose origin lay in the Galenic idea of the formative power. The present study analyses the precise nature of Schegk's theory, by setting it in its historical and intellectual context. It will also discuss the hitherto unappreciated Neoplatonic dimension of Schegk's notion of (...) the soul's vehicle. (shrink)

La référence à Fichte traverse de manière discrète mais non moins fondamentale L’essence de la manifestation, où de nombreuses pages sont consacrées à l’Anweisung — texte avec lequel la pensée henryenne partage explicitement le schéma « dualiste », mais également de manière implicite une même définition de l’être. Ce schéma, qui s’exprime dans la dualité de l’être et de l’existence, de l’immédiat et du médiat, de l’absolu et du moi, de l’infini et du fini, ne manque pas de nous conduire (...) à une difficulté de principe, reconnue en tant que telle dans la philosophie postkantienne : comment l’être se rapporte-t-il à l’existence? Posant la question de l’être pour parvenir au sens de l’être même, Henry s’inscrit, consciemment ou non, dans une telle problématique, en considérant le chemin vers l’être comme une sortie de la finitude. Si tel est le cas et si l’être se définit comme immanence et vie, comment affronte-t-il la question de la relation entre l’immanence et la transcendance? (shrink)

Inspired by Christian Platonism as developed in the late fifteenth-century Florentine milieu, the French physician Jean Fernel proposed a particular interpretation of Galen in a medico-philosophical work entitled On the Hidden Causes of Things. With this interpretation, he responded to the serious and urgent need for a reconciliation of the newly reconstituted Galen of Renaissance humanism with Christian faith. The present study examines Fernel's strategy and method in constructing this singular Galenic body of doctrine, special attention being given to the (...) roles attributed to the Creator, the formative force, and the soul. Subsequently, an analysis of the notions of spirit and of its innate heat as indispensable instruments of Fernel's physiology will uncover the very target of his criticism of materialism. (shrink)

This volume brings Bergson's key ideas from Matter and Memory into dialogue with contemporary themes on memory and time in science, across analytic and continental philosophy. Focusing specifically on the application of Bergson's ideas to cognitive science, the circuit between perception and memory receives full explication in 15 different essays. By re-reading Bergson through a cognitive lens, the essays provide a series of alternative analytic interpretations to the standard continental approach to Bergson's oeuvre, without fully discounting either approach. The relevance (...) of philosophies of mind and memory sit alongside the role of a metaphysics of time in exploring connections to psychology, biology, and physics. This eclecticism includes an exciting focus on numerous topics that are not given sufficient attention in extant studies of Bergson, including the precise nature of his ideas on dualism, memory, and ecological theories of perception, especially in relation to his contemporaries. Led by leading Bergson scholars from France and Japan, this book maps the rich terrain of Bergson's contemporary relevance alongside the historical context of his ideas. (shrink)

The treatise On Formative Power of Ferrara's emblematic medical humanist, Nicolò Leoniceno , is the one of the first embryological monographs of the Renaissance. It shows, at the same time, the continuity of medieval Arabo-Latin tradition and the new elements brought by Renaissance medical humanism, namely through the use of the ancient Greek commentators of Aristotle like Simplicius. Thus this treatise stands at the crossroad of these two currents. The present study analyses the range of Leoniceno's philosophical discussion, determines its (...) exact sources and brings to light premises for the early modern development of the concept of formative force, which will end up in the theory of "plastic nature" at the heart of the Scientific Revolution. (shrink)

Organogenesis and metamorphosis require the intricate orchestration of multiple types of cellular interactions and signaling pathways. Glutamate (Glu) is an excitatory extracellular signaling molecule in the nervous system, while Ca2+ is a major intracellular signaling molecule. The first Glu receptors to be cloned are Ca2+‐permeable receptors in mammalian brains. Although recent studies have focused on Glu signaling in synaptic mechanisms of the mammalian central nervous system, it is unclear how this signaling functions in development. Our recent article demonstrated that Ca2+‐permeable (...) AMPA‐type Glu receptors (GluAs) are essential for formation of a photosensitive organ, development of some neurons, and metamorphosis, including tail absorption and body axis rotation, in ascidian embryos. Based on findings in these embryos and mammalian brains, we formed several hypotheses regarding the evolution of GluAs, the non‐synaptic function of Glu, the origin of GluA‐positive neurons, and the neuronal network that controls metamorphosis in ascidians. (shrink)

One of the most striking features of Giordano Bruno’s philosophy is the marriage of universal animation with atomism. This unusual combination produced an extraordinary image of the universe, which was governed by the World-Soul and its universal intellect along with an infinite number of living atoms or corpuscles, animated by their internal spiritual principle. After examining Bruno’s principal arguments on the World-Soul, universal animation and living atoms or corpuscles, this article explores two possible sources among the works of his near-contemporaries. (...) The first author, Agostino Steuco, tried to reconcile the doctrine of the World-Soul with Christianity, integrating the idea of Anaxagoras on the cosmic mind as the demiurgic agent of the universe. The second figure, Jacob Schegk, further elaborated his unusual atomistic or corpuscular reinterpretation of this Presocratic philosopher’s ideas. (shrink)

池上彰氏が各紙誌で紹介、大反響を呼んだ前作『「昔はよかった」と言うけれど戦前のマナー・モラルから考える』の待望の続編!

戦前にも存在した!席を譲らない若者、車内で化粧をする女性、子どもや老いた親を虐待する人たち。道徳心の欠如について歴史的視点からその本質に迫り、今日起きている様々な社会問題について考える。戦前の日本人の 道徳はいかなる状態だったのか、あまり知られていない歴史の側面を当時の新聞や書籍、統計データなどの資料をひもときながら紹介した。.

精神障害の分類と診断が難しいなか、哲学や精神医学は精神障害とどのように向きあうのか。思考吹入や妄想についての哲学的考察に加え、現象学的精神病理学や精神分析の現状、そして現代の精神医学のさまざまなアプロ ーチの到達点を総観する。.

The neuromodulatory effects of brain stimulation therapies notably involving repetitive transcranial magnetic stimulation on nocturnal sleep, which is critically disturbed in major depression and other neuropsychiatric disorders, remain largely undetermined. We have previously reported in major depression patients that prefrontal rTMS sessions enhanced their slow wave activity power, but not their sigma power which is related to sleep spindle activity, for electrodes located nearby the stimulation site. In the present study, we focused on measuring the spindle density to investigate cumulative (...) effects of prefrontal rTMS sessions on the sleep spindle activity. Fourteen male inpatients diagnosed with medication-resistant unipolar or bipolar depression were recruited and subjected to 10 daily rTMS sessions targeting the left dorsolateral prefrontal cortex. All-night polysomnography data was acquired at four time points: Adaptation, Baseline, Post-1, and Post-2. Clinical and cognitive evaluations were longitudinally performed at Baseline, Post-1, and Post-2 time points to explore associations with the spindle density changes. The PSG data from 12 of 14 patients was analyzed to identify sleep spindles across the sleep stages II–IV at four electrode sites: F3, F4, P3, and P4. Statistical analysis by two-way ANOVA revealed that spindle density at F3 increased at Post-1 but decreased at Post-2 time points. Moreover, the local and transient increase of spindle density at F3 was associated with the previously reported SWA power increase at F3, possibly reflecting a shared mechanism of thalamocortical synchronization locally enhanced by diurnal prefrontal rTMS sessions. Clinical and cognitive correlations were not observed in this dataset. These findings suggest that diurnal rTMS sessions transiently modulate nocturnal sleep spindle activity at the stimulation site, although clinical and cognitive effects of the local changes warrant further investigation. (shrink)

Die Ratnavalitika des Ajitamitra. Edited and explained by Yukihiro Okada. Indica et Tibetica Verlag, Bonn 1990. xxxv, 198 pp. No price given.