The behavior of somatic stem cells is regulated by their niche. Interaction between hematopoietic stem cells (HSCs) and their niches are a representative model to understand stem cell‐niche interplay. Here, we provide an overview of crosstalk between HSCs and their niches in bone marrow and extramedullary organs following the life journey of HSCs from emergence, development, maturation until aging. We highlight the unique differences of HSC niches in different life stages within various organs focusing on recent literature to propose new (...) speculations and hypotheses. (shrink)

In this paper, I first seek a relatively plausible formulation of the safety principle. To this end, I refute a recent form of safety by Duncan Pritchard and then defend another weaker form of safe...

What is called theory of moral community is a socialpolitical idea that was established by Confucius and Mencius on the base of political practice of Yao, Shun, Yu and King of Chou and that was used as ideology of ancient Chinese Empire. Lao Tzu and Zhuang Tzu criticized the theory of moral community and established their naturalistic philosophical system. Lao Tzu said in the first chapter of Tao Te Ching that “The Tao is too great to be described by the (...) name Tao. If it could be named so simply, it would not be the eternal Tao”. If Tao which is indispensable to mortal fortune can be described, it must have existed in discourse of human beings; If the important pole that accords with fact can be named, it must have named by human beings. So people who lived in ancient times regarded the political idea of Yao, Shun, Yu and King of Chou as Tao that has been justified. At the same time they named Yao, Shun, Yu and King of Chou as sons of Heaven who inherited the vocation of Heaven. Hence by all appearances，Lao Tzu was denying the validity of traditional social-political idea. And Lao Tzu thought the traditional social-political practice, in fact, had kept away from intrinsic morality and switched to extrinsic criterions. Zhuang Tzu, as an inheritor of Lao Tzu, criticized the moral community of Confucius straight from the shoulder. First, according to Zhuang Tzu’s opinion, the system of demise is a way of handing over and taking over power accorded with particular instance of the time which was chosen by Yao, Shun and Yu, but it is not a perfect and universal political pattern as Confucius thought. Second, Zhuang Tzu enumerated many immoral behaviors done by these sons of Heaven, on the one hand, on the other hand he regarded the Confucian politics of all over the world was an hegemonic politics in essence which would destroy human’s moral faith on their autonomy. Contrary to Confucian theory of moral community, Lao Tzu brought forward a social idea of “a little state with a small population" which was often misunderstood as “a small state with a little population”, in fact the idea of “a little state with a small population" is a naturalistic political idea that will safeguard and realize freedom, equality and plural values by weakening compulsion of state and lusts of human beings furthest. Lao Tzu and Zhuang Tzu’s critique and reflection of Confucian theory of moral community, with their social-political idea of “a little state with a small population" will be very helpful to establish correct historical consciousness and build wonderful future society. (shrink)

The two-visual-systems hypothesis proposed by Goodale and Milner is a radical one. If it were to be true, then our common sense such as we are acting on what we are perceiving should be completely abandoned. In this paper, I argue that the hypothesis over-generalizes what happens in simple tasks to what happens in complex tasks. By contrast, I demonstrate that what happens in complex tasks is compatible with our common sense. In a word, though what we are acting on (...) may come apart from what we are perceiving in some cases, that is not the whole story. (shrink)

According to the sensitivity account of knowledge, S knows that p only if S's belief in p is sensitive in the sense that S would not believe that p if p were false. It is widely accepted that the sensitivity condition should be relativized to belief-formation methods to avoid putative counterexamples. A remaining issue for the account is how belief-formation methods should be individuated. In this paper, I argue that while a coarse-grained individuation is still susceptible to counterexamples, a fine-grained (...) individuation makes the target belief trivially insensitive. Therefore, there is no principled way of individuating belief-formation methods that helps the sensitivity account to accommodate different cases. (shrink)

Di yi juan. Si wei xue, yuan li lun he zhe xue juan -- Di er juan. Mei xue juan -- Di san juan. Fu hao fen xi he yu yan fen xi juan -- Di si juan. Wen hua xue yu dao de zhe xue juan -- Di wu juan. Shi wen juan.

This article introduces the problem of inexistence to studies in genre and gender, providing a hermeneutic point of reference for literary history and trans theory. It seeks to negotiate the affinities and disaffinities between queer and trans by foregrounding the latter’s struggle for existence against the former’s mobilization of a rhetoric of negative relationality, while at the same time preserving the bonds of intimacy across and beyond the coalition of LGBTQIA+. Such queer intimacy is read in relation to a haptic (...) technology of queer close reading, enabling differentially sexed bodies to imaginatively inhabit each other. I begin by considering how Djuna Barnes’s close, haptic readings of Henry James and Marcel Proust enact a reversal of sex, but I consider how the affective evidence of these trans moments do not amount to trans existence but raise the ethical necessity of holding open the difference between the ephemeral trans experiences within cis existence and the real struggle for trans existence of trans subjects today. Such a divide, however, is simultaneously held against the moments of intimacy that are capable of being produced across cis and trans subjects through such close reading and cross-inhabitation of bodies. To read trans literary history before trans, I thus propose the notion of trans inexistence through an interpretation of Jacques Maritain’s figure of the “angel” and Hegel’s “beautiful soul.” By situating Barnes’s and Jean Genet’s own characterizations of their transfeminine characters in terms of the angel in a post-Romantic, Catholic context, I interpret the trans angel as a figure of inexistence, tied to a minimal transcendence from the terms of history and materiality, including the sexed body. Finally, I consider how Genet’s phenomenology of proprioception draws together the problems of queer intimacy, haptic reading, and trans inexistence. In analyzing how Genet and his characters cross-inhabit each other’s bodies via proprioceptive mimicry, I unfold both the vast potential and the limits of the intimacies constructed across cis male and transfeminine lives and the accompanying role played by the literary mode of romance. (shrink)

In this paper, I explore an intriguing view of definable numbers proposed by a Cambridge mathematician Ernest Hobson, and his solution to the paradoxes of definability. Reflecting on König’s paradox and Richard’s paradox, Hobson argues that an unacceptable consequence of the paradoxes of definability is that there are numbers that are inherently incapable of finite definition. Contrast to other interpreters, Hobson analyses the problem of the paradoxes of definability lies in a dichotomy between finitely definable numbers and not finitely definable (...) numbers. To bypass this predicament, Hobson proposes a language dependent analysis of definable numbers, where the diagonal argument is employed as a means to generate more and more definable numbers. This paper examines Hobson’s work in its historical context, and articulates his argument in detail. It concludes with a remark on Hobson’s analysis of definability and Alan Turing’s analysis of computability. (shrink)

Elgar Advanced Introductions are stimulating and thoughtful introductions to major fields in the social sciences, business and law, expertly written by the world's leading scholars. Designed to be accessible yet rigorous, they offer concise and lucid surveys of the substantive and policy issues associated with discrete subject areas. Shanyang Zhao provides a unique examination of this evolving topic with a framework to address the common questions: What is self? How is self formed? and Why does self matter? Drawing a (...) fascinating distinction between self and self-concept, Zhao regards both as part of a larger constellation named the 'self-phenomenon.' He separates social determinants of self from neurocognitive prerequisites of self. Focusing on the social determinants, he reviews how social schemas shape self-concept through three intertwined mechanisms and how social resources affect self-conscious action through social position and social capital. Key Features: A clear distinction between self and self-concept A study of the self as both a social product and a social force A new framework for the sociology of the self, built on the foundation of classic works A close examination of three mechanisms of self-concept formation with specifications of the scope conditions under which each mechanism operates An analysis of the distinctiveness of human normative selves through cross-species comparison This Advanced Introduction will provide essential reading for scholars and researchers in sociology, social psychology, and social policy. (shrink)

Addressing the western understanding of the status and nature of animals and the relation of animals to the question of life, this book provides a discourse on animality through an interdisciplinary investigation into various areas of humanities. The nature of animals is explored by drawing on materials from literature, art, religion, philosophy, and political science, focusing on discussions of animality about the classical culture of ancient Greece, metaphysics and its application to debates on life, Martin Heidegger's philosophical theories, and biopolitics. (...) Although the distinctive difference between human beings from animals has long been emphasized, the author argues that they are inseparable from one another to achieve understanding. The interrogation of animality, therefore, provides a new perspective on the nature of human beings in this postmodern era. Academics in western literature, literary theory, literary criticism, and comparative literature will find this work an insightful addition to debates in their respective fields, while it will also help senior university students pursuing their studies. (shrink)

本书包括社会建构论与科学社会研究的转向、科学知识社会学的学术实践、双重黑箱:传统社会学的科学观等。.

《王阳明居黔思想及活动研究》重点研究了居黔时期形成的心即理、知行合一等主要观点，探讨这些观点的形成原因、具体内容及意义；同时，对《五经臆说》之残篇进行研究，以期对阳明思想有更为全面的把握。从被贬赴黔起 ，到离开龙场止，尽可能地弄清居黔活动的相关历史问题，如赴黔时间、居黔时间、离黔时间及原因，在龙场及贵阳的讲学情况、在龙场的生活状况、被贬时龙场驿的情况，试图优选可能还原的居黔活动状况，以期对心学思想的 形成原因有更为清楚的了解。.

In a recent paper, Francis Y. Lin proposes a “memory-challenge” to two main interpretations of Wittgenstein’s private language argument: the “no-criterion-of-correctness” interpretation and the “no-stage-setting” interpretation. According to Lin, both camps of interpretation fail to explain why a private language is impossible within a short time period. To answer the “memory-challenge”, Lin motivates a grammatical interpretation of the private language argument. In this paper, I provide a critical discussion of Lin’s objection to these interpretations and argue that Lin’s objection fails. (...) In the case of the “no-stage-setting” interpretation, Lin suggests that the private language user can establish a stage within a short time period. However, I show that this stage is insufficient for a private language to be used correctly. In the case of the “no-criterion-of-correctness” interpretation, Lin believes that since memory is reliable within a short period, no criterion is needed for the correct use of a private language. However, I argue that his objection attacks a strawman, since the interpretation concerns the structure of justification, rather than the weakness of memory itself. I conclude with a critical discussion on memory and primitive expressions, the latter of which are crucial to Wittgenstein’s approach to public language. This discussion will help to draw a sharp line between private language and public language, and cast some doubt on Lin’s grammatical interpretation. (shrink)

As an idealist form of realism, or realist form of idealism, the system of ‘All-under-Heaven’ seeks to find a rational and optimal solution to the problem of political conflict. Howeve...