Alcohol use disorder is one of the most common substance use disorders contributing to both behavioral and cognitive impairments in patients with AUD. Recent neuroimaging studies point out that AUD is a typical disorder featured by altered functional connectivity. However, the details about how voxel-wise functional coordination remain unknown. Here, we adopted a newly proposed method named functional connectivity density to depict altered voxel-wise functional coordination in AUD. The novel functional imaging technique, FCD, provides a comprehensive analytical method for brain's (...) “scale-free” networks. We applied resting-state functional MRI toward subjects to obtain their FCD, including global FCD, local FCD, and long-range FCD. Sixty-one patients with AUD and 29 healthy controls were recruited, and patients with AUD were further divided into alcohol-related cognitive impairment group and non-cognitive impairment group. All subjects were asked to stay stationary during the scan in order to calculate the resting-state gFCD, lFCD, and lrFCD values, and further investigate the abnormal connectivity alterations among AUD-NCI, ARCI, and HC. Compared to HC, both AUD groups exhibited significantly altered gFCD in the left inferior occipital lobe, left calcarine, altered lFCD in right lingual, and altered lrFCD in ventromedial frontal gyrus. It is notable that gFCD of the ARCI group was found to be significantly deviated from AUD-NCI and HC in left medial frontal gyrus, which changes probably contributed by the impairment in cognition. In addition, no significant differences in gFCD were found between ARCI and HC in left parahippocampal, while ARCI and HC were profoundly deviated from AUD-NCI, possibly reflecting a compensation of cognition impairment. Further analysis showed that within patients with AUD, gFCD values in left medial frontal gyrus are negatively correlated with MMSE scores, while lFCD values in left inferior occipital lobe are positively related to ADS scores. In conclusion, patients with AUD exhibited significantly altered functional connectivity patterns mainly in several left hemisphere brain regions, while patients with AUD with or without cognitive impairment also demonstrated intergroup FCD differences which correlated with symptom severity, and patients with AUD cognitive impairment would suffer less severe alcohol dependence. This difference in symptom severity probably served as a compensation for cognitive impairment, suggesting a difference in pathological pathways. These findings assisted future AUD studies by providing insight into possible pathological mechanisms. (shrink)

We examine whether and how CEO foreign experience affects firm’s green innovation. Using a sample of Chinese public companies and hand-collected CEO foreign experience data, we document a positive association between CEO foreign experience and corporate green innovation. Furthermore, consistent with the view that CEOs with foreign experience would play a more significant role when provided with more resources, we find that the positive relationship is more pronounced in less financially constrained firms, in state-owned enterprises, and in less competitive industries. (...) Additional analyses indicate that enhanced environmental ethics and general competency are two potential mechanisms through which CEO foreign experience affects corporate green innovation. Finally, we find that CEO foreign experience is positively related to green innovation quality and internationalization. Collectively, these findings suggest that CEO foreign experience is a significant factor for corporate green innovation in emerging markets. (shrink)

Recent reports of CRISPR/Cas9 genome editing in parasitic helminths open up new avenues for research on these dangerous pathogens. However, the complex morphology and life cycles inherent to these parasites present obstacles for the efficient application of CRISPR/Cas9‐targeted mutagenesis. This is especially true with the trematode flukes where only modest levels of gene mutation efficiency have been achieved. Current major challenges in the application of CRISPR/Cas9 for study of parasitic worms thus lie in enhancing gene mutation efficiency and overcoming issues (...) involved in host passage so that mutated parasites survive. Strategies developed for CRISPR/Cas9 studies on Caenorhabditis elegans, protozoa and mammalian cells, including novel delivery methods, the choice of selectable markers, and refining mutation precision represent novel tactics whereby these impediments can be overcome. Furthermore, employing CRISPR/Cas9‐mediated gene drive to interfere with vector transmission represents a novel approach for the control of parasitic worms that is worthy of further exploration. (shrink)

Abstract:With the development of literati gardens during the Ming dynasty (1368–1644), the layout and design level of gardens reached an unprecedented height. As the representative of Suzhou gardens, The Humble Administrator's Garden (Zhuozhengyuan, 拙政园, 1530) has unique natural conditions and mature garden design, and its water management art is particularly exquisite. The best-preserved graphic information of The Humble Administrator's Garden are the poems and paintings by Wen Zhengming (文徵明, 1470–1559), including Thirty-One Scenes of The Humble Administrator's Garden (拙政园三十一景图, 1533), thirty (...) landscape poems, and the biography Wang's Humble Administrator's Garden (王氏拙政园记, 1533). As the research object, this article aims to restore the image of The Humble Administrator's Garden by analyzing the water scene of the garden, summarizing its water technique and art, and extracting "Source of inflowing water" (为有源头活水来), "Esteem the mountain, revere the water, imitate the heaven and earth" (敬山畏水, 象天法地), "Fusion of the imitation of nature and the subjective ideas of the artist" (外师造化, 中得心源), and "Free and unfettered, enjoy the joy of leisure" (逍遥自得, 享闲居之乐) as the water aesthetic thoughts of the garden. In addition, this article provides some reference for the current landscape design. (shrink)

本书对自组织理论进行综合性研究,并探讨了关于自然界自组织演化的自然图景和自然观,关于自然科学自组织演化的科学图景和科学观。.

A self-perceived lack of training in ethical theories and related pedagogy has kept many engineering faculty members from teaching data ethics, an important aspect of engineering research that has become more salient in recent years. This paper describes the development of a module, which includes concepts, cases, policies, and best practices, to support the teaching of ethical data practice. Based on a user-oriented design approach and a moral literacy framework, the module was designed to be used in different courses and (...) co-curricular activities for students of varying levels of competence to improve their ability to identify and analyze ethical problems associated with the handling of research data. This work seeks to encourage ethical reflection on researchers’ data practice through the idea of an “ecology of data,” which highlights the co-production of data by multiple, interconnected, and heterogeneous actors. This paper also presents online and in-class evidence about the impact and limitations of the module, which is now available for interested researchers and instructors to browse and use. (shrink)

The present study investigated the lasting effects of sickness presenteeism on well-being and innovative job performance in the demanding Chinese work context compounded with the precarities of the post-pandemic business environment. Adopting the conservation of resources theory perspective, especially its proposition of compensation of resources, we incorporated social resources at work as joint moderators in the presenteeism–outcomes relationship. We employed a panel design in which all variables were measured twice with 6 months in between. Data were obtained from 323 Chinese (...) employees working in diverse industries in Taiwan. We found that after controlling for the baseline level of well-being, presenteeism did not have a lasting effect on employees' exhaustion. However, presenteeism did have a negative lasting effect on employees' innovative behavior 6 months later. Moreover, we found a significant three-way interaction of presenteeism, supervisory support, and collegial support on employees' innovative job performance, after controlling for the baseline level of performance. Specifically, when working under illness, employees displayed the best innovative performance with high levels of both supervisory and collegial support, the worst performance with both support being low, and the intermediate when any one of the support being high. This can be taken as the preliminary evidence to support the COR proposition of resource caravans, showing that supervisory support and collegial support compensated for each other as critical resources in alleviating the impact of working under sickness on employees' innovative performance. Theoretical implications of the findings are discussed, taking into account the macro-cultural context of the East Asian Confucian societies. We also reflected on the managerial implications of the lasting damages of sickness presenteeism and benefits of mobilizing social resources on employees' well-being and performance. (shrink)

En el siglo pasado el evento más destacado de la historia cubana fue la Revolución de 1959, movimiento social que fue especialmente influyente en la generación que participó en ella, y comenzaba a vivir la postrevolución. En los años ´50 del siglo pasado los cubanos sufrieron un trauma espiritual y físico difícil de superar. Los personajes de Regreso a Ítaca (2016) representan ese periodo, reflejan un micromundo de la situación general de la época. El regreso de España de uno de (...) los personajes provoca una reunión entre cinco amigos en una azotea de La Habana. La discusión entre ellos solo logra revivir la esperanza, al mismo tiempo que la desilusión de su pasado, presente y futuro. Como la obra se presenta bajo la estructura de guion, respeta las tres reglas del teatro, lo que favorece una mirada desde la interpretación teatral. Para este trabajo nos apoyaremos en una perspectiva sociológica y psicológica, a fin de comprender mejor la recreación que Padura y Cantet hacen de la situación general de ese periodo. Nuestro análisis busca mostrar que la intertextualidad entre la literatura y la historia permite entender tanto una época, como las vivencias humanas que tienen lugar en ella, de una manera más vívida. Padura no solo presenta un guion sobre el reencuentro entre cinco viejos amigos, sino que también manifiesta que todos se enfrentan a una reconsideración de las ilusiones perdidas, por y en la Revolución, de una manera dolorosa, pero al mismo tiempo humorística, cáustica e incluso alegre. (shrink)

The result of an interaction is influenced by its epistemic state, and several epistemic notions are related to multiagent situations. Strong belief-disagreement on a certain proposition between agents means that one agent believes the proposition and the other believes its negation. This paper presents a logical system describing strong belief-disagreement between agents and demonstrates its soundness and completeness. The notion of belief-disagreement as well as belief-agreement can facilitate gaining a clearer understanding of the acts of trade and speech.

Online financial service is an essential part of consumption services provided by companies in modern society. It is vital to figure out the underlying mechanisms that influence online financial service use of college students in China, which is seldom explored. Drawing on the theory of planned behavior, this study explores the effect of personality traits and its joint effect with attitude on online financial service use of college students. Moreover, we examined the interaction effects of key variables in TPB in (...) the context of online financial services. The results indicated that the materialism value of Chinese college students has no direct effect on their intention to use online financial services but exerts an indirect effect through their attitude toward online financial services. College students' attitudes and perceived behavioral control are associated with their subjective norms, and in turn, affect their use intention of online financial services. In addition, perceived risk and perceived usefulness of online financial services also affect use intention through attitude and perceived behavioral control. The discussion of key findings, implications, and conclusions are provided. (shrink)

Fourth-order autonomous nonlinear differential equations can exhibit chaotic properties. In this study, we propose a family of fourth-order chaotic systems with infinite equilibrium points whose equilibria form closed curves of different shapes. First, the phase diagrams and Lyapunov exponents of the system family are simulated. The results show that the system family has complex phase diagrams and dynamic behaviors. Simulation analysis of the Poincarè mapping and bifurcation diagrams shows that the system has chaotic characteristics. The circuit simulation model is constructed (...) and simulated in Multisim. The circuit simulation results coincide with the numerical simulation results, which verifies the circuit feasibility of the system. Then, based on Lyapunov stability theory and the adaptive control method, the synchronous control of the system with infinite equilibria is designed. Numerical simulation results verify that the system synchronization with the adaptive control method is well. Finally, the synchronous drive system is used for image encryption, the response system is used for decryption, and color image encryption is realized by combining deoxyribonucleic acid coding and operating rules. Therefore, this study not only enriched the research on infinite equilibria chaotic systems but also further expanded secure communication technology by combining chaotic synchronization control and DNA coding in image encryption. (shrink)

This exploration aims to study the emotion recognition of speech and graphic visualization of expressions of learners under the intelligent learning environment of the Internet. After comparing the performance of several neural network algorithms related to deep learning, an improved convolution neural network-Bi-directional Long Short-Term Memory algorithm is proposed, and a simulation experiment is conducted to verify the performance of this algorithm. The experimental results indicate that the Accuracy of CNN-BiLSTM algorithm reported here reaches 98.75%, which is at least 3.15% (...) higher than that of other algorithms. Besides, the Recall is at least 7.13% higher than that of other algorithms, and the recognition rate is not less than 90%. Evidently, the improved CNN-BiLSTM algorithm can achieve good recognition results, and provide significant experimental reference for research on learners’ emotion recognition and graphic visualization of expressions in an intelligent learning environment. (shrink)

In _Sino-Theology and the Philosophy of History_ Leopold Leeb presents the ideas of an influential Chinese intellectual, Liu Xiaofeng, whose approach to the question of a Christian theology for China is both controversial and inspiring.

Social media platforms have become an important tool for travel advertisement. This study constructs the bounded confidence model to build an improved cross-platform competitive travel advertising information dissemination model based on open and closed social media platforms. Moreover, this study examines the evolution process of group opinions in cross-platform information dissemination with simulation experiments. Results reveal that based on strong relationships, the closed social media platform opinion leaders better guide in competitive travel advertising and can bring more potential consumers to (...) follow. However, being an opinion leader on an open social media platform will not result in more consumer following. (shrink)

A moderate belief-disagreement between agents on proposition p means that one agent believes p and the other agent does not. This paper presents two logical systems, \ and \, that describe moderate belief-disagreement, and shows, using possible worlds semantics, that \ is sound and complete with respect to arbitrary frames, and \ is sound and complete with respect to serial frames. Syntactically, the logics are monomodal, but two doxastic accessibility relations are involved in their semantics. The notion of moderate belief-disagreement, (...) which is in accordance with the understanding of belief-disagreement in everyday life, is an epistemic one related to multiagent situations, and \ and \ are two epistemic logics. (shrink)

Due to the complexity of the network structure, log analysis is usually necessary for the maintenance of network-based distributed systems since logs record rich information about the system behaviors. In recent years, numerous works have been proposed for log analysis; however, they ignore temporal relationships between logs. In this paper, we target on the problem of mining informative patterns from temporal log data. We propose an approach to discover sequential patterns from event sequences with temporal regularities. Discovered patterns are useful (...) for engineers to understand the behaviors of a network-based distributed system. To solve the well-known problem of pattern explosion, we resort to the minimum description length principle and take a step forward in summarizing the temporal relationships between adjacent events of a pattern. Experiments on real log datasets prove the efficiency and effectiveness of our method. (shrink)

At the end of the 1920s, Tanganyika Territory experienced several serious rodent outbreaks that threatened cotton and other grain production. At the same time, regular reports of pneumonic and bubonic plague occurred in the northern areas of Tanganyika. These events led the British colonial administration to dispatch several studies into rodent taxonomy and ecology in 1931 to determine the causes of rodent outbreaks and plague disease, and to control future outbreaks. The application of ecological frameworks to the control of rodent (...) outbreaks and plague disease transmission in colonial Tanganyika Territory gradually moved from a view that prioritised 'ecological interrelations' among rodents, fleas and people to one where those interrelations required studies into population dynamics, endemicity and social organisation in order to mitigate pests and pestilence. This shift in Tanganyika anticipated later population ecology approaches on the African continent. Drawing on sources from the Tanzania National Archives, this article offers an important case study of the application of ecological frameworks in a colonial setting that anticipated later global scientific interest in studies of rodent populations and rodent-borne disease ecologies. (shrink)

Addiction is a significant issue in many aspects but no explanatory closure has been attained. The overemphasis on the brain disease paradigm upheld by the National Institute on Drug Abuse may run serious risks, and the present study intends to counteract this partiality. Drawing on Ludwik Fleck’s notion of thought collectives, this article offers a close reading of the works of sociologists Bingham Dai and Alfred R. Lindesmith vis-à-vis other coeval biomedical approaches. Individuals within the same thought collective, such as (...) Dai and Lindesmith, have different views although they share certain thought styles. As noted in this study, inter-collective communication is not typically antagonistic and may form some liaison under certain circumstances. These findings imply that communication among collectives may facilitate creative liaison, as suggested by Fleck. This study aims to enrich the understanding of addiction by coordinating biomedical and sociological sciences through minimizing, if not erasing, their intellectual antagonism and social distance. (shrink)

Using agency theory, this study empirically examined the relationship between board composition and corporate philanthropy. Generally, the ratio of insiders to outsiders, the percentage of insider stock ownership, and the proportion of female and minority board members were found to be positively and significantly associated with firms'' charitable contributions.

We propose that local corruption distorts the allocation of government-controlled resources and impairs the contract environment, thereby reducing firms’ use or suppliers’ provision of trade credit. We use a sample of Chinese-listed firms from 2007 to 2020 to examine the role of local corruption in firms’ access to trade credit and find that the level of local corruption is negatively related to firms’ trade credit use. This effect is more pronounced in firms with weak (vs. strong) internal governance, slack (tight) (...) external monitoring and high (low) supplier concentration. The results of path analysis show that local corruption extends short-term bank loans as well as government subsidies and impairs firms’ accounting quality, thereby inhibiting firms’ demand for or suppliers’ provision of trade credit. Moreover, the post-2012 anti-corruption campaign in China plays a significant role in correcting the misallocation of trade credit caused by corruption. The results of this study illuminate the negative external effects of local corruption on trade credit. (shrink)

In this paper, the method of mutual information is used to study the economic dependence among the provinces in Chinaʼs Eastern Coastal Economic Belt from 2015 to 2020, and the core structure of the dependence is depicted. The results show that, first of all, there is a wide range of economic dependence among the provinces in the Eastern Coastal Economic Belt, and the dependence changes with the different states of economic development. Secondly, the phenomenon of geographical clustering is not obvious. (...) Most provinces maintain a strong economic dependence relationship with the economically developed provinces, and this dependence relationship is relatively stable, while the economically underdeveloped provinces are often on the edge of the dependence structure. Finally, the economically developed provinces maintain strong economic dependence with each other, such as Jiangsu, Shandong, and Zhejiang, and Beijing, Guangdong, and Shanghai. However, the former three provinces are more in the core position of this structure, that is, the other provinces maintain the stronger dependence relationship with these three provinces. (shrink)

Post-stroke depression is a serious complication of stroke that significantly restricts rehabilitation. The use of immersive virtual reality for stroke survivors is promising. Herein, we investigated the effects of a novel immersive virtual reality training system on PSD and explored induced effective connectivity alterations in emotional networks using multivariate Granger causality analysis. Forty-four patients with PSD were equally allocated into an immersive-virtual reality group and a control group. In addition to their usual rehabilitation treatments, the participants in the immersive-virtual reality (...) group participated in an immersive-virtual reality rehabilitation program, while the patients in the control group received 2D virtual reality rehabilitation training. The Hamilton Depression Rating Scale, modified Barthel Index, and resting-state functional magnetic resonance imaging data were collected before and after a 4-week intervention. rsfMRI data were analyzed using multivariate GCA. We found that the immersive virtual reality training was more effective in improving depression in patients with PSD but had no statistically significant improvement in MBI scores compared to the control group. The GCA showed that the following causal connectivities were strengthened after immersive virtual reality training: from the amygdala, insula, middle temporal gyrus, and caudate nucleus to the dorsolateral prefrontal cortex; from the insula to the medial prefrontal cortex; and from the thalamus to the posterior superior temporal sulcus. These causal connectivities were weakened after treatment in the control group. Our results indicated the neurotherapeutic use of immersive virtual reality rehabilitation as an effective non-pharmacological intervention for PSD; the alteration of causal connectivity in emotional networks might constitute the neural mechanisms underlying immersive-virtual reality rehabilitation in PSD. (shrink)

Based on a survey of 2,361 directors in 291 of the largest companies of the Southeast States, this study empirically examined boards of directors' stakeholder orientations. The results indicate that there exist distinct stakeholder groups perceived by directors, directors have high stakeholder orientations, directors view some stakeholders differently depending on their occupation and type.

The problem of the balance of power within the European state system constituted an important part of Hume’s historical vision. From the vantage point of mid-eighteenth-century Europe, the maxim of the balance of power, proven to be a universal principle in Greek and Roman history, was believed by many to be essential to mutual prosperity and security.1 This was particularly because France, partaking actively in the international competition for commercial wealth in Europe and the New World, created increasing anxieties over (...) the danger of universal monarchy. Hume was a strong advocate of the classical doctrine of the balance of power, which, he observed, was “founded...... (shrink)

Background: Ethical challenges are common in clinical nursing practice, and an infectious environment could put nurses under ethical challenges more easily, which may cause nurses to submit to negative emotions and psychological pressure, damaging their mental health. Purpose: To examine the ethical challenges encountered by nurses caring for patients with the novel coronavirus pneumonia and to provide nurses with suggestions and support regarding promotion of their mental health. Research design and method: A qualitative study was carried out using a qualitative (...) content analysis. The participants were 18 nurses who agreed to attend an interview and describe their own experiences of providing care to COVID-19 patients in China. They were purposively sampled, and structured, in-depth interviews were performed. Data were iteratively collected and analyzed from February to March 2020. Ethical considerations: The proposal was approved by the Research Ethics Committee of the Second Hospital of Shandong University, China. Findings: The findings revealed three main themes and 10 categories. The themes were the following: ethical challenges ; coping styles ; and impacts on career. Conclusion: Nurses faced ethical challenges on multiple fronts in caring for COVID-19 patients. The results may help nurses with more safety, ethics, and humanistic care in nursing practice. (shrink)

While it is widely assumed that greater diversity in corporate governance will enhance a firm’s corporate social performance, this study considers an alternative thesis which relates managerial control to corporate philanthropy. The study empirically evaluates both board diversity and managerial control of the board as possible predictors of corporate philanthropy. The demonstration of a positive relationship between managerial control and corporate philanthropy contributes to our understanding that corporate social performance results from a complex set of economic and social motives. Possible (...) future research and managerial implications are discussed. (shrink)