The gene regulation function (GRF) provides an operational description of a promoter behavior as a function of the concentration of one of its transcriptional regulators. Behind this apparently trivial definition lies a central concept in biological control: the GRF provides the input/output relationship of each edge in a transcriptional network, independently from the molecular interactions involved. Here we discuss how existing methods allow direct measurement of the GRF, and how several trade‐offs between scalability and accuracy have hindered its application to (...) relatively large networks. We discuss the theoretical and technical requirements for obtaining the GRF. Based on these requirements, we introduce a simplified and easily scalable method that is able to capture the significant parameters of the GRF. The GRF is able to predict the behavior of a simple genetic circuit, illustrating how addressing the quantitative nature of gene regulation substantially increases our comprehension on the mechanisms of gene control. (shrink)

Two of the most important political movements of the late twentieth century are those of environmentalism and feminism. In this book, Val Plumwood argues that feminist theory has an important opportunity to make a major contribution to the debates in political ecology and environmental philosophy. _Feminism and the Mastery of Nature_ explains the relation between ecofeminism, or ecological feminism, and other feminist theories including radical green theories such as deep ecology. Val Plumwood provides a philosophically informed account of the relation (...) of women and nature, and shows how relating male domination to the domination of nature is important and yet remains a dilemma for women. (shrink)

ABSTRACT The major approaches to belief revision and non monotonic reasoning proposed in the literature differ along a number of dimensions, including whether they are “syntax- based” or “semantic-based”, “foundational” or “coherentist”, “consistence-restoring” or “inconsistency-tolerant”. Our contribution towards clarifying the connections between these various approaches is threefold: •We show that the two main approaches to belief revision, the foundations and coherence theories, are mathematically equivalent, thus answering a question left open in [Gar90, Doy92], The distinction between syntax-based approaches to revision (...) and approaches based on (semantic) preferential structures falls along similar lines, and their expressive equivalence is a consequence of this result. •We formally clarify the connection between belief revision and non monotonic reasoning, in a particularly simple way which also throws light on the connection between consistence- restoring and reasoning-from-inconsistency approaches [BDP95]. •As a direct application of the above, we show that Poole's (syntax-based) system of default reasoning and Shoham's preferential semantic for non monotonic reasoning are also expressively equivalent, in that they can represent the same set of non monotonic consequence relations. (shrink)

Feminists working in the area of environmental thought argue that ecology is a feminist issue. They have drawn widely on the conceptual and critical resources of feminist philosophy both to develop a more complete feminist account of the world, and to expose masculinism where it appears in both traditional Western ecological thought and in modern environmental philosophy, producing a rich variety of feminist approaches to environmental philosophies. Their efforts have contributed to extending the critical resources and scope of both feminist (...) thought and environmental thought, bringing to each a further major set of concerns, perspectives, and theoretical constraints. (shrink)

" Mai 68, avec ses slogans parfois stupides et son jargon marxisant - déjà kitsch à l'époque -, était une période joyeuse. On s'y levait tard pour gagner moins. On faisait des pieds de nez aux statues des grands hommes. On prenait au sérieux la question du bonheur. Ceux qui haïssent Mai 68, au fond, sont à plaindre : ils avouent que déjà, à vingt ans, ils étaient des petits vieux qui regardaient passer l'avenir dans un rétroviseur. Et pourtant ce (...) sont eux les vrais utopistes. Ils croient qu'une victoire électorale suffira à faire perdre le goût de l'émancipation à celles et à ceux qui en jouissent. Si ce n'était pas si revanchard, ce serait presque émouvant de naïveté. ". (shrink)

In this much-needed account of what has gone wrong in our thinking about the environment, Val Plumwood digs at the roots of environmental degradation. She argues that we need to see nature as an end itself, rather than an instrument to get what we want. Using a range of examples, Plumwood presents a radically new picture of how our culture must change to accommodate nature.

This paper investigates how specific notions of gender and ethnicity are integrated into diversity discourses presented on 241 top European company websites. Large European companies increasingly disclose equality and diversity policies in statements on websites. Such statements may be used to promote an ethical image of the company in terms of how well it manages diversity and guards against discrimination. In this paper, we argue that diversity statement discourses are important as they play a key part in socially constructing how (...) diversity should be regarded in the company by minority and majority groups, as well as indicating corporate values to external stakeholders. Sometimes, the notions of gender or ethnic diversity are positioned as a liability in need of protection, whilst in others, as a source of competitive advantage. We find evidence of use of discursive tools such as problematisation, rationalisation, fixation, reframing and naturalisation of the notions of gender and ethnic diversity, reinforced by use of symbols, such as statistics, photographs, membership badges and awards. Few statements directly associate gender and ethnic diversity with enhanced corporate performance. We found that diversity statements sometimes appear to reinforce existing business stereotypes of women and people from ethnic minorities, and in a few discourses, create new ones, particularly evident in photographs illustrating the diversity web pages. (shrink)

This paper investigates how specific notions of gender and ethnicity are integrated into diversity discourses presented on 241 top European company websites. Large European companies increasingly disclose equality and diversity policies in statements on websites. Such statements may be used to promote an ethical image of the company in terms of how well it manages diversity and guards against discrimination. In this paper, we argue that diversity statement discourses are important as they play a key part in socially constructing how (...) diversity should be regarded in the company by minority and majority groups, as well as indicating corporate values to external stakeholders (investors, government, community, press etc.). Sometimes, the notions of gender or ethnic diversity are positioned as a liability in need of protection, whilst in others, as a source of competitive advantage. We find evidence of use of discursive tools such as problematisation, rationalisation, fixation, reframing and naturalisation of the notions of gender and ethnic diversity, reinforced by use of symbols, such as statistics, photographs, membership badges and awards. Few statements directly associate gender and ethnic diversity with enhanced corporate performance. We found that diversity statements sometimes appear to reinforce existing business stereotypes of women and people from ethnic minorities, and in a few discourses, create new ones, particularly evident in photographs illustrating the diversity web pages. (shrink)

This paper focuses on a context where interdisciplinarity intersects with interprofessionality: the work of children's services professionals who address the needs of children identified as vulnerable. It draws on evidence and perspectives from two disciplines — educational studies and health care — to consider the issues and challenges posed by learning and/or working across disciplinary boundaries and why these have proved so obdurate.

Paralelamente a su poesía, Bernard Noël desarrolla una obra en prosa que plantea interrogantes de orden cognitivo, en particular en torno a la percepción visual. La exploración de dispositivos tecnológicos (la cámara fotográfica) y de escenificaciones del acto de creación (la escena del pintor trabajando) es ocasión para contrastar la pertinencia de las intuiciones y reflexiones del poeta puestas bajo el foco de las actuales ciencias cognitivas. El trayecto de lo óptico a lo mental queda inscrito en una comprensión encarnada (...) y gestual de la cognición que apunta también hacia el surgimiento del lenguaje. Su poesía ha de ser pues entendida como el tramo final del proceso. (shrink)

Ideal for undergraduate students in philosophy and science studies, Philosophy of Technology offers an engaging and comprehensive overview of a subject vital to our time. An up-to-date, accessible overview of the philosophy of technology, defining technology and its characteristics. Explores the issues that arise as technology becomes an integral part of our society. In addition to traditional topics in science and technology studies, the volume offers discussion of technocracy, the romantic rebellion against technology. Complements The Philosophy of Technology : The (...) Technological Condition: An Anthology, edited by Robert C. Scharff and Val Dusek. (shrink)

Comprehensie collection of historical and contemporary philosophies of technology, including Plato, Aristotle, St. Simon, Comte, Marx, Heidegger, Mumford, Foucault.

Rationalism is the key to the connected oppressions of women and nature in the West. Deep ecology has failed to provide an adequate historical perspective or an adequate challenge to human/nature dualism. A relational account of self enables us to reject an instrumental view of nature and develop an alternative based on respect without denying that nature is distinct from the self. This shift of focus links feminist, environmentalist, and certain forms of socialist critiques. The critique of anthropocentrism is not (...) sacrificed, as deep ecologists argue, but enriched. (shrink)

Yule, Val A series of before-and-after pictures shows the cost to a city that is bombed. A recent example is the UNESCO-listed sites in the Syrian city of Aleppo - one example is given above. After bombing these sites were all rubble.

Dictionary of Jainism and Jaina philosophy.

Power is everywhere. But what is it and how does it infuse personal and institutional relationships in higher education? Power, Knowledge and the Academy: The Institutional is Political takes a close-up and critical look at both the elusive and blatant workings and consequences of power in a range of everyday sites in universities. Chapters focus on specific locations in which power shapes personal and institutional knowledge including student-supervisor relationships, research teams, networking, the Research Assessment Exercise in the UK, and literature (...) reviews. (shrink)

Laws, codes, and rules are essential for any community, public or private, to operate in an orderly and productive fashion. Without laws and codes, anarchy and chaos abound and the purpose and role of the organization is lost. However, danger is significant, and damage serious and far-reaching when individuals or organizations become so focused on rules, laws, and specifications that basic principles are ignored. This paper discusses the purpose of laws, rules, and codes, to help understand basic principles. With such (...) an understanding an increase in the level of ethical and moral behavior can be obtained without imposing detailed rules. (shrink)

Se estudia la conveniencia de incluir el concepto de histéresis en las disciplinas humanistas, así como la necesidad de incorporar el análisis de los fenómenos donde aquél participa. La histéresis se produce en los más diversos campos de la acción y el pensamiento humanos, y su estudio contribuiría a completar y perfeccionar la visión que tenemos de los mismos. Al realizar la inclusión que aquí se propone, se operan varios cambios de orden epistemológico, operativo y conceptual. En las disciplinas humanistas, (...) los conceptos vienen asumiendo por tradición el papel de herramientas analíticas en bastante mayor medida que el de contenidos sobre los que efectuar el análisis. La histéresis manifiesta su alcance como hecho a analizar y también como herramienta de análisis, pero en el caso presente hemos tenido en cuenta más aspectos del segundo enfoque que del primero. De aquí que nos hayamos centrado en ubicar su campo epistemológico. (shrink)

Jane Elllen Harrison (1850-1928) fue una pionera: fue la primera mujer académica de Inglaterra, una de las primeras mujeres en cursar Estudios Clásicos en Newnham College de Cambridge, la primera mujer en recibir un doctorado honoris causa LLD (Doctor of Laws) en la Universidad de Aberdeen y la primera profesora de Cambridge.

In 2002, the Qualifications and Curriculum Authority (QCA) published the report of an independent panel of experts into maintaining standards at Advanced Level (A-Level). One of its recommendations was for: 'limited experimental double marking of scripts in subjects such as English to determine whether the strategy would significantly reduce errors of measurement' (p. 24). This recommendation provided the impetus for this paper which reviews the all but forgotten literature on double marking and considers its relevance now.

People with early-to-mid stage dementia frequently attend groups that provide opportunities for socialising and engaging in group activities, such as quizzes. This article uses conversation analysis to investigate the interactional strategies that the staff use to initiate and keep these quizzes ‘on track’, and what they orient to as impediments and facilitators of quiz progression. Specifically, we outline how staff deal with incorrect or ‘non-answers’, and what happens when players have their own goals or ‘projects’ that do not align with (...) staff members’ orientations to the overarching activity completion. We reflect on the tensions that arise between doing interactional work to progress through the quiz, and how that goal can conflict with attending to the needs or wishes expressed by the person living with dementia, potentially resulting in threats to the ‘face’ of the quiz players. Data are taken from a corpus of 10 quizzes recorded in 4 different group settings in England. (shrink)

Fluctuations in positive and negative caregiving experiences remain only partially explained as the significant variability over time of potential predictive factors themselves is understudied. The current study aims to gain considerable insight into caregiving experiences and perceptions over time by using photovoice methodology to support semi-structured interviews. A case study, longitudinal design is taken with three female caregivers who provide detailed insight into their caregivers' experiences over a 12 month period. The interview transcripts were analyzed using IPA- Interpretative Phenomenological Analysis. (...) This innovative combination of methods resulted in the emergence of three related themes which included consuming the role, feeling consumed by the role, and letting go of the role. The idiographic approach taken allowed both within case differences to be examined over time, and also between carer differences to be highlighted. Implications of illness type and its characteristics, and of attachment and relationship quality with the care recipient were seen in terms of how and when the caregivers moved between the themes identified. The use of others' support or respite care is examined vis-a vis caregiver's own beliefs, emotions, relationship attachment and motivations to care. Caregivers self-efficacy beliefs also shifted over time and were influential in caregiver experience as the care recipient condition or needs changed. No previous studies have found that negative caregiving consequences are, in part, under volitional control and yet our data on the underlying reasons for consuming caregiving or allowing themselves to consume, would suggest this may in part be true. This is important because it suggests that interventions to support caregivers should address relational and motivational factors more fully. (shrink)

Introduction: Motor evoked potentials (MEPs) to transcranial magnetic stimulation are known to be susceptible to several sources of variability. However, conflicting evidences on individual characteristics in relatively small sample sizes have been reported. We investigated the effect of age, height, and sex on MEPs of the motor cortex and spinal roots in a large cohort. Methods: A total of 587 subjects clinically and neuroradiologically intact were included. MEPs were recorded during mild tonic contraction through a circular coil applied over the (...) “hot spot” of the first dorsal interosseous and tibialis anterior muscles, bilaterally. Central motor conduction time (CMCT) was estimated as the difference between MEP cortical latency and the peripheral motor conduction time by cervical or lumbar magnetic stimulation. Peak-to-peak MEP amplitude to cortical stimulation and right-to-left difference of each parameter were also measured. Results: After Bonferroni correction, general linear (multiple) regression analysis showed that both MEP cortical latency and peripheral motor conduction time at four limbs positively correlated with age and height. At lower limbs, an independent effect of sex on the same measures was also observed (with females showing smaller values than males). CMCT correlated with both age (negatively) and height (positively) when analyzed by a single regression; however, with a multiple regression analysis this significance disappeared, due to the correction for the multicollinearity within the dataset. Conclusions: Physical individual features need to be considered for a more accurate and meaningful MEPs interpretation. Both in clinical practice and in research setting, patients and controls should be matched for age, height, and sex. (shrink)

Women, Humanity and Nature Val Plum wood There is now a growing awareness that the Western philosophical tradition which has identified, on the one hand, maleness with the sphere of rationality, and on the other hand, femaleness with the sphere...