Dieser Beitrag nimmt als Ausganspunkt die gegenwärtige kontroverse Debatte um den adäquaten Erklärungsansatz in der Kognitionswissenschaft, und zwar zwischen Enaktivisten einerseits und Repräsentationalisten andererseits. Beispielhaft wurde aufgezeigt, dass in Bezug auf die soziale Kognition der enaktivistische Ansatz eine Voraussetzung machen muss, die er mit seinen eigenen Mitteln nicht einzufangen in der Lage ist. Denn der Versuch, das Verstehen des Anderen durch gemeinsame Sinnstiftung der Akteure innerhalb ihrer sozialen Interaktion zu erklären, gerät in einen Zirkel, da nicht erklärt wird, wie die (...) Kopplung und damit der Prozess der sozialen Interaktion allererst zustande kommen kann. Als Lösung dieses Problems wird eine repräsentationalistische Analyse der vorausgesetzten Fähigkeit, andere als potentielle Kooperationspartner anzusehen, entwickelt, und zwar mit den Mitteln von Millikans Teleosemantik. Diese Theorie aus dem Kontext der Debatte um die Naturalisierung mentaler Repräsentationen liefert mit den PP Repräsentationen den adäquaten Begriff, um sowohl verkörperte, handlungsorientierte Repräsentationen zur Analyse von Affordanzen, als auch verkörperte interaktionsorientierte Repräsentationen zur Analyse sozialer Affordanzen zu entwickeln. Dies erlaubt die Annahme einer zentralen Funktion für die soziale Wahrnehmung, die den blinden Fleck des enaktivistischen Ansatzes ausfüllen kann. Zugleich demonstriert diese Analyse der sozialen Wahrnehmung die explanatorische Überlegenheit (minimal) repräsentationalistischer Erklärungen gegenüber rein enaktivistischen Alternativen. (shrink)

Cancer stem cells (CSC) represent malignant cell subsets in hierarchically organized tumors, which are selectively capable of tumor initiation and self‐renewal and give rise to bulk populations of non‐tumorigenic cancer cell progeny through differentiation. Robust evidence for the existence of prospectively identifiable CSC among cancer bulk populations has been generated using marker‐specific genetic lineage tracking of molecularly defined cancer subpopulations in competitive tumor development models. Moreover, novel mechanisms and relationships have been discovered that link CSC to cancer therapeutic resistance and (...) clinical tumor progression. Importantly, proof‐of‐principle for the potential therapeutic utility of the CSC concept has recently been provided by demonstrating that selective killing of CSC through a prospective molecular marker can inhibit tumor growth. Herein, we review these novel and translationally relevant research developments and discuss potential strategies for CSC‐targeted therapy in the context of resistance mechanisms and molecular pathways preferentially operative in CSC. (shrink)

Physical environmental factors – or ‘artifacts’ – are linked to healthcare outcomes in the field of social psychology. However, the role of artifacts remains rarely examined in the burgeoning discipline of placebo studies. In this paper, we argue that a careful consideration of artifacts – such as provider clothing and office décor – may carry significant potential in eliciting placebo effects in clinical settings. We discuss three potential mechanisms by which artifacts may enhance or diminish placebo (or nocebo) effects: classical (...) conditioning, response expectancy, and mindsets. We propose testable hypotheses and conclude by providing innovative research designs that might help to better advance this novel research agendum. (shrink)

Cigarette smoking and other addictive behaviors are among the main preventable risk factors for several severe and potentially fatal diseases. It has been argued that addictive behavior is controlled by an automatic-implicit cognitive system and by a reflective-explicit cognitive system, that operate in parallel to jointly drive human behavior. The present study addresses the formation of implicit attitudes towards smoking in both smokers and non-smokers, using a Go/NoGo association task, and behavioral and electroencephalographic measures. The GNAT assesses, via quantifying participants’ (...) reaction times, the strength of association between a target category and either pole of an evaluative dimension. EEG analysis is performed to determine the temporal course of the event-related potential components underlying Go/NoGo decisions and implicit attitude formation. Both smokers and non-smokers showed prolonged reaction times to smoking-related pictures when the pictures were coupled with positive evaluative words. This indicates negative implicit attitudes towards smoking in both groups alike at the time point of the behavioral response. However, only the non-smokers, not the smokers, were found to show a delay of the N200 component in the incongruent condition. This is interpreted as reflecting ambivalent or even positive implicit attitudes towards smoking in the smoker group at the time point of the N200. Our study thus provides evidence for the hypothesis that implicit attitudes are subject to changes within several hundred milliseconds after stimulus presentation, and can be altered in the course of their formation. (shrink)

Bullying often results in negative coping in victims, including an increased consumption of alcohol. Recently, however, an increase in alcohol use has also been reported among perpetrators of bullying. The factors triggering this pattern are still unclear. We investigated the role of empathy in the interaction between bullying and alcohol use in an adolescent sample (IMAGEN) at age 13.97 (±0.53) years (baseline (BL), N = 2165, 50.9% female) and age 16.51 (±0.61) years (follow-up 1 (FU1), N = 1185, 54.9% female). (...) General empathic distress served as a significant moderator of alcohol use in perpetrators (F9, 493 = 17.978, p < 0.01), which was specific for males and FU1. Male perpetrators, who are generally less sensitive to distress, might thus be more vulnerable to alcohol abuse. (shrink)

The Twin Earth thought experiment invites us to consider a liquid that has all of the superficial properties associated with water (clear, potable, etc.) but has entirely different deeper causal properties (composed of “XYZ” rather than of H2O). Although this thought experiment was originally introduced to illuminate questions in the theory of reference, it has also played a crucial role in empirically informed debates within the philosophy of psychology about people’s ordinary natural kind concepts. Those debates have sought to accommodate (...) an apparent fact about ordinary people’s judgments: Intuitively, the Twin Earth liquid is not water. We present results from four experiments showing that people do not, in fact, have this intuition. Instead, people tend to have the intuition that there is a sense in which the liquid is not water but also a sense in which it is water. We explore the implications of this finding for debates about theories of natural kind concepts, arguing that it supports views positing two distinct criteria for membership in natural kind categories – one based on deeper causal properties, the other based on superficial, observable properties. (shrink)

The Twin Earth thought experiment invites us to consider a liquid that has all of the superficial properties associated with water (clear, potable, etc.) but has entirely different deeper causal properties (composed of “XYZ” rather than of H2O). Debates about natural kind concepts have sought to accommodate an apparent fact about ordinary people's judgments: Intuitively, the Twin Earth liquid is not water. We present results showing that people do not have this intuition. Instead, people tend to judge that there is (...) a sense in which the liquid is not water but also a sense in which it is water. (shrink)

Extensive research has demonstrated that rs1360780, a common single nucleotide polymorphism within the FKBP5 gene, interacts with early-life stress in predicting psychopathology. Previous results suggest that carriers of the TT genotype of rs1360780 who were exposed to child abuse show differences in structure and functional activation of emotion-processing brain areas belonging to the salience network. Extending these findings on intermediate phenotypes of psychopathology, we examined if the interaction between rs1360780 and child abuse predicts resting-state functional connectivity (rsFC) between the amygdala (...) and other areas of the salience network. We analyzed data of young European adults from the general population (N = 774; mean age = 18.76 years) who took part in the IMAGEN study. In the absence of main effects of genotype and abuse, a significant interaction effect was observed for rsFC between the right centromedial amygdala and right posterior insula (p <.025, FWE-corrected), which was driven by stronger rsFC in TT allele carriers with a history of abuse. Our results suggest that the TT genotype of rs1360780 may render individuals with a history of abuse more vulnerable to functional changes in communication between brain areas processing emotions and bodily sensations, which could underlie or increase the risk for psychopathology. (shrink)

J. N. Adams, Michael Lapidge, and Tobias Reinhardt: IntroductionJ. H. W. Penney: Connections in Archaic Latin ProseJ. Briscoe: Language and Style of the Fragmentary Republican HistoriansJ. N. Adams: The Bellum AfricumChristina Shuttleworth Kraus: Hair, Hegemony, and Historiography: Caesar's Style and its Earliest CriticsJ. G. F. Powell: Cicero's Adaptation of Legal Latin in the De legibusTobias Reinhardt: Language of Epicureanism in Cicero: The Case of AtomismG. O. Hutchinson: Pope's Spider and Cicero's WritingR. G. Mayer: The Impracticability of 'Kunstprosa'H. M. Hine: (...) Poetic Influence on Prose: The Case of the Younger SenecaHarm Pinkster: The Language of Pliny the ElderD. R. Russell: Omisso speciosiore stili genereS. J. Harrison: The Poetics of Fiction: Poetic Influence on the Languages of Apuleius' MetamorphosesD. R. Langslow: 'Langues réduites au lexique'? The Languages of Latin Technical ProseDanuta Shanzer: of Tours and Poetry: Prose into Verse and Verse into ProseMichael Lapidge: Poeticism in Pre-Conquest Anglo-Latin ProseRichard Sharpe: The Varieties of Bede's ProseCarlotta Dionisotti: Translator's LatinWalter Berschin: Realistic Writing in the Tenth Century: : Gerhard of Ausburg's Vita S. UodalriciR. M. Thomson: William of Malmesbury and the Latin Classics RevisitedGiovanni Orlandi: Metrical and Rhythmical Clausulae in Medieval Latin Prose: Some Aspects and Problems. (shrink)

Within translation studies, functionalist translations and even more specifically, translations guided by Skopos theory are very much purposeful activities. Skopos theory applied to Bible translation, however, is sometimes met with resistance by practitioners who believe that Skopos theory betrays too much of the source text. This article began by outlining Skopos theory and the additional notion of loyalty as introduced by Christiane Nord. Even with loyalty applied to the theory, many Bible translation practitioners continue to fear it. After the initial (...) presentation of Skopos theory plus loyalty, the Hebrew lexeme חֶסֶד ( ḥesed ) was introduced in this article and discussed in relation to its biblical use. The discussion of ḥesed was then widened to functionalist Bible translation to redeem the loyalty notion as applied to Bible translation. This article claimed that ḥesed as loyalty further helps to protect both the source text and target audiences from radical or unacceptable translations. Contribution: Bible translation is a purposeful activity. This article attempted to allay the fears that some Bible translation practitioners have about the possibility of radical translations undertaken using Skopos theory. Loyalty as understood through the lens of the Hebrew חֶסֶד ( ḥesed ) was utilised afresh to allay these fears. (shrink)

Upshot: Is education about memorising or about making meaning? Critics of constructivist instruction argue that it is more efficient to teach directly. However, there is an empowering engagement to making meaning and teachers need to know how to guide students in this process.

Full ectogenesis as the complete externalization of human reproduction by bypassing the bodily processes of gestation and childbirth can be considered the culmination of genetic and reproductive technologies. Despite its still being a hypothetical scenario, it has been discussed for decades as the ultimate means to liberate women from their reproductive tasks in society and hence finally end fundamental gender injustices generally. In the debate about the application of artificial wombs to achieve gender equality, one aspect is barely mentioned but (...) is of crucial relevance from a medical‐ethical perspective: whether and how could full ectogenesis be justified as a proper use of medicine? After characterizing the technology as a special form of human enhancement and as an extension of medical practice that goes beyond the traditional field of medicine, this paper critically assesses the theoretical possibilities of legitimizing this extension. We identify two ways of justification: either one argues that ectogenesis fulfils a proper goal of medicine (a justification we call pathologization), or one argues that the application of ectogenesis achieves a non‐medical goal (which we call medicalization). Because it is important from a medical‐ethical point of view to avoid an inappropriate instrumentalization or misuse of medicine and thus an undue medicalization of non‐medical problems, a set of necessary conditions has to be met. It is doubtful whether full ectogenesis for non‐medical purposes could fulfil these conditions. Rather, its comprehensive usage could be seen as a revolutionary modification of what it means to be human. (shrink)

According to the algebraic approach to spacetime, a thoroughgoing dynamicism, physical fields exist without an underlying manifold. This view is usually implemented by postulating an algebraic structure (e.g., commutative ring) of scalar-valued functions, which can be interpreted as representing a scalar field, and deriving other structures from it. In this work, we point out that this leads to the unjustified primacy of an undetermined scalar field. Instead, we propose to consider algebraic structures in which all (and only) physical fields are (...) primitive. We explain how the theory of natural operations in differential geometry—the modern formalism behind classifying diffeomorphism-invariant constructions—can be used to obtain concrete implementations of this idea for any given collection of fields. For concrete examples, we illustrate how our approach applies to a number of particular physical fields, including electrodynamics coupled to a Weyl spinor. (shrink)

ABSTRACTAlthough item-memory for emotional information is enhanced, memory for associations between items is often impaired for negative, emotionally arousing compared to neutral information. We te...

A superb introduction to the ethical aspects of war and peace, this collection of tightly integrated essays explores the reasons for waging war and for fighting with restraint as formulated in a diversity of ethical traditions, religious and secular. Beginning with the classic debate between political realism and natural law, this book seeks to expand the conversation by bringing in the voices of Judaism, Islam, Christian pacifism, and contemporary feminism. In so doing, it addresses a set of questions: How do (...) the adherents to each viewpoint understand the ideas of war and peace? What attitudes toward war and peace are reflected in these understandings? What grounds for war, if any, are recognized within each perspective? What constraints apply to the conduct of war? Can these constraints be set aside in situations of extremity? Each contributor responds to this set of questions on behalf of the ethical perspective he or she is presenting. The concluding chapters compare and contrast the perspectives presented without seeking to adjudicate their differences. Because of its inclusive, objective, comparative, and dialogic approach, the book serves as a valuable resource for scholars, journalists, policymakers, and anyone else who wants to acquire a better understanding of the range of moral viewpoints that shape current discussion of war and peace. In addition to the editor, the contributors are Joseph Boyle, Michael G. Cartwright, Jean Bethke Elshtain, John Finnis, Sohail H. Hashmi, Theodore J. Koontz, David R. Mapel, Jeff McMahan, Richard B. Miller, Aviezer Ravitzky, Bassam Tibi, Sarah Tobias, and Michael Walzer. (shrink)

Cette parution est un événement. Lumière de l’Éternel est le dernier des ouvrages majeurs du rationalisme juif médiéval, ponctuant une série de tentatives de mesurer le judaïsme aux exigences de la rationalité philosophique. Son auteur, Ḥasdaï Crescas (vers 1340-1410), est un pur produit du judaïsme espagnol, philosophe et élève de grands maîtres de la tradition talmudique (notamment Nissim de Gérone, dit « le Ran »). Il fut un dirigeant de la communauté barcelonaise. L’ouvrage aurait été ac..

Signing Ceremony of MOU on Professional Legal Diploma, Government of Dubai 2020.