Precision medicine and molecular systems medicine (MSM) are highly utilized and successful approaches to improve understanding, diagnosis, and treatment of many diseases from bench-to-bedside. Especially in the COVID-19 pandemic, molecular techniques and biotechnological innovation have proven to be of utmost importance for rapid developments in disease diagnostics and treatment, including DNA and RNA sequencing technology, treatment with drugs and natural products and vaccine development. The COVID-19 crisis, however, has also demonstrated the need for systemic thinking and transdisciplinarity and the limits (...) of MSM: the neglect of the bio-psycho-social systemic nature of humans and their context as the object of individual therapeutic and population-oriented interventions. COVID-19 illustrates how a medical problem requires a transdisciplinary approach in epidemiology, pathology, internal medicine, public health, environmental medicine, and socio-economic modeling. Regarding the need for conceptual integration of these different kinds of knowledge we suggest the application of general system theory (GST). This approach endorses an organism-centered view on health and disease, which according to Ludwig von Bertalanffy who was the founder of GST, we call Organismal Systems Medicine (OSM). We argue that systems science offers wider applications in the field of pathology and can contribute to an integrative systems medicine by (i) integration of evidence across functional and structural differentially scaled subsystems, (ii) conceptualization of complex multilevel systems, and (iii) suggesting mechanisms and non-linear relationships underlying the observed phenomena. We underline these points with a proposal on multi-level systems pathology including neurophysiology, endocrinology, immune system, genetics, and general metabolism. An integration of these areas is necessary to understand excess mortality rates and polypharmacological treatments. In the pandemic era this multi-level systems pathology is most important to assess potential vaccines, their effectiveness, short-, and long-time adverse effects. We further argue that these conceptual frameworks are not only valid in the COVID-19 era but also important to be integrated in a medicinal curriculum. (shrink)

Some of the methods for data collection in experimental psychology, as well as many of the inferences from observed behavior or image scanning, are based on the implicit premise that language use can be linked, via the meaning of words, to specific subjective states. Wittgenstein’s well known private language argument (PLA), however, calls into question the legitimacy of such inferences. According to a strong interpretation of PLA, all of the elements of a language must be publicly available. Thus the meaning (...) of words is not fixed by reference to our private experiences, and so data from subjective state claims indicates nothing about our subjective experiences. Application of PLA to psychological studies based on descriptions of the experience of orgasm offers support for the strong version of the conclusion of PLA. We show that PLA has deep implications for data collection methods and inferences in experimental psychology. In particular we critique two contemporary research projects in neuroscience: one studying the ability to remember emotionally loaded words and the other studying experience of attraction. Both of these projects attempt to link subjective experiences and thought processes to particular observable brain states. The research methods appeal to (implicit) inferences from linguistic usage to subjective states. Application of PLA will show that such inferences cannot be made because the meaning of a word is not determined by any subjective state of the speaker. (shrink)

Hastings Center Report, Volume 52, Issue 1, Page 51-58, January/February 2022.

_The Promise of Happiness_ is a provocative cultural critique of the imperative to be happy. It asks what follows when we make our desires and even our own happiness conditional on the happiness of others: “I just want you to be happy”; “I’m happy if you’re happy.” Combining philosophy and feminist cultural studies, Sara Ahmed reveals the affective and moral work performed by the “happiness duty,” the expectation that we will be made happy by taking part in that which (...) is deemed good, and that by being happy ourselves, we will make others happy. Ahmed maintains that happiness is a promise that directs us toward certain life choices and away from others. Happiness is promised to those willing to live their lives in the right way. Ahmed draws on the intellectual history of happiness, from classical accounts of ethics as the good life, through seventeenth-century writings on affect and the passions, eighteenth-century debates on virtue and education, and nineteenth-century utilitarianism. She engages with feminist, antiracist, and queer critics who have shown how happiness is used to justify social oppression, and how challenging oppression causes unhappiness. Reading novels and films including_ Mrs. Dalloway_, _The Well of Loneliness_, _Bend It Like Beckham_, and _Children of Men_, Ahmed considers the plight of the figures who challenge and are challenged by the attribution of happiness to particular objects or social ideals: the feminist killjoy, the unhappy queer, the angry black woman, and the melancholic migrant. Through her readings she raises critical questions about the moral order imposed by the injunction to be happy. (shrink)

A welcome addition to the Routledge Critical Thinkers series, Judith Butler is the first guidebook on this renowned feminist and queer theory scholar, which will help not only students of literary criticism but also students of law, sociology, philosophy, film and cultural studies. Examining Butler's work through a variety of contexts, including the formation of gender performativity, identity and subjecthood, Sarah Salih address Butler's crucial ideas on the gender agenda, the body, pornography, race, gay self-expression and power and psychoanalysis. Concluding (...) with an annotated bibliography, this book will be the ideal starting point for all new to Butler. (shrink)

Decolonial/anti-colonial Black, Indigenous and Mestiza feminist movements and scholar-activists foreground how the oft-touted apocalypse that the Covid-19 pandemic heralds is not new, nor does it signify the great rupture into chaos that those from within modernity-coloniality often claim it to be. Rather Covid-19 is preceded by and will be out-lived by the apocalyptic anti-life onto-epistemological logics that are foundational to the production of hetero-patriarchal capitalist- coloniality. However, one would commit the violence of reproduction of the epistemological logics and rationalities constitutive (...) of the current system if the story ended there. We have survived and our survival points to the urgent necessity and responsibility of social theory to listen to the story of the pandemic from a Black/Indigenous genealogy and to begin the sense-making of the Covid-19 pandemic, from prior to this particular virus, outside, against and beyond the politics of knowledge of critical social theory itself. Thus, I invite you to journey to an affirmative re-enfleshment of reason and theory-making in relation to and dialogue with Black, Indigenous, and subaltern Mestiza feminist movements in southwest Colombia and in southeast so-called Australia in the unceded lands of the Awabakal and the Worimi. I explore this through the metaphor, the materiality, the cosmology and the herstory of the mangrove swamps a knowing-being otherwise visible to the dehumanising gave of Whiteness and bring to thought three stories of a politics of knowledge of/as the Black/racialised and feminised body/flesh. To do this is to suggest that the co-creation of pathways which are life affirming and life making beyond and out of the post-Covid 19 conjuncture involves an epistemological-political project which decolonises and feminises the containments of reason and knowing being of coloniality/modernity. (shrink)

A relation between two secrets, known in the literature as nondeducibility , was originally introduced by Sutherland. We extend it to a relation between sets of secrets that we call independence . This paper proposes a formal logical system for the independence relation, proves the completeness of the system with respect to a semantics of secrets, and shows that all axioms of the system are logically independent.

The article proposes Logic of Secrets in Collaboration Networks, a formal logical system for reasoning about a set of secrets established over a fixed configuration of communication channels. The system’s key feature, a multi-channel relation called independence, is a generalization of a two-channel relation known in the literature as nondeducibility. The main result is the completeness of the proposed system with respect to a semantics of secrets.

Jones (1991) has proposed an issue-contingent model of ethical decision making by individuals in organizations. The distinguishing feature of the issue was identified as its moral intensity, which determines the moral imperative in the situation. In this study, we adapted three scenarios from the literature in order to examine the issue-contingent model. Findings, based on a student sample, suggest that (1) the perceived and actual dimensions of moral intensity often differed; (2) perceived moral intensity variables, in the aggregate, significantly affected (...) an individual''s moral judgments; and (3) some dimensions of moral intensity (namely, perceived social consensus and perceived magnitude of consequences) mattered more than others. (shrink)

The model of feminism as humanist in practice and postmodern in theory is inadequate. Feminist practice and theory directly inform each other to displace both humanist and postmodern conceptions of the subject. An examination of feminism's use of rights discourse suggests that feminist practice questions the humanist conception of the subject as a self-identity. Likewise, feminist theory undermines the postmodern emphasis on the constitutive instability and indeterminacy of the subject.

Cet article expose une analyse sémique d’un ensemble de mots, diffusé par le biais du discours religieux, censé présenter une définition des « non-musulmans ». Il s’agit, essentiellement, de montrer en quoi des mots (polythéiste, idolâtre, mécréant, athée, protégé, Nazaréens, chrétiens, Juifs, égaré), figurant dans le discours d’un prédicateur musulman, façonnent, d’une manière systémique, des images, des imaginaires, et peuvent potentiellement véhiculer une représentation altérée de l’Autre. Ces occurrences, généralement spécifiques à un balisage exégétique ou canonique, débordent de leurs contextes (...) et s’utilisent comme concepts génériques dans la prédication contemporaine. En circulation sur le Web et employés hors de leur contexte historique, ces discours sur l’Altérité, révèlent l’ambiguïté qu’engendre une assimilation d’un ensemble de mots, sémantiquement différents, sous l’hyperonyme de « non-musulmans ». (shrink)

Bayard's book appeared in 2007. Word of mouth about it probably reached me at the time, but it did not catch my attention until the day (in 2012, if I am not mistaken) that a young professor, on the verge of burnout, told me how reading it had functioned for him as a kind of therapy. Though a voracious reader, he found himself confronted by ever more recommendations for reading, some from reviewers whose suggestions were felt as obligations and sounded (...) almost like insults. The line between a reading recommendation and an insult is very thin (the interlocutor may feel infantilized). The young professor was particularly irritated by recurrent advice to read Derrida. Must I read De la grammatologie, he asked, because it is vaguely related to the topic I am working on? Why must I quote him? And if I have not read him, must I pretend that I have?In the academic quotation economy, we very often find ourselves lying to the public, pretending we have read authors whom we have not. For a decade, the title of Bayard's book worked for me as a motto I could repeat internally whenever faced with a reading recommendation, especially when it was broad and general (I have often been advised to read Marx or Lacan, for instance, with no further indication of passages that might interest me). Inversely, when I make a recommendation, I add a little comment on Bayard's book, though until recently I have specified that I have not read it myself. I have hoped my comment would reduce the risk of my recommendations being interpreted as obligations or insults.As is the case with many books, Bayard's became important to me well before I decided to read it (in 2022). An interlocutor, reacting to my recommendation of the book without having read it, told me that the book (he had read it) was more than an antidote for academic name-dropping. It was foremost, he added, an investigation into various modes of nonreading. Apart from pure ignorance (when one does not even know that it exists), one can be familiar with a book just by learning bibliographical details and information about its genre and tradition. One can know a book by hearsay (one can speak extensively about it on the basis of remarks that one has heard). One can consult the table of contents furtively or read some pages randomly.Each mode of nonreading enables us to talk differently about a book, and in each we fill the parts of which we are ignorant with peripheral knowledge and imagination. Therefore, nonreading—active nonreading at least—can be more demanding, Bayard argues, than reading itself. Still, what happens when we talk about books that we have not read happens also when we speak about books that we have read, since we never speak of a book as such without adding what we imagine the book to be. Based on this similarity of reading and nonreading, Bayard comes to a paradoxical conclusion typical of French thinkers: each reading, he contends, from the most inattentive to the most intense, is also a form of nonreading. He misses, however, that by the same argument the inverse proposition could also be defended: what he calls nonreading is already a form of reading.During the decade between beginning to think about Bayard's book and actually reading it, I constructed what he calls a “screen book” (livre-écran)—a work of my imagination. But the book I invented was enriched by my eventually reading it. I discovered that it delivered not simply a criticism of our quoting practices but also a celebration of some forms of active nonreading. In Bayard's enthusiasm, however, I believe that he goes too far when he concludes, with Oscar Wilde among others, that it is better not to read the books we review. Often, as was my case with How to Talk about Books You Haven't Read, they turn out to be more original than our fancy is capable of imagining. Hence I have set forth in this review a reason not mentioned by Bayard in favor of discussing books one has not read: doing so may function as a self-reminder. By dint of speaking about a book, one sometimes ends up reading it. (shrink)

Se reflexiona sobre la reprobabilidad moral de la Gestación por Sustitución a través del debate en torno a la autonomía de la gestante y los derechos reproductivos. En primer lugar, se contrastan las posturas liberal y feminista en países del Norte. Asimismo, se consideran las implicaciones para el debate de los intereses económicos de la industria de las Nuevas Técnicas de Reproducción Humana Asistida. Por último, se examina el fenómeno desde una perspectiva transnacional a través de un análisis interseccional y (...) teniendo en cuenta los estudios etnográficos realizados por investigadoras en la India y sus implicaciones para el debate. (shrink)

Barba non facit philosophum. L'habit ne fait pas le moine. In those proverbs, Latin and French, we find the classical opposition between appearance and reality—between the accessory (the superficial, the beard, the clothing) and the essential (the profound, the philosopher, the monk), the latter being independent from and unchanged by the former. Berliner questions this dichotomy. As an anthropologist, he reviews many situations in which humans wear masks or use other techniques to cover their identities: cosplaying, puppy play, historical reenactments, (...) live-action role-playing, and the use of pseudonyms. Cosplayers, the subject of Berliner's first case study, impersonate characters from movies or video games. On the basis of lengthy interviews, he concludes that role-players change when they wear the costumes of their favorite heroes, behaving, for instance, with more self-confidence. A little psychological experiment not cited in this book suggests the same. In 2012, Hajo Adam and Adam Galinsky asked a group of students to perform a task demanding concentration. Those given a white medical coat to wear during the experiment performed better, probably because they were more prone to adopt traits and postures attributed to doctors—postures thought to enhance concentration. Berliner believes that, in the case of more immersive games, such changes are not necessarily temporary. They can persist after the acting is done. In other words, in some contexts at least, clothes can change the man.To impersonate a historical figure such as Napoleon, another case covered in Berliner's book, the reenactor must pay attention to minute details of the figure's life, habits, and social environment. The reenactor may then experience a moment de bascule, during which he is so much absorbed in his role that he forgets he is playing a character. As such, the activity of imitating is a way of learning some particular forms of paying attention to the individual serving as model. I regret that this aspect of disguise is not discussed when Berliner approaches animal role-playing. He affirms instead that identification with animals “rests upon our imagining what an animal is.” To imitate animals, however, we must first learn about, watch, and interact with them. Imitation is never fully based on the imagination; our imaginations are opened by prior, more or less proximate interactions with the beings that serve as models. It is far from easy to imagine, out of the blue, using our bodies in the ways that imitating animals requires.Despite the book's title, Becoming Other, Gilles Deleuze is barely mentioned in it, probably because he was very critical of the concept of imitation, which is omnipresent in Berliner's thought. Still, the way in which Berliner uses the concept is Deleuzian to a degree. Deleuze is skeptical of the concept of imitation because the success of an imitation is usually judged by whether the model and the imitation correspond in appearance—the imitation, in that case, does not bring any novelty to the world. In contrast to Deleuze, who proposes to abandon the concept of imitation, Berliner invites us to study it in new ways. Indeed, his book teaches us how creative imitation can be. What counts is not whether an imitation is successful but whether it is fruitful, and that we measure by whether it transforms us. The imitator does not become an alter ego of the model impersonated but a superego, an ego more aware of all its capacities. Even if it is never made explicit, the contrast between successful and fruitful—a contrast dear to Vinciane Despret—structures Berliner's analyses, which are a valuable contribution not only to anthropology but also to philosophy. (shrink)

La Antropología filosófica es el ámbito que enmarca el tema que convoca esta presentación. En el terreno filosófico el marco teórico se apoya, primeramente, en el pensamiento de Nietzsche teniendo en cuenta el estatuto que asigna al cuerpo. En segundo lugar, Rancière ofrece aportes en lo que se refiere a la relación polémica entre lo representable y lo irrepresentable. En tercer término, la guía es proporcionada por la crítica cultural de Walter Benjamin, quien procura revelar la influencia del cine en (...) la masa que puede verse a sí misma en la pantalla. Desplazo el tratamiento del cine como recurso útil al plano educativo. Con este fin escojo escenas fílmicas donde intento aplicar las categorías y las determinaciones analizadas para ofrecerlas como herramienta de reflexión sobre la condición humana. (shrink)

In their 2010 article ‘Research Integrity in China: Problems and Prospects’, Zeng and Resnik challenge others to engage in empirical research on research integrity in China. Here we respond to that call in three ways: first, we provide updates to their analysis of regulations and allegations of scientific misconduct; second, we report on two surveys conducted in Hong Kong that provide empirical backing to describe ways in which problems and prospects that Zeng and Resnik identify are being explored; and third, (...) we continue the discussion started by Zeng and Resnik, pointing to ways in which China's high‐profile participation in international academic research presents concerns about research integrity. According to our research, based upon searches of both English and Chinese language literature and policies, and two surveys conducted in Hong Kong, academic faculty and research post‐graduate students in Hong Kong are aware of and have a positive attitude towards responsible conduct of research. Although Hong Kong is but one small part of China, we present this research as a response to concerns Zeng and Resnik introduce and as a call for a continued conversation. (shrink)

In 1996, the anthropologist Eduardo Viveiros de Castro chose a sentence by Gilles Deleuze as the epigraph for an article, published in the Brazilian journal Mana, on Amerindian perspectivism. (A modified version of the article appeared in English two years later, in the Journal of the Royal Anthropological Institute.) Since then, Deleuze's name has appeared often in works about perspectivism, but Chamois's new book is the first monograph to focus on perspectivism and Deleuze. Among the most important contributions of Chamois's (...) analysis is to draw our attention to a little-known passage in a course, “Truth and Time,” that Deleuze taught in 1983 (and that is available for listening online). In it, he criticizes the example of the cube used as a paradigm, at least since Edmund Husserl's day, to conceptualize what a perspective is. It is impossible to see all six faces of a cube at the same time; thus, to “intuit” the cube as a cube, we must add to our own perception of a profile of the cube more possible points of view on it. The problem with this example and description is that it takes for granted that the subject already knows what she needs to see (a cube).Inspired, however, by the process philosophy of Alfred North Whitehead, Deleuze holds that each perception is an invitation to other perceptions: “To perceive is to become capable of perceiving more and more things that were initially not perceived” (percevoir, c'est devenir apte à percevoir de plus en plus de choses qui d'abord n’étaient pas perçues). Deleuze contrasts the “spatial” or “frozen” notion of perspective to the “temporal perspective” that he seeks to emphasize: “It's time that acts as perspective” (C'est le temps qui agit comme perspective). The question, therefore, at the heart of Deleuze's perspectivism is how a perspective changes over time. Chamois goes through the early texts of Deleuze to show how the idea of the temporal perspective emerged from the concept of the structure Autrui. The “structure-Other” is best exemplified by someone else's emotive face—the frightened face of my friend, for instance. If I perceive that face while, say, I am laughing, another possible world would slip into my own: a frightening world penetrates my humorous one, and perhaps I should turn my head to see what danger may be en route. As in the case of the cube, my own limited perception is supplemented by others’ limited perceptions. The object of perception in this case, however, is not presupposed to be stable (the world is changing), and what I am about to see is not known in advance.But what, precisely, in the face of the other must I notice to become aware of the world she perceives? Deleuze does not explore that question in any detail, but Chamois reviews recent anthropological and psychological research that supplies some elements of a response. To confront the writings of Deleuze with relevant scientific data is fruitful. I must admit, though, that I was a bit embarrassed by the framing of the discussion: Chamois presents Deleuze's concepts as hypotheses demanding verification that they are “corroborated by the facts.” For Deleuze, concepts are inseparable from percepts and affects; as opposed to a hypothesis, a concept is true not because it correlates to a set of relevant facts but because it helps us to perceive other aspects of the world (percept) and induces us to act better (affect). Thus, the minute and rewarding analysis of Chamois should be complemented with an assessment of what we learn to focus on and of how we change our actions thanks to the perspectivism of Deleuze—in contrast to other forms of perspectivism (or indeed to other cosmologies). (shrink)

Jakob von Uexküll (1864–1944) was a biologist, but the impact of his work has been perhaps stronger and more persistent in philosophy and the humanities than in the natural sciences. As one of the contributors to this book observes, Uexküll's conception of biology is “more at home among the disciplines composing the Geisteswissenschaften [humanities] than those included in the Naturwissenschaften [sciences], insofar as Uexküll's biology put Verstehen [understanding] before Erklären [explaining].” Uexküll began his career as an experimentalist of a “proto-behaviorist” (...) kind but came rapidly to be dissatisfied with the reduction of physiology to action-and-reaction chains. He argued that the animal-as-machine, the model that lies behind behaviorism, cannot be the starting point of biology. The relation between cause and effect in a machine is direct: the wings of a windmill, say, transfer their movement to a cog even if no one is there to perceive the transfer. In contrast, in the realm of the living, “a stimulus must be ‘noticed’ by a subject” to have any effect. Thus, Uexküll claims, “the first task of [the biologist] consists in seeking out the animal's perception signs”—in searching for what, in its surroundings, an animal perceives and of what it takes notice.Uexküll defined surroundings (Umgebung) as the whole physical reality in the vicinity of an animal, whereas by the term environment (Umwelt) he meant only that part of an animal's surroundings that it perceives. Given Uexküll's understanding of biology as the study of signs of perception (Merkmale), it is no surprise that his work has been a crucial source of inspiration for semiotics. Only one chapter of this new book is devoted to that topic, since Uexküll's presence in the field of semiotics (and in biosemiotics more particularly) is already well documented and analyzed in many publications, whereas his impact on the field of philosophy has been less studied (Brett Buchanan's Onto-Ethologies is, to date, perhaps the best study of that kind). Martin Heidegger was not the first to import the Umwelt theory into philosophy (Max Scheller, Helmuth Plessner, and Ernst Cassirer did so before him, and to each of them a chapter is devoted), but Heidegger is the most famous. It was by reworking an example of Uexküll's—“the rock on which the lizard lies is not given to the lizard as rock, in such a way that it could inquire into its mineralogical constitution for example”—that Heidegger characterized the divergent ways in which animals and humans approach the world. The former can use the things of the world, but humans are uniquely capable of conceiving things as independent of their use of them. We have no more direct access to our physical surroundings than other animals do, but, Heidegger held, we are at least able to imagine our surroundings and the things that fill them as independent of us (and eventually to examine them in the way that a mineralogist examines stones).Thus, Heidegger used Uexküll to set out an “ontological difference” between humans and animals. Gilles Deleuze, on the other hand, made use of Uexküll to advance a nondualistic ontology in which “the affects [that animals] are capable of” is given as the definition of bodies—a definition, he emphasized, “no less valid for us, for humans, than for animals.” Other philosophers whose understanding and use of Uexküll are examined in detail include Maurice Merleau-Ponty, Georges Canguilhem, Hans Blumenberg, and Giorgio Agamben; in addition to the complementary chapter on Uexküll and semiotics, already mentioned, there is one on his place in hermeneutics and one on the influence of Kant. The final chapter concerns the remaking of Uexküll by artists. In this way, this collection of studies offers a varied, detailed, well-structured, and engaging presentation of one of the most original biologists of the last century. As a whole, this book is an example of philosophy at its best—which is: when it specifies, pluralizes, and intensifies the thoughts and works of others. (shrink)

The title of this book, by one of the great editors and publishers of our time, comes from its first and longest chapter: “How to Organize a Library.” In it, Calasso celebrates the “golden rule” proposed by Aby Warburg: “In the perfect library, when we look for a given book, we end up taking the one next to it, which would reveal itself even more useful than the one we were looking for.” It demands effort, knowledge, and sensibility to “curate” (...) such a library, where each book maintains good neighborly relations with the others. Such a library is an oeuvre requiring constantly to be maintained and refreshed, because a book is never a self-contained, self-sufficient object. Each book is connected to others in myriad and surprising ways.Calasso applies this relational understanding of books in a very short chapter on, reputedly, the first book review ever written: Madame de Sablé’s little note of 1665 on her friend La Rochefoucauld's Maximes. In that book, which prefigures some of Nietzsche's ideas, La Rochefoucauld argues that “most often our virtues are nothing but disguised vices” (Nos vertus ne sont, le plus souvent, que des vices déguisés). Before submitting her review to the Journal des Savants, which had been inaugurated only a few months earlier, Madame de Sablé sent it to La Rochefoucauld, asking him to amend it as needed or even to “throw it into the fire.” Calasso compares the original review and the corrected version that was eventually published. La Rochefoucauld erased many passages, making a short text (273 words) even shorter (189 words). In the process, he wiped out the first sentence, the most important, where Sablé summarized what she saw as the achievement of the Maximes: “It is a treatise about movements of the heart of man which we may say have been ignored until now” (C'est un traité des mouvements du cœur de l'homme, qu'on peut dire lui avoir été inconnus jusqu’à cette heure). Calasso comments: “Nothing more radical and more courageous could be written about the Maximes of La Rochefoucauld. However, the author of the work did not hesitate to cancel those very words—perhaps to avoid frightening people, himself included.” In other words, Calasso suggests that Sablé understood the Maximes better than its author did. The culture of book reviewing ushered in by Madame de Sablé taught and continues to teach us that a book may be more than its author believes it to be. Indeed, every book is in need of attentive and penetrating readers to discover its latent potentialities. (shrink)