The correct execution of the DNA replication process is crucially import for the maintenance of genome integrity of the cell. Several types of sources, both endogenous and exogenous, can give rise to DNA damage leading to the DNA replication fork arrest. The processes by which replication blockage is sensed by checkpoint sensors and how the pathway leading to resolution of stalled forks is activated are still not completely understood. However, recent emerging evidence suggests that one candidate for a sensor of (...) replication stress is ATR and that, together with a member of RecQ family helicases, Werner syndrome protein (WRN) and MRE11 complex, can collaborate to promote the restarting of DNA synthesis through the resolution of stalled replication forks. Here, we discuss how WRN, the MRE11 complex and the ATR kinase could work together in response to replication blockage to avoid DNA replication fork collapse and genome instability. BioEssays 26:306–313, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

The Handbook of Formal Argumentation is a community effort aimed at providing a comprehensive and up-to-date view of the state of the art and current trends in the lively research field of formal argumentation. The first volume of the Handbook is organised into five parts, containing nineteen chapters in all, each written by leading experts in the field. The first part provides a general and historical perspective on the field. The second part gives a comprehensive coverage of the argumentation formalisms (...) available in the literature at various levels of abstraction. The third part is devoted to cover some of the many dialogical aspects of argumentation, while the fourth one deals with algorithmic, computational and implementation issues. Finally, the fifth part provides some deeper analyses on the previously introduced topics. The Handbook of Formal Argumentation is an open-ended initiative of which the present volume is the first outcome. Further volumes are planned to cover topics not included in the present one and the initiative is conceived to grow by the support and feeding it receives from the community members. (shrink)

Léon Brunschvicg's contribution to philosophical thought in fin-de-siècle France receives full explication in the first English-language study on his work. Arguing that Brunschvicg is crucial to understanding the philosophical schools which took root in 20th-century France, Pietro Terzi locates Brunschvicg alongside his contemporary Henri Bergson, as well as the range of thinkers he taught and influenced, including Lévinas, Merleau-Ponty, de Beauvoir, and Sartre. Brunschvicg's deep engagement with debates concerning spiritualism and rationalism, neo-Kantian philosophy, and the role of mathematics in (...) philosophy made him the perfect supervisor for a whole host of nascent philosophical ideas which were forming in the work of his students. Terzi outlines Brunchvicg's defence of neo-Kantian judgement, historical analysis and the inextricability of the natural and humanist sciences to any rigorous system of philosophy, with wide-ranging implications for contemporary scholarship. (shrink)

The absence of an English translation of Gonzaga's writings, both as a whole and separately, , inspired me to undertake it with the aim of making it more accessible to the public. If I were to talk briefly about the outline, the first original French version of the text appears as an anonymous author's work. In that first version signed by Sir Thomas Witth whom nothing is known about, Gonzaga doesn’t appear. His name hadn’t been appearing in the first booklet (...) for seven years until it appeared as translator in the 1807 version. Researchers concur that this was actually a trick which Gonzaga has been hiding behind because he probably never had the courage to introduce himself as the author. It is claimed that it has been conducted a lot of research in order to recover the text of Sir Thomas Witth or other possible authors with a similar name but any satisfactory solution to the riddle has not yet been given. Regarding historical data carried out during my research, I would like to offer my opinion that there is the Scottish philosophy of Common Sense hidden behind this pseudonym which deserves attention. (shrink)

This article endeavors to describe and explain the constitution of modernity, its different trajectories, and its ongoing crisis using the Weberian concept of ‘legitimate order’, and by considering the changing relations between orders. One possible basis for the interpretation of the changing constitution of modernity – which involves, most significantly, a move beyond the great public/private dichotomy – is drawn from economic theory, or rather theories, of goods. The ability of certain orders to produce certain types of goods and to (...) allocate them defines different types of society; in different societies, the same good will differ in nature and occupy a place within different property regimes. Changing relations can also be analyzed on the basis of the capacity of an order to impose upon others its negative externalities, and to manage effectively the production and allocation of its characteristic goods at different territorial scales. (shrink)

Léon Brunschvicg's contribution to philosophical thought in fin-de-siècle France receives full explication in the first English-language study on his work. Arguing that Brunschvicg is crucial to understanding the philosophical schools which took root in 20th-century France, Pietro Terzi locates Brunschvicg alongside his contemporary Henri Bergson, as well as the range of thinkers he taught and influenced, including Lévinas, Merleau-Ponty, de Beauvoir, and Sartre. Brunschvicg's deep engagement with debates concerning spiritualism and rationalism, neo-Kantian philosophy, and the role of mathematics in (...) philosophy made him the perfect supervisor for a whole host of nascent philosophical ideas which were forming in the work of his students. Terzi outlines Brunchvicg's defence of neo-Kantian judgement, historical analysis and the inextricability of the natural and humanist sciences to any rigorous system of philosophy, with wide-ranging implications for contemporary scholarship. (shrink)

The paper provides both a description of conspiracy beliefs and an insight into their cultural significance. On one side, it highlights their specific formal features, on the other, and this constitutes its peculiarity in the recent literature on the topic, it considers them within the broader genre of general conceptual beliefs, whose main characteristics are weak methodology and logical structure, strong affective and dispositional constraints, epistemic closure and mauvaise foi, and whose main function is practical and self-representative (not epistemic). The (...) paper also claims that political theory and social sciences had some influence in legitimizing certain ideas and stereotypes that are exacerbated in conspiracy beliefs, while other te(le)ological conceptions, such as finalism and providence, may be an important source of ideas that turn out to be widely spread in contemporary criticism towards those same beliefs. (shrink)

The aim of this paper is to show that humanlanguage is context-dependent in a veryspecific way. In order to support this thesis,a detailed comparison is made between the waysin which verbal expressions depend on thecontext of occurrence and evaluation and animalcommunication systems. The comparisonhighlights a series of analogies anddifferences between human language and thecommunication systems of other animals. Myproposal is to use the term `indexicality' toindicate the characteristic way of using thecontext in human language and to use the moregeneral phrase (...) `context-dependence' for thecorresponding phenomenon in animalcommunication systems. (shrink)

The mention of a “Dog” (Κύων) by Aristot. Rhet. 3,10,1411a24-25 should be interpreted as a reference to Diogenes the Cynic, and not to Antisthenes, as was argued by Goulet- Caze.

Reciprocal libertarianism is a version of left-wing libertarianism that combines self-ownership with an egalitarian distribution of resources according to reciprocity. In this paper, I show that reciprocal libertarianism is a coherent and appealing view. I discuss how reciprocal libertarians can handle conflicts between self-ownership and reciprocity, and I show that reciprocal libertarianism can be realised in a framework of individual ownership of external resources or in a socialist scheme of common ownership (libertarian socialism). I also compare reciprocal libertarianism with left-libertarian (...) approaches: I argue that a reciprocity-sensitive version of left-libertarianism (reciprocal left-libertarianism) is coherent and morally superior to traditional left-libertarianism, on grounds of incorporating a distinctively solidaristic and recognition-oriented aspect of equality. The policy implications of reciprocal libertarianism will differ depending on which rights people can have over external resources, but all reciprocal libertarian views acknowledge the existence of social rights that people have as co-operators. (shrink)

The chapter explores comparatively the attention to the practical dimension that—each in his own way—Michel Foucault, Friedrich Nietzsche, and the classic pragmatist thinker William James pay when confronted with the challenge of providing a non-skeptical response to the relativist stance on truth that arose in the post-Kantian age. Particular focus will be given to the extent to which these three authors conceived of the practical framework as the only one that allows us to meaningfully address and determine truth.

Commentary on Romans The thirtenth Chapiter "Let every soule be subject to the higher powers : for ther is no power but of God : and the powers that be, ...

This chapter explores Nietzsche’s and Wittgenstein’s views on language and knowledge, establishing a philosophical dialogue between two different positions, which are based on a similar anti-essentialist and instrumentalist concern. The chapter will first focus on Nietzsche’s conception of language as the expression of valuational perspectives developing through the natural and cultural history of mankind. It will then consider Wittgenstein’s account of language as the inherited background of our practical engagement with the world. Finally, by bringing Nietzsche’s and Wittgenstein’s views together, (...) the last section reflects on the crucial strategic move they make in their respective battle against the bewitchment of our intelligence by means of language. -/- . (shrink)

The knowledge of truth, in Plato, is an experience that calls for conversion of the soul (μεταστροφή, περιστροφή). The basic feature of this experience consists in some sort of connection, which is constantly at work, between rational arguments and their non-rational conditions, briefly, lógos and páthos. How does this connection show up in Plato? Its crucial importance emerges many times at both narrative (récit) and theoretical level. In the three parts of my contribution, I show how logos-pathos intertwines with Plato's (...) notion of conversion considered as a double-sided phenomenon, as both "process" of moral education and "noetic event". (shrink)

In this paper I discuss the role played by Ernst Mach on Nietzsche’s thought. Starting from the contents of his Beiträge zur Analyse der Empfindungen, I’ll show the close similarities between their view on both human knowledge and the scientific world description. In his writing on science Nietzsche shares Mach’s critique to the 19th century mechanism and its metaphysical ground, as much as his way of defining the substantial notions such as matter, ego and free will. Moreover, my investigation will (...) make it clear that Mach cannot be seen as a direct source of Nietzsche’s thought, since the latter wrote many times on the same subjects long before his first reading one of his works. Rather, it is possible to consider the writings of Lange, Spir and Spencer as the first sources of Nietzsche’s views on the main themes Mach dealt with in his work from 1886. (shrink)

Wilfrid Sellars’ denunciation of the Myth of the Given was meant to clarify, against empiricism, that perceptual episodes alone are insufficient to ground and justify perceptual knowledge. Sellars showed that in order to accomplish such epistemic tasks, more resources and capacities, such as those involved in using concepts, are needed. Perceptual knowledge belongs to the space of reasons and not to an independent realm of experience. Dan Hutto and Eric Myin have recently presented the Hard Problem of Content as an (...) ensemble of reasons against naturalistic accounts of content. In a nutshell, it states that covariance relations—even though they are naturalistically acceptable explanatory resources—do not constitute content. The authors exploit this move in order to promote their preferred radical enactivist and anti-representationalist option, according to which, basic minds—the lower stratum of cognition—do not involve content. Although it is controversial to argue that the Hard Problem of Content effectively dismisses naturalistic theories of representation, a central aspect of it—the idea that information as covariance does not suffice to explain content—finds support among the defenders of classical cognitive representationalism, such as Marcin Miłkowski. This support—together with the acknowledgment this remark about covariance is a point already made by Sellars in his criticism of the Myth of the Given—has a number of interesting implications. Not only is it of interest for the debates about representationalism in cognitive science, where it can be understood as an anticipatory move, but it also offers some clues and insights for reconsidering some issues along Sellarsian lines—a conflation between two concepts of representation that is often assumed in cognitive science, a distinction between two types of relevant normativities, and a reconsideration of the naturalism involved in such explanations. (shrink)

In Part One of Beyond Good and Evil Nietzsche writes that anyone who believes in “immediate certainties” such as “I think” encounters a series of “metaphysical questions”. The most important of these “problems of intellectual knowledge” concerns the existence of an ‘I’, as much as our believing it to be the cause of thinking. Therefore, any remark about our mental faculties directly follows from our defining what we could call the basic psychical unity, i.e. our view on higher-level psychical functions (...) is strictly related with the properties we attribute to the notion of ‘I’. As we know, the main ideas on this subject that Nietzsche states in his book from 1886 come from the neo-kantian views of Lange, Spir and Teichmüller, and we cannot forget the important (even if hidden) reference to Lichtenberg in § 17 of the same work. Nevertheless, Nietzsche seems to move beyond all these sources, and in many of his writings we can find a new definition of the ‘ego’, finally free from any reference to a thing in itself, and for this reason closer to the ideas of the Austrian scientist Ernst Mach. In this paper I shall carry these remarks out. I’ll show the main properties of the notion of ‘I’ Nietzsche concerns with in his writings and, therefore, the grounds of his view on the mind-body problem. Moreover, I will argue that, once we observe that Nietzsche looks at the ‘ego’ as a mere regulative fiction having no ontological value out of the chain of sensation and representation it brings together, we could find out the close similarity with the way Mach defines it in his Beiträge zur Analyse der Empfindungen (1886). This reference could help us to understand in a better way some statements Nietzsche wrote in his notebooks, and, secondly, to show how strictly was his philosophy of mind related with the main outcomes of 19th century science. Indeed, Nietzsche’s refusal of the belief “that there must necessarily be something that thinks” ‒ a view that results from the anti-metaphysical intent leading his naturalism ‒ seems to be one of the most important assumptions of the new born physiological psychology, an idea out of which many of the 20th century philosophical debates arose. (shrink)

Drawing upon multiple research fields, this volume explores the affinities between the work of Marx and Wittgenstein, arguing that although they belong to two different philosophical traditions, their thinking can offer benefits across both political philosophy and philosophy of language.

ITA: Quello del “buon europeo” è in Nietzsche un tema significativo, che si presenta originariamente connesso alle riflessioni di Nietzsche sulla cultura europea, arricchendosi col tempo di una portata filosofica che si lega agli obiettivi del suo pensiero maturo. Scopo del presente articolo è di mostrare la genesi e l’evoluzione di tale concetto, a partire dalle sue prime occorrenze in Umano, troppo umano I fino al suo compiuto sviluppo negli scritti del 1885-87. Tale studio permetterà di evidenziare il particolare valore (...) che Nietzsche attribuisce ai “buoni europei”, in quanto promotori dello sviluppo spirituale conseguente alla compiuta liberazione della morale cristiana. ENG: The “good European” is a rich and important topic in Nietzsche. It is first related to Nietzsche’s early reflections on European culture, and during the 1880’s it gains philosophical value, being strictly connected with the purposes of Nietzsche’s mature thought. The aim of this paper is to track the genesis and development of the notion of “good European”, from Human, all too Human I to Nietzsche’s writings from the years 1885-1887. That investigation shall particularly show the meaning and value that Nietzsche attributes to the good Europeans; as for him, they are in fact the leaders of the spiritual development that follows the overcoming of Christian morality. (shrink)

This critical essay evaluates the potential integration of distinct kinds of expertise in policymaking, especially during situations of critical emergencies, such as the COVID-19 pandemic. This article relies on two case studies: herd immunity and restricted access to ventilators for disabled people. These case studies are discussed as examples of experts’ recommendations that have not been widely accepted, though they were made within the boundaries of expert epistemic authority. While the fundamental contribution of biomedical experts in devising public health policies (...) during the COVID-19 pandemic is fully recognized, this paper intends to discuss potential issues and limitations that may arise when adopting a strict expert-based approach. By drawing attention to the interests of minorities, the paper also claims a broader notion of “relevant expertise.” This critical essay thus calls for the necessity of wider inclusiveness and representativeness in the process underlying public health policymaking. (shrink)

Dans l’étude des relations entre la philosophie et la sociologie naissante en France, un chapitre demeure inexploré : l’interprétation des sciences sociales par Léon Brunschvicg. S’il apprécie la valeur de la recherche ethnologique de Lévy-Bruhl, sa critique de Durkheim est sévère. Il identifie deux problèmes dans le projet durkheimien, étroitement liés : avoir cherché l’origine de la connaissance dans des formes « primitives » de savoir ; avoir soumis l’autonomie du jugement au primat du social. L’idéalisme critique de Brunschvicg cherche (...) alors à opposer aux représentations collectives de Durkheim un autre modèle d’esprit collectif, incarné dans les avancées de la science et dans le progrès de la philosophie scientifique. (shrink)

The conversation between Giorgio Barberio Corsetti and Pietro Montani, led by Dario Cecchi, focuses on some of the principal aspects of the career and work of Paolo Rosa and Studio Azzurro, by making reference also to the occasion when the director and the philosopher met the artist and his team. Of such an artistic path, they have been particularly emphasized the interest for the dialogue among different artistic languages (theatre, video art); the attention to the way images are able (...) to refresh the meaning of action and word within theatre and performing arts generally speaking; the relationship between art and technics in the perspective of a “poetic” (or better “poietic”) use of technologies and media; the importance given to the public (ethical and political) dimension of images and art installations, able to working through the sense of belonging to a community. (shrink)

Friedrich Nietzsche’s criticism towards the substance-concept „I“ plays an important role in his late thought, and can be properly understood by making reference to the 19th century debate on the scientific psychology. Friedrich Lange and Ernst Mach gave an important contribution to that debate. Both of them developed the ideas of Gustav Fechner, and thought about a „psychology without soul“, i.e. an investigation that gives up with the old metaphysics of substance in dealing with the mind-body problem. In this paper (...) I shall deal with both Lange and Mach (whose writings has been read by Nietzsche), in order to shed some light on Nietzsche’s rejection of the „I“ in philosophy. (shrink)

As consumers represent a key actor for the success of businesses implementing socially responsible strategies, companies need to gain further insights on the determinants of responsible behaviors. In this study, we provide a contribution to the ongoing debate on responsible consumers by means of an integrative literature review, which analyzes a set of competing models mainly from social psychology and marketing. Stemming from this preliminary analysis of the existing evidence, we develop a new conceptual model, that is, a framework based (...) on (i) a flexible setting of the boundaries of analysis, (ii) a broader lens taking into account interrelations across behaviors, and (iii) a dynamic approach. The framework, for which an exemplary use is illustrated, represents the basis for advancing a rich agenda for future research. The latter is aimed at overcoming current criticalities in responsible consumer research, and it develops around the need for an integrative, dynamic, and cross-cultural approach on the one hand, and the elaboration of new perspectives on single antecedents, on the other. (shrink)

This paper presents a novel argumentation framework to support Issue-Based Information System style debates on design alternatives, by providing an automatic quantitative evaluation of the positions put forward. It also identifies several formal properties of the proposed quantitative argumentation framework and compares it with existing non-numerical abstract argumentation formalisms. Finally, the paper describes the integration of the proposed approach within the design Visual Understanding Environment software tool along with three case studies in engineering design. The case studies show the potential (...) for a competitive advantage of the proposed approach with respect to state-of-the-art engineering design methods. (shrink)

Orthodox decision theory is fanatical in the way it treats small probabilities of enormous value, if unbounded utility functions are allowed. Some have suggested a fix, Nicolausian discounting, according to which outcomes with small enough probabilities should be ignored when making decisions. However, there are lotteries involving only small-probability outcomes, none of which should intuitively be ignored. So the Nicolausian discounter needs a procedure for distinguishing the problematic cases of small-probability outcomes from the unproblematic ones. In this paper, I present (...) a dilemma for Nicolausian discounting: the view must be coupled either with a procedure that delivers fanatical verdicts of its own, as bad as those of orthodox decision theory, or with one that entails intransitive cyclic preferences. (shrink)

Hans Kleinpeter’s letters to Ernst Mach held in the Deutsches Museum Archive in Munich are of the greatest importance in order to learn some details of the relationship between these scholars. In the three letters here entirely published for the first time, Kleinpeter shows his interest for Nietzsche’s thought, and states that some of the latter’s ideas are in compliance with Mach’s epistemology.

Les premiers Séminaires de Jacques Lacan (1953-1959) offrent une élaboration systématique des notions de l’Imaginaire et du Symbolique, mais font référence de façon seulement sporadique à la notion du Réel. Malgré la rareté des références, la conception du Réel que l’on peut en déduire est précise et cohérente, et confirmée par les séminaires successifs – au moins jusqu’au Séminaire XI (1964). Le Réel est à comprendre comme une matière indéterminée qui, tout en pâtissant du signifiant, lui résiste. Ceci constitue une (...) innovation, de la part de Lacan, par rapport au concept philosophique classique de la matière (du moins tel qu’on le trouve chez Aristote, pour qui la matière n’offre aucune résistance à sa propre mise en forme) et prépare la base pour la théorie de l’objet a en tant que signifiant de la castration du sujet opérée par le langage, telle qu’elle est élaborée à la fin du Séminaire VI (1958-1959) et dans le Séminaire X (1962-1963). (shrink)

Le but de cette contribution c'est d'analyser la lecture derridienne du Monsieur Teste de Valéry afin de montrer que, par cette figure énigmatique, Derrida a voulu proposer une déconstruction double : une déconstruction de l’égologie souveraine au moyen de l’hétérologie contre-souveraine et vice-versa.

We present a logic of evidence that reduces agents’ epistemic idealisations by combining classical propositional logic with substructural modal logic for formulas in the scope of epistemic modalities. To this aim, we provide a neighborhood semantics of evidence, which provides a modal extension of Fine’s semantics for relevant propositional logic. Possible worlds semantics for classical propositional logic is then obtained by defining the set of possible worlds as a special subset of information states in Fine’s semantics. Finally, we prove that (...) evidence is a hyperintensional and non-prime notion in our logic, and provide a sound and complete axiomatisation of our evidence logic. (shrink)

The paper explores the consistency between William James's and Friedrich Nietzsche's approaches towards the general philosophical issue of relativism. As will be shown, Nietzsche as much as James attempted to develop a non-nihilist strategy for dealing with the problem of truth based on the idea that a revaluaton of that notion is in fact possible on practical i.e. experiential basis.

Ineffability in Plato is a conundrum. There are at least four dimensions of ineffability in Platonic texts: epistemic (divine), strategic (religious), unspeakability and incommunicability. In this paper, I deal only with the first dimension, which is strictly epistemic in kind, and defend that Plato rejects divine ineffability, namely, the belief that the knowledge of the divine in general is inaccessible to the human mind. Several crucial passages attest to this rejection unequivocally. They show that Plato attached a great philosophical relevance (...) to what I call the equivalenceprinciple, namely, the interdependence or specularity between human and divine intelligence. The assertion of this principle represents the Platonic path to absolute knowledge, which I try to locate in the broader context of the history of philosophy, from early philosophers to Hegel. (shrink)

We discuss the role of perceptron (or threshold) connectives in the context of Description Logic, and in particular their possible use as a bridge between statistical learning of models from data and logical reasoning over knowledge bases. We prove that such connectives can be added to the language of most forms of Description Logic without increasing the complexity of the corresponding inference problem. We show, with a practical example over the Gene Ontology, how even simple instances of perceptron connectives are (...) expressive enough to represent learned, complex concepts derived from real use cases. This opens up the possibility to import concepts learnt from data into existing ontologies. (shrink)