Qu'est-ce que l'humain? ou comment deux savants assez philosophes et un philosophe assez savant reviennent sur la distinction classique entre nature et culture. Notre tradition culturelle posait une barrière quasiment étanche entre l'animal et l'humain. Nous savons aujourd'hui que nous partageons avec nos cousins les plus récents l'immense majorité de notre matériel génétique. Alors qu'est-ce qui spécifie l'humain? Trois réponses venues de trois disciplines : la neurobiologie, en un va et vient entre sciences cognitives et biologie du système nerveux, la (...) paléoanthropologie, à la charnière de la théorie de l'évolution et de la préhistoire, et la philosophie. (shrink)

New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)

The idea of a common currency underlying our choice behaviour has played an important role in sciences of behaviour, from neurobiology to psychology and economics. However, while it has been mainly investigated in terms of values, with a common scale on which goods would be evaluated and compared, the question of a common scale for subjective probabilities and confidence in particular has received only little empirical investigation so far. The present study extends previous work addressing this question, by showing that (...) confidence can be compared across visual and auditory decisions, with the same precision as for the comparison of two trials within the same task. We discuss the possibility that confidence could serve as a common currency when describing our choices to ourselves and to others. others. (shrink)

The first aim of simulation in virtual environment is to help biologists to have a better understanding of the simulated system. The cost of such simulation is significantly reduced compared to that of in vivo simulation. However, the inherent complexity of biological system makes it hard to simulate these systems on non-parallel architectures: models might be made of sub-models and take several scales into account; the number of simulated entities may be quite large. Today, graphics cards are used for general (...) purpose computing which has been made easier thanks to frameworks like CUDA or OpenCL. Parallelization of models may however not be easy: parallel computer programing skills are often required; several hardware architectures may be used to execute models. In this paper, we present the software architecture we built in order to implement various models able to simulate multi-cellular system. This architecture is modular and it implements data structures adapted for graphics processing units architectures. It allows efficient simulation of biological mechanisms. (shrink)

Au sein du service de placement où exerce en tant que psychologue le premier auteur de cet article a été développée une recherche longitudinale qui vise à explorer le fonctionnement psychique des adolescents auteurs de violences sexuelles et les modalités de leur accompagnement éducatif et thérapeutique. L’article propose de se centrer sur leur placement en famille d’accueil, la dynamique relationnelle témoignant des particularités des liens tissés avec les premiers objets. La présentation de la situation de Nicolas mettra en exergue les (...) difficultés, malentendus et usures qui semblent illustrer un scénario qui se répète et qui conduit à la rupture. Les auteurs ouvrent une réflexion, dans une perspective psychodynamique, pour tenter de comprendre les mouvements psychiques à l’œuvre du côté de l’adolescent, notamment sur un plan intersubjectif, dans la perspective développée par René Kaës, et invitent à s’intéresser aux adaptations nécessaires au sein des dispositifs éducativo-thérapeutiques d’accompagnement. (shrink)

Although complex hallucinations are extremely vivid, painful symptoms in schizophrenia, little is known about the underlying mechanisms of multisensory integration in such a phenomenon. We investigated the neural basis of these altered states of consciousness in a patient with schizophrenia, by combining state of the art neuroscientific exploratory methods like functional MRI, diffusion tensor imaging, cortical thickness analysis, electrical source reconstruction and trans-cranial magnetic stimulation. The results shed light on the functional architecture of the hallucinatory processes, in which unimodal information (...) from different modalities is strongly functionally connected to higher-order integrative areas. (shrink)

As part of the conference commemorating Theoria's 75th anniversary, a round table discussion on philosophy publishing was held in Bergendal, Sollentuna, Sweden, on 1 October 2010. Bengt Hansson was the chair, and the other participants were eight editors-in-chief of philosophy journals: Hans van Ditmarsch (Journal of Philosophical Logic), Pascal Engel (Dialectica), Sven Ove Hansson (Theoria), Vincent Hendricks (Synthese), Søren Holm (Journal of Medical Ethics), Pauline Jacobson (Linguistics and Philosophy), Anthonie Meijers (Philosophical Explorations), Henry S. Richardson (Ethics) and Hans (...) Rott (Erkenntnis). (shrink)

As part of the conference commemorating Theoria's 75th anniversary, a round table discussion on philosophy publishing was held in Bergendal, Sollentuna, Sweden, on 1 October 2010. Bengt Hansson was the chair, and the other participants were eight editors‐in‐chief of philosophy journals: Hans van Ditmarsch (Journal of Philosophical Logic), Pascal Engel (Dialectica), Sven Ove Hansson (Theoria), Vincent Hendricks (Synthese), Søren Holm (Journal of Medical Ethics), Pauline Jacobson (Linguistics and Philosophy), Anthonie Meijers (Philosophical Explorations), Henry S. Richardson (Ethics) and Hans (...) Rott (Erkenntnis). (shrink)

This article examines the philosophical and theological nuances in the works of Étienne Pascal and Étienne Noël, focusing on their interpretations of Saint Augustine and Jean Duvergier de Hauranne. It explores the concept of antithesis (ἀντίθεσις) in both rhetorical and philosophical contexts, drawing upon Platonic and Aristotelian texts. The article highlights the use of antithesis in Augustine’s explanation of evil and its integration into the universal order, connecting this to 17th-century French thought, especially in relation to Blaise Pascal’s (...) ideas on rhetoric. A critical analysis of Étienne Pascal’s letter to Father Noël is presented, emphasizing his understanding of rhetorical figures, notably metaphor and antithesis, and their theological implications. The discussion extends to Saint-Cyran’s interpretation of Augustine, particularly concerning ecclesiastical guidance and priesthood preparation. The article concludes by underscoring the complex interplay between language, thought, and faith in these historical contexts. (shrink)

"Certitude" : le Mémorial -- "Quelle morale la raison devrait dicter sans la lumière de la foi" : l'entretien de M. Pascal avec M. de Sacy -- "La vérité hors de la charité" : du mystère de la pénitence -- "N'y a-t-il point une vérité substantielle?" : infini, rien -- "Qu'on ne prétende pas subtiliser" : les Écrits sur la grâce -- "La maxime de la médisance" : la XVIe Provinciale -- "Ce qui achève notre impuissance" : disproportion de (...) l'homme -- "De nouvelles lumières sur la religion" : la Vie de M. Pascal et De la vraie religion -- De vera religione -- Annexe : "Le chosisme" : Étienne Gilson et Pascal -- "Un portrait porte absence et présence" : De la vraie religion -- "Dans l'ennui" : du divertissement -- "Nous ne nous tenons jamais au temps présent" : du divertissement -- "En lui vous êtes remplis" : la Prière pour le bon usage des maIadies -- L'amitié "sans attachement" : la Vie de M. Pascal. (shrink)

I analyze the complex relations between Pascal and the three figures of Montaigne, Descartes, and St. Augustine, and the relations the first two figures bear to St. Augustine. For Pascal's philosophy, one is in effect a resource , another a way of thinking that he makes his own , and yet another serves as a model . I further investigate Pascal's anti-Augustinism, that is, some of the points of resistance in Pascal against the thought of St. (...) Augustine. Central to this investigation is the famous rapprochement between the cogitos of Augustine and Descartes, which requires a consideration of what, for Pascal, it means "to say the same thing." This analysis leads us to two conclusions: first, Augustine's The City of God should be placed among the number of works that Pascal did not read; second, there are fundamental philosophical reasons for Pascal to reject certain theses central to that work. Above all, there should no longer be any need to assume a merely abstract conception of an unproblematic Augustinianism in Pascal. (shrink)

Focusing on Descartes’ striking phrase “real things” in Discours de la methode, and on the one of “reality of things” written by Pascal in his Pensées, this paper aims to shed light on Cartesian co...

"Réfléchir à la réflexion, penser la pensée et philosopher sur la philosophie, voilà ce que l'on propose de faire ici. Cette démarche est moins formelle qu'il n'y paraît, car interroger la nature et les exigences de la pensée philosophique engage toute une philosophie. Une philosophie qui n'est pas dupe d'elle-même et qui commence par examiner sa propre finitude. "La dernière démarche de la raison, c'est de connaître qu'il y a une infinité de choses qui la surpassent. Elle est bien faible (...) si elle ne va jusque là", disait Pascal. Nous montrons dans un esprit proche que la réflexion est d'autant plus puissante qu'elle reconnaît son impuissance, comme la philosophie authentique doit se savoir doublement bornée, par la pensée scientifique d'une part, et par la pensée mystique d'autre part. Il ne s'agit pas de rabaisser la philosophie, mais au contraire de lui permettre de comprendre ce qui la comprend et de trouver sa juste place dans le champ intellectuel."--Page 4 of cover. (shrink)

The books of Pascal Quignard present themselves as a hunt for the invisible. The ambition that lies at their heart seems particularly compatible with a phenomenological approach. Indeed, this literary intuition – this “suspicion” in the words of Quignard – hinges on the nature and value of representation. This article tries to read the entire work of Quignard through the phenomenological lens. The elucidation of phenomenality is accomplished here through the steps of a process that leads to the very (...) condition of vision. Once the essence of representation is established as a “predation”, the literary writing of the author reveals it as related to an absent, invisible prey. Through the successive and ascending figures of idolatry, love, art and contemplation, can then start a route to invisibility, which is a true pedagogy of seeing. This quest, conceivable as a learning process through which literature finds its ultimate aim, finally leads to a renewed understanding of the concept of representation. (shrink)

Le dernier ouvrage d’Antony McKenna, intitulé Pascal et son libertin, présente en une synthèse claire et précise les résultats de plus de trente années consacrées par l’auteur aux études pascaliennes et à l’étude de la pensée libertine de la période classique. Auteur d’une thèse d’État publiée sous le titre De Pascal à Voltaire : le rôle des Pensées de Pascal dans l’histoire des idées entre 1670 et 1734 puis de plus d’une centaine d’études d’histoire de la philosophie (...) du XVIIe et du XVIIIe si... (shrink)

Analyse critique de deux ouvrages récents dans lesquels Vincent Descombes critique les conceptions cartésiennes et matérialistes contemporaines de l'esprit, d'un point de vue néo-wittgensteinien. Contrairement à ce qu'il croit ni le holisme ni l'externalisme qu'il avance ne sont incompatibles avec une conception causaliste du mental et une forme plus complexe de naturalisme. A critical analysis of two recent books by Vincent Descombes, where he criticizes contemporary Cartesian and materialistic theories of the mind from a neo-Wittgensteinian standpoint. Contrary to (...) what he claims, neither holism nor externalism can be incompatible with a causalist view of the mental and a more sophisticated form of naturalism. (shrink)

Depuis près de quarante ans, Pierre Manent trace une voie originale et féconde. Ses livres interrogent les formes politiques qui donnent sens à l'expérience historique, de la cité grecque aux nations européennes, en passant par l'Empire romain et l'Eglise chrétienne. Cet ouvrage, le premier entièrement consacré à Pierre Manent, aborde les grands thèmes de son oeuvre, autour de trois axes: la philosophie, la politique et la religion. Il examine également les principales étapes de la pensée politique : Aristote, Machiavel, (...) class='Hi'>Pascal, Tocqueville... L'histoire et la philosophie politique éclairent les enjeux du présent, en particulier la crise de la démocratie et de la nation en Europe. Pour Pierre Manent et ceux qui s'en inspirent, la politique constitue le fait générateur des sociétés humaines. Elle façonne l'humanité de l'homme, qui se réalise dans la vie en commun. Aller vers la politique, c'est aller vers l'âme. Une incitation à lire et relire une oeuvre forte et pénétrante. (shrink)

Recent studies have shown that self‐explanation is an effective metacognitive strategy, but how can it be leveraged to improve students' learning in actual classrooms? How do instructional treatments that emphasizes self‐explanation affect students' learning, as compared to other instructional treatments? We investigated whether self‐explanation can be scaffolded effectively in a classroom environment using a Cognitive Tutor, which is intelligent instructional software that supports guided learning by doing. In two classroom experiments, we found that students who explained their steps during problem‐solving (...) practice with a Cognitive Tutor learned with greater understanding compared to students who did not explain steps. The explainers better explained their solutions steps and were more successful on transfer problems. We interpret these results as follows: By engaging in explanation, students acquired better‐integrated visual and verbal declarative knowledge and acquired less shallow procedural knowledge. The research demonstrates that the benefits of self‐explanation can be achieved in a relatively simple computer‐based approach that scales well for classroom use. (shrink)

This paper studies some model-theoretic properties of special groups of finite type. Special groups are a first-order axiomatization of the algebraic theory of quadratic forms, introduced by Dickmann and Miraglia, which is essentially equivalent to abstract Witt rings. More precisely, we consider elementary equivalence, saturation, elementary embeddings, quantifier elimination, stability and Morley rank.

Abstract.We use a model theoretic approach to investigate properties of local-global principles for positive primitive formulas in spaces of orderings, such as the existence of bounds and the axiomatizability of local-global principles. As a consequence we obtain various classes of special groups satisfying local-global principles for all positive primitive formulas, and we show that local-global principles are preserved by some natural constructions in special groups.

Network concepts are omnipresent in contemporary diagnoses, management practices, social science methods and theories. Instigating a critical analysis of network concepts, this article explores the sources and relevance of networks in Foucault’s social theory. I argue that via Foucault we can trace network concepts back to cybernetics, a research programme that initiated a shift from ‘being’ to ‘doing’ and developed a new theory of regulation based on connectivity and codes, communication and circulation. This insight contributes to two debates: Firstly, it (...) highlights a neglected influence on Foucault’s theory that travelled from cybernetics via structuralism and Canguilhem into his concept of power. Secondly, it suggests that network society and governance are neither a product of neoliberalism nor of technological artefacts, such as the Internet. They rather resulted from a distinct tradition of cybernetically inspired theories and practices. (shrink)

Marx says of alienated labor that it does not "belong" to the worker, that it issues in a product that does not belong to her, and that it is unfulfilling, unfree, egoistically motivated, and inhuman. He seems to think, moreover, that the first of these features grounds all the others. All of these features seem quite independent, however: they can come apart; they share no obvious common cause or explanation; and if they often occur together this seems accidental. It is (...) not clear, then, how Marx's concept of alienated labor could possess the strong unity which he takes it to have. I defend a reinterpretation of the concept which explains this unity. The various features of alienated labor, I argue, all follow from a single, hitherto underappreciated feature of its formal motivational structure: the fact that such labor is motivated not by its product but by an incentive. (shrink)

We characterize elementary equivalences and inclusions between von Neumann regular real closed rings in terms of their boolean algebras of idempotents, and prove that their theories are always decidable. We then show that, under some hypotheses, the map sending an L-structure R to the L-structure of definable functions from R n to R preserves elementary inclusions and equivalences and gives a structure with a decidable theory whenever R is decidable. We briefly consider structures of definable functions satisfying an extra condition (...) such as continuity. (shrink)

This book closely examines our commonly held beliefs about human suffering, and offers unique insights into God's role in why we suffer. Dr. Perri critically examines what it means to be human from a Judeo-Christian perspective, and extrapolates from the work of Carl Gustav Jung showing a deeply complex development of human transcendence in human suffering. On an interpersonal level, Dr. Perri elaborates on the work of Martin Buber and Emanuel Levinas and shows how our suffering can be shared and (...) lessened by our unconditionality and presence for the other. Scriptural passages are quoted from both the Hebrew and New Testament texts, and are used to depict the suffering of humankind as seen in the face of Job. It was this face, according to Perri, that Jesus saw in the faces of those He came to redeem, and that ultimately brought Him to the crucifix of redemption. Dr. Perri challenges Sartre's position that our existence precedes our essence, and draws on the work of Abraham Joshua Heschel and Christian theology in this regard. He further elaborates a neurodevelopmental paradigm that creates essence as the basis of our freedom to choose. This book can be read and studied by both professionals in the helping and healing professions, and lay persons seeking to better understand our suffering, and how to better help those who suffer. Dr. Perri offers specific ways in how to be present for those who suffer, how to read and receive the hidden language of human suffering, and how to use silence as a communication skill. (shrink)

Le sceptique nous demande " Comment sais-tu que tu as deux mains? Peut-être rêves-tu, ou es-tu trompé par quelque Malin Génie? Peut-on même définir ce que c'est que la connaissance? Va savoir! " Lui rétorquer, comme le faisaient G.E. Moore et la tradition de la philosophie du sens commun : " Mais je sais bien que j'ai deux mains! " semble à la fois une pétition de principe et une bien mauvaise réponse. Le mieux, depuis que nous avons perdu le (...) souci de fonder nos croyance sur des raisons ultimes, serait, tout simplement, de ne pas se soucier des questions du sceptique. Ce que l'on sait dépend, nous dit-on, des circonstances, et toutes nos connaissances sont faillibles. N'y a-t-il pas plutôt des savoirs, dont l'histoire nous montre combien leurs modes de validations sont variés? Ce livre entend refuser ce type de réponse contextualiste et relativiste. Il propose de revenir à la réponse de sens commun de Moore, à partir des reformulations contemporaines des raisonnements sceptiques issues de la philosophie analytique de la connaissance. Personne ne peut nous envoyer savoir quelque chose que nous ne pourrions pas savoir. De fait, nous savons, mais notre savoir n'est pas transparent : nous n'avons pas besoin de savoir que nous savons. Pour parvenir à cette réponse, il faut replacer la notion de connaissance, plutôt que celle de croyance justifiée ou rationnelle, au centre de l'épistémologie, et reformuler des questions traditionnelles comme celles de la nature de la perception, du témoignage, et de la connaissance a priori. On peut aussi reprendre le vieux projet d'une enquête sur la nature de la connaissance en général. (shrink)