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Nancy Mp King [1]
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  1.  9
    Bioethics reenvisioned: a path toward health justice.Nancy M. P. King - 2022 - Chapel Hill: The University of North Carolina Press. Edited by Gail Henderson & Larry R. Churchill.
    Bioethics needs an expanded moral vision. It is now time for bioethics to take full account of the problems of health disparities and structural injustice that are made newly urgent by the COVID-19 pandemic and the effects of climate change. Nancy M. P. King, Gail E. Henderson, and Larry R. Churchill make the case for a more social understanding and application of justice, a deeper humility in assessing expertise in bioethics consulting, a broader and more relevant research agenda, and greater (...)
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  2.  31
    Defining and Describing Benefit Appropriately in Clinical Trials.Nancy M. P. King - 2000 - Journal of Law, Medicine and Ethics 28 (4):332-343.
    Institutional review boards and investigators are used to talking about risks of harm. Both low risks of great harm and high risks of small harm must be disclosed to prospective subjects and should be explained and categorized in ways that help potential subjects to understand and weigh them appropriately. Everyone on an IRB has probably spent time at meetings arguing over whether a three-page bulleted list of risk description is helpful or overkill for prospective subjects. Yet only a small fraction (...)
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  3. Clarifying the Ethics and Oversight of Chimeric Research.Josephine Johnston, Insoo Hyun, Carolyn P. Neuhaus, Karen J. Maschke, Patricia Marshall, Kaitlynn P. Craig, Margaret M. Matthews, Kara Drolet, Henry T. Greely, Lori R. Hill, Amy Hinterberger, Elisa A. Hurley, Robert Kesterson, Jonathan Kimmelman, Nancy M. P. King, Melissa J. Lopes, P. Pearl O'Rourke, Brendan Parent, Steven Peckman, Monika Piotrowska, May Schwarz, Jeff Sebo, Chris Stodgell, Robert Streiffer & Amy Wilkerson - 2022 - Hastings Center Report 52 (S2):2-23.
    This article is the lead piece in a special report that presents the results of a bioethical investigation into chimeric research, which involves the insertion of human cells into nonhuman animals and nonhuman animal embryos, including into their brains. Rapid scientific developments in this field may advance knowledge and could lead to new therapies for humans. They also reveal the conceptual, ethical, and procedural limitations of existing ethics guidance for human‐nonhuman chimeric research. Led by bioethics researchers working closely with an (...)
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  4.  12
    The Future of Bioethics: It Shouldn't Take a Pandemic.Larry R. Churchill, Nancy M. P. King & Gail E. Henderson - 2020 - Hastings Center Report 50 (3):54-56.
    The Covid‐19 pandemic has concentrated bioethics attention on the “lifeboat ethics” of rationing and fair allocation of scarce medical resources, such as testing, intensive care unit beds, and ventilators. This focus drives ethics resources away from persistent and systemic problems—in particular, the structural injustices that give rise to health disparities affecting disadvantaged communities of color. Bioethics, long allied with academic medicine and highly attentive to individual decision‐making, has largely neglected its responsibility to address these difficult “upstream” issues. It is time (...)
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  5.  15
    Consent forms and the therapeutic misconception.Nancy M. P. King, Gail E. Henderson, Larry R. Churchill, Arlene M. Davis, Sara Chandros Hull, Daniel K. Nelson, P. Christy Parham-Vetter, Barbra Bluestone Rothschild, Michele M. Easter & Benjamin S. Wilfond - 2005 - IRB: Ethics & Human Research 27 (1):1-7.
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  6.  32
    RAC Oversight of Gene Transfer Research: A Model Worth Extending?Nancy M. P. King - 2002 - Journal of Law, Medicine and Ethics 30 (3):381-389.
    Clinical gene transfer research has both a unique history and a complex and layered system of research oversight, featuring a unique review body, the Recombinant DNA Advisory Committee. This paper briefly describes the process of decision-making about clinical GTR, considers whether the questions, problems, and issues raised in clinical GTR are unique, and concludes by examining whether the RAC's oversight is a useful model that should be reproduced for other similar areas of clinical research.Clinical GTR is governed by the same (...)
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  7.  90
    Recommendations for Nanomedicine Human Subjects Research Oversight: An Evolutionary Approach for an Emerging Field.Leili Fatehi, Susan M. Wolf, Jeffrey McCullough, Ralph Hall, Frances Lawrenz, Jeffrey P. Kahn, Cortney Jones, Stephen A. Campbell, Rebecca S. Dresser, Arthur G. Erdman, Christy L. Haynes, Robert A. Hoerr, Linda F. Hogle, Moira A. Keane, George Khushf, Nancy M. P. King, Efrosini Kokkoli, Gary Marchant, Andrew D. Maynard, Martin Philbert, Gurumurthy Ramachandran, Ronald A. Siegel & Samuel Wickline - 2012 - Journal of Law, Medicine and Ethics 40 (4):716-750.
    Nanomedicine is yielding new and improved treatments and diagnostics for a range of diseases and disorders. Nanomedicine applications incorporate materials and components with nanoscale dimensions where novel physiochemical properties emerge as a result of size-dependent phenomena and high surface-to-mass ratio. Nanotherapeutics and in vivo nanodiagnostics are a subset of nanomedicine products that enter the human body. These include drugs, biological products, implantable medical devices, and combination products that are designed to function in the body in ways unachievable at larger scales. (...)
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  8.  30
    An open letter to institutional review boards considering northfield laboratories' polyheme® trial.Ken Kipnis, Nancy M. P. King & Robert M. Nelson - 2006 - American Journal of Bioethics 6 (3):18 – 21.
    At the time of this writing, a widely publicized, waived-consent trial is underway. Sponsored by Northfield Laboratories, Inc. (Evanston, IL) the trial is intended to evaluate the emergency use of PolyHeme®, an oxygen-carrying resuscitative fluid that might prevent deaths from uncontrolled bleeding. The protocol allows patients in hemorrhagic shock to be randomized between PolyHeme® and saline in the field and, still without consent, randomized between PolyHeme® and blood after arrival at an emergency department. The Federal regulations that govern the waiver (...)
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  9.  16
    Beyond the Medical Model: Retooling Bioethics for the Work Ahead.Nancy M. P. King, Gail E. Henderson & Larry R. Churchill - 2021 - American Journal of Bioethics 21 (2):53-55.
    The three important target articles make a strong case for regarding racism as a public health crisis. Each calls for advocacy by the bi...
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  10.  31
    Athletes Are Guinea Pigs.Nancy M. P. King & Richard Robeson - 2013 - American Journal of Bioethics 13 (10):13 - 14.
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  11.  12
    Key Information in the New Common Rule: Can It Save Research Consent?Nancy M. P. King - 2019 - Journal of Law, Medicine and Ethics 47 (2):203-212.
    Informed consent in clinical research is widely regarded as broken, but essential nonetheless. The most recent attempt to reform it comes as part of the first revisions to the Common Rule since it became truly “common” in 1991. This change, the addition of a “key information” requirement for most consent forms, is intended to support and promote a reasoned decision-making process by potential subjects. The key information requirement is both promising and problematic. It is promising because it encourages clarity and (...)
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  12.  11
    Assessing Benefits in Clinical Research: Why Diversity in Benefit Assessment Can Be Risky.Larry R. Churchill, Daniel K. Nelson, Gail E. Henderson, Nancy M. P. King, Arlene M. Davis, Erin Leahey & Benjamin S. Wilfond - 2003 - IRB: Ethics & Human Research 25 (3):1.
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  13.  54
    Athlete or Guinea Pig? Sports and Enhancement Research.Nancy M. P. King & Richard Robeson - 2007 - Studies in Ethics, Law, and Technology 1 (1).
  14.  36
    Genetic Research as Therapy: Implications of "Gene Therapy" for Informed Consent.Larry R. Churchill, Myra L. Collins, Nancy M. R. King, Stephen G. Pemberton & Keith A. Wailoo - 1998 - Journal of Law, Medicine and Ethics 26 (1):38-47.
    In March 1996, the General Accounting Office (GAO) issued the reportScientific Research: Continued Vigilance Critical to Protecting Human Subjects.It stated that “an inherent conflict of interest exists when physician-researchers include their patients in research protocols. If the physicians do not clearly distinguish between research and treatment in their attempt to inform subjects, the possible benefits of a study can be overemphasized and the risks minimized.” The report also acknowledged that “the line between research and treatment is not always cleartoclinicians. Controversy (...)
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  15.  27
    Genetic Research as Therapy: Implications of "Gene Therapy" for Informed Consent.Larry R. Churchill, Myra L. Collins, Nancy M. R. King, Stephen G. Pemberton & Keith A. Wailoo - 1998 - Journal of Law, Medicine and Ethics 26 (1):38-47.
    In March 1996, the General Accounting Office (GAO) issued the reportScientific Research: Continued Vigilance Critical to Protecting Human Subjects.It stated that “an inherent conflict of interest exists when physician-researchers include their patients in research protocols. If the physicians do not clearly distinguish between research and treatment in their attempt to inform subjects, the possible benefits of a study can be overemphasized and the risks minimized.” The report also acknowledged that “the line between research and treatment is not always cleartoclinicians. Controversy (...)
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  16.  13
    DEI Is Not Enough.Nancy M. P. King - 2022 - Hastings Center Report 52 (3):3-3.
    Hastings Center Report, Volume 52, Issue 3, Page 3-3, May–June 2022.
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  17.  21
    Experimental Treatment Oxymoron or Aspiration?Nancy M. P. King - 1995 - Hastings Center Report 25 (4):6-15.
    Giving up the increasingly troubled distinction between “experiment” and “treatment” would make it easier to focus on informed consent and harder to beg questions about uncertainty and shared decisionmaking in medicine.
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  18.  3
    Why We Should Continue to Worry about the Therapeutic Misconception.Larry Churchill, Nancy King & Gail Henderson - 2013 - Journal of Clinical Ethics 24 (4):381-386.
    In a recent article in The Journal of Clinical Ethics, David Wendler argues that worries about the therapeutic misconception (TM) are not only misconceived, but detract from the larger agenda of a proper informed consent for subjects involved in clinical research. By contrast, we argue that Wendler mischaracterizes those who support TM research, and that his arguments are fragmentary, often illogical, and neglect a critical difference between clinical care and clinical research. A clear explanation about the chief aim of research (...)
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  19.  18
    Genetic Research as Therapy: Implications of “Gene Therapy” for Informed Consent.Larry R. Churchill, Myra L. Collins, Nancy M. P. King, Stephen G. Pemberton & Keith A. Wailoo - 1998 - Journal of Law, Medicine and Ethics 26 (1):38-47.
    In March 1996, the General Accounting Office issued the report Scientific Research: Continued Vigilance Critical to Protecting Human Subjects. It stated that “an inherent conflict of interest exists when physician-researchers include their patients in research protocols. If the physicians do not clearly distinguish between research and treatment in their attempt to inform subjects, the possible benefits of a study can be overemphasized and the risks minimized.” The report also acknowledged that “the line between research and treatment is not always clear (...)
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  20.  35
    Conscience, Courage, and “Consent”.Mark A. Hall & Nancy M. P. King - 2016 - Hastings Center Report 46 (2):30-32.
    On September 8, 2015, the Department of Health and Human Services issued a Notice of Proposed Rule Making to revise the Federal Policy for the Protection of Human Subjects, widely known as the “Common Rule.” The NPRM proposes several changes to the current system, including a dramatic shift in the approach to secondary research using biospecimens and data. Under the current rules, it is relatively easy to use biospecimens and data for secondary research. This approach systematically facilitates secondary research with (...)
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  21.  41
    What Research Ethics Should Learn from Genomics and Society Research: Lessons from the ELSI Congress of 2011.Gail E. Henderson, Eric T. Juengst, Nancy M. P. King, Kristine Kuczynski & Marsha Michie - 2012 - Journal of Law, Medicine and Ethics 40 (4):1008-1024.
    In much the same way that genomic technologies are changing the complexion of biomedical research, the issues they generate are changing the agenda of IRBs and research ethics. Many of the biggest challenges facing traditional research ethics today — privacy and confidentiality of research subjects; ownership, control, and sharing of research data; return of results and incidental findings; the relevance of group interests and harms; the scope of informed consent; and the relative importance of the therapeutic misconception — have become (...)
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  22.  19
    Research with Human Subjects: Humility and Deception.Nancy M. P. King - 2018 - IRB: Ethics & Human Research 40 (2):12-14.
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  23.  40
    Vulnerability to influence: A two-way street.Gail E. Henderson, Arlene M. Davis & Nancy M. P. King - 2004 - American Journal of Bioethics 4 (3):50 – 52.
  24.  51
    Loss of Possession: Concussions, Informed Consent, and Autonomy.Richard Robeson & Nancy M. P. King - 2014 - Journal of Law, Medicine and Ethics 42 (3):334-343.
    The principle of informed consent is so firmly established in bioethics and biomedicine that the term was soon bowdlerized in common practice, such that engaging in the informed decision-making process with patients or research subjects is now often called “consenting” them. This evolution, from the original concept to the rather questionable coinage that makes consent a verb, reveals not only a loss of rhetorical precision but also a fundamental shift in the potential meaning, value, and implementation of the informed consent (...)
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  25.  36
    Who ate the apple? A commentary on the core competencies report.Nancy M. P. King - 1999 - HEC Forum 11 (2):170-175.
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  26.  31
    Nanomedicine First-in-Human Research: Challenges for Informed Consent.Nancy M. P. King - 2012 - Journal of Law, Medicine and Ethics 40 (4):823-830.
    First-in-human research has several characteristics that require special attention with respect to ethics and human subjects protections. At least some nanomedical technologies may also have characteristics that merit special attention in clinical research, as other papers in this symposium show. This paper considers how to address these characteristics in the consent form and process for FIH nanomedicine research, focusing principally on experimental nanotherapeutic interventions but also considering nanodiagnostic interventions.It is essential, as a starting point, to recognize that the consent form (...)
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  27.  23
    Who's Winning the IRB Wars? The Struggle for the Soul of Human Research.Nancy M. P. King - 2018 - Perspectives in Biology and Medicine 61 (3):450-464.
    One of my favorite bioethics quotes is nearing 50 years old:Let us not forget that progress is an optional goal, not an unconditional commitment, and that its tempo in particular, compulsive as it may become, has nothing sacred about it. Let us also remember that a slower progress in the conquest of disease would not threaten society, grievous as it is to those who have to deplore that their particular disease be not yet conquered, but that society would indeed be (...)
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  28.  55
    Biodefense Research and the U.S. Regulatory Structure Whither Nonhuman Primate Moral Standing?Rebecca L. Walker & Nancy M. P. King - 2011 - Kennedy Institute of Ethics Journal 21 (3):277-310.
    Biodefense and emerging infectious disease animal research aims to avoid or ameliorate human disease, suffering, and death arising, or potentially arising, from natural outbreaks or intentional deployment of some of the world’s most dreaded pathogens. Top priority research goals include finding vaccines to prevent, diagnostic tools to detect, and medicines for smallpox, plague, ebola, anthrax, tularemia, and viral hemorrhagic fevers, among many other pathogens (National Institute of Allergy and Infectious Diseases [NIAID] priority pathogens). To this end, increased funding for conducting (...)
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  29.  26
    The ethics committee as greek chorus.Nancy M. P. King - 1996 - HEC Forum 8 (6):346-354.
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  30.  35
    An Open Letter to Institutional Review Boards Considering Northfield Laboratories’ PolyHeme® Trial.Robert M. Nelson, Nancy M. P. King & Ken Kipnis - 2010 - American Journal of Bioethics 10 (10):5-8.
    At the time of this writing, a widely publicized, waived-consent trial is underway. Sponsored by Northfield Laboratories, Inc. (Evanston, IL) the trial is intended to evaluate the emergency use of PolyHeme®, an oxygen-carrying resuscitative fluid that might prevent deaths from uncontrolled bleeding. The protocol allows patients in hemorrhagic shock to be randomized between PolyHeme® and saline in the field and, still without consent, randomized between PolyHeme® and blood after arrival at an emergency department. The Federal regulations that govern the waiver (...)
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  31.  16
    The Importance of Amicable and Productive Disagreement.Nancy M. P. King - 2015 - Journal of Medicine and Philosophy 40 (3):286-288.
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  32.  17
    Transparency in Neonatal Intensive Care.Nancy M. P. King - 1992 - Hastings Center Report 22 (3):18-25.
    Medical teams care for severely premature infants under conditions of emergency and uncertainty that make parental involvement very difficult. Parents can be invited into a decisional relationship with the team that enables them to assess more fully the meaning of their child's illness.
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  33.  32
    There's A Lot We Don't Know (and We Ought to Say So).Nancy M. P. King - 2013 - American Journal of Bioethics 13 (12):20-21.
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  34.  12
    Dobbs, the Intrusive State, and the Future of Solidarity.Christine Nero Coughlin & Nancy M. P. King - 2023 - Cambridge Quarterly of Healthcare Ethics 32 (3):344-356.
    The intrusive state has long viewed women as fetal containers. The Dobbs decision goes further, essentially causing women to vanish when fetuses are abstracted from their relationships to pregnant persons. The ways in which women are first controlled and then made invisible are clearly connected with the move from obedience to omission that has historically affected black Americans. When personal decisionmaking and participation in democracy are regarded as threats, those threatened restrict decisional freedom and political power, deepening structural injustices relating (...)
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  35. Studying Benefit in Gene Transfer Research.Gail E. Henderson & Nancy M. P. King - 2001 - IRB: Ethics & Human Research 23 (2):13.
  36. The Philosophy of Ang Lee.Robert Arp, Adam Barkman & Nancy King (eds.) - 2013 - University Press of Kentucky.
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  37.  40
    Ensuring respect for persons in COMPASS: a cluster randomised pragmatic clinical trial.Joseph E. Andrews, J. Brian Moore, Richard B. Weinberg, Mysha Sissine, Sabina Gesell, Jacquie Halladay, Wayne Rosamond, Cheryl Bushnell, Sara Jones, Paula Means, Nancy M. P. King, Diana Omoyeni & Pamela W. Duncan - 2018 - Journal of Medical Ethics Recent Issues 44 (8):560-566.
    _341_ _Objectives: _In patients with multivessel disease both the detection of the culprit lesion and the exact allocation are important preconditions for sufficient treatment and improved outcome. In a vessel based approach the combination of quantitative coronary angiography and fractional flow reserve measured by a pressure wire should be advantageous compared to myocardial SPECT, as morphological and functional information is delivered simultaneously. Therefore our aim was to evaluate MS in the detection and allocation of hemodynamically significant stenoses obtained by the (...)
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  38.  58
    Protection of human subjects and scientific progress: Can the two be reconciled?Kathleen Cranley Glass, David B. Resnik, Stephen Olufemi Sodeke, Halley S. Faust, Rebecca Dresser, Nancy M. P. King, C. D. Herrera, David Orentlicher & Lynn A. Jansen - 2006 - Hastings Center Report 36 (1):4-9.
  39.  50
    Bad Blood Thirty Years Later: A Q&A with James H. Jones.James H. Jones & Nancy M. P. King - 2012 - Journal of Law, Medicine and Ethics 40 (4):867-872.
    Historian James H. Jones published the first edition of Bad Blood, the definitive history of the Tuskegee Syphilis Experiment, in 1981. Its clear-eyed examination of that research and its implications remains a bioethics classic, and the 30-year anniversary of its publication served as the impetus for the reexamination of research ethics that this symposium presents. Recent revelations about the United States Public Health Service study that infected mental patients and prisoners in Guatemala with syphilis in the late 1940s in order (...)
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  40. Faith in science : professional and public discourse on regenerative medicine.Tristan Keys, Nancy M. P. King & Anthony Atala - 2013 - In Michael J. Hyde & James A. Herrick (eds.), After the genome: a language for our biotechnological future. Waco, Texas: Baylor University Press.
     
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  41. Advance care planning and end-of-life decision-making.Nancy M. P. King & John C. Moskop - 2012 - In D. Micah Hester & Toby Schonfeld (eds.), Guidance for healthcare ethics committees. Cambridge, UK: Cambridge University Press.
     
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  42.  26
    Accident & Desire: Inadvertent Germline Effects in Clinical Research.Nancy M. P. King - 2003 - Hastings Center Report 33 (2):23-30.
    Gene therapy is still a very crude way of treating very complicated problems. It's hard to get new genes to go where they're needed, and hard to keep them from going where they're not wanted. The worst‐case scenario is that they find their way into a patient's germ cells—eggs or sperm—and end up harming the patient's offspring. Yet this possibility is hard to study in human trials, and would be hard to deal with in the clinic. It should, instead, simply (...)
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  43.  26
    Benefits, Harms, and Motives in Clinical Research.Nancy M. P. King - 2009 - Hastings Center Report 39 (4):3-3.
  44.  6
    Bioethics, Public Moral Argument, and Social Responsibility.Nancy M. P. King & Michael J. Hyde (eds.) - 2011 - New York: Routledge.
    _Bioethics, Public Moral Argument, and Social Responsibility_ explores the role of democratically oriented argument in promoting public understanding and discussion of the benefits and burdens of biotechnological progress. The contributors examine moral and policy controversies surrounding biomedical technologies and their place in American society, beginning with an examination of discourse and moral authority in democracy, and addressing a set of issues that include: dignity in health care; the social responsibilities of scientists, journalists, and scholars; and the language of genetics and (...)
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  45. Clinical research and the physician–patient relationship: the dual roles of physician and researcher.Nancy Mp King & Larry R. Churchill - 2008 - In Peter A. Singer & A. M. Viens (eds.), The Cambridge textbook of bioethics. New York: Cambridge University Press.
     
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  46.  5
    Moral Entanglements: The Ancillary-Care Obligations of Medical Researchers, written by Henry S. Richardson.Nancy M. P. King - 2015 - Journal of Moral Philosophy 12 (6):787-789.
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  47. Not for Distribution.Nancy M. P. King - 2000 - Journal of Law, Medicine and Ethics 28:332-343.
     
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  48.  12
    Othering and Health Justice.Nancy M. P. King - 2022 - Perspectives in Biology and Medicine 65 (4):604-611.
    ABSTRACT:Bioethics needs to expand its vision. We must examine and interrogate the social and structural barriers that help traditionally privileged communities maintain minoritized groups as inherently inferior "others." Justice requires the field to look beyond the walls of hospitals, clinics, and medical academia to address and ameliorate the structural injustices that give rise to health disparities long before differential access to health services becomes an issue for underserved patients. Doing so means engaging in challenging multidisciplinary collaborations in order to understand (...)
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  49.  7
    Out of This World: re-grounding justice through science fiction.Nancy M. P. King & Larry R. Churchill - 2023 - Perspectives in Biology and Medicine 66 (2):284-298.
    ABSTRACT:Good science fiction can be a successful vehicle for portraying justice. Science fiction can stimulate moral imagination in much the same way as the most effective justice theories, connecting the world in which we live with a range of alternative futures deliberately and creatively made plausible. A selective examination of classic and recent science fiction stories and novels provides contextual framing for considering questions of climate justice, virtuous personal action in the face of structural injustice, and the problem of what (...)
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  50.  10
    The Stories We Tell Ourselves.Nancy M. P. King - 2012 - Hastings Center Report 33 (5):48-48.
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