_341_ _Objectives: _In patients with multivessel disease both the detection of the culprit lesion and the exact allocation are important preconditions for sufficient treatment and improved outcome. In a vessel based approach the combination of quantitative coronary angiography and fractional flow reserve measured by a pressure wire should be advantageous compared to myocardial SPECT, as morphological and functional information is delivered simultaneously. Therefore our aim was to evaluate MS in the detection and allocation of hemodynamically significant stenoses obtained by the (...) combined gold standard QCA plus FFR in patients with multivessel disease. _Methods: _FFR and QCA of 95 vessels in 80 patients have been evaluated. Hemodynamically significant target lesions were defined as intermediate stenoses between 50 and 75% with an FFR. (shrink)

Essays on Ethics and Feminism is a selection of the shorter writings of Sabina Lovibond, one of the most distinctive voices in contemporary philosophy since the 1980s. This work lays claim to a broad thematic unity based on its affiliation to the realist or rationalist traditions in moral philosophy. Some of the essays seek to clarify the relation of feminism to these traditions and to current anti-rationalist tendencies. All of them are concerned with fundamental ethical questions, including questions of (...) feminist ethics--such as the nature of value and the good life; moral requirements and their associated epistemology; character-formation and the ideological critique of the processes by which this is effected. The essays deploy ideas drawn both from Platonic-Aristotelian and from Kantian ethics, as well as from the later philosophy of Wittgenstein. However, they also attempt to respond to the destabilizing impact of Nietzschean and postmodernist thought. (shrink)

Sabina Alkire shows how Nobel Prize-winning economist Amartya Sen's capability approach can be coherently---and practically---put to work in poverty reduction activities so that the voices and values of the poor matter. This provides economists, philosophers, theologians, and development practitioners with a way forward that addresses both theoretical and practical challenges.

While increasing attention has been paid in recent years to the relation between Foucault’s conception of critique and Kant’s, much controversy remains over whether Foucault’s most sustained early engagement with Kant, his dissertation on Kant’s Anthropology, should be read as a wholesale rejection of Kant’s views or as the source of Foucault’s late return to ethics and critique. In this paper, I propose a new reading of the dissertation, considering it alongside 1950s-era archival materials of which I advance the first (...) scholarly appraisal. I argue that Foucault manifests a fundamental ambivalence to Kantian anthropology, rejecting it in theoretical terms while embracing its practical (‘pragmatic’) conception of the subject. Furthermore, I take these texts to collectively evidence Foucault’s attempt to situate himself within the anthropological-critical tradition rather than extricating himself from it. If we interpret Foucault to reject this tradition’s appeal to an essentialized, theoretical conception of subjectivity, what remains of anthropology is its inherent practical reflexivity in structure. Thus, I situate Foucault’s conception of ethics as one’s relation to oneself in continuity with this tradition. (shrink)

This multilevel meta-analysis examines whether emotional intelligence can be enhanced through training and identifies training effects’ determinants. We identified 24 studies containing 28 samples aiming at increasing individual-level EI among healthy adults. The results revealed a significant moderate standardized mean change between pre- and post-measurement for the main effect of EI training, and a stable pre- to follow-up effect. Additionally, the type of EI model, dimensions of the four branch model, length, and type of publication turned out to be significant (...) moderators. The results suggest that EI trainings should be considered effective interventions. (shrink)

This paper claims that Kant’s conception of culture provides a new means of understanding how the two parts of the Critique of Judgment fit together. Kant claims that culture is both the ‘ultimate purpose’ of nature and to be defined in terms of ‘art in general’ (of which the fine arts are a subtype). In the Critique of Teleological Judgment, culture, as the last empirically cognizable telos of nature, serves as the mediating link between nature and freedom, while in the (...) Critique of Aesthetic Judgment, the connection between art and morality passes through culture. In either case, Kant offers distinct, yet interdependent, arguments for how culture demonstrates the amenability of nature to its supersensible ground: the central question Kant claims in the Introduction that the work seeks to answer. Thus, not only does this account advance a concept essential to both parts of the work; it also demonstrates how the two parts can be conceived as complementary, with each supplementing the other to solve Kant’s central question. As such, understanding the Critique of Judgment in terms of culture enables us to see how the two parts of the work do not merely share points of similarity or common themes, but presuppose one another in order to understand how nature is amenable to freedom. (shrink)

An influential strand in philosophy of science claims that scientific paradigms can be understood as relativized a priori frameworks. Here, Kant’s constitutive a priori principles are no longer held to establish conditions of possibility for knowledge which are unchanging and universally true, but are restricted only to a given scientific domain. Yet it is unclear how exactly a relativized a priori can be construed as both stable and dynamical, establishing foundations for current scientific claims while simultaneously making intelligible the transition (...) to a subsequent framework. In this article, I show that important resources for this problem have been overlooked in Kant’s theory of reflective judgement in the third Critique. I argue that Kant accorded the task of formulating new scientific laws to reflective judgement, which is charged with forming new ‘universals’ that guide the experience of nature. I show that this is the very task attributed to the relativized a priori: the constitution of a given conceptual framework, not of the conditions for object-reference as such. I conclude that Kant’s considered conception of science encompasses the operations of both reflective and determining judgement. Relativizations of the a priori should follow Kant’s lead. (shrink)

We propose an account of the subject’s cognition that allows for a full articulation of the phenomenon of ideology. We argue that ideology operates at the level of the a priori: it transcendentally conditions the intelligibility of thought and practice. But we draw from strands of post-Kantian philosophy of science and social philosophy in repudiating Kant’s view that the a priori is necessary and fixed. Instead, we argue, it is contingent, and therefore revisable. More precisely, it is conditioned materially: it (...) must be understood as an activity, continuous with and shaped by material social practice. We conclude with some remarks about the possibility of agency over one’s relativized, materially conditioned a priori; that is, over the possibility of critique. (shrink)

This chapter contains sections titled: 1. 2. 3. 4. 5. Notes References.

This groundbreaking, open access volume analyses and compares data practices across several fields through the analysis of specific cases of data journeys. It brings together leading scholars in the philosophy, history and social studies of science to achieve two goals: tracking the travel of data across different spaces, times and domains of research practice; and documenting how such journeys affect the use of data as evidence and the knowledge being produced. The volume captures the opportunities, challenges and concerns involved in (...) making data move from the sites in which they are originally produced to sites where they can be integrated with other data, analysed and re-used for a variety of purposes. The in-depth study of data journeys provides the necessary ground to examine disciplinary, geographical and historical differences and similarities in data management, processing and interpretation, thus identifying the key conditions of possibility for the widespread data sharing associated with Big and Open Data. The chapters are ordered in sections that broadly correspond to different stages of the journeys of data, from their generation to the legitimisation of their use for specific purposes. Additionally, the preface to the volume provides a variety of alternative “roadmaps” aimed to serve the different interests and entry points of readers; and the introduction provides a substantive overview of what data journeys can teach about the methods and epistemology of research. (shrink)

In 2008, Dutch anti-Islam Member of Parliament Geert Wilders produced a short video called Fitna to visualize his argument that Islam is a dangerous religion. Thousands of men and women across the globe uploaded their own videos to YouTube to criticize or support the film. In this article, we look at these alternative videos from a feminist perspective, contrasting the gender portrayal and narratives in Fitna with those in the alternative videos. We contend that Fitna expressed an extremist Orientalist discourse, (...) in which women are presented as the current and future victims of the oppression of Muslim men and Islam. In contrast, the YouTube videos give voice to women themselves who come from across the globe, are relatively young and often active Muslims. Second, they express different view points in generically new ways, criticizing and ridiculing Wilders or producing serious and committed explanations of their own understanding of Islam. Third, although relatively few women appeared in the videos, those that did speak for themselves, not only take on Wilders, but also claim their right to speak within Islam. We propose to understand these videos as acts of citizenships through which women constitute themselves as global citizens, in some cases by engaging in ‘deliberation’ as it is understood in feminist political theory, in other cases by taking a ‘voice’ that can be responded to. (shrink)

How should actions to redress absolute human deprivation be framed? Current international coordinated actions on absolute poverty are framed by human rights or by goals such as the Millennium Development Goals. But appropriate, effective and sustained responses to needs require localized participation in the definition of those rights/goals/needs and in measures taken to redress them. Human rights or the MDGs do not seem necessarily to require such processes. For this reason some argue that no universal framework can describe economic, social, (...) or cultural rights. Yet to address absolute poverty purely from the local perspective still requires the identification and prioritization of capabilities or needs, and often requires actions by greater-than-local institutions, so in practical terms a framework is not rejected without cost. This paper argues that the identification and prioritisation of rights or MDGs can and should be done at an international level, but that they might be framed as capabilities, and that far greater attention need be given to the iterative specification of these rights, and to the ongoing protection of certain agency freedoms. The paper explores how Wiggins’ account of need can fruitfully inform the specification of needs claims. It also draws significantly on Sen’s work to identify the intrinsic importance of process and opportunity freedoms, and to identify how these can relate to universal priorities. (shrink)

An introduction to an interview with Michel Foucault in 1979, which contextualizes his general stance on the Iranian uprising, as well as his conception of philosophical journalism and political spirituality, his rejection of the teleology of history, and his willingness to let historically silenced subjects speak for themselves.

A critical discussion of three recent monographs on Kantian ethics: Jens Timmermann's Kant's Will at the Crossroads, Barbara Herman's The Moral Habitat, and Mark Timmons' Kant's Doctrine of Virtue. I start by laying out some of the main claims of all three works, and then examine some of the main points of contention between them: principally, the issue of moral complexity, the derivation of duties, and the distinction between theoretical and practical reason. I conclude with some remarks on how the (...) insights of all three works might be fruitfully combined to advance the current state of thought on the structure and composition of the Kantian moral system, as well as on the sense in which it might be taken to parallel, or otherwise be related to, Kant's theoretical system. (shrink)

Is Big Data science a whole new way of doing research? And what difference does data quantity make to knowledge production strategies and their outputs? I argue that the novelty of Big Data science does not lie in the sheer quantity of data involved, but rather in the prominence and status acquired by data as commodity and recognised output, both within and outside of the scientific community and the methods, infrastructures, technologies, skills and knowledge developed to handle data. These developments (...) generate the impression that data-intensive research is a new mode of doing science, with its own epistemology and norms. To assess this claim, one needs to consider the ways in which data are actually disseminated and used to generate knowledge. Accordingly, this article reviews the development of sophisticated ways to disseminate, integrate and re-use data acquired on model organisms over the last three decades of work in experimental biology. I focus on online databases as prominent infrastructures set up to organise and interpret such data and examine the wealth and diversity of expertise, resources and conceptual scaffolding that such databases draw upon. This illuminates some of the conditions under which Big Data needs to be curated to support processes of discovery across biological subfields, which in turn highlights the difficulties caused by the lack of adequate curation for the vast majority of data in the life sciences. In closing, I reflect on the difference that data quantity is making to contemporary biology, the methodological and epistemic challenges of identifying and analysing data given these developments, and the opportunities and worries associated with Big Data discourse and methods. (shrink)

This paper is concerned with monumental art in Slovakia before and after the fall of Communism in 1989. Generally, art in public spaces is important, because it influences the knowledge and feelings the people who use this space have about the past and the present, and thus influences the shared social construction of who we are as a social group. In this article we concentrate on the period of Communism and the formal and iconographic aspects that were essential to art (...) at that time. We also look at the political use of art—the ways in which explicit and implicit meanings and ideas were communicated through art to the general public. We touch also on the present situation regarding the perception of “Communist art”. In the final section we discuss the state of affairs of the last twenty years of chaotic freedom in the post-socialist era. On the one hand, since there is no real cultural politics or conception for artworks in public spaces at the level of the state many artworks simply disappear, often without public discussion, and on the other hand, some actors use their political power to build monuments that promote their private political views. (shrink)

This Editorial introduces the thematic series on 'Toward a New Psychiatry: Philosophical and Ethical Issues in Classification, Diagnosis and Care' http://www.biomedcentral.com/series/newpsychiatry.

This article focuses onsarcasm, for which the definitions have often been loose and confusing, integrating it into the concept ofirony. My approach is based on a large corpus of examples taken from two contemporary television-series, which help identify the wide range of linguistic processes at the core of sarcastic utterances. I present a quantitative and descriptive analysis of the main processes found in two American television-series:House M.D.andThe Big Bang Theory. The results show the intricate meanings created in sarcasm through various (...) linguistic mechanisms, such as repetition, explicitation, metonymy, metaphor, shift of focus, reasoning, and rhetorical questions. This more holistic analysis, including a broad corpus of instances and a more detailed analysis of the examples, aims to fill the unexplored gaps in more classical analyses, emphasizing the complexities and implications that can be drawn in interaction. (shrink)

This paper proposes an account of scientific data that makes sense of recent debates on data-driven and ‘big data’ research, while also building on the history of data production and use particularly within biology. In this view, ‘data’ is a relational category applied to research outputs that are taken, at specific moments of inquiry, to provide evidence for knowledge claims of interest to the researchers involved. They do not have truth-value in and of themselves, nor can they be seen as (...) straightforward representations of given phenomena. Rather, they are fungible objects defined by their portability and prospective usefulness as evidence. (shrink)

Dispositional mindfulness and emotion regulation are two psychological constructs closely interrelated, and both appear to improve with the long-term practice of mindfulness meditation. These constructs appear to be related to subcortical, prefrontal, and posterior brain areas involved in emotional processing, cognitive control, self-awareness, and mind wandering. However, no studies have yet discerned the neural basis of dispositional mindfulness that are minimally associated with emotion regulation. In the present study, we use a novel brain structural network analysis approach to study the (...) relationship between structural networks and dispositional mindfulness, measured with two different and widely used instruments [Mindfulness Attention Awareness Scale and Five Facet Mindfulness Questionnaire ], taking into account the effect of emotion regulation difficulties. We observed a number of different brain regions associated with the different scales and dimensions. The total score of FFMQ and MAAS overlap with the bilateral parahippocampal and fusiform gyri. Additionally, MAAS scores were related to the bilateral hippocampus and the FFMQ total score to the right insula and bilateral amygdala. These results indicate that, depending on the instrument used, the characteristics measured could differ and could also involve different brain systems. However, it seems that brain areas related to emotional reactivity and semantic processing are generally related to Dispositional or trait mindfulness, regardless of the instrument used. (shrink)

Este texto tiene por objetivo investigar los orígenes del movimiento ideológico anarco-feminista en el Río de la Plata, examinando las circunstancias históricas que propiciaron su surgimiento y que lo caracterizaron. Analizando sus posturas y opiniones contenidas en su principal medio impreso de difusión: el periódico La Voz de la Mujer, las bases de su pensamiento crítico, libertario y emancipatorio respecto a la condición de la mujer, contenidos en su consigna: ni dios, ni patrón, ni marido. Así como sus repercusiones en (...) las transformaciones sociales que se gestaron a finales del siglo XIX.Palabras clave: Feminismo. Anarquismo. Río de la Plata. La Voz de la Mujer. AbstractThis text aims to investigate the origins of the anarcho-feminist ideological movement in the Río de la Plata, examining the historical circumstances that led to its emergence and characterized it. Analyzing their positions and opinions contained in their main print media: the newspaper La Voz de la Mujer, the bases of their critical, libertarian and emancipatory thinking regarding the condition of the women, contained in their slogan: neither god, nor boss, nor husband. As well as its repercussions in the social transformations that took place at the end of the 19th century.Keywords: Feminism. Anarchism. Río de la Plata. La Voz de la Mujer. (shrink)

A heated debate surrounds the significance of reproducibility as an indicator for research quality and reliability, with many commentators linking a "crisis of reproducibility" to the rise of fraudulent, careless and unreliable practices of knowledge production. Through the analysis of discourse and practices across research fields, I point out that reproducibility is not only interpreted in different ways, but also serves a variety of epistemic functions depending on the research at hand. Given such variation, I argue that the uncritical pursuit (...) of reproducibility as an overarching epistemic value is misleading and potentially damaging to scientific advancement. Requirements for reproducibility, however they are interpreted, are one of many available means to secure reliable research outcomes. Furthermore, there are cases where the focus on enhancing reproducibility turns out not to foster high-quality research. Scientific communities and Open Science advocates should learn from inferential reasoning from irreproducible data, and promote incentives for all researchers to explicitly and publicly discuss their methodological commitments, the ways in which they learn from mistakes and problems in everyday practice, and the strategies they use to choose which research component of any project needs to be preserved in the long term, and how. (shrink)

Il contributo propone alcune riflessioni maturate nel cantiere di ricerca per l’Atlante linguistico ed etnografico del Piemonte occidentale (ALEPO), lavorando dunque prima alla raccolta, poi all’elaborazione di un corpus di dati complesso e imponente, destinato a un oggetto scientifico peculiare qual è un atlante. Alla luce delle prime pubblicazioni dell’ALEPO è possibile tentare un bilancio delle scelte che hanno guidato la ricerca e iniziare a leggerne i risultati. Per quanto riguarda le prospettive di sviluppo nel trattamento e nella presentazione dei (...) dati, tra le più importanti quelle che riguardano gli etnotesti, componente importante e peculiare del corpus di materiali raccolti per l’ALEPO, che va ancora pienamente valorizzata per metterne in luce i significati etnolinguistici, sociolinguistici e testuali. (shrink)

Increases in international travel and migratory flows have enabled infectious diseases to emerge and spread more rapidly than ever before. Hence, it is increasingly easy for local infectious diseases to become global infectious diseases (GIDs). National governments must be able to react quickly and effectively to GIDs, whether naturally occurring or intentionally instigated by bioterrorism. According to the World Health Organisation, global partnerships are necessary to gather the most up-to-date information and to mobilize resources to tackle GIDs when necessary. Communicable (...) disease control also depends upon national public health laws and policies. The containment of an infectious disease typically involves detection, notification, quarantine and isolation of actual or suspected cases; the protection and monitoring of those not infected; and possibly even treatment. Some measures are clearly contentious and raise conflicts between individual and societal interests. In Europe national policies against infectious diseases are very heterogeneous. Some countries have a more communitarian approach to public health ethics, in which the interests of individual and society are more closely intertwined and interdependent, while others take a more liberal approach and give priority to individual freedoms in communicable disease control. This paper provides an overview of the different policies around communicable disease control that exist across a select number of countries across Europe. It then proposes ethical arguments to be considered in the making of public health laws, mostly concerning their effectiveness for public health protection. (shrink)

In ‘Other Minds’, J.L. Austin advances a parallel between saying ‘I know’ and saying ‘I promise’: much as you are ‘prohibited’, he says, from saying ‘I promise I will, but I may fail’, you are also ‘prohibited’ from saying ‘I know it is so, but I may be wrong’. This treatment of ‘I know’ has been derided for nearly sixty years: while saying ‘I promise’ amounts to performing the act of promising, Austin seems to miss the fact that saying ‘I (...) know’ fails to constitute a performance of the act of knowing. In this paper, I advance a defense of Austin’s position. I diagnose the principal objections to Austin’s account as stemming from detractors’ failure to acknowledge: (1) that Austin never characterizes ‘I know’ as a pure performative; (2) that saying ‘I know p’, unlike simply knowing p, occurs in specific interpersonal contexts in which others rely on our knowledge claims; (3) Austin’s considered account of the felicity conditions of performative utterance; (4) Austin’s ultimate repudiation of the performative/constative distinction. I conclude that Austin’s treatment of ‘I know’ rests on a more general commitment to the intrinsically normative nature of ordinary language. (shrink)

Knowledge-making practices in biology are being strongly affected by the availability of data on an unprecedented scale, the insistence on systemic approaches and growing reliance on bioinformatics and digital infrastructures. What role does theory play within data-intensive science, and what does that tell us about scientific theories in general? To answer these questions, I focus on Open Biomedical Ontologies, digital classification tools that have become crucial to sharing results across research contexts in the biological and biomedical sciences, and argue that (...) they constitute an example of classificatory theory. This form of theorizing emerges from classification practices in conjunction with experimental know-how and expresses the knowledge underpinning the analysis and interpretation of data disseminated online. (shrink)