Despite growing consumerism and skepticism about authority in the culture as a whole, most patients continue to be pliant. If there is a serious threat to physician autonomy, it is more likely to come from third‐party payers and new forms of medical practice, particularly the rise of for‐profit hospital chains, than from patients. Though physicians are restless, they will learn to adapt to the new conditions of practice.

Presents a guide to the basics of quantum mechanics and measurement.

Living organisms act as integrated wholes to maintain themselves. Individual actions can each be explained by characterizing the mechanisms that perform the activity. But these alone do not explain how various activities are coordinated and performed versatilely. We argue that this depends on a specific type of mechanism, a control mechanism. We develop an account of control by examining several extensively studied control mechanisms operative in the bacterium E. coli. On our analysis, what distinguishes a control mechanism from other mechanisms (...) is that it relies on measuring one or more variables, which results in setting constraints in the control mechanism that determine its action on flexible constraints in other mechanisms. In the most basic arrangement, the measurement process directly determines the action of the control mechanism, but in more complex arrangements signals mediate between measurements and effectors. This opens the possibility of multiple responses to the same measurement and responses based on multiple measurements. It also allows crosstalk, resulting in networks of control mechanisms. Such networks integrate the behaviors of the organism but also present a challenge in tailoring responses to particular measurements. We discuss how integrated activity can still result in differential, versatile, responses. (shrink)

The book explores several open questions in the philosophy of statistical mechanics. Each chapter is written by a leading expert in the field. Here is a list of some questions that are addressed in the book: 1) Boltzmann showed how the phenomenological gas laws of thermodynamics can be derived from statistical mechanics. Since classical mechanics is a deterministic theory there are no probabilities in it. Since statistical mechanics is based on classical mechanics, all the probabilities (...) statistical mechanics talks about cannot be fundamental. However, if probabilities are epistemic, how can they play a role, as they seem to do, in laws, explanation, and prediction? 2) Many physicists use the notion of typicality instead of the one of probability when discussing statistical mechanics. What is the connection between the two notions? 3) How can one extend Boltzmann’s analysis to the quantum domain, where some theories are indeterministic? 4) Boltzmann’s explanation fundamentally involves cosmology: for the explanation to go through the Big Bang needs to have had extremely low entropy. Does the fact that the Big Bang was a low entropy state imply that it was, in some sense, “highly improbable” and requires an explanation? 5) What exactly is the connection between statistical and classical mechanics? Is the one of theory reduction or there is no such thing? 6) Statistical mechanics has two main formulation: one due to Botzmann and the other due to Gibbs. What is the connection between the two formulations . (shrink)

This paper will examine the nature of mechanisms and the distinction between the relevant and irrelevant parts involved in a mechanism’s operation. I first consider Craver’s account of this distinction in his book on the nature of mechanisms, and explain some problems. I then offer a novel account of the distinction that appeals to some resources from Mackie’s theory of causation. I end by explaining how this account enables us to better understand what mechanisms are and their various features.

This edited collection provides new perspectives on some metaphysical questions arising in quantum mechanics. These questions have been long-standing and are of continued interest to researchers and graduate students working in physics, philosophy of physics and metaphysics. It features contributions from a diverse set of researchers, ranging from senior scholars to junior academics, working in varied fields, from physics to philosophy of physics and metaphysics. The contributors reflect on issues about fundamentality (is quantum theory fundamental? If so, what is (...) its fundamental ontology?), ontological dependence (how do ordinary objects exist even if they are not fundamental?), realism (what kind of realism is compatible with quantum theory?), indeterminacy (can the world itself exhibit ontological indeterminacy?). With contributions from both physicists (including Nobel Prize winner Gerard 't Hooft), science communicators and philosophers. (shrink)

Mechanisms are the how of chemical reactions. Substances are individuated by their structures at the molecular scale, so a chemical reaction is just the transformation of reagent structures into product structures. Explaining a chemical reaction must therefore involve different hypotheses about how this might happen: proposing, investigating and sometimes eliminating different possible pathways from reagents to products. One distinctive aspect of mechanisms in chemistry is that they are broken down into a few basic kinds of step involving the breaking and (...) making of bonds between atoms. This is necessary for chemical kinetics, the study of how fast reactions happen, and what affects it. It draws on G.N. Lewis’ identification of the chemical bond as involving shared electrons, which from the 1920s achieved the commensuration of chemistry and physics. The breaking or making of a bond just is the transfer of electrons, so a chemical bond on one side of an equation might be balanced on the other side by the appearance of a corresponding quantity of excess charge. A bond is understood to have been exchanged for a pair of electrons. Since reaction mechanisms rely on identities, doesn’t the establishment of a reaction mechanism explain away the chemical phenomena, showing that they are no more than the movement of charges and masses? In one sense yes: these mechanisms seem to involve a conserved-quantity conception of causation. But in another sense no: the ‘lower-level’ entities can do what they do only when embedded in higher-level organisation or structure. There need be no threat of reduction. (shrink)

The social contracts theory claims that, in social exchange circumstances, human reasoning is not necessarily led by logic, but by certain evolved mental mechanisms that are useful for catching offenders. An emblematic experiment carried out with the intention to prove this thesis is the first experiment described by Fiddick, Cosmides, and Tooby in their paper of 2000. Lopez Astorga has questioned that experiment claiming that its results depend on an underlying conditional logical form not taken into account by Fiddick, Cosmides, (...) and Tooby. In this paper, I propose an explanation alternative to that of Lopez Astorga, which does not depend on logical forms and is based on the mental models theory. Thus, I conclude that this other alternative explanation is one more proof that the experiment in question does not demonstrate the fundamental thesis of the social contracts theory. (shrink)

This book explores the prospects of rivaling ontological and epistemic interpretations of quantum mechanics (QM). It concludes with a suggestion for how to interpret QM from an epistemological point of view and with a Kantian touch. It thus refines, extends, and combines existing approaches in a similar direction. -/- The author first looks at current, hotly debated ontological interpretations. These include hidden variables-approaches, Bohmian mechanics, collapse interpretations, and the many worlds interpretation. He demonstrates why none of these ontological (...) interpretations can claim to be the clear winner amongst its rivals. Next, coverage explores the possibility of interpreting QM in terms of knowledge but without the assumption of hidden variables. It examines QBism as well as Healey’s pragmatist view. The author finds both interpretations or programs wanting in certain respects. As a result, he then goes on to advance a genuine proposal as to how to interpret QM from the perspective of an internal realism in the sense of Putnam and Kant. -/- The book also includes two philosophical interludes. One details the notions of probability and realism. The other highlights the connections between the notions of locality, causality, and reality in the context of violations of Bell-type inequalities. (shrink)

Why does one theory "succeed" while another, possibly clearer interpretation, fails? By exploring two observationally equivalent yet conceptually incompatible views of quantum mechanics, James T. Cushing shows how historical contingency can be crucial to determining a theory's construction and its position among competing views. Since the late 1920s, the theory formulated by Niels Bohr and his colleagues at Copenhagen has been the dominant interpretation of quantum mechanics. Yet an alternative interpretation, rooted in the work of Louis de Broglie (...) in the early 1920s and reformulated and extended by David Bohm in the 1950s, equally well explains the observational data. Through a detailed historical and sociological study of the physicists who developed different theories of quantum mechanics, the debates within and between opposing camps, and the receptions given to each theory, Cushing shows that despite the preeminence of the Copenhagen view, the Bohm interpretation cannot be ignored. Cushing contends that the Copenhagen interpretation became widely accepted not because it is a better explanation of subatomic phenomena than is Bohm's, but because it happened to appear first. Focusing on the philosophical, social, and cultural forces that shaped one of the most important developments in modern physics, this provocative book examines the role that timing can play in the establishment of theory and explanation. (shrink)

Even though the evidence‐based medicine movement (EBM) labels mechanisms a low quality form of evidence, consideration of the mechanisms on which medicine relies, and the distinct roles that mechanisms might play in clinical practice, offers a number of insights into EBM itself. In this paper, I examine the connections between EBM and mechanisms from several angles. I diagnose what went wrong in two examples where mechanistic reasoning failed to generate accurate predictions for how a dysfunctional mechanism would respond to intervention. (...) I then use these examples to explain why we should expect this kind of mechanistic reasoning to fail in systematic ways, by situating these failures in terms of evolved complexity of the causal system(s) in question. I argue that there is still a different role in which mechanisms continue to figure as evidence in EBM: namely, in guiding the application of population‐level recommendations to individual patients. Thus, even though the evidence‐based movement rejects one role in which mechanistic reasoning serves as evidence, there are other evidentiary roles for mechanistic reasoning. This renders plausible the claims of some critics of evidencebased medicine who point to the ineliminable role of clinical experience. Clearly specifying the ways in which mechanisms and mechanistic reasoning can be involved in clinical practice frames the discussion about EBM and clinical experience in more fruitful terms. (shrink)

A variety of scientific disciplines have set as their task explaining mental activities, recognizing that in some way these activities depend upon our brain. But, until recently, the opportunities to conduct experiments directly on our brains were limited. As a result, research efforts were split between disciplines such as cognitive psychology, linguistics, and artificial intelligence that investigated behavior, while disciplines such as neuroanatomy, neurophysiology, and genetics experimented on the brains of non-human animals. In recent decades these disciplines integrated, and with (...) the advent of techniques for imaging activity in human brains, the term cognitive neuroscience has been applied to the integrated investigations of mind and brain. This book is a philosophical examination of how these disciplines continue in the mission of explaining our mental capacities. (shrink)

1. The Naturalistic Turn in Philosophy of Science 2. The Framework of Mechanistic Explanation: Parts, Operations, and Organization 3. Representing and Reasoning About Mechanisms 4. Mental Mechanisms: Mechanisms that Process Information 5. Discovering Mental Mechanisms 6 . Summary.

In this essay, we draw on John Haugeland’s work in order to argue that Burge is wrong to think that exercises of perceptual constancy mechanisms suffice for perceptual representation. Although Haugeland did not live to read or respond to Burge’s Origins of Objectivity, we think that his work contains resources that can be developed into a critique of the very foundation of Burge’s approach. Specifically, we identify two related problems for Burge. First, if (what Burge calls) mere sensory responses are (...) not representational, then neither are exercises of constancy mechanisms, since the differences between them do not suffice to imply that one is representational and the other is not. Second, taken by themselves, exercises of constancy mechanisms are only derivatively representational, so merely understanding how they work is not sufficient for understanding what is required for something, in itself, to be representational (and thereby provide a full solution to the problem of perceptual representation). (shrink)

An essay on the connection between the mind-body-problem and quantum mechanics.

It is common to defend the Homeostatic Property Cluster ( HPC ) view as a third way between conventionalism and essentialism about natural kinds ( Boyd , 1989, 1991, 1997, 1999; Griffiths , 1997, 1999; Keil , 2003; Kornblith , 1993; Wilson , 1999, 2005; Wilson , Barker , & Brigandt , forthcoming ). According to the HPC view, property clusters are not merely conventionally clustered together; the co-occurrence of properties in the cluster is sustained by a similarity generating ( (...) or homeostatic ) mechanism . I argue that conventional elements are involved partly but ineliminably in deciding which mechanisms define kinds , for deciding when two mechanisms are mechanisms of the same type, and for deciding where one particular mechanism ends and another begins. This intrusion of conventional perspective into the idea of a mechanism raises doubts as to whether the HPC view is sufficiently free of conventional elements to serve as an objective arbiter in scientific disputes about what the kinds of the special sciences should be. (shrink)

Emergentism is often imagined to be opposed to mechanism. If some phenomenon admits of mechanistic explanation, it is thought to be ipso facto not emergent. In this paper I argue to the contrary that emergence requires mechanism. Whenever some emergent phenomenon occurs, there is a mechanism responsible for its emergence. To make this case I show how mechanisms can explain four commonly held characteristics of emergent phenomena – dependence, autonomy, novelty and holism. By looking at the various kinds of emergence-generating (...) mechanisms, it will be possible to classify different kinds of emergent phenomena by the particular features of the mechanisms that generate them, and so to bring some order to diversity of phenomena that we call emergent. (shrink)

I maintain that quantum mechanics is fundamentally about a system of N particles evolving in three-dimensional space, not the wave function evolving in 3N-dimensional space.

The paper address the question of whether quantum mechanics (QM) favors Priority Monism, the view according to which the Universe is the only fundamental object. It develops formal frameworks to frame rigorously the question of fundamental mereology and its answers, namely (Priority) Pluralism and Monism. It then reconstructs the quantum mechanical argument in favor of the latter and provides a detailed and thorough criticism of it that sheds furthermore new light on the relation between parthood, composition and fundamentality in (...) QM. (shrink)

I argue that quantum mechanics is fundamentally a theory about the representation and manipulation of information, not a theory about the mechanics of nonclassical waves or particles. The notion of quantum information is to be understood as a new physical primitive—just as, following Einstein’s special theory of relativity, a field is no longer regarded as the physical manifestation of vibrations in a mechanical medium, but recognized as a new physical primitive in its own right.

Causal mechanisms theory has provided an important contribution to the theory of social explanation. This article considers whether CMT also makes a contribution to improvement of social science methodology. Methodology serves as a guide to the construction of research questions and explanatory hypotheses. Research is guided by background assumptions about the ontology of the domain of investigation. CMT provides a valuable ontology for social science research. Furthermore, it provides a valuable research heuristic: “seek out the causal mechanisms that underlie an (...) outcome of interest.” CMT does indeed have valuable implications for social science investigation, hypothesis formation, and research strategy. (shrink)

What is called ``orthodox'' quantum mechanics, as presented in standard foundational discussions, relies on two substantive assumptions --- the projection postulate and the eigenvalue-eigenvector link --- that do not in fact play any part in practical applications of quantum mechanics. I argue for this conclusion on a number of grounds, but primarily on the grounds that the projection postulate fails correctly to account for repeated, continuous and unsharp measurements and that the eigenvalue-eigenvector link implies that virtually all interesting (...) properties are maximally indefinite pretty much always. I present an alternative way of conceptualising quantum mechanics that does a better job of representing quantum mechanics as it is actually used, and in particular that eliminates use of either the projection postulate or the eigenvalue-eigenvector link, and I reformulate the measurement problem within this new presentation of orthodoxy. (shrink)

The new mechanistic philosophy is divided into two largely disconnected projects. One deals with a metaphysical inquiry into how mechanisms relate to issues such as causation, capacities and levels of organization, while the other deals with epistemic issues related to the discovery of mechanisms and the intelligibility of mechanistic representations. Tudor Baetu explores and explains these projects, and shows how the gap between them can be bridged. His proposed account is compatible both with the assumptions and practices of experimental design (...) in biological research, and with scientifically accepted interpretations of experimental results. (shrink)

It has long been thought that the ancient Greeks did not take mechanics seriously as part of the workings of nature, and that therefore their natural philosophy was both primitive and marginal. In this book Sylvia Berryman challenges that assumption, arguing that the idea that the world works 'like a machine' can be found in ancient Greek thought, predating the early modern philosophy with which it is most closely associated. Her discussion ranges over topics including balancing and equilibrium, lifting (...) water, sphere-making and models of the heavens, and ancient Greek pneumatic theory, with detailed analysis of thinkers such as Aristotle, Archimedes, and Hero of Alexandria. Her book shows scholars of ancient Greek philosophy why it is necessary to pay attention to mechanics, and shows historians of science why the differences between ancient and modern reactions to mechanics are not as great as was generally thought. (shrink)

This article focuses on the assessment of mechanistic relations with specific attention to medicine, where mechanistic models are widely employed. I first survey recent contributions in the philosophical literature on mechanistic causation, and then take issue with Federica Russo and Jon Williamson’s thesis that two types of evidence, probabilistic and mechanistic, are at stake in the health sciences. I argue instead that a distinction should be drawn between previously acquired knowledge of mechanisms and yet-to-be-discovered knowledge of mechanisms and that both (...) probabilistic evidence and manipulation are essential with respect to newly discovered mechanisms. (shrink)

Any account of “what is special about the human brain” (Passingham 2008) must specify the neural basis of our unique ability to produce speech and delineate how these remarkable motor capabilities could have emerged in our hominin ancestors. Clinical data suggest that the basal ganglia provide a platform for the integration of primate-general mechanisms of acoustic communication with the faculty of articulate speech in humans. Furthermore, neurobiological and paleoanthropological data point at a two-stage model of the phylogenetic evolution of this (...) crucial prerequisite of spoken language: (i) monosynaptic refinement of the projections of motor cortex to the brainstem nuclei that steer laryngeal muscles, presumably, as part of a “phylogenetic trend” associated with increasing brain size during hominin evolution; (ii) subsequent vocal-laryngeal elaboration of cortico-basal ganglia circuitries, driven by human-specificFOXP2mutations.;>This concept implies vocal continuity of spoken language evolution at the motor level, elucidating the deep entrenchment of articulate speech into a “nonverbal matrix” (Ingold 1994), which is not accounted for by gestural-origin theories. Moreover, it provides a solution to the question for the adaptive value of the “first word” (Bickerton 2009) since even the earliest and most simple verbal utterances must have increased the versatility of vocal displays afforded by the preceding elaboration of monosynaptic corticobulbar tracts, giving rise to enhanced social cooperation and prestige. At the ontogenetic level, the proposed model assumes age-dependent interactions between the basal ganglia and their cortical targets, similar to vocal learning in some songbirds. In this view, the emergence of articulate speech builds on the “renaissance” of an ancient organizational principle and, hence, may represent an example of “evolutionary tinkering” (Jacob 1977). (shrink)

It is argued that while classical probability theory, as it is encapsulated in the axioms of Kolmogorov and in his criterion for the independence of two events, can consistently be employed in quantum mechanics, this can only be accomplished at an exorbitant price. By considering rst the classic two-slit experiment, and then the passage of one photon through three polarizers, the applicability of Kolmogorov's last axiom is called into question, but the standard rebu of the Copenhagen interpretation is shown (...) to be adequate to this challenge. In the EPR experiment of Aspect, and the violation of the Bell inequalities, the matter is more delicate: it is not directly the last axiom, but rather the relevance of Kolmogorovian independence that is at issue. It is explained how two events with space-like separation cannot be independent in Kolmogorov's sense, even in the presence of hidden variables. The escape route of supposing these variables to be nonlocal, with a heavy metaphysical ballast of holism, which however is cosmically censored to prevent superluminal information transfer, has all the trappings of an ad hoc makeshift. The adoption of quantum mechanical probability, which does not obey the rules of Kolmogorov, but does survive empirical testing in terms of relative frequencies of events, is more economical. The solution is simple: correlations obey the rules of quantum mechanics and probability is a theory-laden concept that is tested by, but not de ned in terms of, the relative frequency of selected classes of events. (shrink)

his monograph examines the metaphysical commitments of the new mechanistic philosophy, a way of thinking that has returned to center stage. It challenges a variant of reductionism with regard to higher-level phenomena, which has crystallized as a default position among these so-called New Mechanists. Furthermore, it opposes those philosophers who reject the possibility of interlevel causation. Contemporary philosophers believe that the explanation of scientific phenomena requires the discovery of relevant mechanisms. As a result, new mechanists are, in the main, concerned (...) solely with epistemological questions. But, the author argues, their most central claims rely on metaphysical assumptions. Thus, they must also take into account metaphysics, a system of thought concerned with explaining the fundamental nature of being and the world around it. This branch of philosophy does indeed matter to the empirical sciences. The chapters investigate the nature of mechanisms, their components, and the ways in which they can bring about different phenomena. In addition, the author develops a novel account of causation in terms of activities. The analysis provides the basis for many further research projects on mechanisms and their relations to, for example, the mind-body problem, realization, multiple realization, natural kinds, causation, laws of nature, counterfactuals, and scientific levels. (shrink)

Proposes and defends a novel account of the mechanics of divine foreknowledge and providence, arguing that this account is consistent with libertarian freedom.

We are often told that quantum phenomena demand radical revisions of our scientific world view and that no physical theory describing well defined objects, such as particles described by their positions, evolving in a well defined way, let alone deterministically, can account for such phenomena. The great majority of physicists continue to subscribe to this view, despite the fact that just such a deterministic theory, accounting for all of the phe nomena of nonrelativistic quantum mechanics, was proposed by David (...) Bohm more than four decades ago and has arguably been around almost since the inception of quantum mechanics itself. Our purpose in asking colleagues to write the essays for this volume has not been to produce a Festschrift in honor of David Bohm or to gather together a collection of papers simply stating uncritically Bohm's views on quantum mechanics. The central theme around which the essays in this volume are arranged is David Bohm's version of quantum mechanics. It has by now become fairly standard practice to refer to his theory as Bohmian mechanics and to the larger conceptual framework within which this is located as the causal quantum theory program. While it is true that one can have reservations about the appropriateness of these specific labels, both do elicit distinc tive images characteristic of the key concepts of these approaches and such terminology does serve effectively to contrast this class of theories with more standard formulations of quantum theory. (shrink)

In a quantum universe with a strong arrow of time, we postulate a low-entropy boundary condition to account for the temporal asymmetry. In this paper, I show that the Past Hypothesis also contains enough information to simplify the quantum ontology and define a unique initial condition in such a world. First, I introduce Density Matrix Realism, the thesis that the quantum universe is described by a fundamental density matrix that represents something objective. This stands in sharp contrast to Wave Function (...) Realism, the thesis that the quantum universe is described by a wave function that represents something objective. Second, I suggest that the Past Hypothesis is sufficient to determine a unique and simple density matrix. This is achieved by what I call the Initial Projection Hypothesis: the initial density matrix of the universe is the normalized projection onto the special low-dimensional Hilbert space. Third, because the initial quantum state is unique and simple, we have a strong case for the \emph{Nomological Thesis}: the initial quantum state of the universe is on a par with laws of nature. This new package of ideas has several interesting implications, including on the harmony between statistical mechanics and quantum mechanics, the dynamic unity of the universe and the subsystems, and the alleged conflict between Humean supervenience and quantum entanglement. (shrink)

Jeffrey Barrett presents the most comprehensive study yet of a problem that has puzzled physicists and philosophers since the 1930s. The standard theory of quantum mechanics is in one sense the most successful physical theory ever, predicting the behaviour of the basic constituents of all physical things; no other theory has ever made such accurate empirical predictions. However, if one tries to understand the theory as providing a complete and accurate framework for the description of the behaviour of all (...) physical interactions, it becomes evident that the theory is ambiguous, or even logically inconsistent. The most notable attempt to formulate the theory so as to deal with this problem, the quantum measurement problem, was initiated by Hugh Everett III in the 1950s. Barrett gives a careful and challenging examination and evaluation of the work of Everett and those who have followed him. His informal approach, minimizing technicality, will make the book accessible and illuminating for philosophers and physicists alike. Anyone interested in the interpretation of quantum mechanics should read it. (shrink)

Mechanisms are now taken widely in philosophy of science to provide one of modern science’s basic explanatory devices. This has raised lively debate concerning the relationship between mechanisms, laws and explanation. This paper focuses on cases where a mechanism gives rise to a ceteris paribus law, addressing two inter-related questions: What kind of explanation is involved? and What is going on in the world when mechanism M affords behavior B described in a ceteris paribus law? We explore various answers offered (...) by ‘new mechanists’ and others before setting out and explaining our own answers: mechanistic explanations are a species of oldfashioned covering-law explanation and this often accounts in part for their explanatory power; and B is what it takes for some set of principles that govern the features of M’s parts in their arrangement in M all to be instanced together. (shrink)