We address three fundamental questions: What does it mean for an entity to be living? What is the role of inter-organismic collaboration in evolution? What is a biological individual? Our central argument is that life arises when lineage-forming entities collaborate in metabolism. By conceiving of metabolism as a collaborative process performed by functional wholes, which are associations of a variety of lineage-forming entities, we avoid the standard tension between reproduction and metabolism in discussions of life – a tension particularly evident (...) in discussions of whether viruses are alive. Our perspective assumes no sharp distinction between life and non-life, and does not equate life exclusively with cellular or organismal status. We reach this conclusion through an analysis of the capabilities of a spectrum of biological entities, in which we include the pivotal case of viruses as well as prions, plasmids, organelles, intracellular and extracellular symbionts, unicellular and multicellular life-forms. The usual criterion for classifying many of the entities of our continuum as non-living is autonomy. This emphasis on autonomy is problematic, however, because even paradigmatic biological individuals, such as large animals, are dependent on symbiotic associations with many other organisms. These composite individuals constitute the metabolic wholes on which selection acts. Finally, our account treats cooperation and competition not as polar opposites but as points on a continuum of collaboration. We suggest that competitive relations are a transitional state, with multi-lineage metabolic wholes eventually outcompeting selfish competitors, and that this process sometimes leads to the emergence of new types or levels of wholes. Our view of life as a continuum of variably structured collaborative systems leaves open the possibility that a variety of forms of organized matter – from chemical systems to ecosystems – might be usefully understood as living entities. (shrink)

This paper attacks the perennial philosophical and scientific quest for a simple and unified vision of the world. Without denying the attraction of this vision, I argue that such a goal often seriously distorts our understanding of complex phenomena. The argument is illustrated with reference to simplistic attempts to provide extremely general views of biology, and especially of human nature, through the theory of evolution. Although that theory is a fundamental ingredient of our scientific world view, it provides only one (...) of a number of perspectives that are required for an understanding of biology in general, and human behaviour in paticular. The argument is connected to the replacement of views of science in terms of universal laws with views that emphasise ranges of models more locally suited to specific phenomena. (shrink)

This collection of essays explores the metaphysical thesis that the living world is not made up of substantial particles or things, as has often been assumed, but is rather constituted by processes. The biological domain is organised as an interdependent hierarchy of processes, which are stabilised and actively maintained at different timescales. Even entities that intuitively appear to be paradigms of things, such as organisms, are actually better understood as processes. Unlike previous attempts to articulate processual views of biology, which (...) have tended to use Alfred North Whitehead’s panpsychist metaphysics as a foundation, this book takes a naturalistic approach to metaphysics. It submits that the main motivations for replacing an ontology of substances with one of processes are to be found in the empirical findings of science. Biology provides compelling reasons for thinking that the living realm is fundamentally dynamic, and that the existence of things is always conditional on the existence of processes. The phenomenon of life cries out for theories that prioritise processes over things, and it suggests that the central explanandum of biology is not change but rather stability, or more precisely, stability attained through constant change. This edited volume brings together philosophers of science and metaphysicians interested in exploring the consequences of a processual philosophy of biology. The contributors draw on an extremely wide range of biological case studies, and employ a process perspective to cast new light on a number of traditional philosophical problems, such as identity, persistence, and individuality. (shrink)

In an earlier paper (Dupré 1984), I criticized a thesis sometimes defended by theorists of probabilistic causality, namely, that a probabilistic cause must raise the probability of its effect in every possible set of causally relevant background conditions (the "contextual unanimity thesis"). I also suggested that a more promising analysis of probabilistic causality might be sought in terms of statistical relevance in a fair sample. Ellery Eells (1987) has defended the contextual unanimity thesis against my objections, and also raised (...) objections of his own to my positive claims. In this paper I defend and amplify both my objections to the contextual unanimity thesis and my constructive suggestion. (shrink)

Much scientific thinking and thinking about science involves assumptions that there is a deep and pervasive order to the world that it is the business of science to disclose. A paradigmatic statement of such a view can be found in a widely discussed paper by a prominent economist, Milton Friedman (a paper which will be discussed in more detail shortly): A fundamental hypothesis of science is that appearances are deceptive and that there is a way of looking at or interpreting (...) or organizing the evidence that will reveal superficially disconnected and diverse phenomena to be manifestations of a more fundamental and relatively simple structure. (1953/1984, p.231) On the other hand, the person sometimes described as the father of modern science, Francis Bacon, wrote: The human understanding is of its own nature prone to suppose the existence of more order and regularity in the world than it finds. And though there be many things in nature which are singular and unmatched, yet it devises for them conjugates and relatives which do not exist. (1620/1960, p. 50). (shrink)

El siguiente trabajo tiene como objetivo principal describir y analizar la percepción de Manuel Baldomero Ugarte sobre Estados Unidos. Ugarte fue literato y político, pero también fue un pensador interesado por los asuntos internacionales de América Latina. Evidencia de ello son sus propuestas integracionistas y antiimperialistas, en las cuales la presencia de Estados Unidos era evidente. Debido a lo anterior, se estima conveniente explicar qué pensó Ugarte sobre la nación norteamericana, y desde esa perspectiva, contribuir a la discusión sobre tan (...) trascendental intelectual latinoamericano. The purpose of this work is to describe and analyze the perception of Manuel Baldomero Ugarte about the United States. Ugarte was a writer and a politician, but it was also a thinker interested in the Latin America’s international affairs. Testimony of this are his integrationist and anti-imperialist proposals, in which the U.S. presence was evident. Thus, it is considered advisable to explain what he thought about the American nation, and from this perspective, to contribute to the discussion around this important Latin American intellectual. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 42.2 (2004) 220-221 [Access article in PDF] Clyde Lee Miller. Reading Cusanus: Metaphor and Dialectic in a Conjectural Universe. Washington, D.C.: Catholic University of America Press, 2003. Pp. viii + 276. Cloth, $64.95. In an age where the idea of postmodernity gains more and more ground, the period of postmodern thinking has turned into a major challenge to the human mind. Whereas the (...) project of modernity revokes itself through the contradictions it has generated, the need to find new perspectives makes us wonder what happened in the 15th century when the Renaissance paved the way to modernity and still contained seeds of alternative developments which for one reason or another did not get a chance to germinate. This is an invitation to concentrate on the work of Nicholas of Cusa (1401-1464) as one of the major Renaissance thinkers.Miller's book is an attempt to promote the understanding of Cusanus by a close reading of six of the major works of this author. In reading these works he focuses on Cusan thought both as this thought presents itself in these works, and as it appears against the background of traditional philosophy, especially when seen in the light of the Neoplatonic tradition.The works in question are the books On Learned Ignorance (De docta ignorantia) and On Conjectures (De coniecturis), aptly presented under the title: "Envisiong the Whole," and "Conjecturing Oneness and Otherness" respectively. The remaining four works concern the The Layman: About Mind (Idiota de mente) in which Cusanus develops his understanding of the mind and of intellectual authenticity; The Vision of God (De visione Dei), a treatise on mystical theology and an invitation to enter the divine mystery through a combination of prayer and reflection; On the Not Other (De non aliud), a highly speculative work on divine immanence and transcendence; and The Hunt for Wisdom (De venatione sapientiae) in which Cusanus gives an account of his philosophy by connecting it with the metaphor of a hunt in ten different fields. [End Page 220]Miller begins his book with an Introduction in which he outlines his approach to Cusanus, taking the cue from Plato's image of the divided line with its emphasis on the dialectical distinction between noesis (intellect) and dianoia (reason), and from the dialogue On the Hidden God (De Deo abscondito), a brief discussion between a Heathen and a Christian in which Cusanus connects the theme of learned ignorance with the act of adoration. The distinction between reason and intellect is important because the work of Cusanus is a continuous effort to cope with the meaning of distinctions and their impact on our ways of thinking. The reference to the dialogue is significant because this text clearly indicates that the quest for God is the central issue in the thought of Cusanus, and that the notion of ignorance is actually connected with the theoretical and practical meaning of God.In his discussion of the six works Miller follows the text of Cusanus which he presents in the form of argumentative summaries and complementary reflections. His presentation is lucid and to the point. In his reflections on the text and context of Cusan thought he gives valuable insights into the historical position of Cusanus and the manner in which Nicholas appropriated and transformed traditional ways of thinking. At the same time Miller keeps track of the reception of Cusanus by contemporary scholarship and the various interpretations it has to offer.The book ends with a "reprise" of the previous chapters which provides "an overall perspective on Nicholas' thought and its main themes and proposals" (241). The central elements of this perspective are "the metaphysics of the Infinite and the finite" (242) and the doctrine of perspectival relations as it has been developed in De coniecturis. What connects them with one another finds expression in the distinction (and transition) between explanatory and exploratory metaphors (252); that is, between metaphors such as "image-exemplar" and "unfolding-enfolding," which provide explanatory structures for the interpretation of reality, and metaphors such... (shrink)

Standard microbial evolutionary ontology is organized according to a nested hierarchy of entities at various levels of biological organization. It typically detects and defines these entities in relation to the most stable aspects of evolutionary processes, by identifying lineages evolving by a process of vertical inheritance from an ancestral entity. However, recent advances in microbiology indicate that such an ontology has important limitations. The various dynamics detected within microbiological systems reveal that a focus on the most stable entities (or features (...) of entities) over time inevitably underestimates the extent and nature of microbial diversity. These dynamics are not the outcome of the process of vertical descent alone. Other processes, often involving causal interactions between entities from distinct levels of biological organisation, or operating at different time scales, are responsible not only for the destabilisation of pre-existing entities, but also for the emergence and stabilisation of novel entities in the microbial world. In this article we consider microbial entities as more or less stabilised functional wholes, and sketch a network-based ontology that can represent a diverse set of processes including, for example, as well as phylogenetic relations, interactions that stabilise or destabilise the interacting entities, spatial relations, ecological connections, and genetic exchanges. We use this pluralistic framework for evaluating (i) the existing ontological assumptions in evolution (e.g. whether currently recognized entities are adequate for understanding the causes of change and stabilisation in the microbial world), and (ii) for identifying hidden ontological kinds, essentially invisible from within a more limited perspective. We propose to recognize additional classes of entities that provide new insights into the structure of the microbial world, namely “processually equivalent” entities, “processually versatile” entities, and “stabilized” entities. (shrink)

In the context of scientists' reflections on genomics, we examine some fundamental issues in the emerging postgenomic discipline of systems biology. Systems biology is best understood as consisting of two streams. One, which we shall call ‘pragmatic systems biology’, emphasises large‐scale molecular interactions; the other, which we shall refer to as ‘systems‐theoretic biology’, emphasises system principles. Both are committed to mathematical modelling, and both lack a clear account of what biological systems are. We discuss the underlying issues in identifying systems (...) and how causality operates at different levels of organisation. We suggest that resolving such basic problems is a key task for successful systems biology, and that philosophers could contribute to its realisation. We conclude with an argument for more sociologically informed collaboration between scientists and philosophers. BioEssays 27:1270–1276, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

This book is a collection of essays by a leading philosopher of biology and spans his career over almost the last twenty years. Most of the topics that have been of concern to philosophers of biology in this period are touched on to some extent, and the collection of these essays in a convenient volume will certainly be welcomed by everyone working in this field. The essays are arranged chronologically, and divided into three sections. Although the chapters in the first (...) section have substantial interconnections, being involved with fundamental conceptual issues in evolutionary theory, on the whole there is not much attempt to tie the book into anything more than a sequence of independent essays. The later sections, moreover, cover a quite diverse range of topics. The whole is neither more nor less than the sum of the parts. For. (shrink)

Analytic metaphysics has recently discovered biology as a means of grounding metaphysical theories. This has resulted in long-standing metaphysical puzzles, such as the problems of personal identity and material constitution, being increasingly addressed by appeal to a biological understanding of identity. This development within metaphysics is in significant tension with the growing tendency amongst philosophers of biology to regard biological identity as a deep puzzle in its own right, especially following recent advances in our understanding of symbiosis, the evolution of (...) multi-cellular organisms and the inherently dynamical character of living systems. Moreover, and building on these biological insights, the broadly substance ontological framework of metaphysical theories of biological identity appears problematic to a growing number of philosophers of biology who invoke process ontology instead. This volume addresses this tension, exploring to what extent it can be dissolved. For this purpose, the volume presents the first selection of essays exclusively focused on biological identity and written by experts in metaphysics, the philosophy of biology and biology. The resulting cross-disciplinary dialogue paves the way for a convincing account of biological identity that is both metaphysically constructive and scientifically informed, and will be of interest to metaphysicians, philosophers of biology and theoretical biologists. (shrink)

Embodied Care is the first work to argue for the body's centrality to care ethics, doing so by analyzing our corporeality at the phenomenological level.

Regardless of leaders’ efforts to do the right thing and meet performance expectations, they make mistakes, with possible ramifications for followers’ and leaders’ well-being. Some leaders will apologize following transgressions, which may have positive implications for their followers’ and their own well-being, contingent upon the nature and severity of the transgressions. We examine these relationships in two separate studies. In Study 1, leader apologies had a positive relationship with followers’ psychological well-being and emotional health, and these relationships were moderated by (...) the severity of the transgression. In Study 2, leader apologies had a positive relationship with their own psychological well-being, positive emotional health and authentic pride. In addition, the nature of transgressions moderated the relationship between leader apologies and leaders’ positive emotions and authentic pride, while the severity of transgressions moderated the relationship between leader apologies and their positive emotions, psychological health, and authentic pride. Implications and future research directions are discussed. (shrink)

Although molecular biology has meant different things at different times, the term is often associated with a tendency to view cellular causation as conforming to simple linear schemas in which macro-scale effects are specified by micro-scale structures. The early achievements of molecular biologists were important for the formation of such an outlook, one to which the discovery of recombinant DNA techniques, and a number of other findings, gave new life even after the complexity of genotype–phenotype
relations had become apparent. Against this (...) background we outline how a range of scientific developments and conceptual considerations can be regarded as enabling and perhaps necessitating contemporary systems approaches. We suggest that philosophical ideas have a valuable part to play in making sense of complex scientific and disciplinary issues. (shrink)

Viruses have been virtually absent from philosophy of biology. In this editorial introduction, we explain why we think viruses are philosophically important. We focus on six issues, and we show how they relate to classic questions of philosophy of biology and even general philosophy.

How do we use our mental images of the present to reconstruct our past? Maurice Halbwachs addressed this question for the first time in his work on collective memory, which established him as a major figure in the history of sociology. This volume, the first comprehensive English-language translation of Halbwach's writings on the social construction of memory, fills a major gap in the literature on the sociology of knowledge. Halbwachs' primary thesis is that human memory can only function within (...) a collective context. Collective memory, Halbwachs asserts, is always selective; various groups of people have different collective memories, which in turn give rise to different modes of behavior. Halbwachs shows, for example, how pilgrims to the Holy Land over the centuries evoked very different images of the events of Jesus' life; how wealthy old families in France have a memory of the past that diverges sharply from that of the nouveaux riches; and how working class construction of reality differ from those of their middle-class counterparts. With a detailed introduction by Lewis A. Coser, this translation will be an indispensable source for new research in historical sociology and cultural memory. Lewis A. Coser is Distinguished Professor of Sociology Emeritus at the State University of New York and Adjunct Professor of Sociology at Boston College. (shrink)

"This book tries to assess Galileo's work in its historical singularity. It is constructed around a precise question: How did Galileo create the modern science of motion? Starting from this question, I shall go on to determine as accurately as I can what concepts and methods helped classical mechanics to take shape." [Preface].

The loss or absence of vision is probably one of the most incapacitating events that can befall a human being. The importance of vision for humans is also reflected in brain anatomy as approximately one third of the human brain is devoted to vision. It is therefore unsurprising that throughout history many attempts have been undertaken to develop devices aiming at substituting for a missing visual capacity. In this review, we present two concepts that have been prevalent over the last (...) two decades. The first concept is sensory substitution, which refers to the use of another sensory modality to perform a task that is normally primarily sub-served by the lost sense. The second concept is cross-modal plasticity, which occurs when loss of input in one sensory modality leads to reorganization in brain representation of other sensory modalities. Both phenomena are training-dependent. We also briefly describe the history of blindness from ancient times to modernity, and then proceed to address themeansthat have been used to help blind individuals, with an emphasis on modern technologies, invasive (various type of surgical implants) and non-invasive devices. With the advent of brain imaging, it has become possible to peer into the neural substrates of sensory substitution and highlight the magnitude of the plastic processes that lead to a rewired brain. Finally, we will address the important question of the value and practicality of the available technologies and future directions. (shrink)

This paper considers the applicability of standard accounts of causation to living systems. In particular it examines critically the increasing tendency to equate causal explanation with the identification of a mechanism. A range of differences between living systems and paradigm mechanisms are identified and discussed. While in principle it might be possible to accommodate an account of mechanism to these features, the attempt to do so risks reducing the idea of a mechanism to vacuity. It is proposed that the solution (...) to this problem requires the development of a philosophical account of process adequate to apply to living systems. (shrink)

This paper considers the applicability of standard accounts of causation to living systems. In particular it examines critically the increasing tendency to equate causal explanation with the identification of a mechanism. A range of differences between living systems and paradigm mechanisms are identified and discussed. While in principle it might be possible to accommodate an account of mechanism to these features, the attempt to do so risks reducing the idea of a mechanism to vacuity. It is proposed that the solution (...) to this problem requires the development of a philosophical account of process adequate to apply to living systems. (shrink)

In this article, we describe the influence of violations of community standards of fairness on subsequent ethical decision-making and emotions. Across two studies, we manipulated explanations for a common action, and we find that explanations that violate community standards of fairness lead to greater intentions to behave unethically than explanations that are consistent with community standards of fairness. We find that perceptions of justifiability mediate this relationship. We also find that individuals derive significant psychological benefits from engaging in unethical behavior (...) following perceived violations of fairness. (shrink)

Digital phenotyping is the term given to the capturing and use of user log data from health and wellbeing technologies used in apps and cloud-based services. This paper explores ethical issues in making use of digital phenotype data in the arena of digital health interventions. Products and services based on digital wellbeing technologies typically include mobile device apps as well as browser-based apps to a lesser extent, and can include telephony-based services, text-based chatbots, and voice-activated chatbots. Many of these digital (...) products and services are simultaneously available across many channels in order to maximize availability for users. Digital wellbeing technologies offer useful methods for real-time data capture of the interactions of users with the products and services. It is possible to design what data are recorded, how and where it may be stored, and, crucially, how it can be analyzed to reveal individual or collective usage patterns. The paper also examines digital phenotyping workflows, before enumerating the ethical concerns pertaining to different types of digital phenotype data, highlighting ethical considerations for collection, storage, and use of the data. A case study of a digital health app is used to illustrate the ethical issues. The case study explores the issues from a perspective of data prospecting and subsequent machine learning. The ethical use of machine learning and artificial intelligence on digital phenotype data and the broader issues in democratizing machine learning and artificial intelligence for digital phenotype data are then explored in detail. (shrink)

Analytic metaphysics has recently discovered biology as a means of grounding metaphysical theories. This has resulted in long-standing metaphysical puzzles, such as the problems of personal identity and material constitution, being increasingly addressed by appeal to a biological understanding of identity. This development within metaphysics is in significant tension with the growing tendency amongst philosophers of biology to regard biological identity as a deep puzzle in its own right, especially following recent advances in our understanding of symbiosis, the evolution of (...) multi-cellular organisms and the inherently dynamical character of living systems. Moreover, and building on these biological insights, the broadly substance ontological framework of metaphysical theories of biological identity appears problematic to a growing number of philosophers of biology who invoke process ontology instead. This volume addresses this tension, exploring to what extent it can be dissolved. For this purpose, the volume presents the first selection of essays exclusively focused on biological identity and written by experts in metaphysics, the philosophy of biology and biology. The resulting cross-disciplinary dialogue paves the way for a convincing account of biological identity that is both metaphysically constructive and scientifically informed, and will be of interest to metaphysicians, philosophers of biology and theoretical biologists. (shrink)

This paper presents an overview on the concept of cardinal utility in its relations with the literature since the beginning of the XVIIIth century (Part I); an estimate of the cardinal utility function for its negative values, thus completing the estimate of this function for its positive values given in my 1984 Venice paper (Part II); and finally different applications to the theory of choices in the presence of risk and to the wealth transfer and tax questions (Part III).