Background Biobanking and genomic research requires collection and storage of human tissue from study participants. From participants’ perspectives within the African context, this can be associated with fears and misgivings due to a myriad of factors including myths and mistrust of researchers. From the researchers angle ethical dilemmas may arise especially with consenting and sample reuse during storage. The aim of this paper was to explore these ethical considerations in the establishment and conduct of biobanking and genomic studies in Africa. (...) Methods We conducted a narrative synthesis following a comprehensive search of nine (9) databases and grey literature. All primary research study designs were eligible for inclusion as well as both quantitative and qualitative evidence from peer reviewed journals, spanning a maximum of 20 years (2000–2020). It focused on research work conducted in Africa, even if data was stored or analysed outside the region. Results Of 2,663 title and abstracts screened, 94 full texts were retrieved and reviewed for eligibility. We included 12 studies (7 qualitative; 4 quantitative and one mixed methods). Ethical issues described in these papers related to community knowledge and understanding of biobanking and genomic research, regulation, and governance of same by research ethics committees, enrolment of participants, types of informed consents, data collection, storage, usage and sharing as well as material transfer, returning results and benefit sharing. ca. Biospecimen collection and storage is given in trust and participants expect confidentially of data and results generated. Most participants are comfortable with broad consent due to trust in researchers, though a few would like to be contacted for reconsenting in future studies, and this would depend on whether the new research is for good cause. Sharing data with external partners is welcome in some contexts but some research participants did not trust foreign researchers. Conclusion Biobanking and genomic studies are a real need in Africa. Linked to this are ethical considerations related to setting up and participation in biobanks as well as data storage, export, use and sharing. There is emerging or pre-existing consensus around the acceptability of broad consent as a suitable model of consent, the need for Africans to take the lead in international collaborative studies, with deliberate efforts to build capacity in local storage and analysis of samples and employ processes of sample collection and use that build trust of communities and potential study participants. Research ethics committees, researchers and communities need to work together to work together to adapt and use clearly defined ethical frameworks, guidelines, and policy documents to harmonize the establishment and running of biobanking and genomic research in Africa. (shrink)

BackgroundCountries are increasingly devoting significant resources to creating or strengthening research ethics committees, but there has been insufficient attention to assessing whether these committees are actually improving the protection of human research participants.DiscussionResearch ethics committees face numerous obstacles to achieving their goal of improving research participant protection. These include the inherently amorphous nature of ethics review, the tendency of regulatory systems to encourage a focus on form over substance, financial and resource constraints, and conflicts of interest. Auditing and accreditation programs (...) can improve the quality of ethics review by encouraging the development of standardized policies and procedures, promoting a common base of knowledge, and enhancing the status of research ethics committees within their own institutions. However, these mechanisms focus largely on questions of structure and process and are therefore incapable of answering many critical questions about ethics committees' actual impact on research practices.The first step in determining whether research ethics committees are achieving their intended function is to identify what prospective research participants and their communities hope to get out of the ethics review process. Answers to this question can help guide the development of effective outcomes assessment measures. It is also important to determine whether research ethics committees' guidance to investigators is actually being followed. Finally, the information developed through outcomes assessment must be disseminated to key decision-makers and incorporated into practice. This article offers concrete suggestions for achieving these goals.ConclusionOutcomes assessment of research ethics committees should address the following questions: First, does research ethics committee review improve participants' understanding of the risks and potential benefits of studies? Second, does the process affect prospective participants' decisions about whether to participate in research? Third, does it change participants' subjective experiences in studies or their attitudes about research? Fourth, does it reduce the riskiness of research? Fifth, does it result in more research responsive to the local community's self-identified needs? Sixth, is research ethics committees' guidance to researchers actually being followed? (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Literature 30.1 (2006) 299-309 [Access article in PDF] Conscious Fiction Mary Clayton Coleman Bard College Consciousness and the Novel: Connected Essays, by David Lodge; 320 pp. Cambridge, Mass.: Harvard University Press, 2002, $24.95 boards, $16.95 paper. Fictional Minds, by Alan Palmer; 275 pp. Lincoln and London: University of Nebraska Press, 2004, $45.00. Radiant Cool: A Novel Theory of Consciousness, by Dan Lloyd; 357 pp. Cambridge, (...) Mass.: The MIT Press, 2004, $24.95 boards, $14.95 paper. What contributions can fiction make to the representation and investigation of conscious experience? Might fiction help us to develop and advance new theories about the nature of consciousness? And might such theories, in turn, inform our understanding of the process of reading fiction? Three recent volumes—one by English critic and novelist, David Lodge; another by literary theorist, Alan Palmer; and a third by philosopher and (now) novelist, Dan Lloyd—raise these important, genre-bending questions, and they offer challenging if not always convincing answers to them. More generally, these volumes make valuable contributions to the fruitful cross-pollination that has developed between philosophers, scientists, literary theorists, and novelists who are interested in the nature of consciousness.Lodge's new collection of essays is called Consciousness and the Novel: Connected Essays, and like all of the criticism he has written since the late eighties, this volume is intended for a general audience, not for [End Page 299] literary theorists. The title essay, "Consciousness and the Novel," is a revised version of the Richard Ellman Lectures in Modern Literature that Lodge gave at Emory University in 2001, and the other nine essays, all previously published, cover such topics as Howards End; the novels of Evelyn Waugh; The Letters of Kingsley Amis; Martin Amis's memoir, Experience; and the relationship between literature and criticism. I will focus on "Consciousness and the Novel."Lodge's thesis in this essay is that novels play an essential role in our exploration of the nature of human consciousness. This thesis is certainly true, but it is also entirely banal. Much more interesting is what Lodge says in support of it. He argues that because of the unique representative possibilities of the novel, conscious experiences can be represented more effectively in novels than they can be in scientific writing. Taken literally, as an assertion about the relative representational power of novels and scientific discourse, this is extremely implausible. However, taken more loosely—as an invitation to those of us interested in consciousness to take a closer look at the ways conscious experiences are represented in novels—Lodge's claim is sensible and appealing. I will consider the literal reading of Lodge's claim first and then turn to the looser one.It is undoubtedly true that, as a whole, novelists devote more energy to representing conscious experiences than writers of scientific discourse do. However, science writers can use whatever techniques best serve their aims, including the aim of describing conscious experiences, so there is no reason to think that conscious experiences can, in principle, be represented more effectively in novels than in broadly scientific discourse. Given that Lodge discusses such creative science writers as Antonio Damasio, Daniel Dennett, and Steven Pinker in the course of his essay, it is surprising and disappointing to find him caricature scientific writing in the following way: "science... is a third-person discourse. The first-person pronoun is not used in scientific papers. If there were any hint of qualia in a scientific paper... it would be edited out" (p. 11). Qualia are the supposedly subjective qualitative aspects of conscious experiences. How the plucked string of a cello sounds to you; how the rotting fish in the garbage smells to you; and how it feels for you to inch down into the smooth, almost-too-hot water of a perfect bubble bath—these are all (supposedly) examples of qualia. Lodge is simply mistaken when he says that there is no hint of qualia in scientific writing. There is no consensus about whether qualia can be explained scientifically. In fact, there is no consensus about whether they exist. [End Page... (shrink)

Could there be a power world? That is to say, could there be a world consisting of nothing but dispositional properties? If there couldn't be, then, obviously, the actual world is not such a world. That is one reason why answering this question is important. However, even if one thinks it is already obvious that the actual world is not a power world, answering this question is still important, because whether there could be a power world depends, in part, on (...) whether all the properties in a world could be dispositional . It also depends on whether dispositional properties require nondispositional bases. Could water solubility, for example, be a brute feature of salt, or must this disposition be explicable in terms of some further, nondispositional property that salt also possesses? Answering these questions about the nature of properties is clearly essential to arriving at a plausible ontology of the actual world. (shrink)

In my dissertation I aim to further our understanding of practical reasons and practical reasoning. In chapter one I evaluate and reject the most commonly accepted accounts of practical reasons, viz., Objectivism and Humeanism. They each offer an account of the conditions under which we have reasons, but they cannot tell us why these conditions have normative significance for us. I also argue that we cannot use a claim about the relationship between reasons and motivation to determine the nature of (...) practical reasons. ;In chapter two I claim that an acceptable account of what motivates us to act must be compatible with the fact that actions are things we do. I argue that neither desire-based nor belief-based accounts of motivation can accommodate this fact, and I sketch an alternative account according to which we are motivated to act by our decisions. ;I argue in chapter three that to make decisions is to hold oneself subject to certain constitutive laws about how to make decisions. I also claim that person P has a reason to do A if and only if it would be correct for P to decide to do A. A decision is correct, I contend, just in case it conforms with the constitutive laws of decision-making. Furthermore, the conditions under which we have reasons to act have this special status for us because we cannot avoid making decisions about how to act. ;In chapter four I claim that it seems as if there is no room in the world, as science understands it, for the performance of actions. I respond to this worry in two steps. First, I claim that our making decisions and carrying them out in action is compatible with the fact that our bodies move in accordance with physical laws. Second, I argue that our decisions are our own doings in a very deep sense. Therefore, the scientific world view does not preclude the kind of self-expression essential to action. (shrink)

According to the Humean theory of motivation, a person can only be motivated to act by a desire together with a relevantly related belief. More specifically, a person can only be motivated to ϕ by a desire to ψ together with a belief that ϕ-ing is a means to or a way of ψ-ing. In recent writings, Michael Smith gives what has become a very influential argument in favour of the Humean claim that desire is a necessary part of motivation, (...) and a great deal has been written about Smith's defence of this Humean claim. However, no one has yet identified the fundamental weakness of his defence. The fundamental weakness is that there is no single conception of directions of fit that does all the work Smith needs it to do throughout the various stages of his defence. (shrink)

Developing countries face numerous barriers to conducting effective and efficient ethics reviews of international collaborative research. In addition to potentially overlooking important scientific and ethical considerations, inadequate or insufficiently trained ethics committees may insist on unwarranted changes to protocols that can impair a study's scientific or ethical validity. Moreover, poorly functioning review systems can impose substantial delays on the commencement of research, which needlessly undermine the development of new interventions for urgent medical needs. In response to these concerns, the Drugs (...) for Neglected Diseases Initiative, an independent nonprofit organization founded by a coalition of public sector and international organizations, developed a mechanism to facilitate more effective and efficient host country ethics review for a study of the use of fexinidazole for the treatment of late stage African Trypanosomiasis. The project involved the implementation of a novel ‘pre-review’ process of ethical oversight, conducted by an ad hoc committee of ethics committee representatives from African and European countries, in collaboration with internationally recognized scientific experts. This article examines the process and outcomes of this collaborative process. (shrink)

In his classic paper, ‘Why abortion is immoral’, Don Marquis argues that what makes killing an adult seriously immoral is that it deprives the victim of the valuable future he/she would have otherwise had. Moreover, Marquis contends, because abortion deprives a fetus of the very same thing, aborting a fetus is just as seriously wrong as killing an adult. Marquis’ argument has received a great deal of critical attention in the two decades since its publication. Nonetheless, there is a potential (...) challenge to it that seems to have gone unnoticed. A significant percentage of fetuses are lost to spontaneous abortion. Once we bring this fact to our attention, it becomes less clear whether Marquis can use his account of the wrongness of killing to show that abortion is the moral equivalent of murder. In this paper, I explore the relevance of the rate of spontaneous abortion to Marquis’ classic anti-abortion argument. I introduce a case I call Unexpected Death in which someone is about to commit murder, but, just as the would-be murderer is about to strike, his would-be victim dies unexpectedly. I then ask: what does Marquis’ account of killing imply about the moral status of what the would-be murderer was about to do? I consider four responses Marquis could give to this question, and I examine what implications these responses have for Marquis’ strategy of using his account of the wrongness of killing an adult to show that abortion is in the same moral category. (shrink)

In “Constitutivism without Normative Thresholds,” Kathryn Lindeman raises two objections to what she aptly calls Threshold Constitutivism. My aim in this short discussion is to respond to her first objection. Although I will argue that this objection fails, I will also argue that thinking through how to respond to it reminds us of something important, namely, that many of the Norm-Governed Kinds that are directly related to intentional action are social kinds, that is, kinds whose existence conditions we ourselves collectively (...) write. Everyone, whether constitutivist or not, needs to think seriously about what those existence conditions should be. [1] Journal of Ethics and Social Policy 12 (3): 231-258 (2017). [2] Lindeman’s second objection depends on her view, which I do not share, that “Normative Constitutivism has ambitions to be an explanatory strategy for norms in general” (238, my emphasis). (shrink)

This study examines the outcomes of a four-year faculty learning community (FLC) that aimed to transform departmental ethics curriculum by supporting Earth Sciences faculty members as they ethically inquired into their teaching of ethics and refined existing courses in alignment with an Integrated Community-Engaged Learning and Ethical Reflection (ICELER) framework. We present ethnographic case studies that unpack processes through which three faculty members transformed undergraduate courses. We assembled case studies by triangulating interview data, course artifacts, and faculty reflections. We examine (...) how faculty (1) built awareness around teaching ethics, (2) took responsibility for and made judgments about teaching ethics, (3) experimented by designing and implementing ICELER-inspired courses, and (4) interrogated the outcomes of their ethics teaching, utilizing findings to enhance awareness and revise courses. The paper closes by introducing a model detailing how instructors inquire into ethics teaching and how model components might inspire future educational practice and research. (shrink)

According to the knowledge argument, physicalism fails because when physically omniscient Mary first sees red, her gain in phenomenal knowledge involves a gain in factual knowledge. Thus not all facts are physical facts. According to the ability hypothesis, the knowledge argument fails because Mary only acquires abilities to imagine, remember and recognise redness, and not new factual knowledge. I argue that reducing Mary’s new knowledge to abilities does not affect the issue of whether she also learns factually: (...) I show that gaining specific new phenomenal knowledge is required for acquiring abilities of the relevant kind. Phenomenal knowledge being basic to abilities, and not vice versa, it is left an open question whether someone who acquires such abilities also learns something factual. The answer depends on whether the new phenomenal knowledge involved is factual. But this is the same question we wanted to settle when first considering the knowledge argument. The ability hypothesis, therefore, has offered us no dialectical progress with the knowledge argument, and is best forgotten. (shrink)

Frank Jackson's knowledge argument imagines a super-smart scientist, Mary, forced to investigate the mysteries of human colour vision using only black and white resources. Can she work out what it is like to see red from brain-science and physics alone? The argument says no: Mary will only really learn what red looks like when she actually sees it. Something is therefore missing from the science of the mind, and from the 'physicalist' picture of the world based on science. (...) This powerful and controversial argument remains as pivotal as when it was first created in 1982, and this volume provides a thorough and incisive examination of its relevance in philosophy of mind today. The cutting-edge essays featured here break new ground in the debate, and also comprehensively set out the developments in the story of the knowledge argument so far, tracing its impact, past, present, and future. (shrink)

Frank Jackson's case of Mary the colour scientist, and the knowledge argument against physicalism built upon it, are well known. This paper starts from Jackson's other, more neglected, thought experiment, about Fred, who sees a unique shade of red. It explores two senses in which properties are said to be 'objective', roughly corresponding to the ideas of a property's being intersubjectively accessible, on the one hand, and its being knowable without the need for special experiences, on the other. These (...) senses of the objective are contrasted, and their links to the doctrine of physicalism explored, and it is argued that, in the sense of objectivity we should embrace, mental qualities come out as objective and physical properties. The paper ends up by proposing a novel theory about how mental qualities fit into the world—as determinates of determinable physical properties, a view that is distinguished from the closely related 'Russellian monism'. (shrink)

Nineteenth-century imperialist discourses constructed European colonisation of indigenous inhabitants as an inevitable and necessary process for the progress of the colonies and the extension of the British Empire. Within this construct, imperialist and patriarchal discourses intersected to construct ‘white women’ in a manner that denied them legitimacy as autonomous individuals but simultaneously positioned them as actors within the imperial endeavour. Recent feminist scholarship has extended this historiography by considering how some women in nineteenth-century New Zealand were complexly positioned as both (...) agents and critics of colonisation, involved in imperial strategies and yet disruptive of practices of cultural assimilation of Maori. This article furthers this scholarship through an illustrative case study of one woman who embodied this complex positioning within patriarchal and imperialist discourses. English-born wife of the first Chief Justice of New Zealand, and outspoken critic of colonial policies associated with government appropriation of Maori land, Mary Ann Martin was actively involved in establishing Anglican training institutions for young Maori men and women, and in dispensing medical assistance to Maori. Examination of her positioning on the margins of imperial discourses offers an opportunity to consider the operation of colonialism as a discourse implicated by gendered, racialised identities. Detailed textual analyses of selected extracts of her reminiscences of her 34-year residence in New Zealand, which focus on her positioning as a member of the ‘inferior’ sex in the dominant race, offer an opportunity to examine the ways in which she simultaneously challenged and reinforced Victorian prescriptions of respectable womanhood; how her views on and interactions with Maori may have destabilised accepted notions of women's appropriate spheres of influence; and the extent to which her challenges to dominant views on race relations may have been inflected by her positioning within gendered discourses of femininity. (shrink)

I PSYCHOLOGY 5 The Probabilistic Revolution in Psychology--an Overview Gerd Gigerenzer 7 1 Probabilistic Thinking and the Fight against Subjectivity Gerd Gigerenzer 11 2 Statistical Method and the Historical Development of Research Practice in American Psychology Kurt Danziger 35 3 Survival of the Fittest Probabilist: Brunswik, Thurstone, and the Two Disciplines of Psychology Gerd Gigerenzer 49 4 A Perspective for Viewing the Integration of Probability Theory in Psychology David J. Murray 73 II SOCIOLOGY 101 5 The Two Empirical Roots of (...) Social Theory and the Probability Revolution Anthony Oberschall 103 III ECONOMICS 133 The Probabilistic Revolution in Economics--an Overview Mary S. Morgan 135 6 Why Was There No Probabilistic Revolution in Economic Thought? Claude Mènard 139 7 The Rise of Macroeconomic Calculations in Economic Statistics Robert A. Horváth 147 8 Statistics without Probability and Haavelmo’s Revolution in Econometrics Mary S. Morgan 171 IV PHYSIOLOGY 199 9 Experimental Physiology and Statistical Inference: The Therapeutic Trial in Nineteenth-Century Germany William Coleman 201 V EVOLUTIONARY BIOLOGY 227 The Probabilistic Revolution in Evolutionary Biology--an Overview John H. Beatty 229 10 Natural Selection as a Causal, Empirical, and Probabilistic Theory M. J. S. Hodge 233 11 Dobzhansky and Drift: Facts, Values, and Chance in Evolutionary Biology John H. Beatty 271 12 Random Genetic Drift, R. A. Fisher, and the Oxford School of Ecological Genetics John R. G. Turner 313 13 On the Prior Probability of the Existence of Life Bernd-Olaf Küppers 355 VI PHYSICS 371 The Probabilistic Revolution in Physics--an Overview Lorenz Krüger 373 14 Probabilistic Physics the Classical Way Jan von Plato 379 15 Max Born and the Reality of Quantum Probabilities Nancy Cartwright 409 16 Philosophical Problems of Quantum Theory: The Response of American Physicists Nancy Cartwright. (shrink)

This paper deals with various connections that are found to exist between statistical estimation methods for decision-making and rules of group choice in the social choice area. Initially the aggregation of individual opinions is formulated as a pattern recognition problem; firstly it is shown that individual preferences lead to a natural representation in terms of binary patterns. Then we proceed to show how the search for a group preference pattern can be conducted by classifying the input preference patterns into various (...) ‘pattern classes’ and using the resulting classification boundaries to define the area of mutual agreement over some of the available alternatives. This leads to a decision-theoretic problem which consists in defining a decision rule (for classification) that is least likely to lead to misrecognition of arbitrary preference patterns. A maximum likelihood solution is obtained and compared with some well-known rules of group decision-making. Other solutions are also possible, on the basis of different optimality criteria, and their social choice interpretation is suggested. Finally, a method using Coleman's linear model for attributes is applied to yield group decision rules by feature weighting of election issues. (shrink)

Reading the Shape of Nature vividly recounts the turbulent early history of the Museum of Comparative Zoology at Harvard and the contrasting careers of its founder Louis Agassiz and his son Alexander. Through the story of this institution and the individuals who formed it, Mary P. Winsor explores the conflicting forces that shaped systematics in the second half of the nineteenth century. Debates over the philosophical foundations of classification, details of taxonomic research, the young institution's financial struggles, and the (...) personalities of the men most deeply involved are all brought to life. In 1859, Louis Agassiz established the Museum of Comparative Zoology to house research on the ideal types that he believed were embodied in all living forms. Agassiz's vision arose from his insistence that the order inherent in the diversity of life reflected divine creation, not organic evolution. But the mortar of the new museum had scarcely dried when Darwin's Origin was published. By Louis Agassiz's death in 1873, even his former students, including his son Alexander, had defected to the evolutionist camp. Alexander, a self-made millionaire, succeeded his father as director and introduced a significantly different agenda for the museum. To trace Louis and Alexander's arguments and the style of science they established at the museum, Winsor uses many fascinating examples that even zoologists may find unfamiliar. The locus of all this activity, the museum building itself, tells its own story through a wonderful series of archival photographs. (shrink)

According to a profile in The Guardian , Mary Midgley is 'the foremost scourge of scientific pretensions in this country; someone whose wit is admired even by those who feel she sometimes oversteps the mark'. Considered one of Britain's finest philosophers, Midgley exposes the illogical logic of poor doctrines that shelter themselves behind the prestige of science. Always at home when taking on the high priests of evolutionary theory - Dawkins, Wilson and their acolytes - she has famously described (...) evolution as 'the creation-myth of our age'. In Evolution as a Religion , she examines how science comes to be used as a substitute for religion and points out how badly that role distorts it. As ever, her argument is flawlessly insightful: a punchy, compelling, lively indictment of these misuses of science. Both the book and its author are true classics of our time. (shrink)

A long-standing tradition presents economic activity in terms of the flow of fluids. This metaphor lies behind a small but influential practice of hydraulic modelling in economics. Yet turning the metaphor into a three-dimensional hydraulic model of the economic system entails making numerous and detailed commitments about the analogy between hydraulics and the economy. The most famous 3-D model in economics is probably the Phillips machine, the central object of this paper.

Moral pyschology and cultural analysis of the Sam Bankman-Fried fraud and effective altruism generally, with help from Beauvoir, Aristotle, and Bertolt Brecht.

Special issue of the BERA Blog: 'Educators learning through communities of philosophical enquiry', edited by Joanna Haynes. In this blog post, we focus on the need for converting classrooms into place-responsive communities of inquiry that are essential to developing eco-citizen identities – identities that break with socially and environmentally harmful knowledge and habits.

Frustration is widely recognised to be central to many cases of moral anger in a political context, yet little philosophical attention has been paid to it. In this paper, I offer a much-needed philosophical analysis of frustration, working primarily with the example of the recent South African student protests. By developing a deeper philosophical understanding of frustration and its connections to moral anger, I argue that the movement between the two has a couple of important aspects. First, the movement involves (...) a transformation from simply responding to some opposition to viewing that opposition as wrongfully imposed by an agent; second, in the cases that are my focus, the movement is a response to a persistent opposition that is compounded by an erosion of trust, confidence and hope within a moral community, which ultimately changes the very nature of the opposition into a form of wrongdoing. These aspects allow us to assess the appropriateness of the movement, thereby developing a rich analysis of moral anger arising out of frustration in a political context. (shrink)

Philosophical discussions of hatred have tended to examine whether and when hatred can be morally or rationally justified. If hatred is rational, for instance, it might be because it is a fitting response to the given circumstances (Ben-Ze’ev 2000; Bell 2011). At the same time, hatred typically motivates action, and action of quite characteristic types. As Fischer et al. (2018) note, the so-called ‘emotivational’ goal of hatred appears to be not merely to hurt the target of hatred, but to destroy (...) them or let them suffer. Such types of action immediately raise questions about their moral status, but we should also ask questions about their rational status. In particular, when acting on the basis of a hatred that may itself be rational – at least in the sense of being fitting – are we also acting rationally? Working with a conception of rational agency according to which we act rationally when we guide our actions by reasons seen as reasons (see Jones 2003; Carman 2018), and granting that hatred can be fitting and thereby be a response to genuine reasons, I explore the ways in which acting on the basis of hatred could or could not be rational. (shrink)