Recently, there has been a convergence of fields studying the processing of DNA, such as transcription, replication, and repair. This convergence has been centered around the packaging of DNA in chromatin. Chromatin structure affects all aspects of DNA processing because it modulates access of proteins to DNA. Therefore, a central theme has become the mechanism(s) for accessing DNA in chromatin. It seems likely that mechanisms involved in one of these processes may also be used in others. For example, the discovery (...) of transcriptional coactivators with histone acetyltransferase activity and chromatin remodeling complexes has provided possible mechanisms required for efficient repair of DNA in chromatin. BioEssays 21:596–603, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

The purpose of this article is to argue for a position holding that epigenetic responsibility primarily should be a political and not an individual responsibility. Epigenetic is a rapidly growing research field studying regulations of gene expression that do not change the DNA sequence. Knowledge about these mechanisms is still uncertain in many respects, but main presumptions are that they are triggered by environmental factors and life style and, to a certain extent, heritable to subsequent generations, thereby reminding of aspects (...) of Lamarckism. Epigenetic research advances give rise to intriguing challenges for responsibility relations between the society and the individual. Responsibility is commonly understood in a backwards-looking manner, identifying causally responsible actors to blame for a bad outcome. If only a backwards-looking responsibility model is applied, epigenetics might give rise to arduous responsibility ascriptions to individuals for their health and the health of their future descendants. This would put heavy responsibility burdens on actors constrained by unequal social and economic structures. In contrast, a forward-looking responsibility notion takes account of structural conditions and pay attention to who is best placed to do something about conditions contributing to bad outcomes. A forward-looking responsibility notion would partly free disadvantaged individuals from responsibility, and identify actors with power and capacity to do something about structural factors constraining genuine choice. (shrink)

Of all the thinkers of the century of genius that inaugurated modern philosophy, none lived an intellectual life more rich and varied than Gottfried Wilhelm Leibniz. Maria Rosa Antognazza's pioneering biography provides a unified portrait of this unique thinker and the world from which he came. At the centre of the huge range of Leibniz's apparently miscellaneous endeavours, Antognazza reveals a single master project lending unity to his extraordinarily multifaceted life's work. Throughout the vicissitudes of his long life, Leibniz (...) tenaciously pursued the dream of a systematic reform and advancement of all the sciences. As well as tracing the threads of continuity that bound these theoretical and practical activities to this all-embracing plan, this illuminating study also traces these threads back into the intellectual traditions of the Holy Roman Empire in which Leibniz lived and throughout the broader intellectual networks that linked him to patrons in countries as distant as Russia and to correspondents as far afield as China. (shrink)

The purpose of this article is to argue for a position holding that epigenetic responsibility primarily should be a political and not an individual responsibility. Epigenetic is a rapidly growing research field studying regulations of gene expression that do not change the DNA sequence. Knowledge about these mechanisms is still uncertain in many respects, but main presumptions are that they are triggered by environmental factors and life style and, to a certain extent, heritable to subsequent generations, thereby reminding of aspects (...) of Lamarckism. Epigenetic research advances give rise to intriguing challenges for responsibility relations between the society and the individual. Responsibility is commonly understood in a backwards-looking manner, identifying causally responsible actors to blame for a bad outcome. If only a backwards-looking responsibility model is applied, epigenetics might give rise to arduous responsibility ascriptions to individuals for their health and the health of their future descendants. This would put heavy responsibility burdens on actors constrained by unequal social and economic structures. In contrast, a forward-looking responsibility notion takes account of structural conditions and pay attention to who is best placed to do something about conditions contributing to bad outcomes. A forward-looking responsibility notion would partly free disadvantaged individuals from responsibility, and identify actors with power and capacity to do something about structural factors constraining genuine choice. (shrink)

This special focus issue brings to the Journal of Religious Ethics fresh considerations of moral anthropology as practiced by four emergent voices within the field. Each of these essays, in varying ways, seeks not only to advance an understanding of ethics in a particular time, place, and context, but to draw our attention to shared aspects of the human condition: its discontinuities and fractures, its practices of perception and attention, its interplays of emotion, intuition, and reason, and its thoroughly intersubjective (...) nature. To learn something of Thai Buddhist life-worlds, contemporary Russian modes of being, or the experience of immorality in today's China, each essay argues in turn, is to gain new insight into ourselves. (shrink)

Certain emotional processes “bypass the will” and even awareness, whereas others arise due to the deliberative evaluation of objects, states, and events. It is important to differentiate between the automatic versus reflective origins of emotional processes, and sensory versus conceptual bases of diverse negative and positive emotions. A taxonomy of emotions based on different origins is presented. This taxonomy distinguishes between negative and positive automatic versus reflective emotions. The automatic emotions are connected with the (a) homeostatic and (b) hedonistic regulatory (...) mechanisms. The reflective emotions—uniquely human—are described in reference to deliberative processes and appraisals based on two types of conceptual and verbalized evaluative standards: (a) ideal self-standards and (b) general, axiological standards of good and evil. (shrink)

'Ethics' was not developed as a separate branch of philosophy in Buddhist traditions until the modern period, though Buddhist philosophers have always been concerned with the moral significance of thoughts, emotions, intentions, actions, virtues, and precepts. Their most penetrating forms of moral reflection have been developed within disciplines of practice aimed at achieving freedom and peace. This Element first offers a brief overview of Buddhist thought and modern scholarly approaches to its diverse forms of moral reflection. It then explores two (...) of the most prominent philosophers from the main strands of the Indian Buddhist tradition – Buddhaghosa and Śāntideva – in a comparative fashion. (shrink)

This work provides an analysis of the basic cognitive components of envy. In particular, the roles played by the envious party's social comparison with, and ill will against, the better off are emphasised. The ill will component is characterised by the envier's ultimate goal or wish that the envied suffer some harm, and is distinguished from resentment and sense of injustice, which have often been considered part of envy. The reprehensible nature of envy is discussed, and traced back to the (...) analysis of its components. Finally, we explore both points of overlap and distinguishing features between envy and other emotions such as jealousy or emulation, and make a few general remarks, pointing to the necessity of overcoming conceptual looseness in the notion of envy. (shrink)

In the present paper, we explore the impact of singing for girls in rural Bangladesh. Previous findings in this field-based interview study (with 18 girls) have demonstrated that singing can act as a driving force in young girls’ psychological individuation processes, implying increased agency and autonomy. A critical question, however, is to what extent the village girls will manage to maintain a feeling of agency as they pass through puberty. How do they navigate between their own wish to continue singing (...) and pressure from cultural norms (such as getting married)? Using Margareth Archer’s morphogenetic approach and Arjun Appadurai’s approach to culture as a capacity as analytical tools, we connect different modes of reflexivity to the girls’ capacity to aspire. We discuss specific mechanisms that emerge as relevant for the girls/young women as they navigate their way through the Bengali rural society. (shrink)

Following a previous article where I defined how a concept becomes a weapon of ideological wars, this article seeks to clarify why there are semantic connections of the actual concept of ‘populism’ with the semantics of the concept of crisis. My key argument is to focus on how actors use the concept of populism on the public sphere with the goal to inspire fear instead of allowing citizens and theorists to understand what is behind our present political–economic crisis. In my (...) view, both theorists and politicians should be aware how a concept that lacks any precision does not help us to understand our present moment of crisis. We must use other tools and the help of historians to understand why has neo-liberal politics unleashed this present crisis. (shrink)

In this paper I want to leave behind the failed attempts to think about populism as ideology, strategy, style, or even discourse. I will focus on the ‘conceptual battles of politics’ and their potential to influence actors to pursue and effect specific ends. Reinhart Koselleck and his ideas about conceptual history will figure prominently in my discussion, as will his concept of asymmetrical combat-concept as a means of unleashing a theoretical and political war. The goal is to demonstrate that concepts (...) have taken the place of weapons of war among political actors. (shrink)

The present paper analyses how top managers construct the meaning of sustainable human resource management and its responsibility areas and how they identify and prioritize stakeholders in sustainable HRM. The empirical data were collected as part of the Finnish HR Barometer inquiry. A qualitative analysis reveals four dimensions of sustainable HRM: Justice and equality, transparent HR practices, profitability, and employee well-being. It also reveals four broader responsibility areas: Legal and ethical, managerial, social, and economic. Contrary to the prior green HRM (...) literature, ecological responsibility was largely ignored. The study also reveals a wide range of stakeholders, specifically, owners, managers, employees, customers, and employee representatives, as well as their special roles and requirements for sustainable HRM. These findings contribute to the literature of sustainable HRM by illustrating the dimensions and broader responsibilities of sustainable HRM as seen by top managers. Their conceptions of sustainable HRM are largely neglected in the prior literature despite their crucial role in legitimating HRM and thus sustainable HRM in companies. These results also contribute to the theory of stakeholder salience in the sustainable HRM context from the viewpoint of top managers. (shrink)

This work proposes an analysis of the cognitive and motivational components of hope, its basic properties, and the affective dispositions and behaviors it is likely to induce. In our view current treatments of hope do not fully account for its specificity, by making hope overlap with positive expectation or some specification of positive expectation. In contrast, we attempt to highlight the distinctive features of hope, pointing to its differences from positive expectation, as well as from a sense of successful agency, (...) optimism, trust, and faith. Fear and anxiety are also addressed, and the latter is analyzed as a state of mind implying both fear and hope. Finally, the relationship between hope and motivation is explored, and “active” hope is compared with “passive” hope. Some concluding remarks summarize the results of our analysis, and stress the role of hope in fostering the individual’s well-being. (shrink)

Conveying emotions in spoken poetry may be based on a poem’s semantic content and/or on emotional prosody, i.e. on acoustic features above single speech sounds. However, hypotheses of more direct sound–emotion relations in poetry, such as those based on the frequency of occurrence of certain phonemes, have not withstood empirical (re)testing. Therefore, we investigated sound–emotion associations based on prosodic features as a potential alternative route for the, at least partially, non-semantic expression and perception of emotions in poetry. We first conducted (...) a pre-study designed to validate relevant parameters of joy- and sadness-supporting prosody in the recitation, i.e. acoustic production, of poetry. The parameters obtained thereof guided the experimental modification of recordings of German joyful and sad poems such that for each poem, three prosodic variants were constructed: one with a joy-supporting prosody, one with a sadness-supporting prosody, and a neutral variant. In the subsequent experiment, native German speakers and participants with no command of German rated the joyfulness and sadness of these three variants. This design allowed us to investigate the role of emotional prosody, operationalized in terms of sound-emotion parameters, both in combination with and dissociated from semantic access to the emotional content of the poems. The findings from our pre-study showed that the emotional content of poems (based on pre-classifications into joyful and sad) indeed predicted the prosodic features pitch and articulation rate. The subsequent perception experiment revealed that cues provided by joyful and sad prosody specifically affect non-German-speaking listeners’ emotion ratings of the poems. Thus, the present investigation lends support to the hypothesis of prosody-based iconic relations between perceived emotion and sound qualia. At the same time, our findings also highlight that semantic access substantially decreases the role of cross-language sound–emotion associations and indicate that non-German-speaking participants may also use phonetic and prosodic cues other than the ones that were targeted and manipulated here. (shrink)

It is presumed that there is an opposition between the spontaneous, discovered, personal and natural on the one hand, and the taught, imitated, adopted, and artificial, on the other. The opposition is manifested in different kinds of human activity and its products. It can be evaluated and provides a framework for several theories. It is accepted, for instance that, on the one hand, the most valuable are expressive experiences which harmonize with dispositions and sensitivity of man, and on the other, (...) those which are yielded by obtaining knowledge and expanding one’s culture. In artistic creativity inspiration, creativity, originality, and individual expression are the most respected factors but the meaning of a work and the use made of the available stock of creative means are also evaluated. Considering conception of man, the development of the pertinent dispositions which determine particular uniqueness of human individual, is highly estimated but the meaning of the consequences of socialization and education is as well stressed. If man confined himself to expressive acts only, the development of his personality would manifest just what he is. However, an adoption of the generally accepted external values implies a danger of the unauthentic and imitative life. The adoption of values of culture has to undergo in a specific process called internalization of values. But knowledge of values is not all that matters. They must be experienced and included into individual world, they must be accepted and adjusted to the personal traits of the individual. By internalization of values, what is alien to and inherited by man is transformed into a personal and essential element of his life, enriching him by new possibilities of unfolding dispositions of his nature. We apprehend man as ens per se: he becomes himself, due to his own activity, but essential substance of his personality is mode of objectively existing values. The article stresses the importance of activity and contact of man with reality, which constantly bring to light new possibilities of experiencing and acting. In the contact with the world man comes across the phenomena which are contrary to his natural inclinations: by adopting a conscious attitude to them and including them into accepted system of beliefs, he becomes enriched with new values. These oppositions provide a background to the construction of system of values in the world of man. (shrink)

The starting point of these reflections on the personality-creating function of moral examples is a differentiation between two concepts of man: one, which puts stress on the fact that human nature is predetermined and the man’s task is therefore to develop his talents and endowments in order to become a compete man, and the other, which emphasizes the fact that man is himself a specific and uniquely precious value, and thus he should endeavor to learn about himself and how he (...) should realize himself to his own image. In the first instance we have “an ethics of examples”, in the second, “an ethics of authenticity”. In the first case we have a man who creates himself, in the second, a man who is in search for himself. These two conceptions describe different attitudes toward the world and toward oneself. We can reach for their synthesis, however, if we assume that through the search for himself man creates himself, by finding out what his authentic intentions are, man creates himself, and thereby avoids petrification in the established schemes, functioning in social life. Thus he becomes a more valuable individual in his society. (shrink)

GABRIEL BELLO REGUERA: Emigración y ética. Humanizar y deshumanizar, Madrid, Plaza y Valdés, 2011, 341 pp.

Le problème central des Recherches logiques est de déterminer le rapport entre deux types d’actes : les actes de signification et les actes d’in­tuition (perception et imagination), donc entre d’un part des actes dont les objets sont de l’ordre du langage et, d’autre part, les actes qui « accèdent » à la réalité, dans lesquels l’objet réel est présent lui-même. Ce rapport est introduit dans la I re R echerche logique sous le nom de « remplissement » mais sa vraie (...) nature deviendra claire seulement dans la VI e R echerche logique . Le remplissement sera alors la synthèse d’un acte de signification et d’un acte d’intuition visant un même objet. Ce modèle d’une intention vide qui se remplit par la suite pose cependant certains problèmes. Premièrement, les significations peuvent-elles jouer le rôle d’objets et, si oui, quelle est la nature de ceux-ci ? Deuxièmement, peut-on vraiment isoler des intentions de signification, dont l’objet ne serait ni réel (comme dans la perception) ni même possible (comme dans l’imagination), mais d’une tout autre nature ? Puisqu’une imagination peut aussi jouer le rôle d’intuition remplissante, toute intention de signification doit se remplir (aboutir à un objet réel ou, au moins, possible), sans quoi elle ne serait pas une signification du tout, elle n’aurait aucun sens. Enfin, si nous acceptons cette thèse de l’universalité du remplissement, ou au moins de sa possibilité, comment penser le cas des objets idéaux, dont le remplissement ne va pas de soi ? (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Buddhist-Christian Studies 24.1 (2004) 278-283 [Access article in PDF] The Voice of God on Mount Sinai. Rabbinic Commentaries on Exodus 20:1 In Light of Sufi and Zen-Buddhist Texts. By Reinhard Neudecker. Rome: Pontificio Istituto Biblico, 2002. 157 pp. Reinhard Neudecker's study of the central event of the first five books of the Bible, namely the revelation of God on Mount Sinai to Moses and the Israelites, is an important (...) contribution to interfaith studies that should be of interest to both the scholar and layperson alike. The clarity of purpose and treatment makes this study very accessible; each chapter is thoughtfully structured, with rich footnotes that provide documentation, further explanation, and information. The appendixes contain the relevant rabbinic texts in the original Hebrew; indices of terms, subjects, and Bible citations; as well as a helpful list of consulted works.The stated purpose of the study is to shed light on enigmatic rabbinical interpretations of Exodus 20:1, the verse that introduces the TenWords (commandments) [End Page 278] that form the basis of the complete Torah by taking into consideration analogous passages from the Sufi and Zen Buddhist traditions. In explaining his methodology, the author makes three important distinctions. First, Neudecker is "not dealing with Judaism, Islam and Zen Buddhism as such, but with the views and experiences of some rabbinic Jews, some Sufi Muslims and some Zen Buddhists" (p. x). Second, the chosen texts are offered for their spiritual and mystical insight, not for their historical context or content, because "the mystic has learned to convert the great events recorded by tradition into symbols which express the ongoing inner revelation to which he has been exposed" (p. 6). Because spiritual and mystical writers generally refrain from explaining deep experiences openly (especially because of the impossibility of putting them into words), the author refrains from adding his own interpretations and instead invites the reader to a meditative encounter with the texts. Third, the author does not intend to offer simple parallels or to readily claim correspondences between the rabbinic, Sufi, and Zen texts, but leaves it up to the reader to judge what the "different traditions may have in common and to what degree and where one tradition may go a step further than the others (p. 11, n. 30). His main purpose, as stated above, is to understand the rabbinic comments better by using the method of "intercultural reading" in drawing upon Sufi and Zen Buddhist texts.After the introductory chapter, which offers the methodological considerations and basic information about the Rabbinic sources and Buddhist terminology, the author presents Exod. 20:1 in its rabbinic translation: "And God spoke all these words to say." This short verse has become the stumbling block for the rabbinic interpreter, just as much as a Zen koan becomes a stumbling block for the Zen student or an obscure verse in the Koran for the Sufi. What these stumbling blocks have in common is that they open up a new way of nondiscursive understanding of the text that leads to profound insights and a deep spiritual experience.Chapters 4-9 of the book are devoted to unraveling the mysteries of these insights. The reader is drawn into an engaging process that opens up layer upon layer of meaning, comparable to the peeling of an onion. A short exposition of the themes of each chapter as introduction to the texts proves very helpful for orientation in this process. Chapter 4 addresses the question of how the people at Sinai heard the Ten Words. The rabbis differ on whether the people heard all of the commandments or only the first two of them, but the important point of comparison is the enigmatic statement that God pronounced all the Ten Words, including the entire Torah, "in one single sound, as the (human) mouth cannot speak and the (human) ear cannot hear" (p. 35). This statement implies that God's revelation exceeds the limits of human speaking and hearing, and that God communicates in... (shrink)

Heim responds to the five articles by anthropologists concerned with contemporary Buddhist practices and ideologies of emotions, arguing that a history of emotions approach that attends to the centrality of emotions and their evaluations can be important for ethics. She submits that while sometimes studies of moral psychology in Buddhist ethics have focused on individuals, these articles suggest how emotions can have a very public and collective impact on social, economic, and political life. She is also interested in how these (...) anthropological studies of contemporary Buddhist communities trouble textual accounts of Buddhist ethics on central questions of giving, karma, merit, and compassion. (shrink)

In this paper, we introduce the Societal Readiness Thinking Tool to aid researchers and innovators in developing research projects with greater responsiveness to societal values, needs, and expectations. The need for societally-focused approaches to research and innovation—complementary to Technology Readiness frameworks—is presented. Insights from responsible research and innovation concepts and practice, organized across critical stages of project-life cycles are discussed with reference to the development of the SR Thinking Tool. The tool is designed to complement not only shortfalls in TR (...) approaches, but also improve upon other efforts to integrate RRI, sustainability, and design thinking in research and innovation cycles. Operationalization and early-stage user tests of the Tool are reported, along with discussion of potential future iterations and applications. (shrink)

No fictional character is more renowned for his powers of thought and observation than Sherlock Holmes. But is his extraordinary intellect merely a gift of fiction, or can we learn to cultivate these abilities ourselves, to improve our lives at work and at home? We can, says psychologist and journalist Maria Konnikova, and in Mastermind she shows us how. Beginning with the "brain attic"--Holmes's metaphor for how we store information and organize knowledge--Konnikova unpacks the mental strategies that lead to (...) clearer thinking and deeper insights. Drawing on twenty-first-century neuroscience and psychology, Mastermind explores Holmes's unique methods of ever-present mindfulness, astute observation, and logical deduction. In doing so, it shows how each of us, with some self-awareness and a little practice, can employ these same methods to sharpen our perceptions, solve difficult problems, and enhance our creative powers. For Holmes aficionados and casual readers alike, Konnikova reveals how the world's most keen-eyed detective can serve as an unparalleled guide to upgrading the mind. (shrink)

Despite recent research showing that children rapidly interpret human action in terms of intention, a long tradition of empirical research on moral development and recent conceptual analyses of the deontic domain suggest that children do not apply their understanding of intention to the deontic domain. However, two experiments are described showing that children do make that connection. Preschool children heard stories in which a protagonist was obliged to meet a particular condition if an action was to be taken (e.g. obliged (...) to wear a coat if playing outside). When shown four pictures depicting each possible combination of: (1) the protagonist either performing the action or not, and (2) deliberately or accidentally failing to meet the obligation, children appropriately identified the protagonist as naughty when he or she was depicted as deliberately not meeting the obligation while performing the action. The findings proved to be robust across two different cultural settings. Implications for research on children’s developing theory of mind and their understanding of deontic concepts are discussed. (shrink)

"Meaning, the complex phenomenon of individuation and the definition of identity are the core theme of this work. Grounded on a theoretical framework that gives particular emphasis to the semiotic process common to all forms of cognition, human cognitionis conceived here as specific of organisms that, in the course of their interactions, produce symbolic forms, defining the specific physical, social and cultural environments in which they evolve. Individuation, inherent to that semiotic process, is complex and double-sided. It involves, on one (...) hand, the definition of semantic identities and their acknowledgment as world objects naming; on the other hand, it comprehends the specific lexical and morphosyntactic strategies different languages have found todesignate particular entities referring. The definition of world objects and its symbolic translation presents variations from language to language. In the second part of the book, we define what we have called a 'structure-motivated ontology' to represent how this symbolic translation is accomplished in English and European Portuguese. Plus, we try to show how the nature of this symbolic translation affects structural realisation, namely the individuation of reference and the construal of 'one-off referring' expressions."--Publisher's description. (shrink)

We consider small-weight Cutting Planes (CP * ) proofs; that is, Cutting Planes (CP) proofs with coefficients up to $\operatorname{Poly}(n)$ . We use the well known lower bounds for monotone complexity to prove an exponential lower bound for the length of CP * proofs, for a family of tautologies based on the clique function. Because Resolution is a special case of small-weight CP, our method also gives a new and simpler exponential lower bound for Resolution. We also prove the following (...) two theorems: (1) Tree-like CP * proofs cannot polynomially simulate non-tree-like CP * proofs. (2) Tree-like (CP * proofs and Bounded-depth-Frege proofs cannot polynomially simulate each other. Our proofs also work for some generalizations of the CP * proof system. In particular, they work for CP * with a deduction rule, and also for any proof system that allows any formula with small communication complexity, and any set of sound rules of inference. (shrink)