Contemplating one’s own death is a core aspect in the history of Western philosophy. In the modern era, existential philosophy has inherited this tradition and established unique discussions on the concept of “_my_ death,” resting on the premise that this concept is unapproachable via scientific inquiry. Conversely, biological research is essentially conducted within the scope of life phenomena, with death being referred to in the sense of lifespan; thus, death is not among its inherent themes, which automatically excludes the concept (...) of _my_ death from its scope. To establish a dialogue between the two fields, this study questions the widely held premise that _my_ death is unrelated to science and is best examined by philosophy. I consider the movement between continuity and discontinuity as foundational to scientific development, and integrate it with the relationship between the unknown and known. Furthermore, I extend this to the concepts of consciousness and body, and subsequently clarify and define the unknown divisions. Finally, I examine the kinds of unknowns that science confronts to interpret philosophically how an aspect of reproductive theory has unwittingly revealed a completely new dimension of life: _my_ death. Overall, I argue that _my_ death is an essential point of contact between philosophy and biology that reveals the scholarly significance of the unknown. (shrink)

Carbon and nitrogen are essential elements for life. Glucose as a carbon source and glutamine as a nitrogen source are important nutrients for cell proliferation. About 100 years ago, it was discovered that cancer cells that have acquired unlimited proliferative capacity and undergone malignant evolution in their host manifest a cancer‐specific remodeling of glucose metabolism (the Warburg effect). Only recently, however, was it shown that the metabolism of glutamine‐derived nitrogen is substantially shifted from glutaminolysis to nucleotide biosynthesis during malignant progression (...) of cancer—which might be referred to as a “second” Warburg effect. In this review, address the mechanism and relevance of this metabolic shift of glutamine‐derived nitrogen in human cancer. We also examine the clinical potential of anticancer therapies that modulate the metabolic pathways of glutamine‐derived nitrogen. This shift may be as important as the shift in carbon metabolism, which has long been known as the Warburg effect. (shrink)

Investigates Aristotle's views on the ontological status of artifacts in the Metaphysics, with implications for a variety of metaphysical problems.

The purpose of this study is to examine how trends in the use of images in modern life science journals have changed since the spread of computer-based visual and imaging technology. To this end, a new classification system was constructed to analyze how the graphics of a scientific journal have changed over the years. The focus was on one international peer-reviewed journal in life sciences, Cell, which was founded in 1974, whereby 1725 figures and 160 tables from the research articles (...) in Cell were sampled. The unit of classification was defined as a graphic and the figures and tables were divided into 5952 graphics. These graphics were further classified into hierarchical categories, and the data in each category were aggregated every five years. The following categories were observed: data graphics, explanation graphics, and hybrid graphics. Data graphics increased by more than sixfold between 1974 and 2014, and some types of data graphics including mechanical reproduction images and bar charts displayed notable changes. The representation of explanatory graphics changed from hand-painted illustrations to diagrams of Bezier-curves. It is suggested that in addition to the development of experimental technologies such as fluorescent microscopy and big data analysis, continuously evolving application software for image creation and researchers’ motivation to convince reviewers and editors have influenced these changes. (shrink)

Inspired by Rick Grush's emulation theory, we reinterpreted a series of our neuroimaging experiments which were intended to examine the representations of complex movement, modality-specific imagery, and supramodal imagery. The emulation theory can explain motor and cognitive activities observed in cortical motor areas, through the speculation that caudal areas relate to motor-specific imagery and rostral areas embrace an emulator for amodal imagery.

ArgumentThe aim of this paper is two-fold: to offer an interpretation that preserves the natural reading ofPhysicsII 1 – that Aristotle is drawing a stark distinction between what is natural and what is artificial; and to show how there is logical room for atertium quid– a category for things that are products of both nature and art. This aim is attained by highlighting two important qualifications Aristotle makes about the products of art in relation to an innate internal principle of (...) change and pointing out that the proper understanding of the significance of the essential-accidental distinction that Aristotle draws must be viewed in the context where he identifies two kinds of nature – form and matter. Based on these analyses, the following three logical categories are shown to be consistent with the passage: 1) purely natural things; 2) essentially artificial objects; and 3) essentially natural things with artificial aspects. (shrink)

By defending the following views – that Aristotle identifies the generator and perhaps the obstacle remover as an essential cause of the natural sublunary elemental motion in Physics VIII 4; that this view is consistent with the view of Physics II 1 that the sublunary simple bodies have a principle of internal motion; and that the sublunary and the celestial elements have a nature in the very same way – I shall offer what has so far eluded Aristotelian commentators: a (...) consistent interpretation of Aristotle's theory of the natural motions of the sublunary and also the celestial elements. (shrink)

Against the background of enormous interest in virtue ethics, a new trend in moral education has appeared. This new trend, called 'the virtue approach to moral education', faces a strong challenge. If virtues are rooted in and developed within practices of a particular tradition, how is moral relativism to be avoided? Ironically, Alasdair MacIntyre, the foremost proponent of virtue ethics, has drawn the pessimistic conclusion that a shared public system of moral education is impossible in a plural society like ours. (...) This paper aims to challenge MacIntyre's pessimistic conclusion, and to explore the viability of moral education in virtues as a shared public practice. (shrink)

Is Aristotle committed, as a theoretical matter, to fixed species in biology? The answer seems to be a resounding no, if we were to infer his theoretical commitments from the actual practice found in his biological works. The answer, however, is far from clear, if we turn to the ‘philosophical discussion of biology’ found in Book 1 of Parts of Animals. In fact, I shall note that its context suggests that, contrary to some recent interpretations put forward, the phrase τὰ (...) ἔσχατα εἴδη at 644a23 is best translated and understood as ‘infima species’, and that such a reading implies that Aristotle favours the methodology that reflects his theoretical commitment to fixed species. (shrink)

In the contemporary discussion of artifacts, philosophers grapple with what is known as the continuum problem – the problem of drawing a clear distinction between what is and what is not artificial. They begin with the standard definition of artifacts (rooted in Aristotle’s distinction between what exists by nature and what exists by what he calls technē found in the opening passage of Physics II.1) as “objects made intentionally, in order to accomplish something”. But this definition turns out to be (...) rather vague and not as useful as it first appears. For example, does it include nonhuman animal products or a political community? The aim of this paper is to explicate how Aristotle would address the continuum problem by examining what he means by the crucial phrase, ‘from technē’ (apo technēs) which is found at Phys II.1.192b18 (casting doubt that the standard definition of artifacts does not really capture Aristotle’s view) and to explain what truly counts as “artificial products” for Aristotle. (shrink)

Immunity against SARS‐CoV‐2 that is acquired by convalescent COVID‐19 patients is examined in reference to (A) the Th17 cell generation system in psoriatic epidermis and (B) a recently discovered phenomenon in which Th17 cells are converted into tissue‐resident memory T (TRM) cells with Th1 phenotype. Neutrophils that are attracted to the site of infection secrete IL‐17A, which stimulates lung epithelial cells to express CCL20. Natural Th17 (nTh17) cells are recruited to the infection site by CCL20 and expand in the presence (...) of IL‐23. These nTh17 cells are converted to TRM cells upon encounter with SARS‐CoV‐2 and continue to exist as ex‐Th17 cells, which exert Th1‐like immunity during a memory response. G‐CSF can induce nTh17 cell accumulation at the infection site because it promotes neutrophil egress from the bone marrow. Hence, G‐CSF may be effective against COVID‐19. Administration of G‐CSF to patients infected with SARS‐CoV‐2 is worth a clinical trial. (shrink)

なぜ、彼はパリで死んだのか?『世界の中心で、愛をさけぶ』の大ブームから5年、作家・片山恭一が、新たに私たちに問うたもの―それは、孤高の哲学者・森有正の“死に方”であった。.

戦乱の世に仁義道徳を主張して学団を組織し、志士仁人の道を説いた中国古代の思想家・孔子と、民国初期の植民地化という危機を背景に、国民性の改革をめざした魯迅。中国史の豊かな素養を背景に、彼らの活動に共通す る「教育」という側面に着目し、国家と社会の「教育」に生涯を掛けたその思想と行動を浮き彫りにする。.

Rheumatoid arthritis (RA) may not be a multifactorial disease; it can be hypothesized that RA is developed through a series of events following a triggering event, which is the emergence of a chemokine for neutrophils in the synovium. IL‐17A, secreted by infiltrated neutrophils, stimulates synoviocytes to produce CCL20, which attracts various CCR6‐expressing cells, including Th17 cells. Monocytes (macrophages) appear after neutrophil infiltration according to the natural course of inflammation and secrete IL‐1β and TNFα. Then, IL‐17A, IL‐1β, and TNFα stimulate synoviocytes (...) to produce CCL20, amplifying the inflammation. Varieties of chemokines secreted by infiltrating cells accumulate in the synovium and induce synoviocyte proliferation by binding to the corresponding G protein‐coupled receptors, thus expanding the synovial tissue. CCL20 in this tissue attracts circulating monocytes that express both CCR6 and receptor activator of NF‐κB (RANK), which differentiate into osteoclasts in the presence of RANKL. In this way, pannus is formed, and bone destruction begins. (shrink)

幕府を倒し、この国を近代に導いたのは血塗られた思想である水戸学だった! 徳川光圀から三島由紀夫まで、系譜をすべて解き明かす。.

Children, in their everyday lives, encounter several types of humanoid robots. The purpose of this study was to investigate children’s folk knowledge of robots using the card-choice task. In the task, both adults and five- and six-year-old children were given nine questions concerning the biological and psychological properties of robots. They were asked to choose the appropriate stimuli from among five objects including living things, nonliving things, and a robot. The results revealed that the children tended to attribute certain biological (...) properties to the robot. These results accorded with previous results. However, in our study, contrary to previous such studies, even older children showed such a tendency. Moreover, the children were unable to choose all the cards in the same way as the adults. Thus, it can be concluded that children’s knowledge of robots is incomplete. And the children’s knowledge is changed by method. (shrink)

Previous research reported that in processing structurally ambiguous sentences comprehenders often preserve an initial incorrect analysis even after adopting a correct analysis following structural disambiguation. One criticism is that the sentences tested in previous studies involved referential ambiguity and allowed comprehenders to make inferences about the initial interpretation using pragmatic information, suggesting the possibility that the initial analysis persisted due to comprehenders' pragmatic inference but not to their failure to perform complete reanalysis of the initial misanalysis. Our study investigated this (...) by testing locally ambiguous relative clause sentences in Japanese, in which the initial misinterpretation contradicts the correct interpretation. Our study using a self-paced reading technique demonstrated evidence for the persistence of the initial analysis with this structure. The results from an eye-tracking study further suggested that the phenomenon directly reflected the amount of support given to the initial incorrect analysis prior to disambiguating information: The more supported the incorrect main clause analysis was, the more likely comprehenders were to preserve the analysis even after the analysis was falsified. Our results thus demonstrated that the preservation of the initial analysis occurs not due to referential ambiguities but to comprehenders' difficulty to fully revise the highly supported initial interpretation. (shrink)

This article describes the historical development of HPS/NOS mainly in higher education. Because the establishment of universities in Japan in late-nineteenth century was a reaction against Western imperialism, higher education aimed to cultivate scientists and engineers with an emphasis on practical applications. This direction in higher science and engineering education continues into the present. It has conditioned elementary and secondary education via university entrance examinations, where no questions on NOS appear. Hence, HPS research and education has developed in Japanese higher (...) education with little connection to elementary and secondary education. Instead, NOS is communicated in literature, movies, and other media. Scientific and technological communication occurs mainly outside the school curriculum in venues like museums. (shrink)

This study addressed the question of whether L2 learners are able to utilize verb’s argument structure information in online structural analysis. Previous L2 research has shown that L2 learners have difficulty in using verb’s intransitive information to guide online syntactic processing. This is true even though L2 learners have grammatical knowledge that is correct and similar to that of native speakers. In the present study, we contrasted three hypotheses, the initial inaccessibility account, the intransitivity overriding account, and the fuzzy subcategorization (...) frame account, to investigate whether L2 learner’s knowledge of intransitive verbs is in fact ignored in L2 online structural analysis. The initial inaccessibility account and the fuzzy subcategorization frame account predicted that L2 learners cannot access intransitivity information in building syntactic structures in any situation. The intransitivity overriding account predicted that intransitivity information is accessed in L2 parsing, but this process is overridden by the strong transitivity preference when a verb is followed by a noun phrase. Importantly, the intransitivity overriding account specifically predicted that L2 learners would be able to use intransitive information in online syntactic processing when a noun phrase does not appear immediately following a verb. We tested the three accounts in an eye-tracking reading experiment using filler-gap dependency structures. We manipulated verb’s transitivity information and lexically based plausibility information and tested English native speakers as a control L1 group and Japanese-English L2 participants. The results showed that L2 learners as well as native speakers processed sentences differently depending on the subcategorization information of the verb, and adopted transitive analysis only when the verb was optionally transitive, providing support for the intransitivity overriding. The results further demonstrated that L2 learners had strong expectations for the transitive structure, which is consistent with the view proposed by the hyper-active gap-filling hypothesis. In addition, the results showed that the semantic mismatch in the incorrect transitive analysis facilitated native speaker’s processing but caused difficulty for L2 learners. Together, the current study provides evidence that L2 learners use intransitive information of the verbs to guide their structural analysis when there are no overriding constraints. (shrink)

Contents: Hōtoku gaiki -- Ninomiya Sensei goroku -- Sanshi suitō.