Immunity against SARS‐CoV‐2 that is acquired by convalescent COVID‐19 patients is examined in reference to (A) the Th17 cell generation system in psoriatic epidermis and (B) a recently discovered phenomenon in which Th17 cells are converted into tissue‐resident memory T (TRM) cells with Th1 phenotype. Neutrophils that are attracted to the site of infection secrete IL‐17A, which stimulates lung epithelial cells to express CCL20. Natural Th17 (nTh17) cells are recruited to the infection site by CCL20 and expand in the presence (...) of IL‐23. These nTh17 cells are converted to TRM cells upon encounter with SARS‐CoV‐2 and continue to exist as ex‐Th17 cells, which exert Th1‐like immunity during a memory response. G‐CSF can induce nTh17 cell accumulation at the infection site because it promotes neutrophil egress from the bone marrow. Hence, G‐CSF may be effective against COVID‐19. Administration of G‐CSF to patients infected with SARS‐CoV‐2 is worth a clinical trial. (shrink)

Rheumatoid arthritis (RA) may not be a multifactorial disease; it can be hypothesized that RA is developed through a series of events following a triggering event, which is the emergence of a chemokine for neutrophils in the synovium. IL‐17A, secreted by infiltrated neutrophils, stimulates synoviocytes to produce CCL20, which attracts various CCR6‐expressing cells, including Th17 cells. Monocytes (macrophages) appear after neutrophil infiltration according to the natural course of inflammation and secrete IL‐1β and TNFα. Then, IL‐17A, IL‐1β, and TNFα stimulate synoviocytes (...) to produce CCL20, amplifying the inflammation. Varieties of chemokines secreted by infiltrating cells accumulate in the synovium and induce synoviocyte proliferation by binding to the corresponding G protein‐coupled receptors, thus expanding the synovial tissue. CCL20 in this tissue attracts circulating monocytes that express both CCR6 and receptor activator of NF‐κB (RANK), which differentiate into osteoclasts in the presence of RANKL. In this way, pannus is formed, and bone destruction begins. (shrink)

戦乱の世に仁義道徳を主張して学団を組織し、志士仁人の道を説いた中国古代の思想家・孔子と、民国初期の植民地化という危機を背景に、国民性の改革をめざした魯迅。中国史の豊かな素養を背景に、彼らの活動に共通す る「教育」という側面に着目し、国家と社会の「教育」に生涯を掛けたその思想と行動を浮き彫りにする。.

幕府を倒し、この国を近代に導いたのは血塗られた思想である水戸学だった! 徳川光圀から三島由紀夫まで、系譜をすべて解き明かす。.

哲学者・古在由重がひとりの同時代人として、戦争に突き進み拡大する戦中、そして平和と民主主義を希求する戦後のなかで、何を学び、考え、仲間たちとどう交遊・談話し、どう生き、闘ったか。膨大な「古在由重文庫」 (藤沢市湘南大庭市民図書館所蔵)―古在の蔵書・著作はもちろん、原稿メモ、講義テープ、日記・手帳、書簡、新聞スクラップなど―ならびに関係者の著作・文章を渉猟し、さらに多数の人々の聞き取りなど六年をかけて 取材・執筆し、時代に正面から立ち向かった哲学者の実像に迫る力作。.

ウィトゲンシュタインの言語ゲームと龍樹の空思想を軸に、無明=実在論を反実在論に転ずれば、仏教思想は相貌を一変し、和辻哲郎の説く「縁起‐内‐存在」の倫理の哲学史的意義も鮮明になる。本書の透徹した言葉を熟 読玩味するときひらかれる新しい世界像にあなたは驚くに違いない。.

dai 1-kan. Ningen, kyōiku ga umarekawaru tame -- dai 2-kan. Ningen to no deai, kyōiku to no deai -- dai 3 kan. Ningenrashiku naru tedate -- dai 4-kan. Jinrui no kibō, osanago -- dai 5-kan. Shishū, ushinawareta kisetsu o motomete -- dai 6-kan. Aru mazushiki shōgai no kiroku -- [7] Kyōiku to kyōikugaku.

A proof is given for the theorem that at least one bound state exists in a one-dimensional attractive potential however weak it may be. The proof is constructive in that it provides a method to explicitly solve the eigenvalue problem for the eigenvalues as well as the eigenfunctions. The method is well suited to precise numerical calculations.

敗戦、そして戸坂獄死から70年。1930年代、反戦運動が特高警察に根こそぎ弾圧されていくなかで、6年間にわたってしたたかに抵抗を続けた、世界に例のない文化組織「唯物論研究会」。戸坂潤をはじめ、この唯研 に集う若き知識人たちは、ファシズムが吹き荒れる下でも、人生を楽しみ、仲間と交わり、好戦イデオロギーに抗い続け、のちに戦後の民主主義運動の芽となっていった。.

現代を生き抜くための武器としての哲学を、西野カナ、ミスチル、いきものがかり等Jポップの歌詞を題材に、気鋭の哲学者が説く。.

We investigate how weak square principles are denied by Chang’s Conjecture and its generalizations. Among other things we prove that Chang’s Conjecture does not imply the failure of \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\square_{\omega_1, 2}}$$\end{document}, i.e. Chang’s Conjecture is consistent with \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\square_{\omega_1, 2}}$$\end{document}.

The primary objective of this anthology is to make intergenerational justice an issue for intercultural philosophy, and, conversely, to allow the latter to enrich the former. In times of large-scale environmental destabilization, fair- ness between generations is an urgent issue of justice across time, but it is also a global issue of justice across geographical and nation-state borders. This means that the future generations envisioned by the currently living also cross these borders. Thus, different philosophical cultures and traditions of thought (...) should converse to re ect on what is fair to future people. In the remainder of this introduction, we will detail these claims and give an overview of the volume’s chapters. (shrink)

Investigates Aristotle's views on the ontological status of artifacts in the Metaphysics, with implications for a variety of metaphysical problems.

Minami–Sakai :883–898, 2016) investigated the cofinal types of the Katětov and the Katětov–Blass orders on the family of all \ ideals. In this paper we discuss these orders on analytic P-ideals and Borel ideals. We prove the following:The family of all analytic P-ideals has the largest element with respect to the Katětov and the Katětov–Blass orders.The family of all Borel ideals is countably upward directed with respect to the Katětov and the Katětov–Blass orders. In the course of the proof of (...) the latter result, we also prove that for any analytic ideal \ there is a Borel ideal \ with \. (shrink)

We study the relationship between the semistationary reflection principle and stationary reflection principles. We show that for all regular cardinals Λ ≥ ω₂ the semistationary reflection principle in the space [Λ](1) implies that every stationary subset of $E_{\omega}^{\lambda}\coloneq \{\alpha \in \lambda \,|\,{\rm cf}(\alpha)=\omega \}$ reflects. We also show that for all cardinals Λ ≥ ω₃ the semistationary reflection principle in [Λ](1) does not imply the stationary reflection principle in [Λ](1).

This book explores the contributions of East Asian traditions, particularly Buddhism and (Euro)Daoism, to environmental philosophy. It critically examines the conceptions of human responsibility toward nature and across time presented within these traditions as well as in European philosophy. The volume rethinks human relationships to the natural world by focusing on three main themes: Daoist and Eurodaoist perspectives on nature, human responsibility toward nature, and Buddhist perspectives on life and nature. By way of discussing East Asian traditions and European thinkers, (...) this collection reveals that the impact of humanity on the environment is shaped not only by distinctive modes of economic production, but also by cultural beliefs and practices. Representing a unique constellation of environmental and intercultural philosophy, the contributions present systematic approaches to the global need for cultivating environmental responsibility across cultures and generations to address the political, ethical, and aesthetic challenges arising from humanity’s transformative impact on the natural world. (shrink)