The recent emergence of reprogramming technologies to convert brain cell types or epigenetically alter neurons and neural progenitors in vivo and in situ hold significant promises in brain repair and neuronal aging reversal. However, given the significant epigenetic and transcriptomic changes to components of the existing neuronal cells and network, we question if these reprogramming technology might inadvertently alter or erase memory engrams, conceivably resulting in changes in narrative identity or personality. We suggest that the nature of these alterations might (...) be less predictable compared to memory and personality changes known to be associated with diseases, drugs or brain stimulation therapies. While research in applying reprogramming technologies to neurological ailments and aging should continue, more targeted analyses should be put in place in animal experiments to gauge the severity and degree of memory alterations, and appropriate risk and benefit analyses should be conducted before these technologies move into human trials. (shrink)

The graduate course in research ethics in the Graduate School for Integrative Sciences and Engineering at the National University of Singapore consists of a semester long mandatory course titled: “Research Ethics and Scientific Integrity.” The course provides students with guiding principles for appropriate conduct in the professional and social settings of scientific research and in making morally weighted and ethically sound decisions when confronted with moral dilemmas. It seeks to enhance understanding and appreciation of the moral reasoning underpinning various rules (...) and legislative constraints associated with research subjects and procedures. Further, students are trained to critically analyse cases and issues associated with scientific misconduct preparing them to act in a responsible and effective manner should they encounter such cases. The diverse background and training of the cohort also provide a unique setting and opportunity for student-initiated collaborative interdisciplinary learning. This article offers a reflective account of the course and some preliminary insights into learning outcomes. (shrink)

Similar to visual perception, auditory perception also has a clearly described “pop-out” effect, where an element with some extra feature is easier to detect among elements without an extra feature. This phenomenon is better known as auditory perceptual asymmetry. We investigated such asymmetry between shorter or longer duration, and level or falling of pitch of linguistic stimuli that carry a meaning in one language, but not in another. For the mismatch negativity experiment, we created four different types of stimuli by (...) modifying the duration of the first vowel [ɑ] and pitch contour of the stimuli words. The stimuli were synthesized from Estonian words and follow the Estonian language three-way quantity system, which incorporates tonal features together with temporal patterns. This made the meaning of the word dependent on the combination of both features and allows us to compare the relative contribution of duration and pitch contour in discrimination of language stimuli in the brain via MMN generation. The participants of the experiment were 12 Russian native speakers with little or no experience in Estonian and living in Estonia short-term, and 12 Estonian native speakers. We found that participants’ perception of the linguistic stimuli differed not only according to the physical features but also according to their native language, confirming that the meaning of the word interferes with the early automatic processing of phonological features. The GAMM and ANOVA analysis of the reversed design results showed that the deviant with longer duration among shorter standards elicited a MMN response with greater amplitude than the short deviant among long standards, while changes in pitch contour produced neither strong MMN nor asymmetry. Thus, we demonstrate the effect of language background on asymmetric perception of linguistic stimuli that aligns with those of previous studies, and contributes to the growing body of knowledge supporting auditory perceptual asymmetry. (shrink)

Bülow and Helgesson discussed the practice of gift/honorary authorships and expounded on a most devious form of these, termed ‘hostage authorship’. The authors drew a parallel of such situations in research and publishing with the problem of ‘dirty hands’. In this case, acceding, albeit with regrets, may well be ‘… what we ought to do, even if it requires us to do something that is intrinsically bad’, especially if ‘this is both practically necessary and proportionate to the end’. Here, I (...) caution against this being a morally cogent, normative course of action. Tangible benefits from research not yet performed or published could not be predicted with any certainty, and as such could not be deemed sufficiently important to override moral constraints of justice and fairness. The utilitarian argument for any measure of beneficence with ‘dirty hands’ could therefore be nothing more than a self-serving act, or a self-exonerating form of moral disengagement. Such actions could have lasting ill effects on junior... (shrink)

Misconduct in science is often viewed and analyzed through the lenses of normative ethics and moral philosophy. However, notions and methods in the philosophy of science could also provide rather penetrative explanatory insights into the nature and causes of scientific misconduct. A brief illustration in this regard, using as examples the widely popular Popperian falsification and the Kuhnian scientific paradigm, is provided. In multiple areas of scientific research, failure to seek falsification in a Popperian manner constitutes a questionable research practice (...) and could lead to “falsification” in the context of research misconduct. On the other hand, scientific misconduct is often facilitated by its perpetrators using the familiarity, expectations and confines of a Kuhnian paradigm to blend in fabricated data/results. A rudimentary application of these philosophical notions could be useful in our understanding of the nature and cause of research misconduct, and facilitate mitigation of the latter through educational means. (shrink)

This study investigates the efficacy of three corporate social responsibility (CSR) initiatives—sponsorship, cause-related marketing (CRM), and philanthropy—on consumer–company identification (C–C identification) and brand attitude and, in turn, consumer citizenship behaviors. CSR reputation is proposed as the moderating variable that affects the relationship between CSR initiatives, C–C identification, and brand attitude. A conceptual model that integrates the hypothesized relationships and the moderating effect of CSR reputation is used to frame the study. Using a between-subjects factorial designed experiment, the results showed that (...) all three CSR initiatives have a significant effect on C–C identification and brand attitude. The level of that influence, however, varied according to a firm’s CSR reputation. Managerial implications of these findings are also discussed. (shrink)

A retraction notice is a formal announcement for the removal of a paper from the literature, which is a weighty matter. Xu et al. (Science and Engineering Ethics, 29(4), 25 2023) reported that 73.7% of retraction notices indexed by the Web of Science (1927–2019) provided no information about institutional investigations that may have led to the retractions, and recommended that Committee on Publication Ethics (COPE) retraction guidelines should make it mandatory to disclose institutional investigations leading to retractions in such notices. (...) While this recommendation would add to the transparency of the retraction process, a blanket mandate as such could be potentially problematic. For research misconduct (RM)-positive cases, a mandatory investigative disclosure may be abused by some to deflect responsibility. More importantly, a mandatory disclosure could harm authors and institutions in RM-negative cases (i.e. those stemming from honest errors with no misconduct). I illustrate with case vignettes the potential epistemic injustice and confusion that a mandate for investigation disclosure in retraction notices could incur, and suggest a more nuanced approach to its implementation. (shrink)

This article is designed to explore the concept of the social sphere and its relations to public life. `Social sphere' here refers to a societal self-organization to create a common cultural landscape on which various forms of performance and public drama are staged, and through which a social bond among strangers is created and public life maintained. It is argued that different societies have different kinds of social spheres with distinctive forms of cultural performance, and thus create various types of (...) public life. Through a genealogical exploration, four kinds of social spheres (religious ceremonies, public festivals, recreation and consumption), associated with four types of performance (ritual, spectacular, theatrical and magical) are identified. The social transformation of the nature of public life is thereby explored. It is here that I see the structural source of modern individualism and its relations to cultural performance. (shrink)

Zusammenfassung Zahlreiche Fußballvereine der 1. und 2. Bundesliga sind aus Fusionen hervorgegangen, doch bislang ist kaum etwas über dieses Phänomen in der Sportwissenschaft bekannt. Ziel des Aufsatzes ist es, mittels einer organisationssoziologischen Brille den SC Paderborn 07, als Bundesligaverein, der aus mehreren Fusionen hervorgegangen ist und als solcher verschiedene Traditionslinien in sich vereint, zu beleuchten. Dabei werden insbesondere die sozialen Folgen in den Blick genommen.

Irregularities in data/results of scientific research might be spotted pre-publication by co-workers and reviewers, or post-publication by readers typically with vested interest. The latter might consist of fellow researchers in the same subject area who would naturally pay closer attention to a published paper. However, it is increasingly apparent that there are readers who interrogate papers in detail with a primary intention to identify potential problems with the work. Here, we consider post-publication peer review (PPPR) by individuals, or groups of (...) individuals, who perform PPPRs with a perceptible intention to actively identify irregularities in published data/results and to expose potential research fraud or misconduct, or intentional misconduct exposing (IME)-PPPR. On one hand, such activities, when done anonymously or pseudonymously with no formal discourse, have been deemed as lacking in accountability, or perceived to incur some degree of maleficence, and have been labelled as vigilantism. On the other, these voluntary works have unravelled many instances of research misconduct and have helped to correct the literature. We explore the tangible benefits of IME-PPPR in detecting errors in published papers and from the perspectives of moral permissibility, research ethics, and the sociological perspective of science. We posit that the benefits of IME-PPPR activities that uncover clear evidence of misconduct, even when performed anonymously or pseudonymously, outweigh their perceived deficiencies. These activities contribute to a vigilant research culture that manifests the self-correcting nature of science, and are in line with the Mertonian norms of scientific ethos. (shrink)

Cases of research misconduct in the ecological and environmental sciences appear to be relatively rare. A controversial paper published in Science in 2016 documenting the effects of microplastics on the feeding and innate behaviours of fish larvae has recently been retracted, with the authors found guilty of scientific misconduct. In addition to the expected fallout, such as individual and institutional reputational damage from a research misconduct finding, this case has two possibly wider-ranging ramifications. Firstly, there may be a presumptive notion (...) that a strong negative effect could be more successfully published than a neutral effect. This presumption would belie the true stringency and rigor of research adopted by workers in the field. Secondly, the case may have a negative impact on the public’s perception of and trust in legitimate and good science that addresses critical environmental issues, such as anthropogenic climate change. (shrink)

This book introduces a new form of argumentative analysis: rhetorical heuremes. The method applies the concepts of heuristic thinking, probability, and contingency in order to develop a better understanding of complex arguments in classical oratory. A new theory is required because Greek and Roman rhetoric cannot provide detailed answers to problems of strategic argumentation in the analysis of speeches. Building on scholarship in Ciceronian oratory, this book moves beyond the extant terminology and employs a concept of heuristic reasoning derived from (...) the psychology of decision making and mathematical problem solving. The author analyses selected passages from Cicero's forensic speeches where arguments of probability are deployed, and shows that the Sophistic concept of probability can link ancient rhetoric and modern theories of argumentation. Six groups of heuremes are identified, each of which represents a form of probabilistic reasoning by which the orator plays upon the perception of the jurors. (shrink)

Scientific research is supposed to acquire or generate knowledge, but such a purpose would be severely undermined by instances of research misconduct (RM) and questionable research practices (QRP). RM and QRP are often framed in terms of moral transgressions by individuals (bad apples) whose aberrant acts could be made conducive by shortcomings in regulatory measures of organizations or institutions (bad barrels). This notion presupposes, to an extent, that the erring parties know exactly what they are doing is wrong and morally (...) culpable, but had nonetheless proceeded to commit wrongful acts. However, a confession of intent to deceived is often not readily admitted by perpetrators of RM. I posit that beyond the simplistic notion of conscious moral transgression, deficits in epistemic virtues and/or the prevalence of epistemic vices have important roles to play in initiating and driving RM/QRP. For the individual perpetrator, deficits in epistemic virtues could lead to or amplify errors in one’s desperate attempt to be accomplished or to excel, and pushes one across the ethical line or down the slippery slope of misconduct. Likewise, a lack of epistemic virtue within perpetrators’ institution or organization could make it conducive for deceitful acts and suppress indications and warning signs for the former. Furthermore, epistemic vices exhibited by reviewers, editors and journals could also promote RM/QRP. In this view, epistemic failings, rather than widespread moral deficiencies of individuals within the research ecosystem, may underlie the prevalence of RM/QRP. (shrink)

Proteins of the exocytotic (secretory) pathway are initially targeted to the endoplasmic reticulum (ER) and then translocated across and/or inserted into the membrane of the ER. During their anterograde transport with the bulk of the membrane flow along the exocytotic pathway, some proteins are selectively retained in various intracellular compartments, while others are sorted to different branches of the pathway. The signals or structural motifs that are involved in these selective targeting processes are being revealed and investigations into the mechanistic (...) nature of these processes are actively underway. (shrink)

Cicero is increasingly recognised as a highly intelligent contributor to the ongoing ethical debates between Epicureans, Stoics and other schools. In this work on the fundamentals of ethics his learning as a scholar, his skill as a lawyer and his own passion for the truth result in a work which dazzles us in its presentation of the debates and at the same time exhibits the detachment of the ancient sceptic. Many kinds of reader will find themselves engaged with Cicero as (...) well as with the ethical theories he presents. This collection takes the reader further into the debates, opening up new avenues for exploring this fascinating work. (shrink)

This article analyses the online communication of the Estonian extreme right that appears to be characterized by an echo-chamber effect as well as enclosed and hermetic meaning-making. The discussion mainly relies on the theoretical frameworks offered by semiotics of culture.One of the aims of the article is to widen the scope of understanding of autocommunicative processes that are usually related to learning, insight and innovation. The article shows the conditions in which autocommunicative processes result in closed interactions, based on reproducing (...) stereotypes and redundant content. We detect antithetical meaning-making, an orientation towards normative (“correct”) texts and the prevalence of phatic communication as the main dominants that guide closed autocommunication. Such communication leads to polarization of dissimilar views and hinders dialogue. Our case study focuses on the discussion that arose in the context of the European Refugee Crisis that started in spring 2015. (shrink)

Kur’an tasavvuru belli kavramlardan meydana gelmektedir. İnsanın fiziki ve manevî yönünü ifade eden fıtrat kavramı, Kur’an tasavvurunu ifade eden önemli kavramlarından biridir. Fıtrat kavramının ilk günden itibaren tefsircilerin ilgi odağı olması da bundandır. Genellikle fıtrat, İslam dini, ilk yaratılış ve insanın dini kabul etme potansiyeli olarak yorumlanmış ve bunların değişip değişmeyeceği üzerinde durulmuştur. Rum sûresinde geçen “khalqullah” ile Nisâ sûresinde geçen “khalqullah” terkiplerinin bulunduğu âyetler arasında bu çerçevede bağlantı kurulmuştur. Bu çalışmamızda fıtratın mahiyeti ile fıtratla ilgili âyetlerin birbiriyle ilişkilendirilmesi irdelenecek (...) ve fıtratın temel unsurları üzerinde durulacaktır. Akıl, sevgi, aşk, güzel şeylere ilgi duyma ve çirkinliklerden kaçınmanın, insan fıtratının temel bileşenleri arasında yer alıp almadığı tartışılacaktır. Ayrıca fıtrat âyetinde geçen tebdîl kavramı ile Nisâ sûresinde geçen tağyir kavramının, aynı manayı ifade edip etmediği üzerinde durulacaktır. (shrink)