For many viruses, RNA is the holder of genetic information and serves as the template for both replication and translation. While host and viral proteins play important roles in viral decision‐making, the extent to which viral RNA (vRNA) actively participates in translation and replication might be surprising. Here, the focus is on flaviviruses, which include common human scourges such as dengue, West Nile, and Zika viruses, from an RNA‐centric viewpoint. In reviewing more recent findings, an attempt is made to fill (...) knowledge gaps and revisit some canonical views of vRNA structures involved in replication. In particular, alternative views are offered on the nature of the flaviviral promoter and genome cyclization, and the feasibility of refining in vitro‐derived models with modern RNA probing and sequencing methods is pointed out. By tracing vRNA structures from translation through encapsidation, a dynamic molecule closely involved in the self‐regulation of viral replication is revealed. (shrink)

The Adverse Outcome Pathway (AOP) concept is a knowledge assembly and communication tool to facilitate the transparent translation of mechanistic information into outcomes meaningful to the regulatory assessment of chemicals. The AOP framework and associated knowledgebases (KBs) have received significant attention and use in the regulatory toxicology community. However, it is increasingly apparent that the potential stakeholder community for the AOP concept and AOP KBs is broader than scientists and regulators directly involved in chemical safety assessment. In this paper we (...) identify and describe those stakeholders who currently—or in the future—could benefit from the application of the AOP framework and knowledge to specific problems. We also summarize the challenges faced in implementing pathway-based approaches such as the AOP framework in biological sciences, and provide a series of recommendations to meet critical needs to ensure further progression of the framework as a useful, sustainable and dependable tool supporting assessments of both human health and the environment. Although the AOP concept has the potential to significantly impact the organization and interpretation of biological information in a variety of disciplines/applications, this promise can only be fully realized through the active engagement of, and input from multiple stakeholders, requiring multi-pronged substantive long-term planning and strategies. (shrink)

I am indebted to many people, especially Dorsey Armstrong, Shannon French, and Kenneth Hodges, for helpful discussions of this material. An early version of this essay was read at the Thirty-Sixth International Congress on Medieval Studies.This essay is dedicated to the glorious memory of Nina Lindsey.

It is commonly argued that the fact that our universe is fine-tuned for life favors both a design hypothesis as well as a non-teleological multiverse hypothesis. The claim that the fine-tuning of this universe supports a non-teleological multiverse hypothesis has been forcefully challenged however by Ian Hacking and Roger White. In this paper we take this challenge even further by arguing that if it succeeds, then not only does the fine-tuning of this universe fail to support a multiverse hypothesis, but (...) it tends to favor a single-universe hypothesis instead. (shrink)

This article proposes a role for aesthetic judgment in our practical thought. The role is related to those moments when practical reason seems to give out, when it fails to yield a judgment about what to do in the face of a choice we cannot avoid. I argue that these impasses require agents to create, but that not any creativity will do. For we cannot regard a response to one of these problems as arbitrary or capricious if we want to (...) act on it. We must instead regard that response as justified by the problem itself. I suggest that this combination of creativity and normativity is characteristic of aesthetic judgment and this makes it a promising candidate for making these very difficult choices. (shrink)

Michelman's Constitutional Essentials raises important questions about the idea of political liberalism and related idea of public reason. This essay offers a sympathetic commentary while also exploring the importance of the idea of reciprocity for both Rawls and Michelman.

If representation is resemblance, how we do we think of groups or classes of things? According to a tradition Berkeley opposed—a tradition represented by Locke—we do so by forming abstract or incomplete ideas. I show that Berkeley's opposition does not depend on his own personal failure to form abstract images, but on what he took to be the impersonal or objective impossibility of abstract objects. Berkeley himself accounts for general thinking not in terms of abstract or incomplete ideas, but in (...) terms of our selective attention to ideas both concrete and determinate. Contentful thought about the natural world is impossible without ideas as objects, Berkeley believes, but ideas do not, in his view, completely fix the content of our thought. (shrink)

After describing the corpuscularian background of Berkeley's work, I consider whether Berkeley can endorse the existence of immaterial atoms or corpuscles. I suggest that he hopes to avoid a definite commitment. He wants his position to ‘float’, its level to be determined by the kind of empirical evidence that would strike materialists and immaterialists with equal force. This chapter foregrounds the role played by the notion of intelligibility, both in the defence of modern corpuscularian science and in Berkeley's critical response (...) to it. (shrink)

This chapter reviews and assesses Berkeley's main arguments for immaterialism, his arguments against the existence of matter or material substance. I place particular emphasis on the themes of earlier chapters: intentionality, abstraction, necessity, and intelligibility. My aim is to show that Berkeley's thinking about these topics made a powerful contribution to his immaterialism, even if they seem, on the surface, to be distant from it. I provide an account of immediate perception as Berkeley understands it, and emphasize the phenomenalist elements (...) in Berkeley's development of immaterialism. (shrink)

I suggest that in his early, unpublished notebooks, Berkeley experimented with a radically formal conception of necessity, according to which necessity is nothing more than the inclusion of one idea within the definition of another. Berkeley's experiment was defeated by the same objective connections that rule out the existence of simple ideas. Although Berkeley was left without an understanding of the nature of necessity, he never wavered in his conviction that necessity is something objective—that ideas and the world have an (...) inherent, inescapable structure. (shrink)

I offer an interpretation and partial defence of Berkeley's belief that he is a mind or spirit—a spiritual substance—distinct from his ideas. I argue in particular that the arguments examined in earlier chapters, particularly the account of representation or intentionality developed in Ch. 1, and the immaterialist arguments reviewed in Ch. 6, do not force Berkeley to conclude that spiritual substance is no less impossible than matter.

Many empiricists, among them Locke and Hume, make a distinction between simple and complex ideas. Berkeley refuses to do so, because he finds connections—objective connections incompatible with simplicity—even among the ‘simplest’ of ideas. Simple ideas, in his view, are illegitimately abstract.

This is the first of three chapters examining the consequences of Berkeley's immaterialism and the problems to which it gives rise. In the present chapter, I defend a phenomenalist interpretation of Berkeley on unperceived objects. Appealing to his denial of blind agency, I show that a phenomenalist interpretation can be reconciled with texts that seem to go against it. I provide a modest interpretation of Berkeley's doctrine of archetypes, and argue briefly that even in Siris, Berkeley's doctrine of archetypes is (...) unambitious and not especially Platonic. (shrink)

This chapter explores the difference between two kinds of signs that Berkeley followed Locke in recognizing: words and ideas. I argue that Berkeley does not assume that ideas are images of things but concludes it, as part of a deliberate attempt to explain how at least some of our thoughts succeed in referring to the world. For Berkeley, representation—the intentionality or ‘aboutness’ of thought—is sometimes a matter of resemblance.

The naturalist and geologist Charles Darwin ranks as one of the most influential scientific thinkers of all time. In the nineteenth century his ideas about the history and diversity of life - including the evolutionary origin of humankind - contributed to major changes in the sciences, philosophy, social thought and religious belief. This volume provides the reader with clear, lively and balanced introductions to the most recent scholarship on Darwin and his intellectual legacies. A distinguished team of contributors examines Darwin's (...) main scientific ideas and their development; Darwin's science in the context of its times; the influence of Darwinian thought in recent philosophical, social and religious debate; and the importance of Darwinian thought for the future of naturalist philosophy. New readers will find this a most convenient and accessible guide to Darwin. Advanced students and specialists will find a conspectus of recent developments in the interpretation of Darwin. (shrink)

This article reviews the history of medical and research abuses experienced by American Indians since European colonization. This article examines the unethical research of American Indians/Alaska Natives in light of the Tuskegee Study of Untreated Syphilis in the Negro Male. Literature citations indicate that significant unethical research and medical care incidents occurred both before and after the Tuskegee Syphilis Study among American Indians/Alaska Natives. The majority of these unethical abuses were committed by the federal government and within the historical context (...) of a long-term contentious relationship between American Indians and the federal government. Although President Clinton issued a highly visible public apology to the African American survivors of the Tuskegee syphilis experiment in 1997, American Indians have yet to experience such visible federal acknowledgment. To ensure ethical research in which benefits outweigh risks and findings are not value-laden or misrepresented, tribes have instituted their own Institutional Review Boards coupled with community-participatory activities. (shrink)

The author argues for three interconnected theses which provide a cognitive account for why humans intuitively believe that others survive death. The first thesis, from which the second and third theses follow, is that the acceptance of afterlife beliefs is predisposed by a specific, and already well-documented, imaginative process - the offline social reasoning process. The second thesis is that afterlife beliefs are social in nature. The third thesis is that the living imagine the deceased as socially embodied in such (...) a way as to continue to fulfill on-going social obligations with others. The author further suggests six reasons why the fantasy/reality distinction breaks down for the imaginer such that the continued existence of the decedent in the afterlife is believed to be real. Finally, the author suggests avenues for further research which would support this cognitive account. (shrink)

This is a comprehensive investigation into the theme of time in the work of Jacques Derrida and shows how temporality is one of the hallmarks of his thought. Drawing on a wide array of Derrida's texts, Joanna Hodge: compares and contrasts Derrida's arguments concerning time with those Kant, Husserl, Augustine, Heidegger, Levinas, Freud, and Blanchot argues that Derrida's radical understanding of time as non-linear or irregular is essential to his aim of blurring the distinction between past and present, biography (...) and literature, philosophical and religious meditation, and the nature of the self explores the themes of death, touch and transcendence to argue that if considered under the theme of temporality there is more continuity to Derrida's thought than previously considered. (shrink)

This is a comprehensive investigation into the theme of time in the work of Jacques Derrida and shows how temporality is one of the hallmarks of his thought. Drawing on a wide array of Derrida's texts, Joanna Hodge: compares and contrasts Derrida's arguments concerning time with those Kant, Husserl, Augustine, Heidegger, Levinas, Freud, and Blanchot argues that Derrida's radical understanding of time as non-linear or irregular is essential to his aim of blurring the distinction between past and present, biography (...) and literature, philosophical and religious meditation, and the nature of the self explores the themes of death, touch and transcendence to argue that if considered under the theme of temporality there is more continuity to Derrida's thought than previously considered. (shrink)

Historians of science have long been agreeing: what many textbooks of evolutionary biology say, about the histories of Darwinism and the New Synthesis, is just too simple to do justice to the complexities revealed to critical scholarship and historiography. There is no current consensus, however, on what grand narratives should replace those textbook histories. The present paper does not offer to contribute directly to any grand, consensual, narrational goals; but it does seek to do so indirectly by showing how, in (...) just one individual case, details of intellectual biography connect with big picture issues. To this end, I examine here how very diverse scientific and metaphysical commitments were integrated in Sewall Wright’s own personal synthesis of biology and philosophy. Taking as the decisive text the short final section of Wright’s long 1931 paper on ‘Evolution in Mendelian populations,’ I examine how his shifting balance theory related to his optimum breeding strategy research, his physiological genetics, his general theory of homogenising and heterogenesing causation and his panpsychist view of mind and matter; and I discuss how understanding these relations can clarify Wright’s place in the longue durée of evolutionary thought. (shrink)

As a historical figure, Lamarck proves a rather difficult subject. His writings give us few explicit leads to his intellectual debts; nor do they present his theories as the outcome of any sustained course of observations or experimental research; and, what is equally frustrating, it is hard to see how his personal development as a scientific theorist was affected by the dramatic political and social upheavals of the period, in which he took an active and lively interest. And so, with (...) his importance for later writers much clearer than his relationship to those of his own and earlier ages, historians have repeatedly interpreted his works as prophetic of doctrines developed more fully by subsequent generations. No less surprisingly, this facile tactic has provoked a reaction; we have been offered Lamarck as a Stoic, a romantic, harking back to Heraclitus. (shrink)

Bernard Norton's friends in the history of science have had many reasons for commemorating, with admiration and affection, not only his research and teaching but no less his conversation and his company. One of his most estimable traits was his refusal to beat about the bush in raising the questions he thought worthwhile pursuing. I still remember discoursing at Pittsburgh on Darwin's route to his theory of natural selection, and being asked at the end by Bernard what were Darwin's views (...) on heredity. I answered with the conventional waffle to the effect that the theory concerned the populational fate rather than the individual production and transmission of heritable variation, so that whatever views Darwin had on heredity had only a subsidiary place in his theorizing. Bernard was not fooled. ‘I would have thought’, he said, ‘that in order to understand anyone's theorising about evolution it would be necessary to look at his views on heredity’. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Ethics and Time:Lévinas Between Kant and HusserlJoanna Hodge (bio)This article stems from the conviction that the source of the bloody barbarism of National Socialism lies not in some contingent anomaly within human reasoning, nor in some accidental ideological misunderstanding. This article expresses the conviction that this source stems from the essential possibility of elemental evil into which we can be led by logic and against which Western philosophy (...) had not sufficiently insured itself. This possibility is inscribed within the ontology of a being concerned with being—a being, to use the Heideggerian expression, "which in its own being is concerned with that being." Such a possibility still threatens the subject correlative with being as gathering together and as dominating, that famous subject of transcendental idealism that before all else wishes to be free and thinks itself free. We must ask ourselves if liberalism is all we need to achieve the authentic dignity for the human subject. Does the subject ever arrive at the human condition prior to assuming responsibility for the other in the act of election that raises him up to this height? This election comes from a god—or God—who beholds him in the face of the other, the neighbour, the original "site" of the Revelation.—Emmanuel Lévinas, 28 March 1990, introduction to "Reflections on the Philosophy of Hitlerism" (1934)1IntroductionThe intent of this essay is to establish the relevance of various divergent workings of time for an understanding of the difficulties distinctive of moral dilemmas and ethical doubt. It will introduce the thinking of Lévinas (1905-96) to bring into focus the differences entailed in addressing ethical contexts from various perspectives of time, whether in terms of past experience, present contingencies, or considerations of the future. It turns out to be necessary to distinguish between various conceptions of the future as well, in order to grasp the different construals of constraints on moral deliberation. A contrast may be drawn between the individualism and the collectivism, [End Page 107] respectively, of Nietzsche's and Heidegger's visions of the future;1 and between the religious determinacies of Lévinas's invocation of futurity and Derrida's more ascetic, formally indicative recasting of Lévinas's à-dieu.2 It is also the case that distinct conceptions of the past impose significant constraints on what human beings can hope to achieve in their moral efficacy. There is an important difference between the Greco-pagan past, invoked by Nietzsche and Heidegger, and the divine time of creation invoked in the opening pages of Genesis, which is the source of Lévinas's notion of an immemorial time, and which is subjected to deconstructive reading by Jacques Derrida in "The Animal Which Therefore I Am, to Be Continued" [see Derrida, "L'animal autobiographique"].I shall introduce a reading of the second part of Kant's treatise The Conflict of the Faculties (1798) [139-71], on the contest between philosophy and law, to suggest that for ethics, by contrast to concerns with aesthetics, metaphysics, and epistemology, a consideration of conceptions of futurity is especially pressing. This provides a context for responding to Lévinas's early article "Reflections on the Philosophy of Hitlerism" (1934), to which Lévinas wrote an introduction, including my opening citation, some sixty years later.3 Lévinas is not simply engaging with the problem of evil, in relation to the now well-known moral deficiencies of Heidegger's fundamental ontology.4 He is also warning, more generally, against delusions arising from theoretical abstraction, in both absolute idealism and, indeed, in a Nietzschean ethics. His own writings, from Time and the Other (1947) on, suggest that the deficiency arises from oversimplifications [End Page 108] in the thinking of time. Taking this as a clue, the main tasks of this essay are to show that the broadly historical notion of time, which appears oriented toward the past, requires a complementary reflection on futurity, if the ethical significance of different ways of relating to the past is to emerge; and, in relation to that futurity, to show that the broadly teleological, future-directed notions of self-formation, deliberation, and genesis require supplementation... (shrink)

The central unifying element in the philosophy of Peter Browne is his theory of analogy. Although Browne's theory was originally developed to deal with some problems about religious language, Browne regards analogy as a general purpose cognitive mechanism whereby we substitute an idea we have to stand for an object of which we, strictly speaking, have no idea. According to Browne, all of our ideas are ideas of sense, and ideas of sense are ideas of material things. Hence we can (...) conceive of spiritual things – including even our own spirit – only by analogy. One interesting application Browne makes of his theory is an account of how concepts such as knowledge can be correctly applied to beings that have no intrinsic properties in common, such as non-human animals, humans, angels, and God. I argue that this is best understood as what, in the contemporary literature, is known as a ‘multiple realizability’ problem and that Browne's solution to this problem has important similarities to functionalist theories in recent philosophy of mind. (shrink)

Those standard historiographic themes of "evolution" and "revolution" need replacing. They perpetuate mid-Victorian scientists' history of science. Historians' history of science does well to take in the long run from the Greek and Hebrew heritages on, and to work at avoiding misleading anachronism and teleology. As an alternative to the usual "evo-revo" themes, a historiography of origins and species, of cosmologies (including microcosmogonies and macrocosmogonies) and ontologies, is developed here. The advantages of such a historiography are illustrated by looking briefly (...) at a number of transitions: the transition from Greek and Hebrew doctrines to their integrations by medieval authors; the transition from the Platonist, Aristotelian, Christian Aquinas to the Newtonian Buffon and to the no less Newtonian Lamarck; the departures the early Darwin made away from Lamarck's and from Lyell's views. Issues concerning historical thinking about nature, concerning essentialism and concerning classification are addressed in an attempt to challenge customary stereotypes. Questions about originality and influence are raised, especially concerning Darwin's "tree of life" scheme. The broader historiography of Darwinian science as a social ideology, and as a "worldview," is examined and the scope for revisions emphasised. Throughout, graduate students are encouraged to see this topic area not as worked out, but as full of opportunities for fresh contributions. (shrink)

Among the many components of legal preparedness for public health emergencies is the assurance that the public health workforce and its private sector partners are competent to use the law to facilitate the performance of essential public health services and functions. This is a significant challenge. Multiple categories of emergencies, stemming from natural disasters to emerging infectious diseases, confront public health practitioners. Interpreting, assessing, and applying legal principles during emergencies are complicated by the changing legal environment and differences in governmental (...) organization of emergency management functions. While law and legal competencies are essential to routine public health practices, once government declares a state of public health emergency or disaster, the legal landscape changes. Typical legal responses to protect the public's health may no longer be the norm. Public health practitioners, legal counsel, health care partners, and others need to be able to assess changing laws and policies and apply them in real-time. (shrink)

Those standard historiographic themes of "evolution" and "revolution" need replacing. They perpetuate mid-Victorian scientists' history of science. Historians' history of science does well to take in the long run from the Greek and Hebrew heritages on, and to work at avoiding misleading anachronism and teleology. As an alternative to the usual "evo-revo" themes, a historiography of origins and species, of cosmologies and ontologies, is developed here. The advantages of such a historiography are illustrated by looking briefly at a number of (...) transitions: the transition from Greek and Hebrew doctrines to their integrations by medieval authors; the transition from the Platonist, Aristotelian, Christian Aquinas to the Newtonian Buffon and to the no less Newtonian Lamarck; the departures the early Darwin made away from Lamarck's and from Lyell's views. Issues concerning historical thinking about nature, concerning essentialism and concerning classification are addressed in an attempt to challenge customary stereotypes. Questions about originality and influence are raised, especially concerning Darwin's "tree of life" scheme. The broader historiography of Darwinian science as a social ideology, and as a "worldview," is examined and the scope for revisions emphasised. Throughout, graduate students are encouraged to see this topic area not as worked out, but as full of opportunities for fresh contributions. (shrink)

This paper examines the causal theory of knowledge put forth by Alvin Goldman in his 1967 paper “A Causal Theory of Knowing.” Goldman contends that a justified, true belief is knowledge if and only if it is causally connected to the fact that makes it true. This paper provides examples, however, of justified, true beliefs with such causal connections that are clearly not knowledge. The paper further shows that attempts to salvage the causal theory are unsatisfactory.

This lucid and wide-ranging volume constitutes a self-contained introduction to the elements and key issues of the philosophy of language.