In the rod‐shaped cells of E. coli, chromosome segregation takes place immediately after replication has been completed. A septum then forms between the two sister chromosomes. In the absence of certain membrane proteins, cells grow instead as large, multichromosomal spheres that divide successively in planes that are at right angles to one another. Although multichromosomal, the spherical cells cannot be maintained as heterozygotes. These observations imply that, in these mutants, each individual chromosome gives rise to a separate clone of descendant (...) cells. This suggests a model in which sites for cell division form between pairs of sister chromosomes at the time of segregation, but are not used in spherical cells until further rounds of replication have taken place, thus ensuring clonal (‘hierarchical’) segregation of chromosomes into progeny cells. The role of the morphogenetic membrane proteins is to convert the basically spherical cell into a cylinder that is able to divide as soon as replication and segregation have been completed, and thus to maximise the number of viable cells per genome. (shrink)

Wilber's most timely, accessible, and practical work to date. Here is a concise, comprehensive overview of Wilber's revolutionary thought and its application in today's world. Wilber has long been hailed as one of the most important thinkers of our time, but--until now--his work has seemed inaccessible to the general reader who lacks a background in consciousness studies or evolutionary theory. Integral Vision will allow a general audience to fully understand what all the excitement has been about. In clear, non-technical language, (...) Wilber presents complex, cutting-edge theories and models that integrate the realms of body, mind, soul, and spirit. He then demonstrates how these theories and models can be applied to real world problems. Finally, Wilber discusses daily practices that readers take up in order to apply this integrative vision to their own, everyday lives. Wilber begins by presenting a leading model of human evolution, a model called "spiral dynamics." He then goes on to summarize his ground-breaking "all-level, all-quadrant" model for integrating the seemingly contradictory realms of science and religion--the "all-level, all-quadrant" model has already been adopted by leading thinkers in a variety of fields. In a chapter entitle "The Real World," Wilber shows how these rather abstract theories and models are being applied to real-world issues such as politics, medicine, business, education, and the environment. Wilber goes on to present a collection of maps of the Kosmos. These are broader models that can integrate the various worldviews that have been developed around the world throughout the ages. The final chapter of the book, "One Taste," proposes that readers take up an "integral transformative practice" such as meditation to help them to apply and develop this integral vision in their personal, everyday lives. (shrink)

The conscientious are morally conflicted when their moral dilemmas or incommensurabilities, real or apparent, have not been resolved. But such doublemindedness need not lead to ethical disintegration or moral insensitivity. For one may develop the moral virtue of doublemindedness, the settled power to deliberate and act well while morally conflicted. Such action will be accompanied by both moral loss (perhaps ‘dirty hands’) and ethical gain (salubrious agental stability). In explaining the virtue's moral psychology I show, among other things, its consistency (...) with wholeheartedness and the unity of the virtues. To broaden its claim to recognition, I show the virtue's consistency with diverse models of practical reason. In conclusion, Michael Walzer's interpretation of Hamlet's attitude toward Gertrude exemplifies this virtue in a fragmentary but nonetheless praiseworthy form. (shrink)

Part I -- Scientific Composition and the New Mechanism. - 1. Laura Franklin-Hall: New Mechanistic Explanation and the Need for Explanatory Constraints. - 2. Kenneth Aizawa: Compositional Explanation: Dimensioned Realization, New Mechanism, and Ground. - 3. Jens Harbecke: Is Mechanistic Constitution a Version of Material Constitution?. - 4. Derk Pereboom: Anti-Reductionism, Anti-Rationalism, and the Material Constitution of the Mental. Part II -- Grounding, Science, and Verticality in Nature. - 5. Jonathan Schaffer: Ground Rules: Lessons from Wilson. - 6. Jessica Wilson: (...) The Unity and Priority Arguments for Grounding. - 7. Carl Gillett: The Metaphysics of Nature, Science, and the Rules of Engagement. - 8. Andrew Melnyk: Grounding and the Formulation of Physicalism. - 9. Alyssa Ney: Grounding in the Philosophy of Mind: A Defense. (shrink)

Contemplating certain residual mists, the net proceeds of a material world exploded and disintegrated by the relentless penetration of scientific intellect, the more advanced physicist has been led in recent times to co-operate with the philosopher on a common plane. Not so long ago, and not always without reason, the philosopher was regarded somewhat askance. It is the old antithesis between the practical man and the theorist, the scientific man himself having been regarded for long as a dreamer. All depends (...) upon the level of action. Operating in the wilds the black tracker has nothing to gain by pausing for the slow, if sure, dictum of the scientist; and if a Mercator projection of the world, or a sextant, were offered to a primitive navigator of well-known home waters, these important aids to the sailor of longer voyages would probably be thrown in a corner, if not overboard. The launching forth on to wide oceans created the occasion for, and proved the value of, such products of exact thought. Thus, in his highest abstractions, the physicist must perforce become a philosopher. At the very least, the need of review and evaluation from a more general standpoint will be conceded. (shrink)

Ever since the publication of his first book, The Spectrum of Consciousness, written when he was twenty-three, Ken Wilber has been identified as the most comprehensive philosophical thinker of our times. This introductory sampler, designed to acquaint newcomers with his work, contains brief passages from his most popular books, ranging over a variety of topics, including levels of consciousness, mystical experience, meditation practice, death, the perennial philosophy, and Wilber's integral approach to reality, integrating matter, body, mind, soul, and spirit. Here (...) is Wilber's writing at its most reader-friendly, discussing essential ideas of the world's great psychological, philosophical, and spiritual traditions in language that is lucid, engaging, and inspirational. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Literature 27.2 (2003) 475-477 [Access article in PDF] A Small Treatise on the Great Virtues: The Uses of Philosophy in Everyday Life, by André Comte-Sponville, trans. Catherine Temerson; x & 352 pp. New York: Metropolitan Books, 2001. Of two minds, I mirror the two sorts of audience this book's twenty-four translations have sought: "students" and "readers" (p. 5), those for whom the scholarly content and apparatus may (...) be of interest and those hopefully many more who wish to become better, to become virtuous. Although "students" will not find sustained engagement with this book rewarding, its bright virtues will raise "readerly" smiles among them.Reasons for Small's great popularity since its 1995 PUF release derive not from essaying eighteen virtues in its eighteen chapters. Its allure is its dance with love's piquant absences, a dance with virtues as "feeble approximations of love" (p. 98). Indeed, chapter 1 teaches that politeness "is not a virtue but a simulacrum that imitates virtue (in adults) and paves the way for it (in children)" (p. 13). And since love, "the alpha and omega of all virtue" (p. 226), is not itself clearly a virtue, then perhaps at most fifteen virtues are treated. For as all readers will pleasurably discover, purity (chapter 14) is really refractions of love's qualities.The virtues are multiply interconnected, not unified as Socrates thought. This idea finds graceful expression, among other places, at the conclusion of "Generosity" (chapter 7). "Combined with courage, it turns out to be heroism. Joined by justice, it becomes equity. Coupled with compassion, it becomes benevolence. In league with mercy, it becomes leniency" (p. 102). And chap-ter 9's mercy? "Because hatred is a sadness, mercy (like the process of mourning, which it resembles and might even require, since to forgive is to bid farewell to our hatred) is on the side of joy. When it is not yet joyous, it is forgiveness; when it already is, it is love" (p. 131). Simone Weil's meditations on God's absence, or "withdrawal," occasion insights into authentic parental love. [End Page 475] God does not fill the world since "were he to do so, there would be only God and no world"; similarly, "more often than one might think, parents withdraw, step back, cede their space to their children, and refrain from exercising all the power at their disposal. Why? Because they love them" (p. 274).Unfortunately, love's flowers, potted in this garden of Adonis (Phaedrus 276b), must contend with "student" scrutiny from without and a suffocating lack of concision from within. This "student's" efforts failed to disentangle ambivalences about the loving ego in the long, concluding love chapter. Organized into three sections—eros, philia, agape—the first has no patience for subtleties of the Symposium's eros. "Have I begged the question?... So be it," since Plato confuses "love—in all its forms—with [ego's] want" (p. 243). Philia "is a different way of [ego's] possessing, of enjoying" (p. 277). Finally, agape, universal and disinterested love, is simply one's genuine conatus, one's true power of existing (pp. 270f). So ego loves three ways—desire, possession, power—but each is about ego. Eros "usually" (p. 262) intermixes with philia: "we are forever hesitating, oscillating, fluctuating between the two affects [desire and joy] and the two truths (Plato's and Spinoza's), between want and capacity, hope and gratitude, passion and action, religion and wisdom, between the love that desires only what it does not have and wants to possess (ero \ s), and the love [philia] that, since it desires only what is, has everything it desires and finds pleasure and joy in it" (p. 253). Nevertheless, philia without excess Platonic eros is about and for ego, not alter. For the friend per se gives ego joy: ego's joy is the definiens of philia (pp. 249ff). Disconcertingly, there are a few contrary formulations of philia as loving "the other for the other's benefit" (p. 262). If "metaphysics is the... (shrink)

The theory and practice of ecological reason have consistently suffered various shortcomings, versions of anthropocentrism and holism prominent among them. Even definitions of ecological reason that rely on philosophically informed policy studies and that explicitly take the functional and substantive moments of reason into account have not escaped these problems. An account of interdisciplinarity can shed light on how these intractable problems arise, since many of them fail to build interdisciplinarity as such sufficiently into the definition of ecological reason. Genuine (...) interdisciplinarity, distinguished from both multidisciplinarity and metadisciplinarity, can thus be seen to be necessary (not sufficient) to liberate ecological reason and to illuminate its theory and practice for late moderns. (shrink)

It is widely held that Bayesian decision theory is the final word on how a rational person should make decisions. However, Leonard Savage--the inventor of Bayesian decision theory--argued that it would be ridiculous to use his theory outside the kind of small world in which it is always possible to "look before you leap." If taken seriously, this view makes Bayesian decision theory inappropriate for the large worlds of scientific discovery and macroeconomic enterprise. When is it correct to use Bayesian (...) decision theory--and when does it need to be modified? Using a minimum of mathematics, Rational Decisions clearly explains the foundations of Bayesian decision theory and shows why Savage restricted the theory's application to small worlds. The book is a wide-ranging exploration of standard theories of choice and belief under risk and uncertainty. Ken Binmore discusses the various philosophical attitudes related to the nature of probability and offers resolutions to paradoxes believed to hinder further progress. In arguing that the Bayesian approach to knowledge is inadequate in a large world, Binmore proposes an extension to Bayesian decision theory--allowing the idea of a mixed strategy in game theory to be expanded to a larger set of what Binmore refers to as "muddled" strategies. Written by one of the world's leading game theorists, Rational Decisions is the touchstone for anyone needing a concise, accessible, and expert view on Bayesian decision making. (shrink)

The Spectrum of Consciousness (1977)--one of the founding texts of transpersonal psychology--introduces the full-spectrum model, showing how the psychological systems of the West can be integrated with the contemplative traditions of the East. No Boundary: Eastern and Western Approaches to Personal Growth (1979) is a simple yet comprehensive guide to psychologies and therapies available from both Western and Eastern sources. Several important early articles: "The Psychologia Perennis," "Are the Chakras Real?" and "Where It Was, I Shall Become.".

Natural Justice is a bold attempt to lay the foundations for a genuine science of morals using the theory of games. Since human morality is no less a product of evolution than any other human characteristic, the book takes the view that we need to explore its origins in the food-sharing social contracts of our prehuman ancestors. It is argued that the deep structure of our current fairness norms continues to reflect the logic of these primeval social contracts, but the (...) particular fairness norm a society operates is largely a product of cultural evolution. In pursuing this point, the book proposes a naturalistic reinterpretation of John Rawls' original position that reconciles his egalitarian theory of justice with John Harsanyi's utilitarian theory by identifying the environment appropriate to each. (shrink)

Binmore argues that game theory provides a systematic tool for investigating ethical matters.

Wilber's groundbreaking synthesis of religion, philosophy, physics, and psychology started a revolution in transpersonal psychology.

It is widely held that Bayesian decision theory is the final word on how a rational person should make decisions. However, Leonard Savage--the inventor of Bayesian decision theory--argued that it would be ridiculous to use his theory outside the kind of small world in which it is always possible to "look before you leap." If taken seriously, this view makes Bayesian decision theory inappropriate for the large worlds of scientific discovery and macroeconomic enterprise. When is it correct to use Bayesian (...) decision theory--and when does it need to be modified? Using a minimum of mathematics, Rational Decisions clearly explains the foundations of Bayesian decision theory and shows why Savage restricted the theory's application to small worlds. The book is a wide-ranging exploration of standard theories of choice and belief under risk and uncertainty. Ken Binmore discusses the various philosophical attitudes related to the nature of probability and offers resolutions to paradoxes believed to hinder further progress. In arguing that the Bayesian approach to knowledge is inadequate in a large world, Binmore proposes an extension to Bayesian decision theory--allowing the idea of a mixed strategy in game theory to be expanded to a larger set of what Binmore refers to as "muddled" strategies. Written by one of the world's leading game theorists, Rational Decisions is the touchstone for anyone needing a concise, accessible, and expert view on Bayesian decision making. (shrink)

The principal aim of this volume is to elucidate what freedom, sovereignty, and autonomy mean for Nietzsche and what philosophical resources he gives us to re ...

The tension between external forces for better ethics in organizations, represented by legislation such as the Sarbanes–Oxley Act (SOX), and the call for internal forces represented by increased educational coverage, has never been as apparent. This study examines business school faculty attitudes about recent corporate ethics lapses, including opinions about root causes, potential solutions, and ethics coverage in their courses. In assessing root causes, faculty point to a failure of systems such as legal/professional and management (external) and declining personal values (...) (internal). We also found that faculty recommend external forces as a remedy more often than increased ethics educational coverage; we contextualize this finding with recent ethics education literature. We conclude by proposing that neither legislation nor ethics education alone are complete when addressing widespread unethical corporate acts and offer a multi-faceted approach to ethics educational opportunities. (shrink)

Do conventions need to be common knowledge in order to work? David Lewis builds this requirement into his definition of a convention. This paper explores the extent to which his approach finds support in the game theory literature. The knowledge formalism developed by Robert Aumann and others militates against Lewis’s approach, because it shows that it is almost impossible for something to become common knowledge in a large society. On the other hand, Ariel Rubinstein’s Email Game suggests that coordinated action (...) is no less hard for rational players without a common knowledge requirement. But an unnecessary simplifying assumption in the Email Game turns out to be doing all the work, and the current paper concludes that common knowledge is better excluded from a definition of the conventions that we use to regulate our daily lives. (shrink)

Game theory has proved a useful tool in the study of simple economic models. However, numerous foundational issues remain unresolved. The situation is particularly confusing in respect of the non-cooperative analysis of games with some dynamic structure in which the choice of one move or another during the play of the game may convey valuable information to the other players. Without pausing for breath, it is easy to name at least 10 rival equilibrium notions for which a serious case can (...) be made that here is the “right” solution concept for such games. (shrink)

Sometimes neuroscientists discover distinct realizations for a single psychological property. In considering such cases, some philosophers have maintained that scientists will abandon the single multiply realized psychological property in favor of one or more uniquely realized psychological properties. In this paper, we build on the Dimensioned theory of realization and a companion theory of multiple realization to argue that this is not the case. Whether scientists postulate unique realizations or multiple realizations is not determined by the neuroscience alone, but by (...) the psychological theory under examination. Thus, one might say that, in the splitting or non-splitting of properties, psychology enjoys a kind of autonomy from neuroscience. (shrink)

Drawing on social exchange theory, we argue that family-supportive supervisor behavior (FSSB) inhibits employees’ unethical pro-family behavior (UPFB) via the mediation of felt obligation. We further propose that employees’ positive reciprocity beliefs strengthen the hypothesized relationships. Using a sample consisting of 345 full-time employees from an Internet service company located in China, we found that felt obligation partially mediated the negative relationship between FSSB and UPFB and that the FSSB-felt obligation relationship and the mediation relationship were stronger for employees with (...) higher positive reciprocity beliefs. Theoretical and practical implications, limitations, and future directions are discussed. (shrink)

Many have argued that human enhancement, in particular bioenhancement via genetic engineering, brain-interventions or preimplantation embryo selection, is problematic even if it can be safely implemented. Various arguments have been put forward focusing on issues such as the undermining of autonomy, uneven distribution and unfairness, and the alteration of one’s identity, amongst others. Nevertheless, few, if any, of these thinkers oppose vaccines. -/- In what follows, I argue for the permissibility of a limited set of cognitive enhancements – in particular, (...) the enhancement of evaluative judgment and self-control – by analogy with the permissibility of vaccines. As a result, it follows that if one accepts the permissibility of vaccines one will also, other things being equal, be committed to the permissibility of these enhancements. I then consider and respond to a number of possible objections in order to defend and clarify my position. (shrink)

An increasing amount of data is now available from public and private sources. Furthermore, the types, formats, and number of sources of data are also increasing. Techniques for extracting, storing, processing, and analyzing such data have been developed in the last few years for managing this bewildering variety based on a structure called a knowledge graph. Industry has devoted a great deal of effort to the development of knowledge graphs, and knowledge graphs are now critical to the functions of intelligent (...) virtual assistants such as Siri, Alexa, and Google Assistant. The goal of the Ontology Summit 2020 was to understand not only what knowledge graphs are but also where they originated, why they are so popular, the current issues, and their future prospects. The summit sessions examined many examples of knowledge graphs and surveyed the relevant standards that exist and are in development for knowledge graphs. The purpose of this Communiqué is to summarize our understanding from the Summit in order to foster research and development of knowledge graphs. (shrink)

Ken Binmore's previous game theory textbook, Fun and Games, carved out a significant niche in the advanced undergraduate market; it was intellectually serious and more up-to-date than its competitors, but also accessibly written. Its central thesis was that game theory allows us to understand many kinds of interactions between people, a point that Binmore amply demonstrated through a rich range of examples and applications. This replacement for the now out-of-date 1991 textbook retains the entertaining examples, but changes the organization to (...) match how game theory courses are actually taught, making Playing for Real a more versatile text that almost all possible course designs will find easier to use, with less jumping about than before. In addition, the problem sections, already used as a reference by many teachers, have become even more clever and varied, without becoming too technical. Playing for Real will sell into advanced undergraduate courses in game theory, primarily those in economics, but also courses in the social sciences, and serve as a reference for economists. (shrink)

Humans have long been fascinated by the idea of visiting the past and of seeing what the future will bring. Time travel has been one of the most popular themes of science fiction. Most people have seen the TV series ‘Dr Who’ or ‘Quantum Leap’ or ‘Star Trek’. You’ve probably seen one of the ‘Back to the Future’ or ‘Terminator’ movies, or ‘Twelve Monkeys’. Time travel narratives provide fascinating plots, which exercise our imaginations in ever so many ways. But is (...) the idea of travelling forward and backward in time pure fantasy—or can it be done? To be sure, not all time travel scenarios are coherent. But we hope to persuade you that the most common objections to the very idea of time travel have no real force. (shrink)

Molinism promises the strongest account of God's providence consistent with our freedom. But is it a coherent view, and does it provide a satisfying account of divine providence? The essays in this volume examine the status, defensibility, and application of this recently revived doctrine, and anticipate the future direction of the debate.

Some behavioral economists argue that the honoring of social norms can be adequately modeled as the optimization of social utility functions in which the welfare of others appears as an explicit argument. This paper suggests that the large experimental claims made for social utility functions are premature at best, and that social norms are better studied as equilibrium selection devices that evolved for use in games that are seldom studied in economics laboratories.

ContentsThe Self-Images of a Discipline: A Genealogy of International Relations Theory/Steve SmithThe End of the Cold War and International Relations: Some Analytic and Theoretical Conclusions/Fred HallidayInternational Relations and the Triumph of Capitalism/Richard LittleInternational Political Theory and the Idea of World Community/Chris BrownThe Political Theory of International Society/Robert H. JacksonInternational Political Theory and the Global Environment/Andrew HurrellPolitical Economy and International Relations/Susan StrangeRe-visioning Security/J. Ann TicknerThe Level of the Analysis Problem in International Relations Reconsidered/Barry BuzanThe Post-Positivist Debate: Reconstructing Scientific Enquiry and International (...) Relations Theory After Enlightenment's Fall/John A. VasquezNeo-realism in Theory and Practice/Andrew LinklaterInternational Politics and Political Theory/Jean Bethke ElshtainQuestions About Identity in International Relations/Marysia Zalewski and Cynthia EnloeInternational Relations and the Concept of the Political/R. B. J. WalkerDare Not to Know: International Relations Theory Versus the Future/Ken Booth. (shrink)

In this introduction to Mikhail Bakhtin, Ken Hirschkop presents a compact, readable, detailed, and sophisticated exposition of all of Bakhtin's important works. Using the most up-to-date sources and the new, scholarly editions of Bakhtin's texts, Hirschkop explains Bakhtin's influential ideas, demonstrates their relevance and usefulness for literary and cultural analysis, and sets them in their historical context. In clear and concise language, Hirschkop shows how Bakhtin's ideas have changed the way we understand language and literary texts. Authoritative and accessible, this (...) Cambridge Introduction is the most comprehensive and reliable account of Bakhtin and his work yet available. (shrink)

I argue that the three strongest arguments against metaphysical libertarianism—the randomness objection, the constitutive luck objection, and the physicalist objection—are actually unsuccessful and therefore that metaphysical libertarianism is more plausible than the common philosophical wisdom allows. My more positive thesis, what I will refer to as “Agent Exceptionalism,” is that, when making decisions and performing actions, human beings can indeed satisfy the four conditions of metaphysical libertarianism: the control condition, the rationality condition, the ultimacy condition, and the physicalism condition.

The presence of predictive AI has steadily expanded into ever-increasing aspects of civil society. I aim to show that despite reasons for believing the use of such systems is currently problematic, these worries give no indication of their future potential. I argue that the absence of moral limits on how we might manipulate automated systems, together with the likelihood that they are more easily manipulated in the relevant ways than humans, suggests that such systems will eventually outstrip the human ability (...) to make accurate judgments and unbiased predictions. I begin with some reasonable justifications for the use of predictive AI. I then discuss two of the most significant reasons for believing the use of such systems is currently problematic before arguing that neither provides sufficient reason against such systems being superior in the future. In fact, there’s reason to believe they can, in principle, be preferable to human decision makers. (shrink)