Much has been published about the ethical issues encountered by clinicians in genetics/genomics, but those experienced by clinical laboratory scientists are less well described. Clinical laboratory scientists now frequently face navigating ethical problems in their work, but how they should be best supported to do this is underexplored. This lack of attention is also reflected in the ethics tools available to clinical laboratory scientists such as guidance and deliberative ethics forums, developed primarily to manage issues arising within the clinic.We explore (...) what ethical issues are being experienced by clinical scientists, how they think such issues could be best analysed and managed, and whether their practice might be enhanced by more situated approaches to ethics deliberation and practice such as ethical preparedness. From thematic analysis of cases presented by clinical scientists at a specially convened meeting of the UK Genethics Forum, we derived three main ethical themes: (1) the redistribution of labour and responsibilities resulting from the practice of genomic medicine; (2) the interpretation and certainty of results and (3) the proposal that better standardisation and consistency of ethical approaches (for example, more guidelines and policy) could resolve some of the challenges arising.We argue that although standardisation is important for promoting shared understandings of good (including ethical) practice, supplementary approaches to enhance and sustain ethical preparedness will be important to help clinical scientists and others in the recently expanded genetic/genomic medicine environment foster quality ethical thinking. (shrink)

1. T. Differenz Marx'sche Philosophie zur Hegelschen Philosophie -- 2. T. Differenz Marxistische Philosophie zur Hegelschen Philosophie (2 v.) -- 3. T., 4. Buch. Philosophischer Seinsbegriff und historische Dominanz von Weltanschauungen. 5. Buch. Anlagen, weltanschauliche Dominanz in historischer Auswirkung.

Free logic, an alternative to traditional logic, has been seen as a useful avenue of approach to a number of philosophical issues of contemporary interest. In this collection, Karel Lambert, one of the pioneers in, and the most prominent exponent of, free logic, brings together a variety of published essays bearing on the application of free logic to philosophical topics ranging from set theory and logic to metaphysics and the philosophy of religion. The work of such distinguished philosophers as (...) Bas van Fraassen, Dana Scott, Tyler Burge, and Jaakko Hintikka is represented. Lambert provides an introductory essay placing free logic in the logical tradition beginning with Aristotle, developing it as the natural culmination of a trend begun in the Port Royal logic of the 1600s, and continuing through current predicate logic--the trend to rid logic of existence assumptions. His Introduction also provides a useful systematic overview of free logic, including both a standard syntax and some semantical options. (shrink)

The COVID-19 pandemic has highlighted the difficult task of balancing access to misinformation with respect for patient decision-making. Due to its innate antagonism, the paradigm of “physician paternalism” versus “patient autonomy” may not adequately capture the clinical relationship. The authors hypothesized that most patients would, in fact, prefer significant physician input as opposed to unopinionated information when making medical decisions. There is a lack of empirical data corroborating this in the United States. To that end, a survey was distributed to (...) 650 individuals through Amazon Mechanical Turk, of which 499 responses met pre-determined quality criteria. Most respondents believed their doctor's insight would be better than their own if injured or gravely ill. When asked to affirm preferences separately, a significantly higher proportion of respondents preferred guidance from their doctor when making medical decisions compared to being presented with unopinionated information ( p < 0.001). Encouragingly, 93.1% believed that the doctor's primary goal was their health. When asked directly to compare physician guidance to unopinionated information, 69.1% respondents stated they would prefer physician guidance. We found a consistent association between educational/economic background and affirmative responses ( p < 0.001), suggesting particular attention should be paid to patients that are disadvantaged with respect to these demographic factors. The belief in a shared goal, and a consistent preference for physician input, suggests that patients endorse a more collaborative view of the clinical dynamic than is suggested by the paternalism-autonomy paradigm. This pilot study suggests physicians should not be afraid to communicate conviction with regard to treatment decisions. (shrink)

Molecular Revolution in BrazilFélix Guattari and Suely Rolniktranslated by Karel Clapshow and Brian HolmesYes, I believe that there is a multiple people, a people of mutants, a people of potentialities that appears and disappears, that is embodied in social, literary, and musical events.... I think that we're in a period of productivity, proliferation, creation, utterly fabulous revolutions from the viewpoint of this emergence of a people. That's molecular revolution: it isn't a slogan or a program, it's something that I (...) feel, that I live....--from Molecular Revolution in BrazilFollowing Brazil's first democratic election after two decades of military dictatorship, French philosopher Félix Guattari traveled through Brazil in 1982 with Brazilian psychoanalyst Suely Rolnik and discovered an exciting, new political vitality. In the infancy of its new republic, Brazil was moving against traditional hierarchies of control and totalitarian regimes and founding a revolution of ideas and politics. Molecular Revolution in Brazil documents the conversations, discussions, and debates that arose during the trip, including a dialogue between Guattari and Brazil's future President Luis Ignacia Lula da Silva, then a young gubernatorial candidate. Through these exchanges, Guattari cuts through to the shadowy practices of globalization gone awry and boldly charts a revolution in practice.Assembled and edited by Rolnik, Molecular Revolution in Brazil is organized thematically; aphoristic at times, it presents a lesser-known, more overtly political aspect of Guattari's work. Originally published in Brazil in 1986 as Micropolitica: Cartografias do desejo, the book became a crucial reference for political movements in Brazil in the 1980s and 1990s. It now provides English-speaking readers with an invaluable picture of the radical thought and optimism that lies at the root of Lula's Brazil. Félix Guattari, post-'68 French psychoanalyst and philosopher, is the author of Anti-Oedipus, The Anti-Oedipus Papers, 2006), and other books. Semiotext has published the first two volumes of his complete essays, Chaosophy and Soft Subversions, and will publish the final volume, Chaos and Complexity, in 2008. Suely Rolnik is a psychoanalyst, cultural critic, and curator who lives and works in São Paulo, Brazil. She was a close collaborator of Guattari during her exile in Paris from the military dictatorship in Brazil. (shrink)

The authors contend that most contemporary logic textbooks fail the average student because they emphasize the evaluation of arguments over their clarification, assuming that the student already understands what motivations underlie logic.

Public debate on acceptable farm animal husbandry suffers from a confusion of tongues. To clarify positions of various stakeholder groups in their joint search for acceptable solutions, the concept of animal welfare was split up into three notions: no suffering, respect for intrinsic value, and non-appalling appearance of animals. This strategy was based on the hypothesis that multi-stakeholder solutions should be based on shared values rather than on compromises. The usefulness of such an artificial value distinction strategy was tested in (...) a small series of experiments. The results demonstrate that the chosen concept to distinguish between values is effective in a stakeholder context. Farmers’ views on doing good to animals appeared to be largely based on their value to prevent suffering and predominantly focused on the provision of regular care. Their priority for this value is clearly shared with other stakeholders, providing a basis for joint solutions. The concept of intrinsic value does not play a discernable role in farmers’ considerations. Based on the varying views on welfare, it can be inferred that there is a gradual rather than a principal difference between government legislation and farmers’ values, whereas public perception and acceptance of farm practices remains complicated. Distinction between value groups and focusing on a selected notion (such as no suffering) proved to be effective in bringing representatives of stakeholder groups together, but is unlikely to bridge the emotional gap between commercial farm practices and public ideals. (shrink)

En lisant la République et le Timée de Platon, ce livre propose une enquête sur les deux formes de temporalité irréductibles (celle de la cité armée, celle de l'âme immortelle) pour éclairer la question principale, celle de la nature et de la structure de l'âme, de la cité et du cosmos.

In Liberalism’s religion, Laborde defends a liberal egalitarian position and tackles, from a new perspective, some issues dealt with in his republican writings. This article examines some of these issues, paying attention to the place that the recognition of identities occupies both in her republican and in her liberal theories, as well as the type of justification advanced in both cases. The article shows that the recognition of identities has gone from having a peripheral and instrumental role in her republican (...) writings to having a central role in her liberal theory. (shrink)

Dostoevsky wrote that love in action is a harsh and terrible thing compared to love in dreams. That reality is particularly evident in medicine, where there is an almost universal, involuntary participation of physicians and other healthcare workers in the suffering of their patients. This paper explores this phenomenon through the paradigm of ‘mystery’ as explained by the French existentialist philosopher Gabriel Marcel. A mystery is different from a problem in the sense that the former requires the active immersion of (...) the person involved in order to be truly experienced. It is a ‘meta-problem’ that cannot be analyzed objectively and separately from the person that it affects, without changing the nature of the thing experienced. The authors contend that the human suffering encountered in medicine is one such phenomenon, and the paper draws on illustrations of this concept in art and literature. Awareness of the subtle but important difference between mystery and problem may help physicians better understand their personal entanglement with the suffering of patients. (shrink)

This paper provides a finer analysis of the well-known form of the Local Deduction Theorem in contraction-free logics . An infinite hierarchy of its natural strengthenings is introduced and studied. The main results are the separation of its initial four members and the subsequent collapse of the hierarchy.

Intentionally or not, our clinical practice is informed by our philosophical premises. A subtle misunderstanding can have frequent, though insidious, implications in day-to-day clinical encounters....

There is a growing body of literature that has sought to undermine systems of ethical regulation, and governance more generally, within the social sciences. In this paper, we argue that any general claim for a system of research ethics governance in social research depends on clarifying the nature of the stake that society has in research. We show that certain accounts of this stake—protecting researchers’ freedoms; ensuring accountability for resources; safeguarding welfare; and supporting democracy—raise relevant ethical considerations that are reasonably (...) contested. However, these accounts cannot underpin a general claim in favour of, or against, a system of research ethics governance. Instead, we defend governance in social research on the grounds that research, as an institutionalised form of enquiry, is a constitutive element of human flourishing, and that society ought to be concerned with the flourishing of its members. We conclude by considering the governance arrangements that follow from, and are justified by, our arguments. (shrink)

We read with great interest Garland, Morain and Sugarman’s manuscript on the obligations of clinicians to participate in pragmatic clinical trials (PCTs) (Garland, Morain and Sugarman 2023). We bel...

Openness of knowledge was in the Dutch Republic no more a natural state of affairs than in other parts of Europe at the time, but it became dominant there at an earlier date than elsewhere. This puzzling phenomenon is the subject of this essay. The article shows that tendencies to secrecy in crafts and trades in the Netherlands were by no means absent and that public authorities were not principled supporters of openness. Openness of knowledge did not prevail because arguments (...) in favour of a free exchange of knowledge won the day against a rhetoric in defense of secrecy or because a rapid change in methods of production and marketing rendered the maintenance of craft secrecy practically impossible. The weakness of secrecy in the early-modern Netherlands, this essay argues, can be explained by the relative tardiness of the growth of the corporate system and the typical features of the institutional structure of the Dutch Republic. Craft secrecy in the Dutch Republic, as far as it existed before the middle of the eighteenth century, was normally based on a contractual relationship between individual actors rather than on any form of enforcement by public agencies. (shrink)

Pojem řádu má své veliké dějiny od předsókratiků až k H. Kringsovi, který v roce 1941 vydává knihu Ordo. U nás se pojmu řádu a řádovosti věnoval po celý život ze­jména brněnský a olomoucký myslitel J. L. Fischer (1894–1973). Idea řádu byla také jedním z pilířů jeho skladebné filosofie, jež měla základní problémy moderní společnosti vyřešit účinněji než marxismus. Současně s „laickým“ Fischerem usilovala v kritických 30. letech dvacátého století o nastolení kýženého řádu vyhraněně katolická skupina sou­středěná kolem tehdy nově (...) založené revue Řád. Oběma pólům šlo sice o podobný cíl (skoncovat s vládou neblahého kapitalismu), ale neporozuměly si pro různost svých věr. Toto osudové neporozumění bychom měli především na univerzitách v Brně a Olomou­ci napravovat využitím odkazu W. C. Smithe, který zásadně rozlišil setrvačnou tradiční víru (belief) a otevřenou víru všech opravdu tvůrčích lidí (faith). Takovou víru měl totiž podle autora také a snad především nový řád usilovně hledající Josef Ludvík Fischer. (shrink)

Cultuurkritisch essay vanuit de optiek van de anti-psychiatrie.

[Analytical Philosophy in the USA at the end of the 20th Century.].

Under the influence of Leibnitz in oposition to Kant, especially against his philosophy of mathematics, Bolzano analyses several topics discussed in analytic philosophy of today. His starting point is a distinction of concepts and intuitions, being two basic kinds of ideas-in-themselves, based on the postulates of nonemptiness, singularity and simplicity. This dichotomy is utilized in the analysis of conceptual and empirical sentences , the analytic/synthetic distinction and the a priori and a posteriori differentiation. His classification of analytic sentences, based on (...) his logic of variation and the degree of validity, in a narrow and broader sense corresponds to the contemporary view of analyticity for logical and linguistic reasons. Inspite of his ontological atomism he anticipates Quine´s holism according to which empirical sciences are theory-laden. He even accepts, at least for historical reasons, his empiricism concerning the role of observation sentences in theoretical sciences. According to Bolzano, no sharp demarcation between conceptual and empirical sciences can be drawn. (shrink)