Mitochondria have been fundamental to the eco‐physiological success of eukaryotes since the last eukaryotic common ancestor (LECA). They contribute essential functions to eukaryotic cells, above and beyond classical respiration. Mitochondria interact with, and complement, metabolic pathways occurring in other organelles, notably diversifying the chloroplast metabolism of photosynthetic organisms. Here, we integrate existing literature to investigate how mitochondrial metabolism varies across the landscape of eukaryotic evolution. We illustrate the mitochondrial remodelling and proteomic changes undergone in conjunction with major evolutionary transitions. We (...) explore how the mitochondrial complexity of the LECA has been remodelled in specific groups to support subsequent evolutionary transitions, such as the acquisition of chloroplasts in photosynthetic species and the emergence of multicellularity. We highlight the versatile and crucial roles played by mitochondria during eukaryotic evolution, extending from its huge contribution to the development of the LECA itself to the dynamic evolution of individual eukaryote groups, reflecting both their current ecologies and evolutionary histories. (shrink)

We observed that despite international declarations on child-rights, outsourced domestic girl-child labour still persists. Raising the question whether outsourced domestic girl-child labour constitutes hermeneutical injustice, we respond affirmatively. Relying on two indigenous victimology-narratives that are newspaper reports, we expose some of the horrors that the victims of outsourced domestic girl-child labour suffer. Comparing these reports with other victimology-narratives of hermeneutical injustice as reported by Miranda Fricker and Hilkje Hänel, we argue that the victims of outsourced domestic girl-child labour suffer a (...) hermeneutical gap and hermeneutical interference; and that the perpetuators of this practice, help to foster what we call ‘hermeneutical obstruction’. We recommend different counteracting measures such as: a radical feminization of educational curricula, which will allow for the introduction of the relevant hermeneutical resources that female children need in making sense of their experiences, into the classrooms and other places of learning; establishing feminist liberation agencies in all schools, religious institutions and hospitals, as ways of increasing the level of awareness about the rights of the girl-child in children and adults; feminizing legislation and legislative processes, to allow for the enactment of laws to protect the rights of the girl-child; and campaigning for a more rigorous enforcement of child-rights laws. (shrink)

This paper applied the philosophical theory of critical realism to the problem of evil. Using the method of critical analysis of related literature, the paper discovered, among other things, that e...

Humans are unconditionally confronted with social expectations and norms, up to a degree that they, or some of them, have a hard time recognizing what they actually want. This renders them susceptible for introjection, that is, to unwittingly or “unconsciously” mistake social expectations for self-chosen goals. Such introjections compromise an individual’s autonomy and mental health and have been shown to be more prevalent in individuals with rumination tendencies and low emotional self-awareness. In this brain imaging study, we draw on a (...) source memory task and found that introjections, as indicated by imposed tasks that are falsely recognized as self-chosen, involved the bilateral medial prefrontal cortex and the dorsal anterior cingulate cortex. Notably, reduced right MPFC activation within this condition correlated with trait scores of ruminations and reduced emotional self-awareness, but also introversion. Moreover, correct recognition of tasks as self-chosen involved the right MPFC. Accordingly, the right MPFC may play a role in supporting the maintenance of psychological autonomy and counteract introjection, which individuals with certain personality traits seem to be prone to. This research has significant implications for the study of mechanisms underlying autonomous motivation, goal and norm internalization, decision-making, persuasion, education, and clinical conditions such as depression and burnout. (shrink)

Today, we take international collaborations as a necessity, but 150 years ago, when travel was not so convenient, it involved an enduring and time-consuming challenge. This paper presents letters and reports written by German physicist Julius Plücker to his wife, Antonie née Altstädten describing his travels to Great Britain and France between 1853 and 1866. These letters provide a view into how international collaboration and communication were developed and maintained as well as how friendships were built within the scientific (...) community during the early industrial age, prior to telegraph, telephone, email, and internet. (shrink)

Ce texte a déjà paru dans la revue October, N° 131, Winter 2010, p. 23–50. Nous remercions Michael Cowan de nous avoir autorisé à le reproduire ici. In September of 1925, readers leafing through Der Kinematograph or Lichtbildbühne or another such film journal might have encountered a strangely familiar sight : in an advertisement for a major exhibition of the German film and photography industries entitled “Kipho” (“Kino und Photo”), which was to be held in Berlin from September 25th (...) to (...) - Cinéma, animation et vidéo – GALERIE – Nouvel article. (shrink)

Entspringt die Moral den Gefühlen, wie Hume meinte, oder der Vernunft, wie Kant behauptete? In jüngerer Zeit haben Philosophen wie Shaun Nichols, Jesse Prinz und Michael Slote versucht, diese Frage durch die Auswertung empirischer Studien entwicklungspsychologischer und psychiatrischer Provenienz zu klären. Auf den ersten Blick erscheint dieses Unterfangen hoffnungslos. Wie sollten empirische Befunde dabei helfen, metaethische und normative Fragen zu beantworten? Dieser Eindruck ist jedoch irrig, wie ich zu zeigen versuche. Analysiert man die Befunde der experimentellen Moralpsychologie, so legen (...) sich nicht nur Konsequenzen für die Metaethik nahe; Folgen ergeben sich auch für die Normative Ethik. (shrink)

This chapter deals with the following questions: What does Michael Dummett demand of a “systematic” theory of meaning, and what understanding of Frege's “level of sense” leads him to conclude that, if Wittgenstein is correct in denying that there is such a level, then no systematic theory of meaning is possible? For Dummett, an understanding of the meaning side of language is not “systematic” if it must hold that a sentence is understood only because it has been previously learned (...) as a whole. To reconstruct how Dummett arrives at Frege's level of “sense” as crucial for a systematic understanding of complexity, we can begin with a hypothetical concrete situation and proceed step by step to rule out what is not meant by “meaning” when we speak of it as being systematically developed. (shrink)

The fourth volume of Oxford Studies in Ancient Philosophy is devoted to essays in honor of Professor John Ackrill on the occasion of his 65th birthday. Contributors include: David Wiggins, Colin Strand, Julius Moravcsik, Lesley Brown, Gail Fine, Julia Annas, David Charles, Michael Woods, Christopher Kirwan, Bernard Williams, Jonathan Barnes, and Richard Sorabji.

The fourth volume of Oxford Studies in Ancient Philosophy is devoted to essays in honor of Professor John Ackrill on the occasion of his 65th birthday. Contributors include: David Wiggins, Colin Strand, Julius Moravcsik, Lesley Brown, Gail Fine, Julia Annas, David Charles, Michael Woods, Christopher Kirwan, Bernard Williams, Jonathan Barnes, and Richard Sorabji.

Crispin Wright and Bob Hale have defended the strategy of defining the natural numbers contextually against the objection which led Frege himself to reject it, namely the so-called ‘Julius Caesar problem’. To do this they have formulated principles (called sortal inclusion principles) designed to ensure that numbers are distinct from any objects, such as persons, a proper grasp of which could not be afforded by the contextual definition. We discuss whether either Hale or Wright has provided independent motivation for (...) a defensible version of the sortal inclusion principle and whether they have succeeded in showing that numbers are just what the contextual definition says they are. (shrink)

This paper argues that that Caesar problem had a technical aspect, namely, that it threatened to make it impossible to prove, in the way Frege wanted, that there are infinitely many numbers. It then offers a solution to the problem, one that shows Frege did not really need the claim that "numbers are objects", not if that claim is intended in a form that forces the Caesar problem upon us.

The aim of this critical notice is to elucidate Dummett's contributions to the issues surrounding Frege's contextual definition of number (the number of Fs equals the number of Gs if the Fs and the Gs are in one-one correspondence) and the interpretation of "Frege's theorem" -- the theorem that the second order theory consisting of the contextual definition implies the infinity of the natural numbers. To do so, we focus on Dummett's account of the context principle, his discussion of Frege's (...) use of contextual definition, and his treatment of the "Julius Caesar problem.". (shrink)

Michael Jordan and countless other NBA stars credit George Mumford with transforming their game. A widely respected public speaker and coach, Mumford shares his story and strategies in The Mindful Athlete. His proven techniques transform the performance of anyone with a goal, be they an Olympian, weekend warrior, executive, hacker, or artist. A basketball player at the University of Massachusetts (where he roomed with Dr. J, Julius Erving), injuries forced Mumford out of the game he loved. The meds (...) that relieved the pain of his injuries also numbed him to the emptiness he felt without the game and eventually led him to heroin. After years as a functioning addict, Mumford made meditation the center of his life. He kicked drugs, earned a master's degree, and began teaching meditation to inmates and others. Mumford went on to partner with coach Phil Jackson, a long-time mindfulness practitioner, working with him and each of the teams he coached to become NBA champions. His roster of champion clients now includes executives and Olympians. With a charismatic style that combines mindfulness with lessons from icons like Yoda and Bruce Lee, Mumford delivers an engrossing story and an invaluable resource. (shrink)

This commentary on Philip Kitcher’s book What’s the Use of Philosophy? addresses two questions. First, must philosophers be methodologically self-conscious to do good work? Second, is there value in the questions pursued in the traditional areas of analytic philosophy?

Wedin addresses the debate over whether nonsubstantial individuals, that inhere in a subject but are not said of a subject, i.e. accidents, such as the pallor of Socrates, are nonrecurring particulars or a kind of determinate universal. Wedin examines the secondary literature on this topic and divides it into two schools of thought, determined by the contributions of J.L. Ackrill and G.E.L. Owen. According to Ackrill, individuals in non‐substance categories are particular to the substance they are in; Owen critiques Ackrill's (...) view, and proposes that these items can recur in more than one subject and hence are a sort of universal. Wedin finds Owen's thesis unsatisfactory, even after supplementing it with an improved version due to Michael Frede; instead, Wedin argues for a revised version of Ackrill's interpretation of nonsubstantial individuals as nonrecurrent particulars. According to Wedin, Aristotle is committed to individuals only—e.g. to Socrates and to the particular bit of pallor in him: this conclusion has an important bearing on the ontological status of individuals and on the primacy of substance to nonsubstantial items. (shrink)

Wedin considers the problem of the compatibility of the Categories account of primary substance with the theory of substantial form of the Metaphysics. Wedin collects from the secondary literature the most important arguments for incompatibilism, and offers some proposals for restoring their harmony. While admitting the evident differences in the way Aristotle treats the question of substance in each treatise, Wedin is keen to argue that these differences are not sufficient to conclude that the treatises are incompatible. Wedin singles out (...) for particular attention, and criticism, Michael Frede and Gunther Patzig's account of Metaphysics Zeta, according to which the primary substance of the Metaphysics and the basic subject of predications is the form. Wedin considers two ‘philosophical’ arguments and one ‘Aristotelian’ argument for the subjecthood of forms, and argues that the textual evidence does not support the claim that form is the subject of accidents. (shrink)

Michael J. Zimmerman explores whether and how our ignorance about ourselves and our circumstances affects what our moral obligations and moral rights are. He rejects objective and subjective views of the nature of moral obligation, and presents a new case for a 'prospective' view.

The aging of attentional and emotional functions has been extensively studied but relatively independently. Therefore, the relationships between aging and the interactions of attentional and emotional processes remain elusive. This study aimed to determine how age affected the interactions between attentional and emotional processes during adulthood. One-hundred forty adults aged 18–79 performed the emotional variant of the Attention Network Test, which probed alerting, orienting, and executive control in the presence and absence of threatening faces. During this task, contexts with varying (...) levels of task preparatory processes were created to modulate the effect of threatening faces on attention, and functional near-infrared spectroscopy (fNIRS) was used to examine the neural underpinnings of the behavioural effects. The behavioural results showed that aging was associated with a significant decline in alerting efficiency, and there was a statistical trend for age-related deficits in executive control. Despite these age differences, age did not significantly moderate the interactions among attentional networks or between attention and emotion. Additionally, the fNIRS results showed that decreased frontal cortex functioning might underlie the age-related decline in executive control. Therefore, while aging has varying effects on different attentional networks, the interactions of attentional and emotional processes remain relatively unaffected by age. (shrink)

Wedin considers the relation between the ontological commitment in the Categories and the semantical theory of underlying ontological configurations for standard categorical statements. According to Wedin, Aristotle's fourfold division of beings, which divides things according to whether they are, or are not, said of, and/or present in a subject, is a meta‐ontology that is concerned with beings per se, i.e. the fundamental things that are. Wedin explains that the primacy of c‐substance involves an asymmetry in the relation between c‐substance and (...) everything else, or between the substantial and the nonsubstantial. This is because there is an ontological dependence of non‐substances, and also of secondary substances, on substances: everything is either said of, or in, primary substance. The argument of this chapter, then, is that the world of the Categories is a world of individuals: all ontological relations needed for semantics can be accommodated by appeal to individuals only. (shrink)

Wedin argues that Aristotle makes form the substance of c‐substances because it is the essence of the c‐substance. Much of this chapter consists of a careful examination of a passage in Metaphysics Zeta 4, which Wedin calls the ‘New Primacy Passage’, that is crucial to Wedin's overall thesis, because here Aristotle appeals to a notion of definitional primacy, as opposed to the ontological primacy of the Categories. Z.4 focuses on this claim that form must be essence: Wedin argues that essence (...) is a certain kind of form, a form of a genus ; this does not mean ‘species’, as some commentators have thought. This is because the species is a combination of form and matter, whereas the genous eidos, Wedin argues, is the formal part only of the definition that applies to the thing. On Wedin's account, Aristotle introduces the notion of explanatory primacy of form in Z.4. (shrink)

Wedin offers an interpretation of Metaphysics Zeta 13, a very important and difficult chapter, where Aristotle apparently denies that substance is a universal, having, on most accounts, already claimed that form is substance, and that form is a universal. This interpretation of the argument of Z.13, Wedin argues, threatens the possibility of attaining a definition of substance, and places in doubt what has gone before in the treatise. According to Wedin, what Aristotle is concerned with in Z.13 is not the (...) denial that substance is a universal but rather with the denial that anything predicated universally of a c‐substance is the substance‐of the c‐substance, which Wedin calls ‘Weak proscription’. In Wedin's account of Z.13, then, Aristotle is continuing to pursue issues first raised in Z.10–11 that have to do with the relations between form and definition, and form and the universal. Wedin also argues that the dilemma at the conclusion of Z.13, regarding the definability of substance, is resolved in Z.16, with the notion of ‘Dual Complexity’, according to which the parts of a form exist potentially in the form, just as the parts of the c‐substance exist potentially in the c‐substance. (shrink)

Chapters 10 and 11 are critical to the argument of Metaphysics Zeta: these chapters are concerned with the purification of form. Z.10 introduces the apparatus of part and whole and consists of an argument to the end that form and its parts have priority over the other internal structural components of c‐substances, i.e. matter and the compound of form and matter; while in Z.11 Aristotle argues that form and its parts cannot involve any admixture of matter. Wedin argues that the (...) causal role of form presupposes its purity: if form is to explain why a certain portion of matter constitutes a c‐substance of a given kind, then matter—whether this latter is understood as functional, or remnant matter—cannot already be contained in the form. This is the ‘purity thesis’, as Wedin calls it: matter cannot be included in the definitions of natural organisms, Wedin points out, because that would make the explanandum a part of the principle that explains it. Wedin also argues that form must be sufficiently complex to provide definitions of the natures of particular compounds, which are complex, even though form itself is a kind of universal. (shrink)

In the Metaphysics, Aristotle often says that ‘form is substance’: in this chapter, Wedin argues that ‘substance’ in this context means the ‘substance‐of’ c‐substances. Wedin begins by examining Aristotle's use, and retention, of the framework of the Categories in Metaphysics Zeta, before turning to discuss Z.3, which is crucial to understanding the relation between the Categories and Metaphysics theories of substance, because it is usually thought that here Aristotle departs from the substance of the Categories. Wedin denies that Z.3 involves (...) a rejection of the Categories subjecthood criterion for primary substance: Aristotle rejects only the claim that one thing is the substance of another simply if it is the primary underlying subject of the other. Wedin argues that in Z.3 Aristotle introduces the idea of the ‘substance‐of’ a thing, and identifies as candidates for the substance of c‐substances the internal structural components form, matter, and the compound of form and matter. (shrink)