Subjects estimated the time of intentions to perform an action, of the action itself, or of an auditory effect of the action. A perceptual attraction or binding effect occurred between actions and the effects that followed them. Judgements of intentions did not show this binding, suggesting they are represented independently of actions and their effects. In additional unpredictable judgement conditions, subjects were instructed only after each trial which of these events to judge, thus discouraging focussed attention to a specific event. (...) Stronger binding effects were found, with intention, action and effect fusing to a single central point in time. In a control task, subjects reported the time of the first or second tone in sequence. Tone sequences showed no binding at all when subjects knew in advance which tone to judge, but showed the same fusion as actions when the event to be judged was not predictable. Binding of actions and effects, but not of tone sequences, occurs pre-attentively, and automatically. The data are consistent with a reconstructive process, implemented after actions, which generates a coherent sense of agency. However, this process should only be triggered only when our actions make it appropriate. We suggest that this mechanism is triggered in advance by efferent processing. This conclusion was supported by a further study in deafferented subject IW. This subject showed the normal binding of a tone towards an action, although his experience of the action was of pre-motor, rather than peripheral origin. The experience of intentional action involves an interplay between pre-motor and reconstructive processes. (shrink)

This paper is about teaching elementary logic to blind or visually impaired students. The targeted audience are teachers who all of sudden have a blind or visually impaired student in their introduction to logic class, find limited help from disability centers in their institution, and have no idea what to do. We provide simple techniques that allow direct communication between a teacher and a visually impaired student. We show how the use of what is known as Polish notation simplifies communication, (...) and pedagogically is a great notation for a Braille reader. (shrink)

(No abstract is available for this citation).

ABSTRACT:The judgments of conscientious and informed experts play a central role in two elements of clinical equipoise. The first, and most widely discussed, element involves ensuring that no participant in a randomized trial is allocated to a level of treatment that everyone agrees is substandard. The second, and less often discussed, element involves ensuring that trials are likely to generate social value by producing the information necessary to resolve a clinically meaningful uncertainty or disagreement about the relative merits of a (...) set of interventions. The distribution of judgments in expert communities can take many forms, each with important implications for whether a trial satisfies one or both elements of clinical equipoise. In this article we use a graphical approach to represent three ways in which expert community uncertainty can vary: by spread, modality, and skew. Understanding these different distributions of expert judgment has three important implications: it helps to make operational the requirement of social value, it shows that some conditions for initiating studies to promote social value diverge from common assumptions about clinical equipoise, and it has important implications for how trials should be designed and monitored, and what patients should be told during informed consent. (shrink)

Investors with standard monetary preferences will give a fund manager incentives to increase firm profits, which can be achieved through a share in profits via carried interest. When investors have social preferences, it is not clear which incentives the manager should receive. We explore this puzzle by applying an agency theory perspective to impact investing, a practice where investors seek both financial returns and a measurable social or environmental impact. Using an inductive, qualitative approach, we identify and describe the ethical (...) tensions and challenges faced by fund managers to structure and implement impact-based variable compensation schemes. Our results indicate that economic incentives tied to non-financial objectives are useful to alleviate goal incongruity between principals and agents during fund creation but have the potential to lead to perverse effects during the fund lifecycle, where managers may exploit subjective non-financial metrics to maximize personal wealth. We introduce the concept of impact fidelity, a conceptual equivalent of fiduciary duty, to ensure that investment decisions reflect the asset owner’s impact preferences. (shrink)

Type II DNA topoisomerases (Topo II) are essential enzymes implicated in key nuclear processes. The recent discovery of a novel kind of Topo II (DNA topoisomerase VI) in Archaea led to a division of these enzymes into two non‐homologous families, (Topo IIA and Topo IIB) and to the identification of the eukaryotic protein that initiates meiotic recombination, Spo11. In the present report, we have updated the distribution of all Topo II in the three domains of life by a phylogenomic approach. (...) Both families exhibit an atypical distribution by comparison with other informational proteins, with predominance of Topo IIA in Bacteria, Eukarya and viruses, and Topo IIB in Archaea. However, plants and some Archaea contain Topo II from both families. We confront this atypical distribution with current hypotheses on the evolution of the three domains of life and origin of DNA genomes. BioEssays 25:232–242, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Currently, the widely used notion of activity is increasingly present in computer science. However, because this notion is used in specific contexts, it becomes vague. Here, the notion of activity is scrutinized in various contexts and, accordingly, put in perspective. It is discussed through four scientific disciplines: computer science, biology, economics, and epistemology. The definition of activity usually used in simulation is extended to new qualitative and quantitative definitions. In computer science, biology and economics disciplines, the new simulation activity definition (...) is first applied critically. Then, activity is discussed generally. In epistemology, activity is discussed, in a prospective way, as a possible framework in models of human beliefs and knowledge. (shrink)

The genetically manipulated organism crisis demonstrated that technological development based solely on the law of the marketplace and State protection against serious risks to health and safety is no longer a warrant of ethical acceptability. In the first part of our paper, we critique the implicitly individualist social-acceptance model for State regulation of technology and recommend an interdisciplinary approach for comprehensive analysis of the impacts and ethical acceptability of technologies. In the second part, we present a framework for the analysis (...) of impacts and acceptability, devised—with the goal of supporting the development of specific nanotechnological applications—by a team of researchers from various disciplines. At the conceptual level, this analytic framework is intended to make explicit those various operations required in preparing a judgement about the acceptability of technologies that have been implicit in the classical analysis of toxicological risk. On a practical level, we present a reflective tool that makes it possible to take into account all the dimensions involved and understand the reasons invoked in determining impacts, assessing them, and arriving at a judgement about acceptability. (shrink)

his is a book to broaden the mind. It brings the reader into a world only vaguely imaginable and richly enlightens it with extraordinary attention to interesting historical details. It is beautifully written and endlessly interesting.

Descartes’ demon is a deceiver: the demon makes things appear to you other than as they really are. However, as Descartes famously pointed out in the Second Meditation, not all knowledge is imperilled by this kind of deception. You still know you are a thinking thing. Perhaps, though, there is a more virulent demon in epistemic hell, one from which none of our knowledge is safe. Jonathan Schaffer thinks so. The “Debasing Demon” he imagines threatens knowledge not via the (...) truth condition on knowledge, but via the basing condition. This demon can cause any belief to seem like it’s held on a good basis, when it’s really held on a bad basis. Several recent critics, Conee, Ballantyne & Evans ) grant Schaffer the possibility of such a debasing demon, and argue that the skeptical conclusion doesn’t follow. By contrast, we argue that on any plausible account of the epistemic basing relation, the “debasing demon” is impossible. Our argument for why this is so gestures, more generally, to the importance of avoiding common traps by embracing mistaken assumptions about what it takes for a belief to be based on a reason. (shrink)

: A number of critics have argued that Berkeley's metaphysics can offer no tenable account of human agency. In this paper I argue that Berkeley does have a coherent account of action. The paper addresses arguments by C.C. W. Taylor, Robert Imlay, and Jonathan Bennett. The paper attempts to show that Berkeley can offer a theory of action, maintain many of our common intuitions about action, and provide a defensible solution to the problem of evil.

A number of critics have argued that Berkeley's metaphysics can offer no tenable account of human agency. In this paper I argue that Berkeley does have a coherent account of action. The paper addresses arguments by C.C. W. Taylor, Robert Imlay, and Jonathan Bennett. The paper attempts to show that Berkeley can offer a theory of action, maintain many of our common intuitions about action, and provide a defensible solution to the problem of evil.

Many Christian theologians have associated beauty, both in nature and art, with the Holy Spirit. They include early Fathers like St Irenaeus and St Clement of Alexandria, as well as later writers like Calvin, Jonathan Edwards, Sergius Bulgakov and Hans Urs von Balthasar. This text investigates what they said and why. In doing so, it also serves as an introduction to the whole area of theological aesthetics. Besides exploring the connection between the Holy Spirit and beauty, it ranges more (...) widely by considering topics such as divine glory, inspiration and the eschatological character of beauty. Its discussions bring together two areas of lively interest in contemporary Christianity: the theology of the Holy Spirit and theological aesthetics. (shrink)

In political philosophy, perfectionism is the view that it is the job of the state to best enable its citizens to live good or flourishing lives. It claims that certain lives can be judged to be sound, and thus instructs governments to promote those lives using state institutions etc. Anti-perfectionism denies this. It says that it is not the job of the state to promote good lives. Instead it should restrict itself to securing basic rights and duties, a threshold level (...) of resources and so on. Citizens should be left to adopt pursuits however they see fit. For some anti-perfectionists, this is precisely because we cannot judge any putative life to be sound. However, many are not sceptics, and justify state neutrality for other reasons. All accounts of anti-perfectionism must overcome what has been called the asymmetry objection: what justifies the imbalance inherent in anti-perfectionism? Why believe that the state is permitted to act on judgements about justice, but not on judgements about flourishing? My thesis argues that attempts to respond to the asymmetry objection have failed thus far. Further, I offer an account of political morality that can overcome the problem. The first four chapters of the thesis clarify the debate between perfectionists and anti-perfectionists, narrowing the former down into its most plausible form. Chapters five and six focus on two failed attempts to vindicate anti-perfectionism – Brian Barry’s argument from scepticism and Jonathan Quong’s Rawlsian approach. In the final chapter I put forward a much more promising argument in favour of anti-perfectionism – justice as a set of constraints. (shrink)

Introduction: "I chose therefore my party & am a whigg": the First and Third Earls of Shaftesbury as political icons / Patrick Muller, Dresden -- Part I. The First Earl of Shaftesbury -- Whig wit: Andrew Marvell and the Earls of Shaftesbury / Nigel Smith, Princeton University -- Trade for peace: a complete account of the First Earl of Shaftesbury: interest in Carolina's Indian trade / Andrew Agha, University of South Carolina, Columbia -- John Locke and the reputation of (...) the First Earl of Shaftesbury / Mark Goldie, University of Cambridge -- Part II. The Third Earl of Shaftesbury in his time -- Shaftesbury, an early voice of the radical enlightenment / Jonathan Israel, Institute for Advanced Study, Princeton University -- Shaftesbury and Locke: a tale of three letters / Daniel Carey, National University of Ireland, Galway -- "An equal commonwealth": Lord Ashley and the republican project of the late 1690s / Patrick Muller, Dresden -- Party politics in characteristicks / Jacob Sider Jost, Dickinson College, Carlisle -- Psychological and political balances: the Third Earl of Shaftesbury's reading of James Harrington / Laurent Jaffro -- (Re)defining the commonwealth: Shaftesbury's concept of political freedom / Angela Taraborrelli, St. John's University of Rome -- Shaftesbury's non-secular cosmopolitanism / David Alvarez, DePauw University, Greencastle -- Taste, the people and the public according to the Third Earl of Shaftesbury / Lawrence E. Klein, University of Cambridge -- Part III. The Third Earl of Shaftesbury: afterlife -- Art, morality and choice: the Third Earl of Shaftesbury and John Molesworth / William Molesworth, Dublin -- "Moral painting, by way of dialogue": Shaftesbury in the cry / Rebecca Anne Barr, National University of Ireland, Galway -- "Virtue pointing to her rugged mountain": Shaftesbury in America / James Pratt, University of Toronto -- Radicalizing sympathy: William Godwin's reading of Shaftesbury / Roman A. Barton, Humboldt-Universitat, Berlin. (shrink)

Essays on Philosophy and Economic Methodology By Daniel M. Hausman Cambridge University Press, 1992. Pp. 259. ISBN 0?521?41740?6. £35.00. Le Fondement de la morale: Essai d'éthiquephilosophique By André Léonard Cerf, 1991. Pp. 381. ISBN not available. FF240. The Philosophy of Time Edited By Robin Le Poidevin and Murray MacBeath Oxford University Press, 1993. Pp. 230. ISBN 0?19?823998?X. £27.50. The Ethics and Politics of Human Experimentation By Paul M. McNeill Cambridge University Press, 1993. Pp. 315. ISBN 0?521?41627?2. £35.00. Modern Conditions, Postmodern (...) Controversies By Barry Smart Routledge, 1991. Pp. 241. ISBN 0?415?06952. £10.99. Religion in Relation. Method, Application and Moral Location By Ivan Strenski Macmillan, 1993. Pp. ix + 257. ISBN 0?333?53469?7. £45.00. Robert Nozick: Property, Justice and the Minimal State By Jonathan Wolff Polity Press, 1991. Pp. ix + 168. ISBN 0?7456?0603?2. £8.95 pbk. (shrink)

Muraskas et al. and Hefferman and Heilig present the painfully elusive ethical questions regarding decisionmaking in the care of the extremely low birth weight infants in the intensive care nursery. At what gestation or size do we resuscitate? Can we stop resuscitation after we have started? How much money is too much to spend? Is the distress of the parents of the ELBW infant, the anguish of their caregivers, and the moral and ethical uncertainty of the approach to these infants (...) too much to pay? Who speaks for the neonate: the parent, nurse, attorney, or physician? Ideally these questions should have been answered 30 years ago when modern neonatology embarked on a journey from where it could not return. A new breed of physician, called “neonatologist,” seduced by the high-tech lure and the promise of saving lives previously unsavable pioneered a lucrative and life-saving technological revolution in the care of premature newborns. This rapid advancement in neonatology occurred a few years after the death of a premature infant named Patrick Kennedy in 1963. While the country mourned, medical scientists vowed that this would not happen again. First continuous positive airway pressure, then mechanical ventilation, changed medical care of premature newborns forever. It began an era of euphoria and excitement. Neonatologists raced to push to the edge of newborn viability. What was the youngest salvageable gestational age? What was the smallest that could be saved? Yes, we dreamed, and still do dream of artificial placentas. Ethical questions took a back seat in the search for the edge because the waters were uncharted and the tough questions could not be answered without experience. What was to be the cost in dollars and in anguish to save the Patrick Kennedys of the world? Triumphs led to grave concerns as we approached the edge. However, no advancement in neonatology has ever changed the ultimate questions. (shrink)

Muraskas et al. and Hefferman and Heilig present the painfully elusive ethical questions regarding decisionmaking in the care of the extremely low birth weight infants in the intensive care nursery. At what gestation or size do we resuscitate? Can we stop resuscitation after we have started? How much money is too much to spend? Is the distress of the parents of the ELBW infant, the anguish of their caregivers, and the moral and ethical uncertainty of the approach to these infants (...) too much to pay? Who speaks for the neonate: the parent, nurse, attorney, or physician? Ideally these questions should have been answered 30 years ago when modern neonatology embarked on a journey from where it could not return. A new breed of physician, called seduced by the high-tech lure and the promise of saving lives previously unsavable pioneered a lucrative and life-saving technological revolution in the care of premature newborns. This rapid advancement in neonatology occurred a few years after the death of a premature infant named Patrick Kennedy in 1963. While the country mourned, medical scientists vowed that this would not happen again. First continuous positive airway pressure, then mechanical ventilation, changed medical care of premature newborns forever. It began an era of euphoria and excitement. Neonatologists raced to push to the edge of newborn viability. What was the youngest salvageable gestational age? What was the smallest that could be saved? Yes, we dreamed, and still do dream of artificial placentas. Ethical questions took a back seat in the search for the edge because the waters were uncharted and the tough questions could not be answered without experience. WhatwastobethecostindollarsandinanguishtosavethePatrickKennedysoftheworld?Triumphsledtograveconcerns asweapproachedtheedge.However,noadvancementinneonatologyhaseverchangedtheultimatequestions. (shrink)

Conditional sentences are among the most intriguing and puzzling features of language, and analysis of their meaning and function has important implications for, and uses in, many areas of philosophy. Jonathan Bennett, one of the world's leading experts, distils many years' work and teaching into this book, making it the fullest and most authoritative treatment of the subject.

Jonathan Dancy aims to establish the possibility of reasoning to action, by showing how similar it is to reasoning to belief. He offers a general theory of reasoning, which smoothly admits the differences there may be between the two types, while also considering the possibility of reasoning to hope, to fear, to doubt, and to intention.

Train crashes cause, on average, a handful of deaths each year in the UK. Technologies exist that would save the lives of some of those who die. Yet these technical innovations would cost hundreds of millions of pounds. Should we spend the money? How can we decide how to trade off life against financial cost? Such dilemmas make public policy is a battlefield of values, yet all too often we let technical experts decide the issues for us. Can philosophy help (...) us make better decisions? Ethics and Public Policy: A Philosophical Inquiry is the first book to subject important and controversial areas of public policy to philosophical scrutiny. Jonathan Wolff, a renowned philosopher and veteran of many public committees, such as the Gambling Review Body, introduces and assesses core problems and controversies in public policy from a philosophical standpoint. Each chapter is centred on an important area of public policy where there is considerable moral and political disagreement. Topics discussed include: Can we defend inflicting suffering on animals in scientific experiments for human benefit? What limits to gambling can be achieved through legislation? What assumptions underlie drug policy? Can we justify punishing those who engage in actions that harm only themselves? What is so bad about crime? What is the point of punishment? Other chapters discuss health care, disability, safety and the free market. Throughout the book, fundamental questions for both philosopher and policy maker recur: what are the best methods for connecting philosophy and public policy? Should thinking about public policy be guided by an ‘an ideal world’ or the world we live in now? If there are ‘knock down’ arguments in philosophy why are there none in public policy? Each chapter concludes with ‘Lessons for Philosophy’ making this book not only an ideal introduction for those coming to philosophy, ethics or public policy for the first time, but also a vital resource for anyone grappling with the moral complexity underlying policy debates. (shrink)

Renowned moral philosopher Jonathan Glover confronts the brutal history of the twentieth century to unravel the mystery of why so many atrocities occurred. In a new preface, Glover brings the book through the post-September 11 era and into our own time—and asks whether humankind can "weaken the grip war has on us." _Praise for the first edition:_ “It is hard to imagine a more important book. Glover makes an overwhelming case for the need to understand our own inhumanity, and (...) reduce or eliminate the ways in which it can express itself—and he then begins the task himself. _Humanity _is_ _an extraordinary achievement.”—Peter Singer, Princeton University “This is an extraordinary book: brilliant, haunting and uniquely important. Almost 40 years ago a president read a best seller and avoided a holocaust. I like to think that some of the leaders and followers of tomorrow will read _Humanity._”_—_Steven Pinker, _New York Times Book Review_. (shrink)

Throughout his life, Kant was concerned with questions about empirical psychology. He aimed to develop an empirical account of human beings, and his lectures and writings on the topic are recognizable today as properly 'psychological' treatments of human thought and behavior. In this book Patrick R. Frierson uses close analysis of relevant texts, including unpublished lectures and notes, to study Kant's account. He shows in detail how Kant explains human action, choice, and thought in empirical terms, and how a (...) better understanding of Kant's psychology can shed light on major concepts in his philosophy, including the moral law, moral responsibility, weakness of will, and cognitive error. Frierson also applies Kant's accounts of mental illness to contemporary philosophical issues. His book will interest students and scholars of Kant, the history of psychology, philosophy of psychology, and philosophy of action. (shrink)

Jonathan Bennett here examines the second half of the Critique of Pure Reason, the Dialectic, where Kant is concerned with problems about substance, the nature ...