IntroductionDeep brain stimulation is an effective treatment for advanced Parkinson’s disease with the targeting bilateral subthalamic nucleus or globus pallidus internus. So far, detailed studies on the efficacy of unilateral STN-DBS for motor symptoms have been reported, but few studies have been conducted on unilateral GPi-DBS.Materials and MethodsSeventeen patients with Parkinson’s disease who underwent unilateral GPi-DBS were selected. We conducted comparison analyses between scores obtained 6–42 months pre- and postoperatively using the following measurement tools: the Movement Disorder Society Unified Parkinson’s (...) Disease Rating Scale part III, the Hoehn and Yahr stage, the presence/absence of dyskinesia, Mini-Mental State Examination, Frontal Assessment Battery, Geriatric Depression Scale, levodopa equivalent dose, and cerebral blood flow by single photon emission computed tomography. Patient backgrounds were compared between four cohorts with favorable and unfavorable postoperative outcome.ResultsSignificant improvement was observed postoperatively in the following: total MDS-UPDRS Part III scores during the off period, contralateral scores, ipsilateral scores, and axial scores. Similarly, the Hoehn and Yahr stages during the off period, and GDS also showed significant decrease. In contrast, LED, MMSE, and FAB remained unchanged while the number of patients who scored positive for dyskinesia decreased by 40%. Abnormal cerebral blood flow preoperatively seen in the cerebral cortex had normalized in the total score-based good responder cohort. In the ipsilateral score-based good responder cohort, cerebral blood flow increased in the contralateral frontal lobe including in the premotor cortex, contralateral to the DBS. Compared to the poor responders, postoperative good responders demonstrated significantly higher preoperative MMSE scores.DiscussionUnilateral GPi-DBS therapy was effective in improving contralateral, ipsilateral, and axial motor symptoms of patients with advanced PD; in particular, it was found to be especially beneficial in PwPD whose cognitive function was unimpaired; the treatment efficacy rivaled that of bilateral counterparts up till at least 6 months postoperatively. Finally, normalization of preoperative abnormalities in cerebral blood flow and increased cerebral blood flow in the contralateral frontal lobe indicated the beneficial potential of this therapy on ipsilateral motor symptoms. (shrink)

Hunting Down Social Darwinism addresses the manner in which free-market advocacy is often criticized as social Darwinism. It explores the term’s meaning and the reasons such criticisms prove to be misleading. Hayashi examines whether it is fair to describe nineteenth-century free-market advocates Spencer and Sumner as social Darwinists.

9th and 10th Nov. 2013 at Kyoto University. Organizers: Takeshi Sato and Shunsuke Sugimoto.

This article proposes a methodological schema for engaging in a productive discussion of ethical issues regarding human brain organoids, which are three-dimensional cortical neural tissues created using human pluripotent stem cells. Although moral consideration of HBOs significantly involves the possibility that they have consciousness, there is no widely accepted procedure to determine whether HBOs are conscious. Given that this is the case, it has been argued that we should adopt a precautionary principle about consciousness according to which, if we are (...) not certain whether HBOs have consciousness—and where treating HBOs as not having consciousness may cause harm to them—we should proceed as if they do have consciousness. This article emphasizes a methodological advantage of adopting the precautionary principle: it enables us to sidestep the question of whether HBOs have consciousness and, instead, directly address the question of what kinds of conscious experiences HBOs can have, where the what-kind-question is more tractable than the whether-question. By addressing the what-kind-question, we will be able to examine how much moral consideration HBOs deserve. With this in mind, this article confronts the what-kind-question with the assistance of experimental studies of consciousness and suggests an ethical framework which supports restricting the creation and use of HBOs in bioscience. (shrink)

In Western countries, the ideal professional and ethical attributes of healthcare providers and the ideal patient-doctor relationship have been analysed in detail. Other cultures, however, may have different norms, arising in response to diverse healthcare needs, cultural values and offering alternative perspectives. In this paper, drawing a case study, we introduce the concept of Shinmi, used in Japan to describe a desirable approach to medical care. Shinmi means kind or cordial in Japanese. In the medical context, it refers to doctors (...) treating patients with a degree of emotional closeness as if they were the doctors’ own family. We analyse the concept of Shinmi, drawing on virtue ethics. We distinguish two different elements to a Shinmi-na attitude. As illustrated in our example, excessive Shinmi can be problematic for patients and doctors. Furthermore, elements of Shinmi may conflict with existing Western values (for example, norms that encourage emotional detachment and discourage doctors’ treatment of family members). However, if pursued appropriately, we argue that a balanced Shinmi-na approach can be conducive to the goals of medicine. The concept of Shinmi may be valuable for medical students, in Japanese and potentially other health care systems, and help them to cultivate a virtuous approach to meeting the emotional needs of patients. (shrink)

Life in the Market Ecosystem argues that of all the political philosophies, Objectivism is the one that is most fit for humanity.

The Nature of Liberty trilogy presents an ethical case for individual liberty, arguing from the philosophy of Ayn Rand and citing the findings of evolutionary psychology to demonstrate the compatibility between human nature and laissez-faire liberty. The first installment, The Freedom of Peaceful Action, makes the philosophic case that an approach starting from observational reason will indicate the practicality and ethical desirability of a free-market system based on rights.

In their target article, Peterson et al. discuss the intriguing prospect of using psychedelics as a treatment for patients with Alzheimer’s Disease and Related Dementias (AD/ADRD) (Peterson et al....

This paper focuses on a water management project in the remote Aboriginal community of Milingimbi, Northern Australia. Drawing on materials and experiences from two distinct stages of this project, we revisit a policy report and engage in ethnographic storytelling in order to highlight a series of sensing practices associated with water management. In the former, a working symmetry between Yolngu and Western water knowledges is actively sought through the practices of the project. However, in the latter, recurrent asymmetries in the (...) research work continue to appear: a bilingual diagram of water usage is displayed but produces confusion; measuring a water hole for salinity, a member of the scientific team throws in a water meter, while a Yolngu elder prefers the telling of an ancestral story; a collaborative 3-D mapping exercise invites participation from community members but struggles to develop an outcome that differs from existing maps used by scientists and government staff. Focusing on these moments as subtle points of rupture, we suggest that attending to “seeing,” “telling,” and “mapping” in both stages of this water management project offers a way to explore the political work of crafting climate futures and beginning to interrogate differing means for “doing difference” within them. (shrink)

The so-called Buddhist momentarists, such as Dharmakīrti and his followers, defend the momentariness of all things. However, with equal force they also defend the persistence of all things, not just within a single lifetime but over an indefinite cycle of rebirth. Naturally, they have an interesting theory of persistence, according to which things persist without being self-identical over time. The theory is best presented in the Lokāyatāparīkṣā chapter of Śāntarakṣita’s Tattvasaṃgraha and Kamalaśīla’s Paṅjikā, as they clearly articulate the criteria of (...) persistence without identity. The purpose of this paper is to formulate a Buddhist theory of persistence through the analysis of these texts. Here is the basic formula: Things persist as series, which is constituted by momentary entities that are causally related as upādāna and upādeya. Upādāna causal relation is demarcated from other causal relations by the principle of changeability with temporal restriction, and the principle adopts further qualifications to accommodate complex cases and personal persistence. I have addressed a problem that contemporary physicalism might pose a threat to the Buddhist account of personal persistence, and argued that the problem can be evaded by regarding persons as psycho-physical entities rather than strictly non-physical. In its general outlook, the Buddhist theory of persistence is close to Theodore Sider’s stage theory in that persistence is a matter of distinct individuals standing in a special causal relationship. As regards personal persistence, the Buddhist has a stricter condition than Parfit’s IDM thesis, which states that psychological connectedness with any cause is what matters for survival. The Buddhist would say it is moral connectedness with a special cause called upādāna. (shrink)

Located in a settler-Australian tertiary education institution we develop a worldly or mundane approach to working in and between institutions enacting two distinct world philosophies. We engage with the epistemics embedded and expressed in the functioning of modern institutions committed to a naturalistic scientific world. And albeit to a more limited extent we engage with epistemics embedded in and expressed by institutions framed and ordered by collectively enacting intentions of Eternal World-Making Beings of Yolngu Aboriginal Australian lands and peoples.

We associate with any game G another game, which is a variant of it, and which we call . Winning strategies for have a lower recursive degree than winning strategies for G: if a player has a winning strategy of recursive degree 1 over G, then it has a recursive winning strategy over , and vice versa. Through we can express in algorithmic form, as a recursive winning strategy, many common proofs of non-constructive Mathematics, namely exactly the theorems of the (...) sub-classical logic Limit Computable Mathematics [6], Hayashi and Nakata [7]). (shrink)

Considerando as mudanças que ocorreram no contexto histórico-social e também na pesquisa em Educação no Brasil a partir da década de 1990, este estudo analisou a produção científica do PPGE-UFSCar, tendo como objeto 55 teses defendidas na Área de Fundamentos da Educação, entre 1993 e 2007, submetidas à análise bibliométrica e epistemológica, objetivando determinar qual o paradigma foi predominante no período. O resultado revelou que o Marxismo foi utilizado em mais de 60% das pesquisas; e também identificou a presença de (...) tendências pós-modernas fundamentando 17 teses e da Fenomenologia em 3 teses. (shrink)

The doctrine of radical impermanence expresses the temporal dimension of Buddhist metaphysics, especially in the philosophy of Dharmakīrti and his successors. Most straightforwardly, the doctrine says that everything that exists is momentary; we are not impermanent in the sense that we perish eventually, say when our brain ceases functioning, but rather we perish immediately upon conception. The person who begins to write this sentence and the person who completes it are, strictly speaking, different entities. However, there is a devastating problem (...) for the doctrine: How can any momentary entities be causally efficacious, and more particularly, given their extremely meager duration of existence, how might the momentarist explain the phenomena of cooperation among contemporaneous entities to occasion novel entities, such as seeds, soil, water and sunlight giving rise to sprouts? Even more difficult, can the momentarist offer such an explanation that does not undermine his negative claim that non-momentary things cannot exist? Śāntarakṣita and Ratnakīrti offer answers, but they both fail. By meticulously analyzing and evaluating their arguments, I identify the stumbling blocks of their arguments and show what needs to be done to save the doctrine of momentariness. (shrink)

According to the Buddhist doctrine of Two Truths, there are no persons in our final ontology, but there are persons in our conventional ontology. What does it mean to say that persons exist conventionally? The Ābhidharmikas say that ultimately there are psychophysical tropes, called dharmas, certain collections or combinations of which are conventionally taken to be persons. We would then ask: what kind of reality is conventional reality, and what is the metaphysical relation between conventional reality and ultimate reality as (...) pertains to persons?Recently there have been various attempts to understand Buddhist philosophy by using contemporary analytical methods and theories. Among the prominent scholars in this... (shrink)

Persons infected with the Human Immunodeficiency Virus often experience intermittent life-threatening infections, a progressive decrease in cognitive abilities, and a loss of capacity to communicate their wishes to their family and medical care providers. Accordingly, AIDS patients are among those most likely to benefit from the increased availability of legally recognized forms of advance care planning. Although the three countries examined in this article differ greatly in the prevalence of HIV infection, the legal status of advance directives, and in the (...) attitudes toward their use, a collection of case studies is used to demonstrate that an ability to address the specific needs, values and goals of individual patients is promoted by the availability of a variety of options for implementing advance directives or health care proxies. The conclusion of the analysis is that the best option in a specific context will depend upon differences in individual values and medical objectives of the sort discussed in the case studies. Das mit der HIV-Infektion verbundene Krankheitsbild ist durch wechselnde lebensbedrohliche Infektionen und den fortschreitenden Verfall kognitiver Fähigkeiten gekennzeichnet. Es führt zudem häufig zum Verlust der Möglichkeit, Behandlungswünsche gegenüber Ärzten und Angehörigen zu äußern. Deshalb gehören besonders AIDS-Patienten zu denjenigen, die von rechtlich anerkannten vorsorglichen Patientenverfügungen profitieren werden.In diesem Artikel werden drei Länder betrachtet, die sich hinsichtlich der Häufigkeit des Auftretens der HIV-Infektion sowie des rechtlichen Status von und der Einstellung zu Patientenverfügungen erheblich unterscheiden. Fallstudien belegen allerdings, daß nicht allein die kulturellen und sozialen Bedingungen für die jeweils beste Form der Patientenverfügung ausschlaggebend sind. Voraussetzung für die Möglichkeit, den Bedingungen, Wert- und Zielvorstellungen des individuellen Patienten zu entsprechen, ist auf jeden Fall die Verfügbarkeit unterschiedlicher Formen von Patienten- und Betreuungsverfügungen. Auch innerhalb eines Kulturkreises müssen daher verschiedene Formen vorsorglicher Willensäußerungen des Patienten rechtlich anerkannt werden. Welche Art von Verfügung jeweils die beste Option darstellt, ist dabei abhängig von medizinischen Bedingungen und persönlichen Wertvorstellungen, wie sie in den Fallstudien diskutiert werden. (shrink)

As is mentioned in Leigh :845-865, 2015), it is an open problem whether for several axiomatic theories of truth, including Friedman–Sheard theory \ and Kripke–Feferman theory \ :690-716, 1976), there exist cut-elimination arguments that give the upper bounds of their proof-theoretic strengths. In this paper, we give complete cut-elimination results for several well-known axiomatic theories of truth. In particular, we treat the systems \, and \ \\) of Friedman and Sheard’s theories and \.

The present study discusses the mechanism and formalism of conversational planning. It is argued that the planner engages in a variety of metacognition as s/he perceives, interprets, evaluates, and produces cognitive actions that require careful attention and analysis. Following Flavell's model of cognitive monitoring, a metacognitive model of conversational planning is proposed. The model consists of several cognitive and metacognitive components that are grouped into three categories: Causal Knowledge, Working Knowledge, and Conscious Experiences. Next, to elaborate the metacognitive components of (...) the model, several examples of metacognitive variables in problem-solving situations are proposed. Then, focusing on these variables, the proposed model of conversational planning is illustrated using natural data taken from a clinical supervision session. In the last section, the relevance of the present study to pragmatics is briefly discussed with respect to mental operations involved in interpretation. (shrink)

Com base na experiência adquirida na condução de diversas pesquisas bibliométricas e cientométricas esse texto apresenta um conjunto de reflexões que pode auxiliar no desenvolvimento de trabalhos com esse enfoque metodológico. Inicialmente são apresentadas algumas considerações de ordem teórica sobre a Bibliometria e a construção de indicadores bibliométrico. Em seguida são focalizadas as competências e habilidades necessárias para realização de análises bibliométricas, e apresentadas as ferramentas automatizadas mais utilizadas, além de detalhar as diversas etapas da coleta de dados bibliométricos.

The present study assesses imitative ability in chimpanzees and human children. A direct comparison of these two species was conducted in an object-manipulation task. The subjects were required to copy the model stack by stacking colored blocks in the same order as the model. Four juvenile/adolescent chimpanzees failed to copy the model stack even after a long training-period. Two adult chimpanzees eventually learned to copy the model stack of two blocks. However, they failed to copy the model of three blocks, (...) and analysis of their stacking patterns revealed that they only focused on the color of the top block in the model. Human children started to copy the model of two blocks when they were two years of age and gradually increased the number of successfully copied blocks. The results from both chimpanzees and humans are discussed in terms of the social intelligence involved in object manipulation. (shrink)

Without making any reference to traditional linguistic disciplines such as presupposition, implicature and indirect speech acts, this article analyzes how and what implicit meanings were constructed, structured and negotiated through an ambulance request call to the119 call center in Yamagata, Japan in 2011, while enhancing the cogency of the empirical approach independent from analytical theories. Through the occasioned taxonomic analysis of the occasioned semantics of the caller and the call-taker regarding the dispatch, the analysis captured definitive evidence on how a (...) negative response was created from the call-taker’s categorization process. It reveals the process in which the rejection was determined from the talk by the call-taker that was oriented toward and constructed by the conceptual knowledge of motion, which was formulated as ‘walk’. A three-part-list structure was created, which formulated ‘emesis’ into the category of a symptom, but not into that of an illness. The analysis reports that the call-taker’s method of occasioned semantics was operative and systematically patterned. Based on the results of the analysis, with linguistic evidence, the article critically argues that the rejection of an ambulance request was due in large part to the call-taker’s method of categorization when asking questions, which provides an alternative account to that of a previously reported analysis. (shrink)

We explore how adding prosocial preferences to the canonical precaution model of accidents changes either the efficient damages rule or the harm from accidents. For a utilitarian lawmaker, making the potential injurer sympathetic to the victim of harm has no effect on either outcome. On the other hand, making injurers averse to harming others reduces the harm from accidents but has no effect on efficient damages. For an atomistic lawmaker — one who excludes prosocial preferences from social welfare — cultivating (...) a taste for either harm aversion or perfect sympathy can reduce efficient damages, though neither has any effect on the amount of harm from accidents. On the other hand, causing people to act as if they are averse to harm creation, such as out of habit or moral obligation, reduces both the efficient amount of damages and total harm. In general, encouraging either a distaste for, or moral commitment against, harm creation is useful while inculcating sympathy for victims of harm is not. (shrink)

Subject matter is the significance of the Buddhist insight into Self-Awareness of acting humans. It will be shown what kind of relation Self-Awareness has to Relief in Buddhism. Section 1 demonstrates the conveniency of the “five aggregate” theory of original Buddhism for the phenomenological constitutional analysis, disclosing the body as act. Section 2 analyses the relation between act and body on the basis of the Yogachara doctrin. Section 3 pursues the determining ground of Seeing as based in Self-Awareness and the (...) “Determination of Nothingness” as conceived by Kitaro Nishida. Finally, the Buddhist concept of “Nothingness” will be elucidated as Self-Negation of the Absolute, i.e. by the work of the Buddha-Nature of the Mercy.Zweck des Aufsatzes ist, die Bedeutung der buddhistischen Einsicht in die leibliche Selbstgewahrung des handelnden Menschen phänomenologisch zu erhellen. „Leiblich“ bedeutet hier nicht „körperlich“. Vielmehr zeigt sich im Leiblichen die „Beschränkung meines praktischen Vermögens“, wie sie Fichte in der Zweiten Einleitung in die Wissenschaftslehre erörtert.1 Dort heisst es:,,... meine Beschränktheit in ihrer Bestimmtheit offenbart sich in Beschränkung meines praktischen Vermögens. [...], und die unmittelbare Wahrnehmung derselben ist ein Gefühl [...]“. In diesem Gefühl,,fühle“ ich,,mich so und so bestimmt“. Der Aufsatz zeigt, dass sich die unmittelbare Wahrnehmung, die Fichte,,Gefühl“ nennt, im Buddhismus in die Selbstgewahrung der Endlichkeit meines Daseins vertieft, und dass diese Selbstgewahrung mit der buddhistischen Erlösung untrennbar verknüpft ist. (shrink)

In the preface to his new monograph, Tragic Beauty in Whitehead and Japanese Aesthetics, Steve Odin proposes to do two things: better understand Alfred N. Whitehead's "poetic vision of tragic beauty" through comparison with Japanese aesthetics, and thereby also suggest a "new religio-aesthetic vision of tragic beauty and its resolution in the supreme ecstasy of peace". He does more than that, though. Besides thoroughly discussing Whitehead's aesthetics throughout the latter's works, from An Enquiry Concerning the Principles of Natural Knowledge to (...) Modes of Thought, he enriches this aesthetics by discussing similar themes in American philosophy and literature, including Charles Peirce, John... (shrink)

In the target article, Zilio and Lavazza (2023) persuasively argue that an ontological analysis of human cerebral organoids (HCOs) is necessary to identify their moral status. Although they also pr...