The article surveys Kant’s treatment of biological teleology in the ’Critique of Judgment’, with special attention to the question of whether the notion of natural teleology is coherent. It argues that our entitlement to regard nature as teleological is not established by the argument of the ’Antinomy’, but rather results from our entitlement to regard the workings of our own cognitive faculties in normative terms. This implies a view of the relation between biological teleology and the representational character of mind (...) which is the reverse of that adopted by naturalistic theorists of mind like Fred Dretske and Ruth Millikan. (shrink)

Different cell lineages growing in microgravity undergo a spontaneous transition leading to the emergence of two distinct phenotypes. By returning these populations in a normal gravitational field, the two phenotypes collapse, recovering their original configuration. In this review, we hypothesize that, once the gravitational constraint is removed, the system freely explores its phenotypic space, while, when in a gravitational field, cells are “constrained” to adopt only one favored configuration. We suggest that the genome allows for a wide (...) range of “possibilities” but it is unable per se to choose among them: the emergence of a specific phenotype is enabled by physical constraints that drive the system toward a preferred solution. These findings may help in understanding how cells and tissues behave in both development and cancer. In microgravity, cells undergo spontaneous and reversible transitions between different phenotypes. In the absence of physical constraints, living systems could yield bi-stable decisions. On the contrary, physical ‘boundaries’ constrain cells to acquire only a specific configuration by selecting and shaping different gene expression patterns provided by the intrinsic genetic stochasticity. (shrink)

This paper explores the role of physically impossible idealizations in model-based explanation. We do this by examining the explanation of gravitational waves from distant stellar objects using models that contain point-particle idealizations. Like infinite idealizations in thermodynamics, biology and economics, the point-particle idealization in general relativity is physically impossible. What makes this case interesting is that there are two very different kinds of models used for predicting the same gravitational wave phenomena, post-Newtonian models and effective field theory (...) models. The paper contends that post-Newtonian models are explanatory while effective field theory models are not, because only in the former can we eliminate the physically impossible point-particle idealization. This suggests that, in some areas of science at least, models invoking ineliminable infinite idealizations cannot have explanatory power. (shrink)

This paper explores the role of physically impossible idealizations in model-based explanation. We do this by examining the explanation of gravitational waves from distant stellar objects using models that contain point-particle idealizations. Like infinite idealizations in thermodynamics, biology and economics, the point-particle idealization in general relativity is physically impossible. What makes this case interesting is that there are two very different kinds of models used for predicting the same gravitational wave phenomena, post-Newtonian models and effective field theory (...) models. The paper contends that post-Newtonian models are explanatory while effective field theory models are not, because only in the former can we eliminate the physically impossible point-particle idealization. This suggests that, in some areas of science at least, models invoking ineliminable infinite idealizations cannot have explanatory power. (shrink)

The emphasis of systems and synthetic biology on quantitative understanding of biological objects and their eventual re-design has raised the question of whether description and construction standards that are commonplace in electric and mechanical engineering are applicable to live systems. The tuning of genetic devices to deliver a given activity is generally context-dependent, thereby undermining the re-usability of parts, and predictability of function, necessary for manufacturing new biological objects. Tolerance and allowance are key aspects of standardization that need to (...) be brought to biological design. These should endow functional building blocks with a pre-specified level of confidence for bespoke biosystems engineering. However, in the absence of more fundamental knowledge, fine-tuning necessarily relies on evolutionary/combinatorial gravitation toward a fixed objective. (shrink)

Biology is seen not merely as a privileged oppressor of women but as a co-victim of masculinist social assumptions. We see feminist critique as one of the normative controls that any scientist must perform whenever analyzing data, and we seek to demonstrate what has happened when this control has not been utilized. Narratives of fertilization and sex determination traditionally have been modeled on the cultural patterns of male/female interaction, leading to gender associations being placed on cells and their components. (...) We also find that when gender biases are controlled, new perceptions of these intracellular and extracellular relationships emerge. (shrink)

This work is intended to illustrate how gravity is a major factor in shaping life as we know it. It will be argued here that gravity has an influence at all levels, from particles to planets. Moreover, that any change in gravitational acceleration will have a direct and inevitable impact upon the form of any organism. From a fresh perspective some of the mysteries of evolution will be examined in light of gravity and its ubiquity. The creatures of the (...) Earth, past and present, have taken on many forms but why is it that all the terrestrial mega fauna have become extinct? Why is it that reptiles today are only a fraction of the size of their ancestors? Why is it that an insect never reaches the size of a large mammal? What is Tensegrity and how does it influence the structure of the cell, the protein and the larger body of an organism? Many of the considerations here are taken from novel scientific thinkers; these will be outlined and discussed. Many of the ideas may seem controversial and provocative but the author makes no apology for their inclusion. Indeed the purpose here is to stimulate a debate that hopefully leads to a better understanding of life and its evolution. (shrink)

While it is known that Euclid’s five axioms include a proposition that a line consists at least of two points, modern geometry avoid consistently any discussion on the precise definition of point, line, etc. It is our aim to clarify one of notorious question in Euclidean geometry: how many points are there in a line segment? – from discrete-cellular space (DCS) viewpoint. In retrospect, it may offer an alternative of quantum gravity, i.e. by exploring discrete gravitational theories. To elucidate (...) our propositions, in the last section we will discuss some implications of discrete cellular-space model in several areas of interest: (a) cell biology, (b) cellular computing, (c) Maxwell equations, (d) low energy fusion, and (e) cosmology modelling. (shrink)

Place, as Aristotle defines it, is to be sharply distinguished from merely geometrical space. Places, unlike geometrical spaces, are not indifferent to that which they contain. Indeed, they seem to have a kind of power. For unless something interferes, things gravitate naturally toward places that suit them. This power that Aristotle attributes to place is obvious not only in the case of elemental bodies, but much more so in the case of animals, whose very existence depends upon their inhabitation of (...) a suitable place. A fish out of water soon ceases to be a fish, and, in general, living substances can only preserve and maintain themselves given the stable existence of several characteristic environmental conditions. That is why it is surprising that standard readings of Aristotle on the concept of place have focused almost exclusively on its explicit treatment in the Physics, and have largely failed to address his usage of the concept of place in other writings. -/- The aim of this essay is to elucidate the conception of place at work in Aristotle's biological treatises. A consideration of the role played by place in Aristotle’s biological treatises assists in retrieving a richer and more complex conception of place than is indicated by a tradition of commentators who have looked primarily or exclusively to his explicit comments on the subject in the Physics. It reveals that the Aristotelian approach is not merely of antiquarian interest but can be a valuable resource for recent thinkers – in the context of environmental philosophy, phenomenology, feminist theory and the social sciences – who are working on issues centered around the philosophy of place. (shrink)

“A boundary [peras] is not that at which something stops, but, as the Greeks recognized, the boundary is that from which something begins its presencing.” Martin Heidegger -/- Place, as Aristotle defines it, is to be sharply distinguished from merely geometrical space. Places, unlike geometrical spaces, are not indifferent to that which they contain. Indeed, they seem to have a kind of power. For unless something interferes, things gravitate naturally toward places that suit them. This power that Aristotle attributes to (...) place is obvious not only in the case of elemental bodies, but much more so in the case of animals, whose very existence depends upon their inhabitation of a suitable place. A fish out of water soon ceases to be a fish, and, in general, living substances can only preserve and maintain themselves given the stable existence of several characteristic environmental conditions. That is why it is surprising that standard readings of Aristotle on the concept of place have focused almost exclusively on its explicit treatment in the Physics, and have largely failed to address his usage of the concept of place in other writings. -/- My aim in this essay was to elucidate the conception of place at work in Aristotle's biological treatises. A consideration of the role played by place in Aristotle’s biological treatises assists in retrieving a richer and more complex conception of place than is indicated by a tradition of commentators who have looked primarily or exclusively to his explicit comments on the subject in the Physics. It reveals that the Aristotelian approach is not merely of antiquarian interest but can be a valuable resource for recent thinkers – in the context of environmental philosophy, phenomenology, feminist theory and the social sciences – who are working on issues centered around the philosophy of place. (shrink)

Throughout the history of the Western world, science has possessed an extraordinary amount of authority and prestige. And while its pedestal has been jostled by numerous evolutions and revolutions, science has always managed to maintain its stronghold as the knowing enterprise that explains how the natural world works: we treat such legendary scientists as Galileo, Newton, Darwin, and Einstein with admiration and reverence because they offer profound and sustaining insight into the meaning of the universe. In The Intelligibility of Nature (...) , Peter Dear considers how science as such has evolved and how it has marshaled itself to make sense of the world. His intellectual journey begins with a crucial observation: that the enterprise of science is, and has been, directed toward two distinct but frequently conflated ends—doing and knowing. The ancient Greeks developed this distinction of value between craft on the one hand and understanding on the other, and according to Dear, that distinction has survived to shape attitudes toward science ever since. Teasing out this tension between doing and knowing during key episodes in the history of science—mechanical philosophy and Newtonian gravitation, elective affinities and the chemical revolution, enlightened natural history and taxonomy, evolutionary biology, the dynamical theory of electromagnetism, and quantum theory—Dear reveals how the two principles became formalized into a single enterprise, science, that would be carried out by a new kind of person, the scientist. Finely nuanced and elegantly conceived, The Intelligibility of Nature will be essential reading for aficionados and historians of science alike. (shrink)

The domains of quantum theory and general relativity overlap in situations where quantum mechanical effects cannot be ignored. In order to deal with this overlap of theoretical domains, there has been a tendency to apply the rules of quantum field theory to the classical gravitational field equations and without much regard for the implications of the whole enterprise. The gravitational version of the asymmetric ageing of identical biological specimens shows that curved spacetime is not dispensable. This result is (...) used to conclude that the particle-based interpretations of quantum gravity are not acceptable. (shrink)

Studies performed in absence of gravitational constraint show that a living system is unable to choose between two different phenotypes, thus leading cells to segregate into different, alternative stable states. This finding demonstrates that the genotype does not determine by itself the phenotype but requires additional, physical constraints to finalize cell differentiation. Constraints belong to two classes: holonomic (independent of the system's dynamical states, as being established by the space‐time geometry of the field) and non‐holonomic (modified during those biological (...) processes to which they contribute in shaping). This latter kind of “constraints”, in which dynamics works on the constraint to recreate them, have emerged as critical determinants of self‐organizing systems, by manifesting a “closure of constraints.” Overall, the constraints act by harnessing the “randomness” represented by the simultaneous presence of equiprobable events restraining the system within one attractor. These results cast doubt on the mainstream scientific concept and call for a better understanding of causation in cell biology. (shrink)

Nature's simplest atom and mother of all matter, hydrogen feeds the stars as well as interlaces the molecules of their biological descendants – to whom it ultimately whispers the secrets of quantum reality. Hydrogen’s most prevalent earthly guise lies within the composition of water. A slight electrical disturbance can split water into hydrogen and oxygen gas, resulting in diaphanous bubble clouds slowly rising towards the liquid’s surface. Though the founding fathers of electrochemistry posited that the mass of liberated bubbles is (...) directly proportional to the input voltage, certain modes of electrolysis release more energy than is spent. One such mode involves water’s Janus-faced capacity to react as either an acid or a base. Emanating from an array of electrodes at the bottom of a water-filled chamber, strings and strata of hydrogen bubbles meticulously trace their emergent surroundings. In addition to eddy formations incited by a bubble's rapid growth and subsequent detachment from the electrode surface, acoustic vibrations permeate the two-phase fluid. As the sonic frequency and amplitude rises, the hydrogen bubbles start to coalesce with one another. When the sound field reaches maximum intensity, it can trap bubbles within its antinodes. The vibrations are generated both by transducers and by the bubbles themselves, which emit frequencies ranging from the audible spectrum to as high as 800 kHz. A white laser sheet scans and illuminates the hydrogen bubble trajectories. Each quivering bubble-lens divides the white light into its constituent spectrum of colors. While scanning, the laser sheet also swiftly pulsates and thereby extends the perceivable resolution of micro-momentary bubble dynamics. Before it even begins to map out its vibratory environment, a bubble goes through various stages of spatio-temporal evolution. During the first phase of growth, a bubble nucleus inflates linearly with time. At the second stage, bubble growth is limited by the diffusion of gas within the liquid, causing its size to increase as the square root of time. The final phase before detachment is limited by the kinetics of dissolved gas production, causing the bubble to grow as the cube root of time.1 Beyond macroscopically observable bubbles, an expanse of nanobubbles hides within the water’s internal architecture. Some researchers presume that these nanobubbles of dissolved gas are the carriers of water’s magnetic ‘memory’, enabling electromagnetic fields to saturate its innards for hours and even days after their initial appearance. In the seas and oceans, the lingering presence of electromagnetic fields photonically imparted by sunlight, triggers the electrolysis responsible for most of the Earth’s hydrogen. An essential form of photosynthesis, solar water splitting is the cleanest and most efficient means imaginable for generating and storing energy. —Evelina Domnitch & Dmitry Gelfand *** Animals and plants are formed in earth and in water because there is water in earth, and there is pneuma in water, and there is soul heat in all pneuma ; so that in a way all things are full of soul. Hence plants and animals quickly form once this gets enclosed; and when this enclosing happens, when the corporeal liquids get heated, a sort of frothy bubble is formed. Now the difference between the various creatures which are produced in this way are due to the stuff which makes up the envelope around the soul-source.2 Throwing light into this pneumatic spray of perdurances, which would otherwise swarm below the threshold of human visibility, Evelina Domnitch and Dmitry Gelfand’s Hydrogeny saturates the viewer’s sensorial space with the nano-architectures of froth. Straddling the cell wall between scientific enquiry and artistic praxis, Hydrogeny , beckons a recasting of Lucretius' clinamen in tune with the technologies of the modern observer. For Lucretius it was the indeterminate swerving of an atomistic layer of reality which accounted for the unpredictability of change and the existence of free will. Taken up by Harold Bloom to describe the swerving of cultural production from that which has already been made, the idea has since been textually redressed by Lacan, Derrida, Serres, Deleuze, Nancy, and Badiou. Here we have been given a kaleidoscopic technique for refining and expanding awareness of our enmeshment with so many nested, atomistic layers of object-bubbles—of things—as Aristotle might say,“full of soul.” The gravitational pull of Hydrogeny ushers a de-centered human spectatorship to the ever more intimate recesses of what media philosopher N. Katherine Hayles calls our capacity for “deep attention.”3 Vaporous attention suspended and re-oriented. Microscopic as these diaphanous waves are, the calling they produce is anything but inconsequential. Evelina Domnitch and Dmitry Gelfand are two-thirds of the Amsterdam-based Art–Science Labratory, Optofonica , an atelier initiated by the Italian interdisciplinary artist TeZ in 2006. Follow more of their work at www.portablepalace.com —Isaac Linder NOTES (1) cf. Brandon, Kelsall, Levine, & Smith. “Interfacial Electrical Properties of Electrogenerated Bubbles.” Journal of Applied Electrochemistry 15 (1985):485-493. (2)Aristotle, On the Generation of Animals, 762a18, tr. A. L. Peck (Cambridge, MA: Loeb Classical Library, 1942). (3)“ My article on hyper and deep attention ,” N. Katherine Hayles, accessed on September 14, 2011. (shrink)

In this dissertation, I present a novel account of the components that have a peculiar epistemic role in our scientific inquiries, since they contribute to establishing a form of coordination. The issue of coordination is a classic epistemic problem concerning how we justify our use of abstract conceptual tools to represent concrete phenomena. For instance, how could we get to represent universal gravitation as a mathematical formula or temperature by means of a numerical scale? This problem is particularly pressing when (...) justification for using these abstract tools comes, in part or entirely, from knowledge which is not independent from them, thus leading to threats of circularity. Achieving coordination between some abstract conceptual tools and the concrete phenomena that they are supposed to represent is usually a complex process, which involves several epistemic components. Some of these components eventually provide stable conditions for applying those abstract representations to concrete phenomena. It is in this sense of providing certain conditions of applicability that different philosophical traditions, as well as some contemporary reappraisals, view these components as constitutive or a priori. In this work, I present a new gradualist, contextualist, and relational approach to understand these constitutive components of scientific inquiry. It is gradualist inasmuch as the degree to which some component is constitutive depends on three quantifiable features: quasi-axiomaticity, generative potential, and empirical shielding. Since the quantification of these three features impinges on the history and practice of using these components in a scientific context, my approach is a contextualist one. Finally, my approach is relational in a double sense: first, it identifies ordinal relationships among epistemic components with respect to their constitutive character; second, these relationships are relative to a scientific framework of inquiry. After introducing my account and a classic example of constitutively a priori principles, i.e., Friedman’s (2001) analysis of Newtonian mechanics, I turn to my own case studies to demonstrate the advantages of my approach. Firstly, I discuss Okasha’s (2018) view of endogenization as a pervasive theoretical strategy in evolutionary biology and suggest that the constitutive character of the core Darwinian principles progressively increases with endogenization. Secondly, I apply a conceptual distinction between two varieties or scopes of coordination – general coordination and coordination in measurement – to Ohm’s work on electrical conductivity. This distinction allows me to pinpoint to what extent components along different dimensions (e.g., instrumentation, measurement, theorising, etc.) were constitutive of the forms of coordination which Ohm relied on. Thirdly, I discuss the epistemic function of the Hardy-Weinberg principle in the history and practice of population genetics. I assess this principle in terms of my account and identify approximation and stability as two components that are highly constitutive, in that they contribute to justifying its use in population genetics. Finally, applying my account to these case studies enables me to identify at least three qualitatively different types of constitutive components: domain-specific theoretical principles, material components, and domain-independent assumptions underlying reasoning abilities. In the light of my results, I draw some general conclusions on epistemic justification and scientific knowledge. (shrink)

As we approach the end of the twentieth century, humanity is facing a crisis in definition and ways of thinking across the boundaries of identity, politics, and culture. This paper briefly addresses unusual forums and forms for expressing the anxiety surrounding change and the ability to analyze it, forms linked to the media and its intensive focus on particular “human interest” stories, but also to the uncertainty that a lack of precedent for thinking creates. One of the questions that most (...) interests me is how the malaise of society and the malaise of political change is expressed through the debates around maternity, birth, and the custody of children, how socio-political problems are made intelligible through dramatization of individual struggle involving family relations. What is compelling is the way in which certain stories followed by the media gravitate around facts that speak of what we do not know. Recent advances in reproductive technologies have put into question the belief (whether implicit or explicit) that biology, as a teleological process, can hold cultural chaos in abeyance. The doors have been opened wide as the definition and status of mother, father, and child have all been deeply questioned. Yet at the very moment when the so-called nuclear family is endangered, it is the extraordinarily powerful metaphor of the family that rings insistently in social and political discourse. There is a sense that the threat to the family signals a disintegration of order, leaving the contemporary sense of self bereft of a discourse that can represent universal order. (shrink)

“Hypernormal science” has minimal potential for contestation on matters of principle and practice so that information exchange can be unproblematic. Sciences comprise hypernormal domains and more contestable “normal” domains where knowledge diffusion, like acquiring linguistic fluency, depends on face-to-face interaction. Hypernormal domains belonging to molecular biology are contrasted with normal domains in gravitational wave detection physics. Sciences as a whole should not be confused with their typical domains. The analysis has immediate implications for proposed transitions out of the (...) Covid-19 lockdown, proposed solutions to the replication crisis, and, perhaps, our understanding of the early development of social studies of science. (shrink)

The universality of gravity (1g) in our daily lives makes it difficult to appreciate its importance in morphology and physiology. Bone and muscle support systems were created, cellular pumps developed, neurons organised and receptors and transducers of gravitational force to biologically relevant signals evolved under 1g gravity. Spaceflight provides the only microgravity environment where systematic experimentation can expand our basic understanding of gravitational physiology and perhaps provide new insights into normal physiology and disease processes. These include the surprising (...) extent of our body's dependence on perceptual information, and understanding the effect and importance of forces generated within the body's weightbearing structures such as muscle and bones. Beyond this exciting prospect is the importance of this work towards opening the solar system for human exploration. Although both appear promising, we are only just beginning to taste what lies ahead. (shrink)

Microphysical laws are time reversible, but macrophysics, chemistry and biology are not. This paper explores how this asymmetry arises due to the cosmological context, where a non-local Direction of Time is imposed by the expansion of the universe. This situation is best represented by an Evolving Block Universe, where local arrows of time emerge in concordance with the Direction of Time because a global Past Condition results in the Second Law of Thermodynamics pointing to the future. At the quantum (...) level, the indefinite future changes to the definite past due to quantum wave function collapse events. (shrink)

The sciences, from their ancient beginnings, use a double way of investigation. One was applied to mineral and astronomical bodies, another to living ones. A ruling, tacit, common sense methodological or epistemological principle was this: The method of description should respect the inner essential properties of the object. For instance, neither the movements of the astronomical bodies, nor the behavior of the living bodies should be described in the scale of subatomic interactions. In modern times quite another methodological principle has (...) been enthroned. The cosmos, astronomical, mineral and alive bodies altogether, have, allegedly, to be considered as a single natural whole, ruled by essentially the same set of principles. The properties of the mineral world are accepted as a universal model of descriptive concepts, and the explanatory concepts proper to the mineral world are accepted as a universal model of explanation in biology. So, up to now, the academic sciences have been dominated by the philosophical option of materialist monism, or panmaterialism. This option—we may call it antiteleologism and fragmentarism—has a profound impact on empirical research and the way biological phenomena are described. This strange, unnatural, arbitrarily imposed conceptual framework ignores the most fundamental biological dynamisms, and precludes our intellect from seeing the right questions and striving towards the right answers. Consequently it arbitrarily reduces the range of “scientifically acceptable” explanations. This antiteleological methodology of sciences, imposed on biological mind by philosophers, led to major change in the ideas of philosophers of nature. The physiology and anatomy of the fully developed living bodies has become their central object of study. Much less attention is paid to developmental processes such as biosynthesis, morphogenesis, embryogenesis, phenotypic adaptation and regeneration. The fully shaped structures and their functional properties are considered a hopeful basis of all the necessary explanations. For instance the structure of tile DNA molecule has become more important than the problem of its origin, and the structure of the brain more important than the developmental processes which lead to its construction. However, the enormous progress of biological sciences in spite of the widespread, dominating antiteleological and fragmentarist approach corroborates the very ancient, Aristotelian insight, which put the principal stress on the developmental aspect of life. Aristotle, and his more modern followers, was fascinated by the integrated and intrinsically heterogenous tendencies visible in the course of life. Today, we can say that at least eight such tendencies are universal, i.e. appear in every single form of life : The tendency to select the proper kind of raw material and the proper kind of raw energy present in the environment. The tendency to synthesize new, highly selective forms of chemical structures. The tendency to utilize biological material in the process of building the nano-, micro-, and macro-machines. The tendency for a relatively rapid, continuous production and replacement of all the elements of the functional structures of the body. The tendency for a relatively rapid, continuous modification of the functional structures in a way which makes them more efficient within a changing environment. The tendency to repair and to regenerate the damaged elements of the functional structures of the body. The tendency for multiplication, which means the production of such structures and the depots of the biological material as seeds, eggs, spores or buds. These structures, providing the environmental conditions are favorable, are starting points of new instances of the above described tendencies. The tendency—possibly universal—to provide all the structures of the body with the “recognition marks” which help to eliminate all the, “alien” bodies and to recognize members of the own kind. These tendencies are not homogeneous. Homogeneous tendencies can be illustrated by the tendency of bodies to attract one another. This kind of tendency was the empirical source of such abstract concepts as gravitation, electrostatic force or magnetic force. Biological tendencies are heterogeneous and, at the same time, integrated. Human intellect is capable of recognizing the fundamental indivisibility of the set. A great number of observations and experiments have revealed and verified the fundamental indivisibility of the whole set of these tendencies. The concrete, bodily outcomes of these tendencies, however, are quite different in different families and orders of living things. Because of these differences the existence of different kinds of integrative principles was postulated. In this way a plurality of living substances was assumed. (shrink)

The sciences, from their ancient beginnings, use a double way of investigation. One was applied to mineral and astronomical bodies, another to living ones. A ruling, tacit, common sense methodological or epistemological principle was this: The method of description should respect the inner essential properties of the object. For instance, neither the movements of the astronomical bodies, nor the behavior of the living bodies should be described in the scale of subatomic interactions. In modern times quite another methodological principle has (...) been enthroned. The cosmos, astronomical, mineral and alive bodies altogether, have, allegedly, to be considered as a single natural whole, ruled by essentially the same set of principles. The properties of the mineral world are accepted as a universal model of descriptive concepts, and the explanatory concepts proper to the mineral world are accepted as a universal model of explanation in biology. So, up to now, the academic sciences have been dominated by the philosophical option of materialist monism, or panmaterialism. This option—we may call it antiteleologism and fragmentarism—has a profound impact on empirical research and the way biological phenomena are described. This strange, unnatural, arbitrarily imposed conceptual framework ignores the most fundamental biological dynamisms, and precludes our intellect from seeing the right questions and striving towards the right answers. Consequently it arbitrarily reduces the range of “scientifically acceptable” explanations. This antiteleological methodology of sciences, imposed on biological mind by philosophers, led to major change in the ideas of philosophers of nature. The physiology and anatomy of the fully developed living bodies has become their central object of study. Much less attention is paid to developmental processes such as biosynthesis, morphogenesis, embryogenesis, phenotypic adaptation and regeneration. The fully shaped structures and their functional properties are considered a hopeful basis of all the necessary explanations. For instance the structure of tile DNA molecule has become more important than the problem of its origin, and the structure of the brain more important than the developmental processes which lead to its construction. However, the enormous progress of biological sciences in spite of the widespread, dominating antiteleological and fragmentarist approach corroborates the very ancient, Aristotelian insight, which put the principal stress on the developmental aspect of life. Aristotle, and his more modern followers, was fascinated by the integrated and intrinsically heterogenous tendencies visible in the course of life. Today, we can say that at least eight such tendencies are universal, i.e. appear in every single form of life : The tendency to select the proper kind of raw material and the proper kind of raw energy present in the environment. The tendency to synthesize new, highly selective forms of chemical structures. The tendency to utilize biological material in the process of building the nano-, micro-, and macro-machines. The tendency for a relatively rapid, continuous production and replacement of all the elements of the functional structures of the body. The tendency for a relatively rapid, continuous modification of the functional structures in a way which makes them more efficient within a changing environment. The tendency to repair and to regenerate the damaged elements of the functional structures of the body. The tendency for multiplication, which means the production of such structures and the depots of the biological material as seeds, eggs, spores or buds. These structures, providing the environmental conditions are favorable, are starting points of new instances of the above described tendencies. The tendency—possibly universal—to provide all the structures of the body with the “recognition marks” which help to eliminate all the, “alien” bodies and to recognize members of the own kind. These tendencies are not homogeneous. Homogeneous tendencies can be illustrated by the tendency of bodies to attract one another. This kind of tendency was the empirical source of such abstract concepts as gravitation, electrostatic force or magnetic force. Biological tendencies are heterogeneous and, at the same time, integrated. Human intellect is capable of recognizing the fundamental indivisibility of the set. A great number of observations and experiments have revealed and verified the fundamental indivisibility of the whole set of these tendencies. The concrete, bodily outcomes of these tendencies, however, are quite different in different families and orders of living things. Because of these differences the existence of different kinds of integrative principles was postulated. In this way a plurality of living substances was assumed. (shrink)

The sciences, from their ancient beginnings, use a double way of investigation. One was applied to mineral and astronomical bodies, another to living ones. A ruling, tacit, common sense methodological or epistemological principle was this: The method of description should respect the inner essential properties of the object. For instance, neither the movements of the astronomical bodies, nor the behavior of the living bodies should be described in the scale of subatomic interactions. In modern times quite another methodological principle has (...) been enthroned. The cosmos, astronomical, mineral and alive bodies altogether, have, allegedly, to be considered as a single natural whole, ruled by essentially the same set of principles. The properties of the mineral world are accepted as a universal model of descriptive concepts, and the explanatory concepts proper to the mineral world are accepted as a universal model of explanation in biology. So, up to now, the academic sciences have been dominated by the philosophical option of materialist monism, or panmaterialism. This option—we may call it antiteleologism and fragmentarism—has a profound impact on empirical research and the way biological phenomena are described. This strange, unnatural, arbitrarily imposed conceptual framework ignores the most fundamental biological dynamisms, and precludes our intellect from seeing the right questions and striving towards the right answers. Consequently it arbitrarily reduces the range of “scientifically acceptable” explanations. This antiteleological methodology of sciences, imposed on biological mind by philosophers, led to major change in the ideas of philosophers of nature. The physiology and anatomy of the fully developed living bodies has become their central object of study. Much less attention is paid to developmental processes such as biosynthesis, morphogenesis, embryogenesis, phenotypic adaptation and regeneration. The fully shaped structures and their functional properties are considered a hopeful basis of all the necessary explanations. For instance the structure of tile DNA molecule has become more important than the problem of its origin, and the structure of the brain more important than the developmental processes which lead to its construction. However, the enormous progress of biological sciences in spite of the widespread, dominating antiteleological and fragmentarist approach corroborates the very ancient, Aristotelian insight, which put the principal stress on the developmental aspect of life. Aristotle, and his more modern followers, was fascinated by the integrated and intrinsically heterogenous tendencies visible in the course of life. Today, we can say that at least eight such tendencies are universal, i.e. appear in every single form of life : The tendency to select the proper kind of raw material and the proper kind of raw energy present in the environment. The tendency to synthesize new, highly selective forms of chemical structures. The tendency to utilize biological material in the process of building the nano-, micro-, and macro-machines. The tendency for a relatively rapid, continuous production and replacement of all the elements of the functional structures of the body. The tendency for a relatively rapid, continuous modification of the functional structures in a way which makes them more efficient within a changing environment. The tendency to repair and to regenerate the damaged elements of the functional structures of the body. The tendency for multiplication, which means the production of such structures and the depots of the biological material as seeds, eggs, spores or buds. These structures, providing the environmental conditions are favorable, are starting points of new instances of the above described tendencies. The tendency—possibly universal—to provide all the structures of the body with the “recognition marks” which help to eliminate all the, “alien” bodies and to recognize members of the own kind. These tendencies are not homogeneous. Homogeneous tendencies can be illustrated by the tendency of bodies to attract one another. This kind of tendency was the empirical source of such abstract concepts as gravitation, electrostatic force or magnetic force. Biological tendencies are heterogeneous and, at the same time, integrated. Human intellect is capable of recognizing the fundamental indivisibility of the set. A great number of observations and experiments have revealed and verified the fundamental indivisibility of the whole set of these tendencies. The concrete, bodily outcomes of these tendencies, however, are quite different in different families and orders of living things. Because of these differences the existence of different kinds of integrative principles was postulated. In this way a plurality of living substances was assumed. (shrink)

The causal closure of physics is usually discussed in a context free way. Here I discuss it in the context of engineering systems and biology, where strong emergence takes place due to a combination of upwards emergence and downwards causation. Firstly, I show that causal closure is strictly limited in terms of spatial interactions because these are cases that are of necessity strongly interacting with the environment. Effective Spatial Closure holds ceteris parabus, and can be violated by Black Swan (...) Events. Secondly, I show that causal closure in the hierarchy of emergence is a strictly interlevel affair, and in the cases of engineering and biology encompasses all levels from the social level to the particle physics level. However Effective Causal Closure can usefully be defined for a restricted set of levels, and one can experimentally determine Effective Theories that hold at each level. This does not however imply those effective theories are causally complete by themselves. In particular, the particle physics level is not causally complete by itself in the contexts of solid state physics, digital computers, or biology. Furthermore Inextricably Intertwined Levels occur in all these contexts. (shrink)

This paper examines several issues related to information, speed of computation, and simulation of a physical process. It is argued that mental processes proceed at a rate close to the optimal based on thermodynamic considerations. Problems related to the simulation of a quantum mechanical system on a computer are reviewed. Parallels are drawn between biological and adaptive quantum systems.

It was recently shown that the Madelung equations, that is, a hydrodynamic form of the Schrödinger equation, can be derived from a canonical ensemble of neural networks where the quantum phase was identified with the free energy of hidden variables. We consider instead a grand canonical ensemble of neural networks, by allowing an exchange of neurons with an auxiliary subsystem, to show that the free energy must also be multivalued. By imposing the multivaluedness condition on the free energy we derive (...) the Schrödinger equation with “Planck’s constant” determined by the chemical potential of hidden variables. This shows that quantum mechanics provides a correct statistical description of the dynamics of the grand canonical ensemble of neural networks at the learning equilibrium. We also discuss implications of the results for machine learning, fundamental physics and, in a more speculative way, evolutionary biology. (shrink)

Throughout the _Histoire naturelle_ Buffon was ever aware of epistemological issues involving the reproduction of species, the only beings in nature. By the 1760s he had come to believe that empirical evidence, the source of all human knowledge, revealed that reproduction was a physical process, involving a common living (minute, active, and lively) matter and material forces, all of which he traced to the foundational force of gravitational attraction.

In the first part of this contribution, we review the development of the theory of scale relativity and its geometric framework constructed in terms of a fractal and nondifferentiable continuous space-time. This theory leads (i) to a generalization of possible physically relevant fractal laws, written as partial differential equation acting in the space of scales, and (ii) to a new geometric foundation of quantum mechanics and gauge field theories and their possible generalisations. In the second part, we discuss some examples (...) of application of the theory to various sciences, in particular in cases when the theoretical predictions have been validated by new or updated observational and experimental data. This includes predictions in physics and cosmology (value of the QCD coupling and of the cosmological constant), to astrophysics and gravitational structure formation (distances of extrasolar planets to their stars, of Kuiper belt objects, value of solar and solar-like star cycles), to sciences of life (log-periodic law for species punctuated evolution, human development and society evolution), to Earth sciences (log-periodic deceleration of the rate of California earthquakes and of Sichuan earthquake replicas, critical law for the arctic sea ice extent) and tentative applications to systems biology. (shrink)

A systematic effort is here made to express some of the general results of quantum mechanics in a conceptual form closer to ordinary language than is the case with most modern physics. Many of the implications of the theory appear much more clearly thereby, in particular the fact that the laws of quantum mechanics are only statistical propositions about classes, not referring to individual objects. Conversely, the microscopic structure of an object cannot be precisely defined in quantum mechanical terms. To (...) say that an object has a definite microscopic structure is an operationally meaningless statement; it is on the same level as saying in relativity that a selected coordinate system is “at rest.” This raises the need for a “theory of matching”: What is the best statement about the structure of an object, given that the tools of description are only statistical? A technique is known for this: the theory of inductive probabilities. There is no longer one true description but a manifold of statistical descriptions, some of which have a greater likelihood of being satisfactory than others. The main concrete application of this type of conceptual reasoning lies in its power to clean out the speculative underbrush which so far has prevented the transition from theoretical physics to theoretical biology. (shrink)

This volume concludes a series dedicated to the understanding of nature by philosophers, scientists, and technicians from antiquity to today. This understanding is an issue largely debated today by philosophers as well as nonphilosophers. Being the fourth and the last, this volume includes also an index rerum of the items dealt with in this as well as in the preceding three volumes. The seven essays it presents are primarily concerned with the positions of Newton, Kant, and Einstein. In fact, the (...) volume begins with a paper by Andreas Bartels on the understanding of nature according to the theory of relativity. Basing his essay on Michael’s Friedman interpretation of Kant’s reconstruction of Newtonian physics, Bartels points out that it is not correct to see in Einstein the accomplishment of the relational theory of space. Such an interpretation would require the following two assumptions: first, that Leibniz’s theory of space is the expression of a physical principle of relativity; second, that Einstein’s relativity implies the most complete form of relativity of movement. According to Bartels, one can debate about Leibniz, but the second assumption is surely false because Einstein’s theory does not imply a complete relativity of movement. On the contrary, Einstein maintains that it is matter, as a whole, that is in motion; and this is not far from what Aristotle said about matter’s essential, natural tendency to move. The Copernican cosmos was governed by fundamental laws, Newton transformed it into a contingent world of gravitational islands, and Einstein pushed further the transformation into a wider frame of possible spacetime experience. Manfred Stöckler’s paper deals with quantum theory. With regard to the debate on realism, that is, on the scope and validity of physical theories, Stöckler remarks that it is not true that quantum physics would give any further reason against realism that is not already given by classical physics and by everyday life. Michael Drieschner refers himself first to Kant’s concepts of “nature in material significance” and “nature in formal significance,” the former for the whole of the object in reality and the latter for the essences of things, and shows that in today’s physics the rigor of this distinction has faded. In fact, today’s science declares it impossible to identify anything like a whole of all objects. The ontology of classical physics has to give place to flexible concepts such as mesocosmos, that is, something between the microcosmos and the macrocosmos. In fact, scientists like Franco Selleri have recently advocated a new form of realism with regard to quantum theory, according to which the validity of quantum physics rests upon a very defined scope of local reciprocal actions, so that everything going beyond that must be doubted. Alfred Gierer turns to biology and especially to the question of biology’s reduction to physics. Against the reductionists, Gierer proves that, on the contrary, biology is founding not only all social behaviors, but also all forms of consciousness, that is, all forms of awareness of limits, therefore also man’s answer to the ecological crisis. Elisabeth Ströcker writes on nuclear scission as possibly inaugurating a new age of nature dominance, pointing out that the evaluation of the consequences of technical application proves rather the contrary. In the concluding paper, Lothar Schäfer sketches a new idea of nature as something to be taken care of. Referring himself to Husserlian phenomenology, Schäfer invites us to reconsider the standpoint of corporeity. What eventually counts for man’s understanding of nature is its physiological relevance. (shrink)

This article centers on Hume’s position on the intelligibility of natural philosophy. To that end, the controversy surrounding universal gravitation shall be scrutinized. It is very well-known that Hume sides with the Newtonian experimentalist approach rather than with the Leibnizian demand for intelligibility. However, what is not clear is Hume’s overall position on the intelligibility of natural philosophy. It shall be argued that Hume declines Leibniz’s principle of intelligibility. However, Hume does not eschew intelligibility altogether; his concept of causation itself (...) stipulates mechanical intelligibility. (shrink)

Weinberg's 1972 work, in his description, had two purposes. The first was practical to bring together and assess the wealth of data provided over the previous decade while realizing that newer data would come in even as the book was being printed. He hoped the comprehensive picture would prepare the reader and himself to that new data as it emerged. The second was to produce a textbook about general relativity in which geometric ideas were not given a starring role for (...) (in his words) too great an emphasis on geometry can only obscure the deep connections between gravitation and the rest of physics. (shrink)

Does the gravitational field described in general relativity possess genuine stress-energy? We answer this question in the affirmative, in a weak sense applicable in a certain class of frames of a certain class of models of the theory, and arguably also in a strong sense, applicable in all frames of all models of the theory. In addition, we argue that one can be a realist about gravitational stress-energy in general relativity even if one is a relationist about spacetime (...) ontology. In each case, our reasoning rests upon a functionalist approach to the definition of physical quantities. (shrink)

The recent detection of gravitational waves by the LIGO team has rightly been hailed as “the crowning achievemen of classical physics”. This detection, which came at the end of a decade-long quest, involved 950 investigators, and cost around one billion US dollars, was the scientific star of the year 2015. What, if any, is the philosophical impact of this scientific breakthrough, which Albert Einstein had anticipated one century earlier? To answer this question we start by examining the central equations (...) of Einstein’s theory of gravitation, also known as general relativity. Subsequently we analyze the special case of a hollow sphere, in an attempt to answer the question of the reality and even materiality of space or, rather, spacetime. As well, the view that gravitation is a manifestation of the curvature of spacetime is discussed, and the reality of gravitational waves is regarded as the coup de grâce to that view. (shrink)

García-Barranquero et al explore the desirability of human ageing. They differentiate between chronological and biological views of ageing and contend that the positive aspects of ageing are solely linked to chronological ageing. Consequently, the authors embrace the potential for technological interventions in biological ageing. Contrary to their stance, I argue that there are sometimes desirable aspects associated with biological ageing. Therefore, proposals aiming to eliminate, mitigate or diminish biological ageing are not without problems.

Gravitational decoherence (GD) refers to the effects of gravity in actuating the classical appearance of a quantum system. Because the underlying processes involve issues in general relativity (GR), quantum field theory (QFT), and quantum information, GD has fundamental theoretical significance. There is a great variety of GD models, many of them involving physics that diverge from GR and/or QFT. This overview has two specific goals along with one central theme:(i) present theories of GD based on GR and QFT and (...) explore their experimental predictions;(ii) place other theories of GD under the scrutiny of GR and QFT, and point out their theoretical differences. We also describe how GD experiments in space in the coming decades can provide evidence at two levels:(a) discriminate alternative quantum theories and non-GR theories;(b) discern whether gravity is a fundamental or an effective theory. (shrink)

This collection of revised and new essays argues that biology is an autonomous science rather than a branch of the physical sciences. Ernst Mayr, widely considered the most eminent evolutionary biologist of the 20th century, offers insights on the history of evolutionary thought, critiques the conditions of philosophy to the science of biology, and comments on several of the major developments in evolutionary theory. Notably, Mayr explains that Darwin's theory of evolution is actually five separate theories, each with (...) its own history, trajectory and impact. Ernst Mayr, commonly referred to as the "Darwin of the 20th century" and listed as one of the top 100 scientists of all-time, is Professor Emeritus at Harvard University. What Makes Biology Unique is the 25th book he has written during his long and prolific career. His recent books include This is Biology: The Science of the Living World (Belknap Press, 1997) and What Evolution Is (Basic Books, 2002). (shrink)

This article gives an explicit presentation of Newtonian gravitation on the backdrop of Maxwell space-time, giving a sense in which acceleration is relative in gravitational theory. However, caution is needed: assessing whether this is a robust or interesting sense of the relativity of acceleration depends on some subtle technical issues and on substantive philosophical questions over how to identify the space-time structure of a theory.

There are well-known problems associated with the idea of gravitational energy in general relativity. We offer a new perspective on those problems by comparison with Newtonian gravitation, and particularly geometrized Newtonian gravitation. We show that there is a natural candidate for the energy density of a Newtonian gravitational field. But we observe that this quantity is gauge dependent, and that it cannot be defined in the geometrized theory without introducing further structure. We then address a potential response by (...) showing that there is an analogue to the Weyl tensor in geometrized Newtonian gravitation. (shrink)

The impressive variation amongst biological individuals generates many complexities in addressing the simple-sounding question what is a biological individual? A distinction between evolutionary and physiological individuals is useful in thinking about biological individuals, as is attention to the kinds of groups, such as superorganisms and species, that have sometimes been thought of as biological individuals. More fully understanding the conceptual space that biological individuals occupy also involves considering a range of other concepts, such as life, reproduction, and agency. There has (...) been a focus in some recent discussions by both philosophers and biologists on how evolutionary individuals are created and regulated, as well as continuing work on the evolution of individuality. (shrink)

Providing a new conceptual scaffold for further research in biology and cognition, this book introduces the new field of cognitive biology, a systems biology approach showing that further progress in this field will depend on a deep recognition of developmental processes, as well as on the consideration of the developed organism as an agent able to modify and control its surrounding environment. The role of cognition, the means through which the organism is able to cope with its (...) environment, cannot be underestimated. In particular, it is shown that this activity is grounded on a theory of information based on Bayesian probabilities. The organism is considered as a cybernetic system able to integrate a processor as a source of variety (the genetic system), a regulator of its own homeostasis (the metabolic system), and a selecting system separating the self from the non-self (the membrane in unicellular organisms). Any organism is a complex system that can survive only if it is able to maintain its internal order against the spontaneous tendency towards disruption. Therefore, it is forced to monitor and control its environment and so to establish feedback circuits resulting in co-adaptation. Cognitive and biological processes are shown to be inseparable. (shrink)

The aim of this paper is to discuss some aspects of the nature gravitational energy within the general theory of relativity. Some aspects of the difficulties to ascribe the usual features of localization and conservation to gravitational energy are reviewed and considered in the light of the dual of role of the dynamical gravitational field, which encodes both inertio-gravitational effects and the chronogeometrical structures of spacetime. These considerations will lead us to discuss the fact that the (...) very notion of energy - gravitational or not - is actually well-defined in the theory only with respect to some background structure. (shrink)

In recent years, a proliferation of books about empathy, cooperation and pro-social behaviours (Brooks, 2011a) has significantly influenced the discourse of the life-sciences and reversed consolidated views of nature as a place only for competition and aggression. In this article I describe the recent contribution of three disciplines – moral psychology (Jonathan Haidt), primatology (Frans de Waal) and the neuroscience of morality – to the present transformation of biology and evolution into direct sources of moral phenomena, a process here (...) named the ‘moralization of biology’. I conclude by addressing the ambivalent status of this constellation of authors, for whom today ‘morality comes naturally’: I explore both the attractiveness of their message, and the problematic epistemological assumptions of their research programmes in the light of new discoveries in developmental and molecular biology. (shrink)