Nanomedicine is yielding new and improved treatments and diagnostics for a range of diseases and disorders. Nanomedicine applications incorporate materials and components with nanoscale dimensions where novel physiochemical properties emerge as a result of size-dependent phenomena and high surface-to-mass ratio. Nanotherapeutics and in vivo nanodiagnostics are a subset of nanomedicine products that enter the human body. These include drugs, biological products, implantable medical devices, and combination products that are designed to function in the body in ways unachievable at larger scales. (...) Nanotherapeutics andin vivonanodiagnostics incorporate materials that are engineered at the nanoscale to express novel properties that are medicinally useful. These nanomedicine applications can also contain nanomaterials that are biologically active, producing interactions that depend on biological triggers. Examples include nanoscale formulations of insoluble drugs to improve bioavailability and pharmacokinetics, drugs encapsulated in hollow nanoparticles with the ability to target and cross cellular and tissue membranes and to release their payload at a specific time or location, imaging agents that demonstrate novel optical properties to aid in locating micrometastases, and antimicrobial and drug-eluting components or coatings of implantable medical devices such as stents. (shrink)

Roots are good to think with indeed most of us use them as a metaphor every day. A root can signify the hiddenness of our beginnings, or, in its bifurcating structure, the various possibilities in the life of an individual or a collective. This book looks at rootedness as a metaphor for the genealogical origins of people and their attachment to place and how this metaphor transformed so rapidly in twentieth-century Europe. Christy Wampole s case study is France, with its (...) contradictory legacies of Enlightenment universalism, anti-Semitism, and colonialism. At one time, French nationalist rhetoric portrayed the Jews as unrooted and thus unrighteous people. After the two world wars, the root metaphor figured in the new French philosophy (notably Deleuze and Guattari). And recently, Caribbean thinkers in Haiti, Guadeloupe, and Martinique have debated whether their roots were in Africa, France, the Caribbean, or in some pan-national network that could not be identified on a map. Walpole argues that while the metaphor was perhaps once useful in the establishment of communities and identities, that usefulness has expired. The longer we remain attached to the figure of rootedness, the more discord it sows. Giving up on the metaphor of rootedness, Wampole urges, allows us to see at last that we are in fact unbound by the land we inhabit.". (shrink)

Recasting French literary history in terms of the cultures and peoples that interacted within and outside of France's national boundaries, this volume offers a new way of looking at the history of a national literature, along with a truly global and contemporary understanding of language, literature, and culture. The relationship between France's national territory and other regions of the world where French is spoken and written (most of them former colonies) has long been central to discussions of "Francophonie." Boldly expanding (...) such discussions to the whole range of French literature, the essays in this volume explore spaces, mobilities, and multiplicities from the Middle Ages to today. They rethink literary history not in terms of national boundaries, as traditional literary histories have done, but in terms of a global paradigm that emphasizes border crossings and encounters with "others." Contributors offer new ways of reading canonical texts and considering other texts that are not part of the traditional canon. By emphasizing diverse conceptions of language, text, space, and nation, these essays establish a model approach that remains sensitive to the specificities of time and place and to the theoretical concerns informing the study of national literatures in the twenty-first century. (shrink)

Este artículo examina una etapa poco explorada de la historia del afiche chileno y que coincide cronológicamente con la denominada edad dorada del cartelismo europeo. Interesa descubrir indicios de influencia del trabajo del francés Jules Chéret en afiches originales o en aquellos reproducidos en las revistas ilustradas locales, en el contexto del nacimiento del afiche artístico en el país.

Este artículo examina una etapa poco explorada de la historia del afiche chileno y que coincide cronológicamente con la denominada edad dorada del cartelismo europeo. Interesa descubrir indicios de influencia del trabajo del francés Jules Chéret en afiches originales o en aquellos reproducidos en las revistas ilustradas locales, en el contexto del nacimiento del afiche artístico en el país.

When you learn that a large body of highly intelligent, fair-minded, reasonable, and relatively unbiased thinkers disagree with you, does that give you good reason to think you’re wrong? Should you think, “Wait a minute. Maybe I’ve missed something here”? Should you at least drastically reduce your confidence? There is a general epistemological problem here regarding controversial beliefs, one that has nothing especially to do with religious belief. I argue that applying this discussion to religion transforms the problem in unexpected (...) and interesting ways, and that the religious believer is often epistemically reasonable in sticking with her controversial belief. (shrink)

In epistemology the nagging voice of the sceptic has always been present, whispering that 'You can't know that you have hands, or just about anything else, because for all you know your whole life is a dream.' Philosophers have recently devised ingenious ways to argue against and silence this voice, but Bryan Frances now presents a highly original argument template for generating new kinds of radical scepticism, ones that hold even if all the clever anti-sceptical fixes defeat the traditional (...) sceptic. Sharp, witty, and fun to read, Scepticism Comes Alive will be highly provocative for anyone interested in knowledge and its limits. (shrink)

Introduction: representationalismMost theorists of cognition endorse some version of representationalism, which I will understand as the view that the human mind is an information-using system, and that human cognitive capacities are representational capacities. Of course, notions such as ‘representation’ and ‘information-using’ are terms of art that require explication. As a first pass, representations are “mediating states of an intelligent system that carry information” (Markman and Dietrich 2001, p. 471). They have two important features: (1) they are physically realized, and so (...) have causal powers; (2) they are intentional, in other words, they have meaning or representational content. This presumes a distinction between a representational vehicle—a physical state or structure that has causal powers and is responsible for producing behavior—and its content. Consider the following characterization of a device that computes the addition functionReaders will recognize the similarity t. (shrink)

Frances Tustin's classic text _Autistic States in Children_ put forward convincing clinical evidence that some forms of childhood autism are psychogenic and respond to methods of treatment very different from the behavioural techniques often adopted without success. Her pioneering work with such children has gained ground since the book was first published and she herself has revised her understanding of the aetiology of psychogenic autism. This revised edition of the book incorporates her new thinking based on recent infant observational (...) studies and her own clinical experience. (shrink)

In their important paper “Autonomous Agents”, Floridi and Sanders use “levels of abstraction” to argue that computers are or may soon be moral agents. In this paper we use the same levels of abstraction to illuminate differences between human moral agents and computers. In their paper, Floridi and Sanders contributed definitions of autonomy, moral accountability and responsibility, but they have not explored deeply some essential questions that need to be answered by computer scientists who design artificial agents. One such question (...) is, “Can an artificial agent that changes its own programming become so autonomous that the original designer is no longer responsible for the behavior of the artificial agent?” To explore this question, we distinguish between LoA1 (the user view) and LoA2 (the designer view) by exploring the concepts of unmodifiable, modifiable and fully modifiable tables that control artificial agents. We demonstrate that an agent with an unmodifiable table, when viewed at LoA2, distinguishes an artificial agent from a human one. This distinction supports our first counter-claim to Floridi and Sanders, namely, that such an agent is not a moral agent, and the designer bears full responsibility for its behavior. We also demonstrate that even if there is an artificial agent with a fully modifiable table capable of learning* and intentionality* that meets the conditions set by Floridi and Sanders for ascribing moral agency to an artificial agent, the designer retains strong moral responsibility. (shrink)

Among the cognitive capacities of evolved creatures is the capacity to represent. Theories in cognitive neuroscience typically explain our manifest representational capacities by positing internal representations, but there is little agreement about how these representations function, especially with the relatively recent proliferation of connectionist, dynamical, embodied, and enactive approaches to cognition. In this talk I sketch an account of the nature and function of representation in cognitive neuroscience that couples a realist construal of representational vehicles with a pragmatic account of (...) mental content. I call the resulting package a deflationary account of mental representation and I argue that it avoids the problems that afflict competing accounts. (shrink)

Much of computational cognitive science construes human cognitive capacities as representational capacities, or as involving representation in some way. Computational theories of vision, for example, typically posit structures that represent edges in the distal scene. Neurons are often said to represent elements of their receptive fields. Despite the ubiquity of representational talk in computational theorizing there is surprisingly little consensus about how such claims are to be understood. The point of this chapter is to sketch an account of the nature (...) and function of representation in computational cognitive models. (shrink)

In this article I am concerned with whether it could be morally significant to distinguish between doing something 'in order to bring about an effect' as opposed to 'doing something because we will bring about an effect'. For example, the Doctrine of Double Effect tells us that we should not act in order to bring about evil, but even if this is true is it perhaps permissible to act only because an evil will thus occur? I discuss these questions in (...) connection with a version of the so-called Trolley Problem known as the Loop Case. I also consider how these questions may bear on whether a rational agent must aim at an event which he believes is causally necessary to achieve an end he pursues. (shrink)

A common kind of explanation in cognitive neuroscience might be called functiontheoretic: with some target cognitive capacity in view, the theorist hypothesizes that the system computes a well-defined function (in the mathematical sense) and explains how computing this function constitutes (in the system’s normal environment) the exercise of the cognitive capacity. Recently, proponents of the so-called ‘new mechanist’ approach in philosophy of science have argued that a model of a cognitive capacity is explanatory only to the extent that it reveals (...) the causal structure of the mechanism underlying the capacity. If they are right, then a cognitive model that resists a transparent mapping to known neural mechanisms fails to be explanatory. I argue that a functiontheoretic characterization of a cognitive capacity can be genuinely explanatory even absent an account of how the capacity is realized in neural hardware. (shrink)

What personal truths reside in biological ties that are absent in adoptive ties? And why do we think adoptive and biological ties are essentially different when it comes to understanding who we are? At a time when interest in DNA and ancestry is exploding, Frances Latchford questions the idea that knowing one's bio-genealogy is integral to personal identity or a sense of family and belonging. Upending our established values and beliefs about what makes a family, Steeped in Blood examines (...) the social and political devaluation of adoptive ties. It takes readers on an intellectual journey through accepted wisdom about adoption, twins, kinship, and incest, and challenges our naturalistic and individualistic assumptions about identity and the biological ties that bind us, sometimes violently, to our families. Latchford exposes how our desire for bio-genealogical knowledge, understood as it is by family and adoption experts, pathologizes adoptees by posing the biological tie as a necessary condition for normal identity formation. Rejecting the idea that a love of the self-same is fundamental to family bonds, her book is a reaction to the wounds families suffer whenever they dare to revel in their difference. A rejoinder to rhetoric that defines adoptees, adoptive kin, and their family intimacies as inferior and inauthentic, Steeped in Blood's view through the lens of critical adoption studies decentres our cultural obsession with the biological family imaginary and makes real the possibility of being family in the absence of blood. (shrink)

The purpose of this article is to investigate how cultural meanings associated with the left ventricular assist device inform acceptance and experience of this innovative technology when it is used as a destination therapy. We conducted open-ended, semistructured interviews with family caregivers and patients who had undergone LVAD-DT procedures at six U.S. hospitals. A grounded theory approach was used for the analysis. Thirty-nine patients and 42 caregivers participated. Participants described a sense of obligation to undergo the procedure because of its (...) promise for salvation. However, once the device was implanted, patients described being placed into a liminal state of being neither sick nor healthy, with no culturally scripted role. Consideration of end-of-life decisions was complicated by the uncertainties about how patients with LVADs die. Pre-implantation communications among patient, family, and clinicians should take into account the impact of the technology on meaning, identity, and patient experience. (shrink)

Philosophers often find themselves in disagreement with contemporary philosophers they know full well to be their epistemic superiors on the topics relevant to the disagreement. This looks epistemically irresponsible. I offer a detailed investigation of this problem of the reflective epistemic renegade. I argue that although in some cases the renegade is not epistemically blameworthy, and the renegade situation is significantly less common than most would think, in a troublesome number of cases in which the situation arises the renegade is (...) blameworthy in her disagreement with recognized epistemic superiors. I also offer some thoughts on what it would mean for philosophical practice for us to refrain from being renegades. Finally, I show how a new kind of radical skepticism emerges from modest theses regarding the renegade. (shrink)

Phenomenology is a well‐founded qualitative methodology that is frequently used by nurse researchers and considered of value when addressing research questions in nursing practice and nurse education. However, at present, nurse researchers using phenomenology tend to divide phenomenological methodology into the descriptive and interpretive formats. The nursing literature suggests that there is a deep divide between researchers following the methodological underpinnings and basic precepts pertaining to these two camps. If we are to reach a clearer understanding of the theory underlying (...) phenomenological methods it would be more helpful if we started to recognise that there are also important associations between transcendental and interpretive phenomenology. One such association is that a paradigm of movement exists that is not unique to transcendental and interpretive phenomenology but is common to them, as well as being inherent within a variety of fields of study. If we consider the universality of such imagery, looking to examples through parallel texts, we can obtain insights into phenomenology and its transposition into a workable scientific method that can be of use to the nurse researcher. (shrink)

The computational theory of mind construes the mind as an information-processor and cognitive capacities as essentially representational capacities. Proponents of the view claim a central role for representational content in computational models of these capacities. In this paper I argue that the standard view of the role of representational content in computational models is mistaken; I argue that representational content is to be understood as a gloss on the computational characterization of a cognitive process.Keywords: Computation; Representational content; Cognitive capacities; Explanation.

Researchers in the health sciences regularly discover information of potential health importance unrelated to their object of study in the course of their research. However, there appears to be little guidance available on what researchers should do with this information, known in the scientific literature as incidental findings. The study described here was designed to determine the extent of guidance available to researchers from public sources. This empirical study was part of a larger two-year project funded by the National Human (...) Genome Research Institute to generate guidance on how incidental findings should be managed in human subjects research, especially genetics, genomics, and imaging research. We generated empirical analysis of publicly available guidance and consent forms to help guide a multidisciplinary Working Group of experts in their formulation of normative recommendations reported in this symposium. (shrink)

Many people with religious beliefs, pro or con, are aware that those beliefs are denied by a great number of others who are as reasonable, intelligent, fair-minded, and relatively unbiased as they are. Such a realization often leads people to wonder, “How do I know I’m right and they’re wrong? How do I know that the basis for my belief is right and theirs is misleading?” In spite of that realization, most people stick with their admittedly controversial religious belief. This (...) entry examines the epistemology of such belief retention, addressing issues of disagreement, agnosticism, skepticism, and the rationality of reflective religious belief. (shrink)

When is industry self-regulation (ISR) a legitimate form of governance? In principle, ISR can serve the interests of participating companies, regulators and other stakeholders. However, in practice, empirical evidence shows that ISR schemes often under-perform, leading to criticism that such schemes are tantamount to firms marking their own homework. In response, this paper explains how current management theory on ISR has failed to separate the pragmatic legitimacy of ISR based on self-interested calculations, from moral legitimacy based on normative approval. The (...) paper traces three families of management theory on ISR and uses these to map the pragmatic and moral legitimacy of ISR schemes. It identifies tensions between the pragmatic and moral legitimacy of ISR schemes, which the current ISR literature does not address, and draws implications for the future theory and practice of ISR. (shrink)

In this essay I respond to commentators on Ethics for Enemies, including Caspar Hare on torture and other harms imposed on an agent after his act, Suzanne Uniacke on conceptual issues related to terrorism, Thomas Hurka on right reason and proportionality conditions in the justice of going to war, Jeff McMahan on liability, proportionality, and harm in jus ad bellum, and Gabriella Blum and John Goldberg on the moral and legal status of action prompted by bad intentions.

This book brings C.G. Jung into conversation with the French philosopher Emmanuel Levinas, taking a radical view of post-modernist theory which, the author argues, is relentlessly introverted. Frances Gray presents completely new research which extends analytical psychology into the world of dispute resolution in mediation within a deeply philosophical framework. Arguing that mediation is a therapeutics that entails a psycho-social archaeology which, in turn, requires recognition of the foundational roles of sex/gender, time and narrative in inter-subjective relationships, this book (...) develops Jung’s approach to projection as an ethical process that assumes the presence of a sex/gendered Other. Chapters explore the possibility of a psycho-social archaeology through development of the argument that a radical turn to the fundamentals of our own consciousnesses can open up a landscape on which we begin to fashion the moral courage necessary for the practice of alternative dispute resolution in mediation. This book highlights Jung’s contention that withdrawal of projection is a fundamentally moral endeavour and that although Levinas’ face of the Other can be seen as a way of acknowledging the Otherness of the Other, there are limits to its application in Jungian thinking. This book maintains that the face of the Other is critical to any moral encounter and, above all, brings us to the transformational possibilities of the process of dispute resolution in mediation. Jung and Levinas will appeal to researchers, students and practitioners of analytical psychology, dispute resolution, applied ethics, conflict studies and transformation. (shrink)

Externalism about the mind holds that the explanation of our representational capacities requires appeal to mental states that are individuated by reference to features of the environment. Externalists claim that ‘narrow’ taxonomies cannot account for important features of psychological explanation. I argue that this claim is false, and offer a general argument for preferring narrow taxonomies in psychology.

Businesses promote their environmental awareness through green buildings, eco-labels, sustainability reports, industry pledges and clean technologies. When are these symbols wasteful corporate spin, and when do they signal authentic environmental improvements? Based on twenty years of research, three rich case studies, a strong theoretical model and a range of practical applications, this book provides the first systematic analysis of the drivers and consequences of symbolic corporate environmentalism. It addresses the indirect cost of companies' symbolic actions and develops a new concept (...) of the 'social energy penalty' - the cost to society when powerful corporate actors limit the social conversation on environmental problems and their solutions. This thoughtful book develops a set of tools for researchers, regulators and managers to separate useful environmental information from empty corporate spin, and will appeal to researchers and students of corporate responsibility, corporate environmental strategy and sustainable business, as well as environmental practitioners. (shrink)

We advance the thesis that the method of experimental economics can make significant contributions to normative, as opposed to descriptive, business ethics. We contend that there are two basic ways in which experimental economics may make this contribution, and we exemplify these ways by pointing to experimental support of social contract theory as rational foundation for business ethics. These two ways are: (1) adding psychological realism; and (2) testing some quasi-empirical assumptions present in normative theory. In order to make good (...) our methodological claim, we first describe the methodological rules of experimental economics, distinguishing this method from other behavioral business ethics approaches. We also contemplate the possible objection that empirical methods cannot bear on normative ethics because there is no way of bridging the gap between descriptive theory (how people behave) and normative theory (how people ought to behave). (shrink)

Representationalism, in its most widely accepted form, is the view that the human mind is an information-using system, and that human cognitive capacities are to be understood as representational capacities. This chapter distinguishes several distinct theses that go by the name "representationalism," focusing on the view that is most prevalent in cogntive science. It also discusses some objections to the view and attempts to clarify the role that representational content plays in cognitive models that make use of the notion of (...) representation. (shrink)

In this essay, I summarize major points of my Ethics for Enemies. I first consider whether torture of a wrongdoer to save his victim could be permissible. In order to do this, I consider whether we may do comparable things to him while he is setting up a threat in order to stop his act, get him to stop it, or otherwise use him as he acts to stop harm to his victim. I also consider possible differences between harming the (...) wrongdoer as he acts and after his act in order to help his victim. I next describe my view that the intention to harm and terrorize civilians need not make an act be terrorism or be morally impermissible. I consider what makes terrorism distinctively morally wrong and whether it is always impermissible. Finally, I describe my views that having a right reason is not necessary in order for starting a war to be morally just and that goods that are not part of a just cause may weigh in a proportionality calculation needed to determine if a war is just. (shrink)

It has recently been argued that the success of the connectionist program in cognitive science would threaten folk psychology. I articulate and defend a "minimalist" construal of folk psychology that comports well with empirical evidence on the folk understanding of belief and is compatible with even the most radical developments in cognitive science.