Debates over adaptationism can be clarified and partially resolved by careful consideration of the ‘grain’ at which evolutionary processes are described. The framework of ‘adaptive landscapes’ can be used to illustrate and facilitate this investigation. We argue that natural selection may have special status at an intermediate grain of analysis of evolutionary processes. The cases of sickle-cell disease and genomic imprinting are used as case studies.

This commentary questions the applicability of the Newell Test for evaluating the utility of connectionism. Rather than being a specific theory of cognition (because connectionism can be used to model nativist, behaviorist, or constructivist theories), connectionism, we argue, offers researchers a collection of computational and conceptual tools that are particularly useful for investigating and rendering specific fundamental issues of human development. These benefits of connectionism are not well captured by evaluating it against Newell's criteria for a unified theory of cognition.

Building Information Modelling (BIM) is a process for managing construction project information in such a way as to provide a basis for enhanced decision-making and for collaboration in a construction supply chain. One impediment to the uptake of BIM is the limited interoperability of different BIM systems. To overcome this problem, a set of Industry Foundation Classes (IFC) has been proposed as a standard for the construction industry. Building on IFC, the ifcOWL ontology was developed in order to facilitate representation (...) of building data in a consistent fashion across the Web by using the Web Ontology Language (OWL). This study presents a critical analysis of the ifcOWL ontology and of the associated interoperability issues. It shows how these issues can be resolved by using Basic Formal Ontology (ISO/IEC 21838-2) as top-level architecture. A set of competency questions is used as the basis for comparison of the original ifcOWL with the enhanced ontology, and the latter is used to align with a second ontology – the ontology for building intelligent environments (DOGONT) – in order to demonstrate the added value derived from BFO by showing how querying the enhanced ifcOWL yields useful additional information. (shrink)

Recent debates within the autism advocacy community have raised difficult questions about who can credibly act as a representative of a particular population and what responsibilities that...

The quest for ecological sustainability—specifically via prioritizing degrowth—creates significant, often overlooked challenges for the chronically ill. I focus on type-1 diabetes, treatment for which depends on nonrenewables and materials implicated in the global proliferation of toxins that harm biospheric functions. Some commentators suggest obliquely that seeking to develop ecologically sustainable treatments for type-1 shouldn’t be prioritized. Other medical concerns take precedence in a post-carbon world marked by climate change and widespread ecological devastation. I challenge this view on three grounds. Its (...) proponents (i) fail to treat type-1 as the public health issue it is, particularly within the context of what Sunaura Taylor calls disabled ecologies. They (ii) deny persons with type-1 an equal opportunity to pursue survival. And they (iii) presume without warrant that treating type-1 is an all-or-nothing affair. Indeed, research by biohackers points to suboptimal but potentially workable ways to make type-1 survivable in a post-carbon future—so long, I stress, as their findings are cripped in a manner that foregrounds the demands of environmental justice. (shrink)

Guanxi is essential to doing business in China. Even those who are minimally familiar with business in the People’s Republic seem to know this. How should Western business organizations look at guanxi? Further, if guanxi is seen as essential, what is the responsible approach to guanxi building? These questions may have different answers depending on one’s perspectives. First, what is guanxi?

Guanxi is essential to doing business in China. Even those who are minimally familiar with business in the People’s Republic seem to know this. How should Western business organizations look at guanxi? Further, if guanxi is seen as essential, what is the responsible approach to guanxi building? These questions may have different answers depending on one’s perspectives. First, what is guanxi?

In this paper we present a paradigmatic example of the use in knowledge management of techniques from other fields, namely mathematical analysis. We also highlight that the Jacobi method presented here takes precedence over the better known Hungarian method. Finally, we signify that the Jacobi method represents the first known or recognized case of serendipity in both knowledge management and operational research. This paper thus demonstrates the intersection between knowledge management, mathematical analysis and operational research and how taking historical perspectives (...) are important for recognising future applications of knowledge management. This results in a better understanding of knowledge management and how it can be applied in the future. It has been shown how knowledge management relates to historical mathematical principles. (shrink)

The target article suggests inter-individual variability is a weakness of microbiota-gut-brain research, but we discuss why it is actually a strength. We comment on how accounting for individual differences can help researchers systematically understand the observed variance in microbiota composition, interpret null findings, and potentially improve the efficacy of therapeutic treatments in future clinical microbiome research.

The Protein Ontology (PRO) is designed as a formal and principled Open Biomedical Ontologies (OBO) Foundry ontology for proteins. The components of PRO extend from a classification of proteins on the basis of evolutionary relationships at the homeomorphic level to the representation of the multiple protein forms of a gene, including those resulting from alternative splicing, cleavage and/or posttranslational modifications. Focusing specifically on the TGF-beta signaling proteins, we describe the building, curation, usage and dissemination of PRO. PRO provides a framework (...) for the formal representation of protein classes and protein forms in the OBO Foundry. It is designed to enable data retrieval and integration and machine reasoning at the molecular level of proteins, thereby facilitating cross-species comparisons, pathway analysis, disease modeling and the generation of new hypotheses. (shrink)

Both the theory that traumatic childhood memories can be repressed, and the reliability of the techniques used to retrieve these memories are challenged in this paper. Questions are raised about the robustness of the theory and the literature that purports to provide scientific evidence for it. Evidence to this end is provided by the demographic and qualitative results of a research study conducted by the authors which surveyed New Zealand families in which one member had accused another (or others) of (...) sexual abuse on the basis of recovered memories. It is shown that a number of these allegations involve very low probability events. Since memory repression theory is not currently scientifically substantiated it is argued that care needs to be taken in the mental health, legal and insurance compensation arenas. Memories recalled during therapy may be treated as metaphorical but, in the absence of corroborative evidence, should not be considered factually true. Clinicians who wish to use memory recovery techniques should inform patients of their experimental and controversial nature, point out potential adverse effects, and obtain consent before proceeding. (shrink)

ABSTRACT The destruction of the environment is a matter for moral concern and cannot be halted in the long term by appeals to human utility. However, the inadequacy and naïvety of humanist styles of ethical argument become apparent when attempts are made to extend them to environmental issues. They usually abstract certain supposed features of natural objects, e.g. sentience, and reify these as essential characteristics which operate to carry or ground ethical values. These arguments necessarily lead to the exclusion of (...) objects which are, in fact, ethically valued or entail an unacceptably expansive egalitarianism. Such egalitarianism is often followed by a return to human‐centred prejudices opposed to the originally stated aims of ‘biocentric’ethicists like Taylor. Similarly, those physical and ecological holisms which rely not upon shared ‘natural’features, but upon sharing in nature itself cannot solve this dilemma as they are incapable of explaining differential ethical values. The attempt to place boundaries on moral considerability should be abandoned in favour of an ethical pluralism which places emphasis on the context of valuations. (shrink)

This article explores how ministerial and leadership formation could be enabled to adopt transformational diaconia in addressing poverty in South Africa, engaging in ways in which pastoral care and leadership formation can respond to the addressing of poverty. The fact that transformation aims at changing the worldviews, paradigms and approaches to life and problem solving informs the author’s concept of transformational diaconia, which was proposed as an aspect of spiritual leadership capital (SLC), defined as, ‘The inner virtues afforded individuals by (...) their spirituality in formulating their leadership paradigms which contributes to social capital formation for addressing social problems’. Spiritual leadership capital is hereby argued to be a transformative spirituality that can enable an understanding and sustainable responses to poverty and other social problems. This is needed for Africa and particularly for the present day South Africa, seemingly a country with the best infrastructure in Africa; yet its poverty seems pronounced because the dregs of apartheid still lurk in the social fibre, where poor people blame rich people for their plight and vice versa. Bowers Du Toit’s view that ‘[m]ost congregations respond to poverty by providing relief and not empowerment’, re-echoes here. From a mixed-methods research, SLC is a theory recently advanced as a congregational development paradigm and a theology of poverty, which views public theology as an educative praxis that can respond to transformational needs in poverty-related contexts. The authors suggest that for a Church that is responsive to the plight of society, fresh empowerment approaches to address poverty are needed. (shrink)

Symbioculture involves nurturing the lives of those in one’s ecology, including the beings one eats. More specifically, it is a kinship-based conception of food and food systems rooted in Indigenous considerations of sustainability. Relations among food sources; cultivators, distributors, and eaters; and the land they share are sustainable when they function as extended kinship arrangements. Symbioculture hereby offers salient means to resist the ecocidal, agroindustrial food system that currently dominates transnationally in a manner that responds to the urgent need—both in (...) terms of Indigenous justice and prudence for us all—to decolonize foodways and decommodify food, food-based knowledge, and food labor. (shrink)

Herein we examine the theory and practical limits of designing a voluntary incentive scheme to protect endangered species on private land. We consider both an ay-ante scheme, in which a contract to the landholder depends only on what the landholder reports, and an ay-post scheme, in which a contract to the landholder depends on reports from all landowners. Except in special cases, the ex-ante scheme never implements the full information allocation, and can actually set aside too much land. In contrast, (...) expected habitat size under the ex-post scheme is smaller than both the ex-ante and full information allocations. (C) 2001 Elsevier Science (USA). (shrink)

History reveals how civilisations can be decimated by changes in climate. More recently modern methods of warfare have exposed the vulnerability of the artefacts of civilisation. Bringing together a range of subjects - from science, energy and sustainability to aesthetics theory and civilization theory - this book uniquely deals with climate change and the ensuing catastrophes in relation to cultural factors, urbanism and architecture. It links the evolution of civilisation, with special emphasis on the dynamics of beauty as displayed in (...) architecture and urbanism, to climate change. It then considers both the historic and predicted impacts of climate change and the threat it poses to the continued viability of human civilisation when survival is the top priority. This book gives students, researchers and professionals in architecture and sustainable design as well as anyone interested in the threat of global warming to civilisation, new insights as to what could be lost if action is not taken at a global level. (shrink)

Symbioculture involves nurturing the lives of those in one’s ecology, including the beings one eats. More specifically, it is a kinship-based conception of food and food systems rooted in Indigenous considerations of sustainability. Relations among food sources; cultivators, distributors, and eaters; and the land they share are sustainable when they function as extended kinship arrangements. Symbioculture hereby offers salient means to resist the ecocidal, agroindustrial food system that currently dominates transnationally in a manner that responds to the urgent need—both in (...) terms of Indigenous justice and prudence for us all—to decolonize foodways and decommodify food, food-based knowledge, and food labor. (shrink)

This is the introduction of the special issue,.

Cyclin-dependent kinase 5 has been implicated in Alzheimer's disease pathogenesis. Here, we demonstrate that overexpression of p25, an activator of cdk5, led to increased levels of BACE1 mRNA and protein in vitro and in vivo. A p25/cdk5 responsive region containing multiple sites for signal transducer and activator of transcription was identified in the BACE1 promoter. STAT3 interacts with the BACE1 promoter, and p25-overexpressing mice had elevated levels of pSTAT3 and BACE1, whereas cdk5-deficient mice had reduced levels. Furthermore, mice with a (...) targeted mutation in the STAT3 cdk5 responsive site had lower levels of BACE1. Increased BACE levels in p25 overexpressing mice correlated with enhanced amyloidogenic processing that could be reversed by a cdk5 inhibitor. These data demonstrate a pathway by which p25/cdk5 increases the amyloidogenic processing of APP through STAT3-mediated transcriptional control of BACE1 that could have implications for AD pathogenesis. (shrink)

Many proponents of deliberative democracy expect reasonable citizens to engage in rational argumentation. However, this expectation runs up against findings by behavioral economists and social psychologists revealing the extent to which normal cognitive functions are influenced by bounded rationality. Individuals regularly utilize an array of biases in the process of making decisions, which inhibits our argumentative capacities by adversely affecting our ability and willingness to be self-critical and to give due consideration to others’ interests. Although these biases cannot be overcome, (...) I draw on scientifically corroborated insights offered by Adam Smith to show that they can be kept in check if certain affective and cognitive capacities are cultivated. Smith provides a compelling account of how to foster sympathetic, impartial, and projective role-taking in the process of interacting with others, which can greatly enhance our capacity and willingness to critically assess our own interests and fairly consider those of others. (shrink)