The cohesin complex is best known for its role in sister chromatid cohesion. Over the past few years, it has become apparent that cohesin also regulates gene expression, but the mechanisms by which it does so are unknown. Recently, three groups mapped numerous cohesin-binding sites in mammalian chromosomes and found substantial overlap with the CCCTC-binding factor (CTCF).1-3 CTCF is an insulator protein that blocks enhancer–promoter interactions, and the investigators found that cohesin also contributes to this activity. Thus, these studies demonstrate (...) at least one mechanism by which cohesin can control gene expression. BioEssays 30:715–718, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Written in honor of Dale K. Van Kley, leading specialist on religion and politics in the Old Regime and the French Revolution, these essays examine how Jansenist belief shaped enlightenment ideas, cultural identities, social relations and politics in France throughout the long eighteenth century. Van Kley's work has invited scholars to think beyond the traditional parameters of the Enlightenment and to consider how religious faith functioned in the broader context of Old Regime, Revolutionary, and post-Revolutionary France. In different ways, (...) each essay challenges the idea of an inherent opposition between faith and Enlightenment, which likewise equates modernity with secularization. The authors within this volume address two main questions. Firstly, how did religious belief continue to shape identities and experiences in the long eighteenth century? Secondly, how does this narrative of enduring religious belief in eighteenth-century France help historians rethink the Enlightenment and the French Revolution? The various methodologies used by the contributors illustrate how belief, Enlightenment, and Revolution coexisted and indeed co-mingled in different contexts: politics and political culture, the social and cultural history of ideas, and the history of material culture. (shrink)

Since argument frames precede most other arguing processes, argument editing among them, one’s frames may well predict one’s preferred editorial standards. This experiment assesses people’s arguing frames, gives them arguments to edit, and tests whether the frames actually do predict editorial preferences. Modest relationships between argument frames and argument editing appear. Other connections among frames, editing, and additional individual differences variables are more substantial. Particularly notable are the informative influences of psychological reactance. A new theoretical contribution is offered, connecting argument (...) frame research to Erving Goffman’s frame analysis. (shrink)

We introduce a new metric for interdisciplinarity, based on co-author publication history. A published article that has co-authors with quite different publication histories can be deemed relatively “interdisciplinary,” in that the article reflects a convergence of previous research in distinct sets of publication outlets. In recent work, we have shown that this interdisciplinarity metric can predict citations. Here, we show that the journal Cognitive Science tends to contain collaborations that are relatively high on this interdisciplinarity metric, at about the 80th (...) percentile of all journals across both social and natural sciences. Following on Goldstone and Leydesdorff, we describe how scientometric tools provide a valuable means of assessing the role of cognitive science in broader scientific work, and also as a tool to investigate teamwork and distributed cognition. We describe how data-driven metrics of this kind may facilitate this exploration without relying upon rapidly changing discipline and topic keywords associated with publications. (shrink)

A balanced survey of the most important historical and contemporary topics in the philosophy of mind.

Gottlob Frege is one of the founding figures of analytic philosophy, whose contributions to logic, philosophical semantics, philosophy of language, and philosophy of mathematics set the agenda for future generations of theorists in these and related areas. Dale Jacquette's lively and incisive biography charts Frege's life from its beginnings in small-town north Germany, through his student days in Jena, to his development as an enduringly influential thinker. Along the way Jacquette considers Frege's ground-breaking Begriffschrift, in which he formulated his (...) 'ideal logical language', his magisterial Grundgesetze der Arithmetik, and his complex relation to thinkers including Husserl and especially Russell, whose Paradox had such drastic implications for Frege's logicism. Jacquette concludes with a thoughtful assessment of Frege's legacy. His rich and informative biography will appeal to all who are interested in Frege's philosophy. (shrink)

In this challenging and provocative analysis, Dale Jacquette argues that contemporary philosophy labours under a number of historically inherited delusions about the nature of logic and the philosophical significance of certain formal properties of specific types of logical constructions. Exposing some of the key misconceptions about formal symbolic logic and its relation to thought, language and the world, Jacquette clears the ground of some very well-entrenched philosophical doctrines about the nature of logic, including some of the most fundamental seldom-questioned (...) parts of elementary propositional and predicate-quantificational logic. Having presented difficulties for conventional ways of thinking about truth functionality, the metaphysics of reference and predication, the role of a concept of truth in a theory of meaning, among others, Jacquette proceeds to reshape the network of ideas about traditional logic that philosophy has acquired along with modern logic itself. In so doing Jacquette is able to offer a new perspective on a number of existing problems in logic and philosophy of logic. (shrink)

The human relationship to nature is a deeply ambiguous one. Human animals are both a part of nature and distinct from it. They are part of nature in the sense that, like other forms of life, they were brought into existence by natural processes, and, like other forms of life, they are dependent on their environment for survival and success. Yet humans are also reflective animals with sophisticated cultural systems. Because of their immense power and their ability to wield it (...) intentionally, humans have duties and responsibilities that other animals do not. (shrink)

Drawing inspiration from Iris Murdoch, I develop a systematic account of love that countenances love beyond persons. I then show how this account applies to nature, and explain why loving nature matters.

This book addresses several dimensions of the transformation of English Nonconformity over the course of an important century in its history. It begins with the question of education for ministry, considering the activities undertaken by four major evangelical traditions to establish theological colleges for this purpose, and then takes up the complex three-way relationship of ministry/churches/colleges that evolved from these activities. As author Dale Johnson illustrates, this evolution came to have significant implications for the Nonconformist engagement with its message (...) and with the culture at large. These implications are investigated in chapters on the changing perception or understanding of ministry itself, religious authority, theological questions, and religious identity.In Johnson's exploration of these issues, conversations about these topics are located primarily in addresses at denominational meetings, conferences that took up specific questions, and representative religious and theological publications of the day that participated in key debates or advocated contentious positions. While attending to some important denominational differences, The Changing Shape of English Nonconformity, 1825-1925 focuses on the representative discussion of these topics across the whole spectrum of evangelical Nonconformity rather than on specific denominational traditions.Johnson maintains that too many interpretations of nineteenth-century Nonconformity, especially those that deal with aspects of the theological discussion within these traditions, have tended to depict such developments as occasions of decline from earlier phases of evangelical vitality and appeal. This book instead argues that it is more appropriate to assess these Nonconformist developments as a collective, necessary, and deeply serious effort to come to terms with modernity and, further, to retain a responsible understanding of what it meant to be evangelical. It also shows these developments to be part of a larger schema through which Nonconformity assumed a more prominent place in the English culture of the nineteenth and early twentieth centuries. (shrink)

The ability to gain knowledge from text in widely different subject matter areas is key to academic success and lifelong leaming. The process of attaining critical understanding of ideas in text requires a robust repertoire of leaming or study strategies, metacognitive knowledge for regulating their use, and willingness to apply them. Although much is known about the basic design of leaming environments to develop higher-order thinking skills and motivation to learn, educators have, in general, not changed their practices to reflect (...) new knowledge. The lack of procedures that are easy for teachers to administer and provide results that teachers may use in their classrooms for assessment of complex cognitive skill development is a major obstacle to widespread adoption of new approaches. This paper describes a new technology, referred to as HyLighter, and a pedagogically sound implementation of this technology, referred to as the Interaclive Annotation Model. This approach suggests a promising direction for improving the quality of instruction and promoting active reading (i.e., an approach to the development of leaming ability that combines reading with critical thinking and a range of learning-to-Iearn skills) for students in higher education across academic disciplines. (shrink)

The origins of object theory in the philosophical psychology and semantics of Alexius Meinong and the Graz school can be traced both to the insight and failure of Franz Brentano's immanent objectivity or intentional in-existence thesis. The immanence thesis is documented, together with its critical reception in Alois Höfler's Logik, Twardowski's Zur Lehre vom Inhalt und Gegenstand der Vorstellungen, and Meinong's mature Gegenstandstheorie, in which immanent thought content and transcendent intentional object are distinguished, and Brentano's thesis of immanent intentionality as (...) the mark of the mental is reinterpreted to imply that only content is the immanently intentional component of presentations. Brentano's thought from the early immanence thesis through the so-called Immanenzkrise and his later reism is explored against the background of his students' reactions to the original 1874 intentionality thesis and its idealist implications, in the emergence of Meinong's object theory and Edmund Husserl's transcendental phenomenology. Finally, Brentano's reism in the later ontology is critically examined, as his solution to ontic problems of immanent intentionality, limiting intentional objects to transcendent concrete particulars. (shrink)

Meinong introduces the concept of implexive being and nonbeing to explain the metaphysics of universals, and as a contribution to the theory of reference and perception. Meinong accounts for Aristotle's doctrine of the inherence of secondary substances in primary substances in object theory terms as the implection of incomplete universals in complete existent or subsistent objects. The derivative notion of implexive so-being is developed by Meinong to advance an intuitive modal semantics that admits degrees of possibility. A set theoretical interpretation (...) of Meinong's mereological concept of the implection of incomplete beingless objects in existent or subsistent complete objects is proposed. The implications of Meinong's concept of implection are exploited to answer extensionalist objections about "Meinong's jungle", defending the ontic economy of an extraontological neo-Meinongian semantic domain that supports individual reference and true predication of constitutive properties to beingless objects. (shrink)

This article seeks to situate pharmacological cognitive enhancement as part of a broader relationship between cultural understandings of the body-brain and the political economy. It is the body of the worker that forms the intersection of this relationship and through which it comes to be enacted and experienced. In this article, we investigate the imaginaries that both inform and are reproduced by representations of pharmacological cognitive enhancement, drawing on cultural sources such as newspaper articles and films, policy documents, and pharmaceutical (...) marketing material to illustrate our argument. Through analysis of these diverse cultural sources, we argue that the use of pharmaceuticals has come to be seen not only as a way to manage our brains, but through this as a means to manage our productive selves, and thereby to better manage the economy. We develop three analytical themes. First, we consider the cultural representations of the brain in connection with the idea of plasticity – captured most graphically in images of morphing – and the representation of enhancement as a desirable, inevitable, and almost painless process in which the mind-brain realizes its full potential and asserts its will over matter. Following this, we explore the social value accorded to productive employment and the contemporary ethos of working on or managing oneself, particularly in respect of improving one’s productive performance through cognitive enhancement. Developing this, we elaborate a third theme by looking at the moulding of the worker’s productive body-brain in relation to the demands of the economic system. (shrink)

Philosophical semantics requires an ontology that includes negative as well as positive states of affairs as truth-makers and truth-breakers. Theories that try to do without negative states of affairs while interpreting propositional truth as positive correspondence with existent states of affairs are inherently inadequate and incomplete. A semantics and ontology of negative states of affairs can also do justice to positive states of affairs, since the iterated negative state of affairs that a negative state of affairs exists describes a positive (...) state of affairs, but the iterated positive state of affairs that a positive state of affairs exists never describes a negative state of affairs. Negative states of affairs are not only essential to semantics, but to a complete description of the world; they include phenomena of presence in absence and the metaphysics of gaps, lacks, holes and interstitia. The conceivability of an empty or null universe as consisting of nothing but negative states of affairs recalls a famous problem of Parmenides. (shrink)

Meinong's doctrine of the modal moment and the watering-down of extranuclear properties to surrogate nuclear counterparts was offered in response to Russell's problem of the existent round square. To avoid an infinite regress of successively watered-down factualities, Meinong stipulates that the modal moment itself cannot be watered-down. This limits free assumption, since it means that the idea of the existent-cum-modal-moment round square cannot be entertained in thought. It is possible to eliminate the modal moment and watering-down from Meinongian semantics in (...) favor of a strict enforcement of the distinction between nuclear and extranuclear properties. This provides a simpler, more economical Meinongian object theory, and regains unrestricted free assumption. (shrink)

The possibilities are explored of considering nothing as the intended object of thoughts that are literally about the concept of nothing first, and thereby of nothing. Nothing, on the proposed analysis, turns out to be nothing other than the property of being an intendable object. There are propositions that look to be both true and to be about nothing in the sense of being about the concept and ultimate intended object of what is here formally defined and designated as N-nothing. (...) We have been thinking about it already in reading and understanding the meaning of this abstract. Nothing nothings, we shall assert in all seriousness and with a definite formally definable literal meaning. The concept of N-nothing in that sense is a concept with identity conditions like that of any entity, the difference being that the concept of N-nothing is a nonentity and nonexistent intended object. (shrink)

The fallacy of many questions or the complex question, popularized by the sophism ‘Have you stopped beating your spouse?’ (when a yes-or-no answer is required), is similar to the fallacy of begging the question orpetitio principii. Douglas N. Walton inBegging the Question has recently argued that the two forms are alike in trying unfairly to elicit an admission from a dialectical opponent without meeting burden of proof, but distinct because of the circularity of question-begging argument and noncircularity of many questions. (...) I offer a reconstruction of the many questions fallacy according to which it is just as circular as begging the question, concluding that many questions begs the question. The same analysis contradicts Walton's claim that questions can beg the question, drawing a distinction between questions as the instruments of question-begging, and as vehicles for categorical noninterrogative presuppositions that beg the question. (shrink)

In a chapter of - so to speak - an intellectual autobiography I sketch the reasons and ways I became a practitioning Meinongian logician. The way is a chain of transgressions, e.g., the transgression of extensionalism or of the law of excluded middle, and a struggle against widespread misinterpretations of Meinong's Gegenstandstheorie. Although the opposition towards Meinong's theory of objects persists in analytic philosophy, its main insights - that thought is intentional and that logic must be ontologically neutral - haven't (...) lost their attraction. Moreover: there is no substantive criticism to show that we cannot refer and truely predicate properties of intended objects regardless of their ontic status. (shrink)

I consider three conditions to explain the emergence of scientific philosophy in Austrian thought at the turn of the century, concentrating on Vienna and Graz as distinct centers of philosophical development: An outlook that seeks philosophical truth in sound reasoning, combined with a commitment to developing and practicing a methodology that is not essentially dependent on any particular culture's literary–philosophical traditions; The desire to transcend national boundaries in the pursuit of philosophical understanding, as manifested in international professional conferences, publications, and (...) training of international students; and Cultural infrastructure that sustains ambitious philosophical projects, including tangible assets like financial resources, established educational institutions and communication networks, but also less conspicuous elements, such as, among others, a political environment of open inquiry, a relatively free press, community support for the enhancement of learning, and participation in an international language of science. (shrink)

Meinong's doctrine of the modal moment and the watering-down of extranuclear properties to surrogate nuclear counterparts was offered in response to Russell's problem of the existent round square. To avoid an infinite regress of successively watered-down factualities, Meinong stipulates that the modal moment itself cannot be watered-down. This limits free assumption, since it means that the idea of the existent-cum-modal-moment round square cannot be entertained in thought. It is possible to eliminate the modal moment and watering-down from Meinongian semantics in (...) favor of a strict enforcement of the distinction between nuclear and extranuclear properties. This provides a simpler, more economical Meinongian object theory, and regains unrestricted free assumption. (shrink)

Meinong's doctrine of the modal moment and the watering-down of extranuclear properties to surrogate nuclear counterparts was offered in response to Russell's problem of the existent round square. To avoid an infinite regress of successively watered-down factualities, Meinong stipulates that the modal moment itself cannot be watered-down. This limits free assumption, since it means that the idea of the existent-cum-modal-moment round square cannot be entertained in thought. It is possible to eliminate the modal moment and watering-down from Meinongian semantics in (...) favor of a strict enforcement of the distinction between nuclear and extranuclear properties. This provides a simpler, more economical Meinongian object theory, and regains unrestricted free assumption. (shrink)

Meinong's theory of defective objects in On Emotional Presentation is ambiguous in ways which give rise to a dilemma. It is not clear whether or not defective objects are supposed to be a special kind of intentional object. If they are intentional objects, then a strengthened version of Mally's paradox about self-referential thought can be given which contradicts the intentionality thesis. But if they are not intentional objects, then thoughts with defective objects themselves constitute immediate counter-examples to the intentionality thesis. (...) In either case, the theory of defective objects cannot be made logically consistent with both the possibility of self-referential thought and the intentionality thesis in its full generality. (shrink)

The use of medical records in research can yield information that is difficult to obtain by other means. When such records are released to investigators in identifiable form, however, substantial privacy and confidentiality risks may be created. These risks become more common and more serious as medical records move to an electronic format. In 1996, the state of Minnesota enacted legislation with respect to consent requirements for the use of medical records in research. This legislation has been widely criticized because—it (...) is claimed—it creates an unnecessary impediment to research. In this article, we show that these arguments rest upon misinterpretation and/or misrepresentation of the 1996 legislation. A consent requirement had actually been present in Minnesota since 1976 (though codified in a patient rights statute rather than a privacy statute). The 1996 law does not require specific consent, as often claimed, but rather only a general authorization. The campaign against the Minnesota legislation appears to have been motivated by concern with respect to the then impending federal privacy rule. The HIPAA rule, as enacted, is in fact less stringent with respect to consent than the Minnesota consent law. On the other hand, the Minnesota consent law has not been effectively applied or enforced. As we change the way we manage sensitive medical information, new efforts are needed to provide protection against the confidentiality risks in research. Patient consent is an important tool in this regard. New instrumentalities are needed to solicit and document consent. (shrink)

The new field of quantitative health risk assessment owes its emergence much more to the 'market pull' of demand from societal decision-making processes than to dramatic advances in our ability to make the desired predictions. This paper discusses problems and opportunities in the current practice of quantitative risk estimation under three broad headings: Basic (Technical) Assessment Methodology, and Methods for Assessing Uncertainty; Conception of the Problem for Analysis, and Ways of Expressing Results; and Defining Appropriate Roles for Expert Analysts in (...) Social Decision Processes. Finally, borrowing from work of McMullin, the paper offers some criteria for judging risk assessment theories other than the generally unavailable 'goodness-of-fit' procedures. (shrink)

ABSTRACTThe ideological and methodological oppositions that divide philosophy generally into realisms and idealisms, objectivisms and subjectivisms, also pervade aesthetic theory. The question arises whether there was beauty in the world prior to the emergence of intelligent perceivers like ourselves, or whether beauty itself comes into existence only through the perceptual idiosyncrasies with which we happen to encounter the objects we happen to consider beautiful. The experience of beauty and its opposites under this description can easily seem to be an altogether (...) subjective phenomenon, available at most only to those psychological subjects conditioned or predisposed to recognize certain features as possessing specific aesthetic properties. The article examines topics related to the intentionality of expression in art. Intention is often rejected as a basis for aesthetic judgment. The present discussion, by focusing on the role of perception in art production and appreciation, considers ways of addressing those objections to restore an intuitive sense of the intentional expressiveness of art. The proposed solution also helps uphold an approach toward answering the question of whether aesthetic value generally is only subjective or also has a distinctively objective element. (shrink)

Marx and Engels argue that capitalism must ultimately destroy itself because it contains an internal contradiction: Capitalism requires wage laborers at first to be in competitive isolation from one another, lest their common interests become transparent and they unite collectively to improve their employment conditions. At a certain later stage of capitalism's historical development, however, competition eventually forces capitalists to bring their workers together in common workplaces , where their shared interests can be immediately perceived and mutual grievances directly communicated. (...) The Communist Manifesto's argument for the inevitable downfall of capitalism is epistemically naïve in several ways, resting as it does on the idea that material interests are perceivable, and that an awareness of common problems translates automatically into a sense of shared interests powerful enough to motivate coordinated action for the sake of achieving economic-political reform. (shrink)

The concept of conditional intent is pervasive in practical reasoning and action. Although conditional intent has not received the detailed attention it deserves, it is worth remarking that much if not most of the intentions we formulate and on the basis of which we act or try to act are conditional in logical form.