Bacteria have evolved advanced strategies for surviving during nutritional stress, including expression of specialized enzyme systems that allow them to grow on unusual nutrient sources. Inorganic phosphate (Pi) is limiting in most ecosystems, hence organisms have developed a sophisticated, enzymatic machinery known as carbon‐phosphorus (C‐P) lyase, allowing them to extract phosphate from a wide range of phosphonate compounds. These are characterized by a stable covalent bond between carbon and phosphorus making them very hard to break down. Despite the challenges involved (...) in both synthesizing and catabolizing phosphonates, they are widespread in nature. The enzymes required for the bacterial C‐P lyase pathway have been identified and for the most part structurally characterized. Nevertheless, the mechanistic principles governing breakdown of phosphonate compounds remain enigmatic. In this review, an overview of the C‐P lyase pathway is provided and structural aspects of the involved enzyme complexes are discussed with a special emphasis on the role of ATP‐binding cassette (ABC) proteins. (shrink)

Bacteria have evolved advanced strategies for surviving during nutritional stress, including expression of specialized enzyme systems that allow them to grow on unusual nutrient sources. Inorganic phosphate (Pi) is limiting in most ecosystems, hence organisms have developed a sophisticated, enzymatic machinery known as carbon‐phosphorus (C‐P) lyase, allowing them to extract phosphate from a wide range of phosphonate compounds. These are characterized by a stable covalent bond between carbon and phosphorus making them very hard to break down. Despite the challenges involved (...) in both synthesizing and catabolizing phosphonates, they are widespread in nature. The enzymes required for the bacterial C‐P lyase pathway have been identified and for the most part structurally characterized. Nevertheless, the mechanistic principles governing breakdown of phosphonate compounds remain enigmatic. In this review, an overview of the C‐P lyase pathway is provided and structural aspects of the involved enzyme complexes are discussed with a special emphasis on the role of ATP‐binding cassette (ABC) proteins. (shrink)

Bjarne Melkevik, docteur s droit de Paris II, est professeur titulaire la Facult de droit de l'Universit Laval (Qubec) et professeur associ au Dpartement de droit et Justice, Universit Laurentienne (Ontario).

Although Denmark managed to stay neutral throughout World War I, it nevertheless generated a heated debate in the country; most people took a clear stand for one side or the other. After the traumatic Danish defeat in the 1864 war with Prussia and Austria, Germany was regarded as the arch enemy and not unexpectedly mostDanes sided against the Central Powers in the public debate. This was not least the case amongst the national-conservative politicians, intellectuals and artists. They form the focus (...) of my article, and the questions I address are: how did the national-conservatives experience the mental watershed of the war? Was it as a blessing or a curse? (shrink)

This introduction to the history, philosophy and methodology of human geography explores complex ideas in an intelligible and accessible style. It takes into account the new developments in geographical thought and methods.

How does man find himself in a society that cannot offer clear answers to the fundamental question: What is the meaning of existence? This introduction to Søren Kierkegaard's psychological thinking may provide part of the answer. For those interested in psychology and philosophy and anyone else interested in existential dilemmas.

Since the 1980s the concept of ANT has remained unsettled. ANT has continuously been critiqued and hailed, ridiculed and praised. It is still an open question whether ANT should be considered a theory or a method or whether ANT is better understood as entailing the dissolution of such modern ‘‘genres’’. In this paper the authors engage with some important reflections by John Law and Bruno Latour in order to analyze what it means to ‘‘do ANT,’’ and, doing so after ‘‘doing (...) ANT on ANT.’’ In particular the authors examine two post-ANT case studies by Annemarie Mol and Marilyn Strathern and outline the notions of complexity, multiplicity, and fractality. The purpose is to illustrate the analytical consequences of thinking with post-ANT. The analysis offers insights into how it is possible to ‘‘go beyond ANT,’’ without leaving it entirely behind. (shrink)

Quels sont les horizons de la philosophie du Droit? Quelle place occupe-t-elle dans notre modernité juridique? Quels sont ses enjeux? L'euthanasie, les droits des minorités et l'écologie sont des thèmes qui s'inscrivent naturellement dans le contexte contemporain de la philosophie du droit. Les essais présentés dans cet ouvrage expliquent les enjeux des domaines de réflexion qui divisent notre modernité juridique et nous révèlent comment le droit contemporain se construit à partir de présupposés théoriques. Par une réflexion qui invite au dialogue (...) et à la production d'arguments réfléchis, l'auteur cherche à démontrer que la philosophie du droit peut combler certaines lacunes du positivisme juridique qui marque notre modernité. (shrink)

La philosophie du droit a pour fonction d’assister la réflexion sur le monde du juridique, sur « le droit qui se fait », sur la doctrine juridique et notre façon de l’écrire, et sur l’appréciation (ou l’indifférence, l’hostilité, etc.) qu’un individu distancié peut éprouver à l’égard du droit et des juristes. Elle assiste et elle participe en examinant notre façon d’opérationnaliser les sources du droit, de forger des arguments pouvant être juridiques, d’évaluer les narrations qui se présentent au droit, d’examiner (...) la pertinence de la doctrine, notre façon de pratiquer le droit et de faire des jugements judiciaires. Elle ne réside de toute évidence pas « en haut » et elle ne « surplombe » pas l’écriture de la doctrine. Elle ne se glorifie pas en distribuant (en toute incompétence) l’étiquette de « scientificité » au bon candidat, que celui-ci soit auteur d’un article, d’un livre ou d’une théorie. Admettons plutôt lucidement que la philosophie du droit ne donne pas de certificat de « scientificité » et que toute revendication en ce « sens » n’a pas de « sens ». (shrink)

logique. Dans la société moderne et pluraliste, l'identité des sujets est en fait une combinaison de ces identités. Ainsi, la pluralité n'est pas extérieure ...

Listening to the Concerto for Violin and Orchestra in D-major by Brahms takes twenty-two minutes. It varies a few minutes depending of the soloist and conductor, but the duration is fairly constant. Reading Anna Karenina by Leo Tolstoy takes many hours. The duration varies a lot depending on the reader's pace, but reading literature, just as listening to music, takes a considerable amount of time. Looking at a work of visual art, on the other hand, typically takes less than a (...) minute. This may be an exaggeration, but museum studies show that visitors to an art museum usually spend only a few moments in front of the individual work of art. Jeffrey K. Smith and Lisa F. Smith found that visitors to the Metropolitan... (shrink)

The influence of conscience on nurses in terms of guilt has frequently been described but its impact on care has received less attention. The aim of this study was to describe nurses' conceptions of the influence of conscience on the provision of inpatient care. The study employed a phenomenographic approach and analysis method. Fifteen nurses from three hospitals in western Sweden were interviewed. The results showed that these nurses considered conscience to be an important factor in the exercise of their (...) profession, as revealed by the descriptive categories: conscience as a driving force; conscience as a restricting factor; and conscience as a source of sensitivity. They perceived that conscience played a role in nursing actions involving patients and next of kin, and was an asset that guided them in their efforts to provide high quality care. (shrink)

Starting out from the presumption that inscriptions are texts indissolubly connected to the physical objects on which they are written, this collection of essays aims to provide a multi-disciplinary perspective on the physical and material aspects of writing in antiquity. It argues that there is a need to ‘increase modern sensibilities to material aspects of our texts which are often elided in modern printed editions’. This call is not new: recognition of the importance of the materiality of...

The desire to guide research and innovation in more ‘responsible’ directions is increasingly emphasised in national and international policies, the funding of inter- and trans-disciplinary collaborations and academic scholarship on science policy and technology governance. Much of this growth has occurred simultaneously with the development of nanoscale sciences and technologies, where emphasis on the need for responsible research and innovation has been particularly widespread. This paper describes an empirical study exploring the potential for RRI within nanosafety research in Norway and (...) Denmark. It identifies three different ways nanosafety scientists relate to core RRI criteria, demonstrating areas of both convergence and divergence between their views and those of academics and policymakers currently defining and working to promote RRI. The paper identifies a range of practical barriers and cultural differences that are creating such divergences and inhibiting the enactment of RRI within the particular site of research laboratories. It concludes that the identified differences and challenges demand critical reflection on both the appropriateness and applicability of RRI characteristics for enactment at the level of individual research scientists. Significant changes are therefore advocated as required if RRI, as currently imagined and promoted, is to become an integral mode of scientific culture. (shrink)

This article argues for the value of working with conflicts in social practice as resources for collaboration, learning and development. The interest in conflicts in social practice is rooted in a preoccupation with social power relations and how to understand and analyse power relations from a subject-science perspective. Following this interest, a methodological framework, best described as a kind of ‘mobile ethnography’, is discussed and exemplified through an empirical example. A preliminary conceptual framework for understanding power as a capacity for (...) action is presented. The overarching ambition of the article is to consider what democratic collaboration and coexistence entails and how it might be supported conceptually and analytically by the notion of conflicts as heuristics for social inquiry and by the notion of power as a capacity for action and social participation. (shrink)

The psychological effects of aesthetic education have often been discussed, and major studies such as Michael Parsons’s inquiry into art understanding show that the development of understanding works of visual art is influenced by education.1 His findings show that the way people talk about art can be structured in five stages of development according to the model of Jean Piaget’s theory of cognitive development. He believes that the understanding of art, just like general cognition, is based on mental maturation but (...) that some kind of education is necessary to acquire the different skills of the understanding of art at each stage of development. Parsons’s study does not include educational strategies, but his .. (shrink)

Ethical decision making is of concern to researchers across all fields. However, researchers typically focus on the biases that may act to undermine ethical decision making. Taking a new approach, this study focused on identifying the most common compensatory strategies that counteract those biases. These strategies were identified using a series of interviews with university researchers in a variety of areas, including biological, physical, social, and health as well as scholarship and the performing arts. Interview transcripts were assessed with two (...) scoring procedures, an expert rating system and computer-assisted qualitative analysis. Although the expert rating system identified Understanding Guidelines, Recognition of Insufficient Information, and Recognizing Boundaries as the most frequently used compensatory strategies across fields, other strategies, Striving for Transparency, Value/norm Assessment, and Following Appropriate Role Models, were identified as most common by the computer-assisted qualitative analyses. Potential reasons for these findings and implications for training and practice are identified and discussed. (shrink)

A number of researchers have begun to demonstrate that the widely discussed ?Knobe effect? (wherein participants are more likely to think that actions with bad side-effects are brought about intentionally than actions with good or neutral side-effects) can be found in theory of mind judgments that do not involve the concept of intentional action. In this article we report experimental results that show that attributions of knowledge can be influenced by the kinds of (non-epistemic) concerns that drive the Knobe effect. (...) Our findings suggest there is good reason to think that the epistemic version of the Knobe effect is a theoretically significant and robust effect, and that the goodness or badness of side-effects can often have greater influence on participant knowledge attributions than explicit information about objective probabilities. Thus, our work sheds light on important ways in which participant assessments of actions can affect the epistemic assessments participants make of agents? beliefs. (shrink)

The increasing interconnectedness of academic research and external industry has left research vulnerable to conflicts of interest. These conflicts have the potential to undermine the integrity of scientific research as well as to threaten public trust in scientific findings. The present effort sought to identify themes in the perspectives of faculty researchers regarding conflicts of interest. Think-aloud interview responses were qualitatively analyzed in an effort to provide insights with regard to appropriate ways to address the threat of conflicts of interest (...) in research. Themes in participant responses included disclosure of conflicts of interest, self-removal from situations where conflict exists, accommodation of conflict, denial of the existence of conflict, and recognition of complexity of situations involving conflicts of interest. Moral disengagement operations are suggested to explain the appearance of each identified theme. In addition, suggestions for best practices regarding addressing conflicts of interest given these themes in faculty perspectives are provided. (shrink)

Research misconduct is of growing concern within the scientific community. As a result, organizations must identify effective approaches to training for ethics in research. Previous research has suggested that biases and compensatory strategies may represent important influences on the ethical decision-making process. The present effort investigated a training intervention targeting these variables. The results of the intervention are presented, as well as a description of accompanying exercises tapping self-reflection, sensemaking, and forecasting and their differential effectiveness on transfer to an ethical (...) decision-making task. (shrink)

This cutting-edge book brings together eminent experts who propose ways to bridge cultural and developmental approaches to human psychology. The experts heed the call of cultural psychology to study different peoples around the world and to recognize that culture profoundly impacts how we think, feel, and act. At the same time, they also take seriously the developmental science perspective that humans everywhere share common life stage tasks and ways of learning. Doing what has not previously been done, the experts integrate (...) key insights and findings from cultural and developmental research. The result is a book brimming with new and creative syntheses for theory, research, and policy. This book is in step with a world where culturally diverse peoples interact with one another more than ever due to migration, worldwide media, and international trade and travel. With these interactions come changes to cultures and the psychological development of their members, and the implications for scholarship and policy are thoughtfully examined here. The book covers a wide range of related topics. It addresses the intersection of development and culture for psychological processes such as learning and memory, for key contexts of development such as family and civil society, for conceptions of self and identity, and for how the life course is partitioned including a focus on childhood and emerging adulthood.With its inclusion of diverse life phases, diverse topics, and experts from diverse disciplines and cultures, this volume speaks to a broad range of developmental and cultural issues. The synthesis of cultural and developmental approaches should be exciting and eye-opening to anyone with an interest in human psychology in today's global world. (shrink)

Ernst Cassirer Ernst Cassirer was the most prominent, and the last, Neo-Kantian philosopher of the twentieth century. His major philosophical contribution was the transformation of his teacher Hermann Cohen ’s mathematical-logical adaptation of Kant’s transcendental idealism into a comprehensive philosophy of symbolic forms intended to address all aspects of human cultural life and creativity. In … Continue reading Ernst Cassirer →.

The shared circuits model (SCM) is a useful explanatory framework that can be applied to interpersonal synchrony by incorporating temporal dynamics. Temporally precise predictive simulations and mirroring enable interpersonal synchrony. When partners' movements are highly synchronous, the self/other distinction can be blurred.

Thomas Nagel recognizes that it is commonly believed that people can neither be held morally responsible nor morally assessed for what is beyond their control. Yet he is convinced that although such a belief may be intuitively plausible, upon reflection we find that we do make moral assessments of persons in a large number of cases in which such assessments depend on factors not under their control. Of such factors he says: (p. 26).

Long‐range correlation is a general class of coordination pattern found to be common to the intrinsic dynamics of complex systems, including human behavior. Balasubramaniam, Hove, and Médé investigate intrinsic dynamics in repeated finger movements, and they find that different measures of movement dynamics yield different long‐range correlations. Results shed light on the way that coordination patterns are expressed as a function of measurement context.

Increasing interest in applying the theory and practice of deliberative democracy to new and varied political contexts leads us to ask whether or not deliberation is a universal political practice. While deliberation does manifest a universal competence, its character varies substantially across time and space, a variation partially explicable in cultural terms. We deploy an intersubjective conception of culture in order to explore these differences. Culture meets deliberation where publicly accessible meanings, symbols, and norms shape the way political actors engage (...) one another in discourse. Fuller understanding of political deliberation requires comparative and historical studies of particular contexts. We look at one case from Egypt in some depth and provide shorter illustrations from Botswana, Europe, India, Japan, Madagascar, the United States, Yemen, and elsewhere. Cross-cultural learning can enrich the theory of deliberative democracy, and give democratic theory a more universal reach. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Communicative Implications of Kant’s Aesthetic TheoryThomas HoveIn recent discussions of aesthetic theory, critics who raise social, cultural, and political concerns have issued important challenges to the Kantian legacy. Kant’s Critique of the Power of Judgment (1790) continues to be widely regarded as one of the founding documents of modern aesthetic theory. But the arguments he laid out in that notoriously enigmatic work remain controversial on a variety of fronts. (...) One of those arguments concerns his distinction between pleasures that are beautiful and those that are agreeable. According to Kant’s definition, what makes experiences of the beautiful special is that they have a potentially communicable universal validity. By contrast, pleasures that are merely agreeable are incommunicable and remain confined to private sensation. Philosophers have found this distinction problematic for a variety of reasons. Their detailed commentaries have examined the intricate logical and conceptual difficulties that Kant’s theory raises (see Allison 2001; Guyer 1982, 1997, 2002; Kalar 2000; Wenzel 2005). On another front, sociologists and cultural critics—whom I will broadly refer to as “social critics”—typically raise concerns about the theory’s hidden social implications (Bourdieu 1984; Eagleton 1990; Smith 1988; Shumway 2005). Specifically, they question Kant’s proposal that judgments about the beautiful ought to have universal validity. Taking an external standpoint, they tend to regard aesthetic judgments either as the peculiar habits of [End Page 103] specific social classes, or as badges of hierarchical distinction, or as weapons in symbolic struggles for cultural dominance.To suggest why Kant’s theory is worth revisiting in the wake of such critiques, the following analysis defends his theoretical effort to distinguish the experience of the beautiful from that of the agreeable. This feature of his aesthetic theory highlights an alternative to the cognitive and practical concerns that social critics emphasize. In particular, I indicate how Kant’s aesthetic theory offers directions for the effort to explain how aesthetic experience promotes communicative sociability. By emphasizing this theme, I hope to supplement the rival emphasis that social critics place on the Kantian legacy’s elitist undercurrents. Social critiques characteristically overlook the affective type of sociability to which aesthetic experience gives rise. This oversight occurs because those critiques tend to privilege the theoretical and practical dimensions of communication. In the process, they disregard the special types of validity claims that are unique to aesthetic discourse. Following the lead of his academic precursors Meier and Baumgarten, Kant tried to define a possible third mental “faculty” that differs from cognitive and practical reason (see Henrich 1992, 31–36). But the difficulty of defining this third faculty, much less determining its existence, continues to vex both philosophers and communication theorists.Kant’s Account of Aesthetic Experience and Its CriticsIn the opening sections of the Critique of Judgment, Kant attempts to establish the independence of aesthetic judgment from theoretical and practical cognition. Those faculties are concerned with cognitive and moral concepts. By contrast, the aesthetic properties that concern taste judgments have a unique ontological and epistemological status. Kant’s argument about that status is itself enormously complex, involving as it does an intricate network of idiosyncratically defined concepts (for example, the understanding, the imagination, intuition, representations, objects, etc.). But to avoid getting lost in those intricacies, we can bracket them by simply referring to aesthetic “experience.” Also, we can concentrate on the two properties that distinguish aesthetic experience from other kinds of experience. First, aesthetic properties relate to the feelings of pleasure that are aroused by certain encounters with objects. Second, aesthetic properties are “merely subjective” (Kant 2000, 75). They do not have an objective status because we cannot associate the feelings they arouse with determinate concepts and objects. [End Page 104] As Miles Rind puts it, “in making a cognitive judgment one requires everyone to conceptualize an object in a certain way, while in making a judgment of taste one requires others to share one’s liking for an object” (Rind 2000, 83). In sum, Kant differentiates aesthetic judgment from both theoretical and practical cognition because it is radically subjective and because its unique grounding lies in feelings of pleasure and displeasure.Social critics tend to downplay the idea that there... (shrink)

Anthony K. Jensen - Nietzsche's Life Sentence: Coming to Terms with Eternal Recurrence - Journal of the History of Philosophy 44:4 Journal of the History of Philosophy 44.4 671-672 Muse Search Journals This Journal Contents Reviewed by Anthony K. Jensen Emory University Lawrence J. Hatab. Nietzsche's Life Sentence: Coming to Terms with Eternal Recurrence. New York-London: Routledge, 2005. Pp. xix + 191. Paper, $24.95. In his latest book, Lawrence Hatab brings together several threads from his previous writing into (...) an elegant expression that examines a wide range of Nietzsche's thought through the single prism of his notoriously obscure conception of "Eternal Recurrence." The opening chapters establish the affirmation of becoming and the "tragic" view of the world (which Nietzsche had already articulated in his earliest.. (shrink)