MYC is a transcription factor, which not only directly modulates multiple aspects of transcription and co‐transcriptional processing (e.g. RNA‐Polymerase II initiation, elongation, and mRNA capping), but also indirectly influences several steps of RNA metabolism, including both constitutive and alternative splicing, mRNA stability, and translation efficiency. As MYC is an oncoprotein whose expression is deregulated in multiple human cancers, identifying its critical downstream activities in tumors is of key importance for designing effective therapeutic strategies. With this knowledge and recent technological advances, (...) we now have multiple angles to reach the goal of targeting MYC in tumors, ranging from the direct reduction of MYC levels, to the dampening of selected house‐keeping functions in MYC‐overexpressing cells, to more targeted approaches based on MYC‐induced secondary effects. (shrink)

The relationship between the neurobiology of speech and music has been investigated for more than a century. There remains no widespread agreement regarding how (or to what extent) music perception utilizes the neural circuitry that is engaged in speech processing, particularly at the cortical level. Prominent models such as Patel’s Shared Syntactic Integration Resource Hypothesis (SSIRH) and Koelsch’s neurocognitive model of music perception suggest a high degree of overlap, particularly in the frontal lobe, but also perhaps more distinct representations in (...) the temporal lobe with hemispheric asymmetries. The present meta-analysis study used activation likelihood estimate analyses to identify the brain regions consistently activated for music as compared to speech across the functional neuroimaging (fMRI and PET) literature. Eighty music and 91 speech neuroimaging studies of healthy adult control subjects were analyzed. Peak activations reported in the music and speech studies were divided into four paradigm categories: passive listening, discrimination tasks, error/anomaly detection tasks and memory-related tasks. We then compared activation likelihood estimates within each category for music versus speech, and each music condition with passive listening. We found that listening to music and to speech preferentially activate distinct temporo-parietal bilateral cortical networks. We also found music and speech to have shared resources in the left pars opercularis but speech-specific resources in the left pars triangularis. The extent to which music recruited speech-activated frontal resources was modulated by task. While there are certainly limitations to meta-analysis techniques particularly regarding sensitivity, this work suggests that the extent of shared resources between speech and music may be task-dependent and highlights the need to consider how task effects may be affecting conclusions regarding the neurobiology of speech and music. (shrink)

Spoken communication between social robotic devices, powered by generative AI tools such as ChatGPT, and the senior population offers great potential for researching social interaction and robot identity perceptions as well as exploring the potential opportunities and challenges when implementing this human-machine interactions in real life situations and health care. In this paper we explore people’s perceptions of the social robot Furhat when administering verbal tasks similar to those used in screening for Alzheimer’s disease. We describe the Slovak system mounted (...) on the robot that includes a speech recognizer, the scenarios powered by generative large language model ChatGPT, and a speech synthesizer. We tested the functionality of the proposed approach with two groups of participants: attendees of a large science fair and a scientific conference. The observations from 87 collected questionnaires suggest good potential and applicability of such an approach for the given task and more positive attitudes of older subjects compared to younger ones. (shrink)

Job motivation remains an area of concern among researchers due to the rising issues of poor or lack of motivation among workers. This refers to one’s personal will or drives to perform a task at work. Meanwhile, job satisfaction refers to an employee’s sense of fulfillment with his or her work experience. Therefore, the current study utilized the descriptive- correlational research design to investigate the impact of job motivation on the job satisfaction of accountants. To gather essential data and achieve (...) the objectives of the study, Multidimensional Work Motivational Scale (MWMS) and Minnesota Satisfaction Questionnaire (MSQ) were administered to the target respondents. The collected data were then analyzed using a Multiple Regression Analysis; findings revealed that job motivation has a significant impact on the job satisfaction of accountants. Additionally, the results of this study were carefully evaluated and discussed, and recommendations were made to benefit the stakeholders of the study and contribute to the existing body of knowledge. (shrink)

Jerry Fodor’s arguments against the possibility of concept learning, and the responses that have been offered in defense of the coherence of concept learning, have both by and large assumed that concept learning is a descriptive process. I offer an alternative, ostensive approach to concept learning and explain how descriptive concept learning can be explained as a version of ostensive concept learning. I argue that an ostensive view of concept learning offers an empirically plausible and philosophically adequate account of concept (...) learning that is explanatorily superior to traditional descriptive views. (shrink)

This paper aims to show that the Middle Platonists’ appeal to the Timaeus was grounded in a complex and effective philosophical reasoning: the Middle Platonists conceived of Plato’s text as a web of passages which Plato himself had carefully established. Only a few of them were granted a qualified priority, namely, those offering a complete and comprehensive philosophical account of the key elements which the Platonists regarded as fundamental. This will allow us to show that the Middle Platonists’ preference for (...) the Timaeus does not depend on the fact that it is systematic. Rather it is systematic insofar as it proves capable of giving context to passages from other dialogues and provides them with an account that is philosophically sound. (shrink)

Under the influence of the mysterious Ammonius Saccas, Plotinus conceived a desire to learn Persian and Indian philosophy firsthand. This led him to a romantic participation in the emperor Gordian's ill-fated Persian expedition. He managed to escape to Antioch and two years later began teaching in Rome.1 It is unlikely he was vouchsafed any contact with Hinduism or Buddhism,2 but the parallels between his thought and especially Buddhist philosophy are striking. The parallels with Buddhism are closer than with Hinduism since (...) Buddhism worked with three rather than two levels or substructures of reality,3 yet the Hindu connection has been more frequently explored by Neoplatonist scholars than the Buddhist.4... (shrink)

A partire dal corso al Collège de France L’ermeneutica del soggetto , l'analisi del complesso rapporto fra retorica e filosofia permette a Foucault di riformulare la questione della verità dal punto di vista delle pratiche di veridizione. Rispetto alla filosofia, la retorica è il modo d’essere altro del discorso attraverso il quale la parr ē sia può definirsi nella sua differenza costitutiva: la messa alla prova di una parola che sia “performance” creativa, una drammatica del vero come potenza di alterazione.

The concept of hermeneutic science is outlined by Habermas as a reflection within the ordinary language, addressed to the dialogic dimension of intersubjective recognition and connected to the juridical guarantee. The guarantee function fulfilled by the discursive agreement towards every real dialogue is obvious: it indicates the main reference point for the regulation and coordination of social action, tracing a line of demarcation between being and having to be, facts and norms. Speech, communicative agreement and legal guarantee are mutually qualified (...) terms where the public discussion of institutional issues makes it possible to define the normative validity as non-assimilatory generality, placed beyond any populistic yearning, tracing a line of demarcation between law and power. The idea of deliberative democracy expresses the relationship and distinction between the universalism of rights and the factuality of the norm issuing, between the idea of good and the idea of right, in order to support democratic decision-making legitimacy. Combining the reasons of the markets with those of civil solidarity, through independent forms of regulation both from the obsolete state sovereignties and from the traditional international perspectives, represents a primary challenge of the Habermasian theory where the critical role of the rational public sphere appears fundamental. (shrink)

Large Language Models (LLMs) could be a useful tool for lawyers. However, empirical research on their effectiveness in conducting legal tasks is scant. We study securities cases involving cryptocurrencies as one of numerous contexts where AI could support the legal process, studying GPT-3.5’s legal reasoning and ChatGPT’s legal drafting capabilities. We examine whether a) GPT-3.5 can accurately determine which laws are potentially being violated from a fact pattern, and b) whether there is a difference in juror decision-making based on complaints (...) written by a lawyer compared to ChatGPT. We feed fact patterns from real-life cases to GPT-3.5 and evaluate its ability to determine correct potential violations from the scenario and exclude spurious violations. Second, we had mock jurors assess complaints written by ChatGPT and lawyers. GPT-3.5’s legal reasoning skills proved weak, though we expect improvement in future models, particularly given the violations it suggested tended to be correct (it merely missed additional, correct violations). ChatGPT performed better at legal drafting, and jurors’ decisions were not statistically significantly associated with the author of the document upon which they based their decisions. Because GPT-3.5 cannot satisfactorily conduct legal reasoning tasks, it would be unlikely to be able to help lawyers in a meaningful way at this stage. However, ChatGPT’s drafting skills (though, perhaps, still inferior to lawyers) could assist lawyers in providing legal services. Our research is the first to systematically study an LLM’s legal drafting and reasoning capabilities in litigation, as well as in securities law and cryptocurrency-related misconduct. (shrink)

The article investigates the influence that the theological debates on divine grace have exercised on the evolution of Dante’s reflection on the relationship between nobility of the soul and natural predisposition, from the Vita nuova to the Commedia. If in his youthful work, commenting the sonnet Negli occhi porta la mia donna amore, Dante had attributed to Beatrice the ability to «induce Love in potentiality where he is not» (Vn. 12, 6) - an ability that Augustine’s doctrine of grace had (...) reserved to God -, in Le dolci rime d’amor and, above all, in the IV book of the Convivio, Dante affirms, with Guinizelli, the essential correlation between a «gentle heart» and love, that is to say the necessity of a natural predisposition for the purpose of possessing nobility, i. e. the divine «grace» (Cv. IV XX 7). Finally, in the Commedia, the poet returns to freeing God’s gift from any preventive natural disposition, as demonstrated not only by the repeated references to the twins Jacob and Esau, destined to opposite fates by virtue of the «grace» with which God «at his own pleasure endows each creature differently» (Pd. XXXII, vv. 65-6), but also by the XXX canto of Purgatorio, where Dante no longer appears uncertain whether to attribute his genius to a «good star» or to «a better thing» (If. XXVI, vv. 21-24), but clearly affirms its dependence on the «largess of celestial graces» (v. 112). (shrink)

The aim of this paper is to explore how the cosmic soul works and how it accomplishes its providential and demiurgic tasks in Chrysippus’ system. Drawing on (i) the analogy Chrysippus establishes between the individuum and the cosmos and (ii) biological and medical theories of respiration, digestion, and pulse, I will show that the movements of Chrysippus’ cosmic soul reproduce the processes of digestion, pulse, and respiration at a cosmic level. My claim is that Chrysippus, in addition to adopting Praxagoras’ (...) notion that inhaled air nourishes pneuma—well established in the scholarship—appropriated Aristotle’s complex mechanism of respiration and digestion based on the teleological role of cold air, crucial for preserving vital heat. So understood, Chrysippus’ application of biological notions to cosmology allows him to endow the active principle with effective causation throughout the cosmos. (shrink)

The paper presents different clustering approaches in legal judgments from the Special Civil Court located at the Federal University of Santa Catarina. The subject is Consumer Law, specifically cases in which consumers claim moral and material compensation from airlines for service failures. To identify patterns from the dataset, we apply four types of clustering algorithms: Hierarchical and Lingo, K-means and Affinity Propagation. We evaluate the results based on the following criteria: entropy and purity; algorithm's ability in providing labels; legal expert’s (...) evaluation; and experimental complexity. The results demonstrate that the most advantageous approach is Hierarchical Clustering, since it has the best entropy and purity numbers, as well as the least difficulty for the expert to analyze the clusters, and the least experimental complexity. The main contribution of the paper is to show the advantages and disadvantages of each approach, especially to identify labels in unstructured and non-indexed legal texts. (shrink)

What is the relationship between inquiry and epistemology? Are epistemic norms the norms that guide us as inquirers—as agents in the pursuit of knowledge and understanding? Recently, there has been growing support for what I, following Friedman (Philosophical Review 129(4):501–536, 2020), will call the zetetic turn in epistemology, the view that all epistemic norms are norms of inquiry. This paper investigates the prospects of an inquiry-centered approach to epistemology and develops several motivations for resisting it. First, I argue that the (...) norms of inquiry are most plausibly seen as practical, not as distinctively epistemic. Second, I argue that a zetetically-grounded epistemology is unable to properly account for the rationality of belief. It fails to account for cases where intuitively irrational beliefs promote inquiry, or where intuitively rational beliefs are zetetically useless or counterproductive to inquiry. The main upshot is this: there must be a source of epistemic normativity that isn’t ultimately zetetic. (shrink)

Much of the recent work on epistemology of inquiry defends two related theses. First, inquiry into a question rationally prohibits believing an answer to that question. Second, knowledge is the aim of inquiry. I develop a series of cases which indicate that inquiry is not as narrow as these views suggest. These cases can be accommodated if we take a broader approach and understand inquiry as aiming at epistemic improvement, described more generally. This approach captures a wider range of inquiring (...) phenomena because it accounts for forms of epistemic improvement that fall short of, or go beyond, coming to know the answer to a question. (shrink)

This article develops a new approach for theorizing about hermeneutical injustice. According to a dominant view, hermeneutical injustice results from a hermeneutical gap: one lacks the conceptual tools needed to make sense of, or to communicate, important social experience, where this lack is a result of an injustice in the background social methods used to determine hermeneutical resources. I argue that this approach is incomplete. It fails to capture an important species of hermeneutical injustice which doesn’t result from a lack (...) of hermeneutical resources, but from the overabundance of distorting and oppressive concepts which function to crowd-out, defeat, or preempt the application of a more accurate hermeneutical resource. I propose a broader analysis that better respects the dynamic relationship between hermeneutical resources and the social and political contexts in which they are implemented. (shrink)

A puzzle arises when combining two individually plausible, yet jointly incompatible, norms of inquiry. On the one hand, it seems that one shouldn’t inquire into a question while believing an answer to that question. But, on the other hand, it seems rational to inquire into a question while believing its answer, if one is seeking confirmation. Millson (2021), who has recently identified this puzzle, suggests a possible solution, though he notes that it comes with significant costs. I offer an alternative (...) solution, which doesn’t involve these costs. The best way to resolve the puzzle is to reject the prohibition on inquiring into a question while believing an answer to it. Resolving the puzzle in this way makes salient two fruitful areas in the epistemology of inquiry which merit further investigation. The first concerns the nature of the inquiring attitudes and the second concerns the aim(s) of inquiry. (shrink)

Throughout more than two millennia philosophers adhered massively to ideal standards of scientific rationality going back ultimately to Aristotle’s Analytica posteriora. These standards got progressively shaped by and adapted to new scientific needs and tendencies. Nevertheless, a core of conditions capturing the fundamentals of what a proper science should look like remained remarkably constant all along. Call this cluster of conditions the Classical Model of Science. In this paper we will do two things. First of all, we will propose a (...) general and systematized account of the Classical Model of Science. Secondly, we will offer an analysis of the philosophical significance of this model at different historical junctures by giving an overview of the connections it has had with a number of important topics. The latter include the analytic-synthetic distinction, the axiomatic method, the hierarchical order of sciences and the status of logic as a science. Our claim is that particularly fruitful insights are gained by seeing themes such as these against the background of the Classical Model of Science. In an appendix we deal with the historiographical background of this model by considering the systematizations of Aristotle’s theory of science offered by Heinrich Scholz, and in his footsteps by Evert W. Beth. (shrink)

According to Vallicella's 'Relations, Monism, and the Vindication of Bradley's Regress' (2002), if relations are to relate their relata, some special operator must do the relating. No other options will do. In this paper we reject Vallicella's conclusion by considering an important option that becomes visible only if we hold onto a precise distinction between the following three feature-pairs of relations: internality/externality, universality/particularity, relata-specificity/relata-unspecificity. The conclusion we reach is that if external relations are to relate their relata, they must be (...) relata-specific (and no special operator is needed). As it eschews unmereological complexes, this outcome is of relevance to defenders of the extensionality of composition. (shrink)

An analysis of theological and philosophical understandings of debt and its role in contemporary capitalism. Max Weber’s account of the rise of capitalism focused on his concept of a Protestant ethic, valuing diligence in earning and saving money but restraint in spending it. However, such individual restraint is foreign to contemporary understandings of finance, which treat ever-increasing consumption and debt as natural, almost essential, for maintaining the economic cycle of buying and selling. In The Debt of the Living, Elettra Stimilli (...) returns to this idea of restraint as ascesis, by analyzing theological and philosophical understandings of debt drawn from a range of figures, including Saint Paul, Schmitt and Agamben, Benjamin and Marx, Nietzsche and Freud, and Foucault. Central to this analysis is the logic of “profit for profit’s sake”—an aspect of Weber’s work that Stimilli believes has been given insufficient attention. Following Foucault, she identifies this as the original mechanism of a capitalist dispositif that feeds not on a goal-directed rationality, but on the self-determining character of human agency. Ascesis is fundamental not because it is characterized by renunciation, but because the self-discipline it imposes converts the properly human quality of action without a predetermined goal into a lack, a fault, or a state of guilt: a debt that cannot be settled. Stimilli argues that this lack, which is impossible to fill, should be seen as the basis of the economy of hedonism and consumption that has governed global economies in recent years and as the premise of the current economy of debt. Elettra Stimilli is research fellow of theoretical philosophy at Scuola Normale Superiore in Pisa, Italy. Arianna Bove is the translator of many books, including Factory of Strategy: Thirty-Three Lessons on Lenin, by Antonio Negri. (shrink)

Is it necessary to contrast the spreading process of genetic engineering in the agri-food stuff sector? Can EU rules really consider the impact of this brand new technologies on biology and, consequently, on public health? Despite the general trend, a firm opposition is what is happening in some Regions of Italy, where GMOs production and placing on the market are foibidden.

The new scientific acquisitions are numerous and even more are their future promises. The debate on bio-technologies involves the fundamental rights of the individual and the advancements in research must merge with the supremacy of the human being on the interests both of the ‘science’ and of society at large. In the attempt to combine ‘democracy’ with techno-scientific issues, Law has turned from pure technical rules (meant to reflect, without any critique, some knowledge) into a tool meant to fill cognitive (...) gaps and its role is showing to be not only crucial, but also innovative for legal professionals themselves. (shrink)

Predictive genetic testing for susceptibility to psychiatric conditions is likely to become part of standard practice. Because the onset of most psychiatric diseases is in late adolescence or early adulthood, testing minors could lead to early identification that may prevent or delay the development of these disorders. However, due to their complex aetiology, psychiatric genetic testing does not provide the immediate medical benefits that current guidelines require for testing minors. While several authors have argued non-medical benefits may play a crucial (...) role in favour of predictive testing for other conditions, little research has explored such a role in psychiatric disorders. This paper outlines the potential non-medical benefits and harms of psychiatric genetic testing in minors in order to consider whether the non-medical benefits could ever make such testing appropriate. Five non-medical themes arise in the literature: psychological impacts, autonomy/self-determination, implications of the biomedical approach, use of financial and intellectual resources, and discrimination. Non-medical benefits were prominent in all of them, suggesting that psychiatric genetic testing in minors may be appropriate in some circumstances. Further research needs to empirically assess these potential non-medical benefits, incorporate minors in the debate, and include normative reflection to evaluate the very purposes and motivations of psychiatric genetic testing in minors. (shrink)

According to Vallicella's‘Relations, Monism, and the Vindication of Bradley's Regress’ , if relations are to relate their relata, some special operator must do the relating. No other options will do. In this paper we reject Vallicella's conclusion by considering an important option that becomes visible only if we hold onto a precise distinction between the following three feature‐pairs of relations: internality/externality, universality/particularity, relata‐specificity/relata‐unspecificity. The conclusion we reach is that if external relations are to relate their relata, they must be relata‐specific (...) . As it eschews unmereological complexes, this outcome is of relevance to defenders of the extensionality of composition. (shrink)

What are the most useful lenses to wear and from which positioning is most effective to speak today, in order to answer the need for a paradigm shift within the critical thinking concerning the culture of Capitalism? An increasing number of authors support an interdisciplinary approach carried out, not only in academic environments, by political ecology and ecofeminism, connecting the critique of capitalism with that of patriarchy, and re-establishing a relationship between theory and praxis, in which the latter produces knowledge (...) through embodied experience. The following article agrees with this hypothesis, but its aim is not so much to delineate the contours of what feminist political ecology is and what new conceptual categories it introduces, but to understand instead what is the dialectical necessity that produces this approach and what it distances itself from. To do so, I will use the process of resignifying the category of vulnerability in the contemporary feminist debate in the poststructuralist approach, as an antithetical example to the feminist political ecology lens and posture. The aim is to begin paving an autonomous path for this critical matter, beginning by delineating the antagonism toward poststructural feminism as one of the conflicts which produces it. (shrink)

Twenty years after the outbreak of the threat posed by international jihadist terrorism, which triggered the need for democracies to balance fundamental rights and security needs, 9/11 and the Rise of Global Anti-Terrorism Law offers an overview of counter-terrorism and of the interplay among the main actors involved in the field since 2001. This book aims to give a picture of the complex and evolving interaction between the international, regional and domestic levels in framing counter-terrorism law and policies. Targeting scholars, (...) researchers and students of international, comparative and constitutional law, it is a valuable resource to understand the theoretical and practical issues arising from the interaction of several levels in counter-terrorism measures. It also provides an in-depth analysis of the role of the United Nations Security Council. (shrink)

Recent pragmatic accounts of slurs argue that the offensiveness of slurs is generated by a speaker's free choice to use a slur opposed to a more appropriate and semantically equivalent neutral counterpart. I argue that the theoretical role of neutral counterparts on such views is overstated. I consider two recent pragmatic analyses, Bolinger (Noûs, 51, 2017, 439) and Nunberg (New work on speech acts, Oxford University Press, 2018), which rely heavily upon the optionality of slurs, namely, that a speaker exercises (...) a deliberate lexical choice to use a slur when they could have easily used a neutral counterpart instead. Against such views, I argue that across a range of different offensive uses of slurs, a speaker's choice to use a slur opposed to a neutral counterpart plays little to no role in accounting for why the slur generates offence. Such cases cast serious doubt upon the explanatory depth of these pragmatic analyses, and raise more general concerns for views which draw upon the relationship between a slur and its neutral counterpart. The main upshot is this: theorists should exercise caution in assuming that neutral counterparts play any fundamental or systemic role in explaining why slurs are offensive. (shrink)

The production, manipulation and exploitation of future visions are increasingly important elements in practices of visioneering socio-technical processes of innovation and transformation. This becomes obvious in new and emerging science and technologies and large-scale transformations of established socio-technical systems. A variety of science and technology studies provide evidence on correlations between expectations and anticipatory practices with the dynamics of such processes of change. Technology assessment responded to the challenges posed by the influence of visions on the processes by elaborating methodologies (...) for a “vision assessment” as a contribution to what is now increasingly known as “hermeneutical TA”. But until now, the practical functions of visions in the processes have not been explained in a way that satisfies the empirical needs of TA’s vision assessment—that is to provide future-oriented knowledge based on the analysis of ongoing changes in the present without knowing the future outcomes. Our leading hypothesis is that we can only understand the practical roles of visions in current processes if we analyse them as socio-epistemic practices which simultaneously produce new knowledge and enable new social arrangements. We elaborate this by means of two cases: the visions of In Vitro meat and of the smart grid. Here, we interpret visioneering more in its collective dimension as a contingent and open-ended process, emerging from heterogeneous socio-epistemic practices. This paper aims at improving TA’s vision assessments and related STS research on visionary practices for real-time analysis and assessments. (shrink)

An argument that the major metaphysical theories of facts give us no good reason to accept facts in our catalog of the world. -/- In this book Arianna Betti argues that we have no good reason to accept facts in our catalog of the world, at least as they are described by the two major metaphysical theories of facts. She claims that neither of these theories is tenable—neither the theory according to which facts are special structured building blocks of (...) reality nor the theory according to which facts are whatever is named by certain expressions of the form “the fact that such and such.” There is reality, and there are entities in reality that we are able to name, but, Betti contends, among these entities there are no facts. -/- Drawing on metaphysics, the philosophy of language, and linguistics, Betti examines the main arguments in favor of and against facts of the two major sorts, which she distinguishes as compositional and propositional, giving special attention to methodological presuppositions. She criticizes compositional facts (facts as special structured building blocks of reality) and the central argument for them, Armstrong's truthmaker argument. She then criticizes propositional facts (facts as whatever is named in “the fact that” statements) and what she calls the argument from nominal reference, which draws on Quine's criterion of ontological commitment. Betti argues that metaphysicians should stop worrying about facts, and philosophers in general should stop arguing for or against entities on the basis of how we use language. (shrink)

Digital Humanities is a research field engaged in exploring how humanities scholarship is transformed and extended by the digital and vice versa. The core practice of DH research is modelling which implies the translation of complex systems of knowledge into computationally processable models. In our work we contextualise DH practices within a semiotic framework; namely we consider modelling as a strategy to make sense via practical thinking. A semiotic approach of this kind contributes to stress the dynamic nature of models (...) and modelling, and to reinstate in renewed terms the understanding of modelling as open process of signification enacting a triadic cooperation. Referring to Peirce classification of hypoicons, we reflect on some DH examples of modelling in the form of images, diagrams and metaphors, claiming that a semiotic understanding of modelling could ultimately allow us to surpass the duality object versus model. We thus propose to consider modelling as a creative and highly pragmatic process of thinking and reasoning in which metaphors assume a central role and where meaning is negotiated through the creation and manipulation of external representations combined with an imaginative use of formal and informal languages. (shrink)

Cultural code-switching concerns how we adjust our overall behaviours, manners of speaking, and appearance in response to a perceived change in our social environment. We defend the need to investigate cultural code-switching capacities in artificial intelligence systems. We explore a series of ethical and epistemic issues that arise when bringing cultural code-switching to bear on artificial intelligence. Building upon Dotson’s (2014) analysis of testimonial smothering, we discuss how emerging technologies in AI can give rise to epistemic oppression, and specifically, a (...) form of self-silencing that we call “cultural smothering.” By leaving the sociodynamic features of cultural code-switching unaddressed, AI systems risk negatively impacting already-marginalised social groups by widening opportunity gaps and further entrenching social inequalities. (shrink)

Nurses die by suicide at a higher rate than the general population. Previous studies have observed mental health problems, including substance use, as a prominent antecedent before death. The purpose of this study was to explore the characteristics of nurses who died by suicide documented in the death investigation narratives from the National Violent Death Reporting System from 2003 to 2017 using thematic analysis and natural language processing. One thousand three hundred and fifty‐eight subjects met these inclusion criteria. Narratives from (...) 601 subjects were thematically analyzed and 2544 individual narratives were analyzed using natural language processing. The analyses revealed five themes: “mental health treatment,” “poor general health and chronic pain,” “substance use,” “worsening mental health after bereavement,” and “repeating a family member's suicide.” Mental health/substance use, chronic illness, and chronic pain were seen to coexist in a complex, interdependent manner that appeared to be entangled in the nurses' narratives before death. These findings echo the need for reducing the stigmatization of mental health problems in nursing and removing barriers to help‐seeking behaviors as early preventative interventions. Future research is needed to determine if a comprehensive healthcare integration approach to address these entangled problems would reduce suicide vulnerability in nurses and improve their quality of life. (shrink)

Les explications de ce pourquoi mentir est mal sont toutes inadéquates. Leur problème commun se situe dans leur structure unitaire. Ces analyses présupposent que tous les mensonges sont mauvais pour la même raison unificatrice. Cette supposition ne rend cependant pas justice au phénomène du mensonge, et ce, parce qu’on peut s’objecter à l’acte de mentir de différentes façons. Ainsi je suggère qu’il faut un changement dialectique en direction d’un traitement pluraliste de ce qui est mauvais dans le mensonge. Il ne (...) faut pas forcer une unité sur la structure morale du mensonge lorsqu’il y a en fait pluralité. (shrink)

Since it is now broadly acknowledged that ethics should receive early consideration in discourse on emerging technologies, ethical debates tend to flourish even while new fields of technology are still in their infancy. Such debates often liberally mix existing applications with technologies in the pipeline and far-reaching visions. This paper analyses the problems associated with this use of ethics as “preparatory” research, taking discourse on human enhancement in general and on pharmaceutical cognitive enhancement in particular as an example. The paper (...) will outline and discuss the gap between the scientific and technological state of the art and the ethical debates, pointing out epistemic problems in this context. Furthermore, it will discuss the future role of genuine ethical reflection in discourse on human enhancement, arguing also that such discourse needs to include a technology assessment—in the broad sense of the term—which encompasses, inter alia, anthropological perspectives and aspects of social theory. (shrink)