In the nineteenth and early twentieth centuries, scientific and technological developments made surgery safer, more reliable, and, with the corresponding increase in experimentation permitted, more exploratory and successful than ever before. The age of the heroic surgeon, however, obscured procedures that relied on the patient’s cooperation for a final, positive outcome. This essay focuses on the debates surrounding cleft palate surgery in Britain, Europe, and North America between about 1800 and 1930, where the constancy of failure dogged the (...) surgeon, even with improved operative surroundings. Although an anatomical correction could eventually be secured by surgery, without the patient’s participation in learning “normal” speech, the ultimate result was unsuccessful. Patient responsibility and self-control became, therefore, the key to success. By exploring what this meant for patients, their families, and surgeons, a new way of thinking about surgical outcomes, even during a period of increasing confidence in surgery, can be posited. -/- . (shrink)

The improvement of ultrasound scan techniques is enabling ever earlier prenatal diagnosis of developmental anomalies. In France, apart from cases where the mother’s life is endangered, the detection of “particularly serious” conditions, and conditions that are “incurable at the time of diagnosis” are the only instances in which a therapeutic abortion can be performed, this applying up to the 9th month of pregnancy. Thus numerous conditions, despite the fact that they cause distress or pain or are socially disabling, do not (...) qualify for therapeutic abortion, despite sometimes pressing demands from parents aware of the difficulties in store for their child and themselves, in a society that is not very favourable towards the integration and self-fulfilment of people with a disability. Cleft lip and palate (CLP), although it can be completely treated, is one of the conditions that considerably complicates the lives of child and parents. Nevertheless, the recent scope for making very early diagnosis of CLP, before the deadline for legal voluntary abortion, has not led to any wave of abortions. CLP in France has the benefit of a exceptional care plan, targeting both the health and the integration of the individuals affected. This article sets out, via the emblematic instance of CLP, to show how present fears of an emerging “domestic” or liberal eugenic trend could become redundant if disability is addressed politically and medically, so that individuals with a disability have the same social rights as any other citizen. (shrink)

ObjectivePregnancy leads to long-lasting changes in brain structure for healthy women; however, little is known regarding alterations in the cortical features of pregnant women with malformed fetuses. Isolated clefts of the lip and/or palate (ICL/P) are the most common congenital anomaly in the craniofacial region, which is highly gene-associated. We speculated that pregnant women carrying fetuses with ICL/P may have associated risk genes and specific brain changes during pregnancy.MethodsIn this study, we investigated T1-weighted brain magnetic resonance imaging data from (...) 48 pregnant women: 24 women carrying fetuses with ICL/P (ICL/P group) and 24 women carrying normal fetuses (normal controls), then explored intergroup differences in gray matter volume (GMV), cortical thickness (CT) and cortical complexity (gyrification).ResultsCompared with controls, the ICL/P group had decreased total intracranial volume (TIV) than normal controls; besides, they exhibited increased GMV in the left cuneus, decreased GMV in the right superior temporal gyrus; increased CT in the left precuneus and left superior parietal gyrus, decreased CT involving parsopercularis, fusiform, middle temporal in the left hemisphere and supramarginal, precentral gyrus (PreCG) in the right hemisphere; increased gyrification in the left insula and PreCG, the left middle temporal, and the right supratemporal gyrus.ConclusionPregnant women with ICL/P fetuses had brain morphology changes involving language, auditory, vision, and sensory cortex, which may be their special brain changes compared to normal pregnant women. This study may provide clues for the early detection of fetuses with ICL/P, and be vital for preconception and prenatal counseling with non-invasive methods. (shrink)

Since the end of the Second World War, the Australasian economies have fared poorly relative both to the high-income states of western Europe and North America and to the `miracle' economies strung along the Pacific coasts of Asia. This article attempts to analyze the post-war trajectories of antipodean economies in the context of the reconstruction of the world market under US hegemony after the end of the Second World War. The first section traces the rise of Japan and the emergence (...) of Pacific Asia as a consolidated nexus of densely interwoven patterns of relational networks. The second section examines how ongoing processes of capitalist restructuring undermined the Asian miracle economies. Finally, the last section seeks to analyze the causes for the disproportionately adverse impact that processes of worldwide transformation have had for the two antipodean settler states. (shrink)

I am currently caring for a child named Priscilla who is ventilator-dependent and whose care confronted me with questions of justice. Priscilla was born at the County Hospital after a normal pregnancy to a 17-year-old single mother. At birth, she was noted to have some dysmorphic features: widely spaced eyes, low-set ears, and a cleft palate. Her chest X-ray showed hypoplastic ribs and scapulae. Her chromosome studies were normal. Eventually, a diagnosis of a rare dwarfing syndrome campomelic dysplasia (...) – was made. (shrink)

We propose a biochemical mechanism for celiac disease and non‐celiac gluten sensitivity that may rationalize many of the extradigestive disorders not explained by the current immunogenetic model. Our hypothesis is based on the homology between the 33‐mer gliadin peptide and a component of the NMDA glutamate receptor ion channel – the human GRINA protein – using BLASTP software. Based on this homology the 33‐mer may act as a natural antagonist interfering with the normal interactions of GRINA and its partners. The (...) theory is supported by numerous independent data from the literature, and provides a mechanistic link with otherwise unrelated disorders, such as cleft lip and palate, thyroid dysfunction, restless legs syndrome, depression, ataxia, hearing loss, fibromyalgia, dermatitis herpetiformis, schizophrenia, toxoplasmosis, anemia, osteopenia, Fabry disease, Barret's adenocarcinoma, neuroblastoma, urinary incontinence, recurrent miscarriage, cardiac anomalies, reduced risk of breast cancer, stiff person syndrome, etc. The hypothesis also anticipates better animal models, and has the potential to open new avenues of research. (shrink)

Surgery is an important part of health care worldwide. Without access to surgical treatments, morbidity and mortality increase. Access to surgical treatment is a significant problem in global public health because surgical services are not equally distributed in the world. There is a disproportionate scarcity of surgical access in low-income countries. There are many charitable organizations around the world that sponsor surgical missions to under served nations. One such organization is Operation Smile International, a group with which both authors have (...) volunteered. This paper will describe the purpose and processes involved in Operation Smile and identify some of the key ethical issues that arise in short term medical volunteer work highlighting the importance of sustainability. (shrink)

O estudo caracterizou a clientela atendida em um serviço interdisciplinar de atendimento aos portadores de fissura labial e/ou palatal numa cidade de porte médio, destacando o perfil sociodemográfico, o tipo de fissura, o histórico do atendimento e a situação psicossocial. O método adotado foi o doc..

Introduction -- The syntax of English clefts -- Clefts and the licensing of relative clauses -- Clefts in Slavonic languages -- The syntax of specificational sentences -- Conclusion.

Plant-based milk alternatives–or mylks–have surged in popularity over the past ten years. We consider the politics and consumer subjectivities fostered by mylks as part of the broader trend towards ‘plant-based’ food. We demonstrate how mylk companies inherit and strategically deploy positive framings of milk as wholesome and convenient, as well as negative framings of dairy as environmentally damaging and cruel, to position plant-based as the ‘better’ alternative. By navigating this affective landscape, brands attempt to make mylk as simultaneously palatable and (...) disruptive to the status quo. We examine the politics of mylks through the concept of palatable disruption, where people are encouraged to care about the environment, health, and animal welfare enough to adopt mylks but to ultimately remain consumers of a commodity food. By encouraging consumers to reach for “plant-based” as a way to cope with environmental catastrophe and a life out of balance, mylks promote a neoliberal ethic: they individualize systemic problems and further entrench market mechanisms as solutions, thereby reinforcing the political economy of industrial agriculture. In conclusion, we reflect on the limits of the current plant-based trend for transitioning to more just and sustainable food production and consumption. (shrink)

It is often believed that attentional bias for food is a stable trait of certain groups, like restrained eaters. However, empirical evidence from this domain is inconsistent. High-calorie foods are double-faceted, as they are both a source of reward and of weight/health concern. Their meaning might depend on the food-related context, which in turn could affect AB for food. This study primed 85 females with hedonic, healthy, and neutral contexts successively and examined whether food-related context affected AB for food and (...) if effects were moderated by dietary restraint. Both the mean tendencies of AB for food and variability of AB for food were assessed in a food dot-probe task with a recording of both reaction times and eye movements. Contrary to our hypotheses, AB for food was not significantly affected by either context or the interaction between context and dietary restraint. Instead, liking of the presented food stimuli was related to longer initial fixations and longer dwell time on the food stimuli. In addition, in line with prior research, body mass index was correlated with variability of AB for food instead of mean AB for food. In conclusion, this study did not find any support that AB for food is dependent on food-related context, but interestingly, reaction time-based variability of AB for food seems to relate to BMI, and eye movement-based mean AB seems to relate to appetitive motivation. (shrink)

The paper examines Pierre Bourdieu’s extensive writings on the production of scientific knowledge. The study shows that Bourdieu offered not one but two - significantly different - approaches to scientific knowledge production, one formulated in his theoretical, or programmatic, writings on the subject, the other developed in his empirical writings. Addressing the question as to the relevance of Bourdieu’s work for science studies, the analysis argues that the former of these two approaches is at once very visible in Bourdieu’s work (...) but characterized by limitations from the standpoint of scholarship in STS, whereas the latter approach is less conspicuous but of broader empirical value. (shrink)

This pretty little work of the obscure Tymnes has recently been examined by A. Wilhelm in the course of a learned attempt to explain the puzzling phrase πολλ πολλν . With the result of his research in general I am not now concerned and the interpretation of this epigram does not greatly affect the value of his conclusions; but it seems worth while to point out what I believe to be the right explanation of a curious and much-emended phrase in (...) the second couplet. (shrink)

To the instances of non-syllabic ε after -ιλ- or -υλ- which were given in Class. Quart. XVII. 196 , two more may be added: Σιλεωνας, Kaibel, Epigrammata Graeca 783 , occurs in a trochaic line, and is scanned Cup – Cup –. Kaibel calls it a ‘nomen suspectum’; but in the re-edition in Anc. Gr.Inscr.in the British Museum, No. 796, the reading is defended by a comparison with Σιλνιος in C.I.G. 1577. 3 = I.G. 7. 2429.

Scholars have long debated the relationship between morality and the market. Some argue that morality tempers market interests, while others argue that the market has its own moral order. Meanwhile, feminist scholars have argued that a false binary between altruism, family, and intimacy on the one hand, and the cold calculus of the market on the other, is based in gender ideologies. Norms around motherhood, in particular, emphasize self-sacrifice, love, and altruism in opposition to self-interested market logics. Commercial surrogacy blurs (...) the line between family and commerce and is therefore an ideal setting for studying tensions between altruism and profit. Drawing on ethnographic research and interviews with 114 actors in the Mexican surrogacy industry, I demonstrate that treating altruism and commercialism as dichotomous can further market interests by preserving the moral palatability and profitability of the industry while perpetuating power asymmetries rooted in gender, race, class, and nationality between surrogate mothers and intended parents. (shrink)

Upshot: This is a book for thoughtful science and mathematics teachers and curriculum developers and educational philosophers. Quale helps us to challenge pernicious received “truths‘ and offers us intriguing perspectives, valuable discourse ventures and practical paedagogic strategies to engage the youth of today who are turning away from science in droves, to their and our cost.

Pseudo-clefts are the building blocks of coherent discourse progression and serve as a rhetorical toolkit to construct an authorial stance in the academic discourse. Despite an increasing interest in grammatical constructions in the academic discourse, researchers have not treated pseudo-clefts in much detail. This paper explores the features of pseudo-clefts in the corpus of academic discourse in the field of applied linguistics. Here, we take the textual and the interpersonal perspectives, focusing on the use of pseudo-clefts in terms of their (...) distribution in generic structure, discourse functions with reference to clefted constituents, and evaluative meaning. The results show that pseudo-clefts were more frequently used in “Results and Discussion” and Literature Review, performing the functions such as the specification of key terms, generalization of the literature, the description and explanation of findings, etc. They are facilitative in creating information gaps and establishing a logic-semantic expansive relationship between the clauses. The findings also suggest that the pseudo-clefts are evaluative devices and are involved in the construction of authorial identities. (shrink)

Background Inadequate knowledge among health care providers (HCPs) and parents of affected children limits the understanding and utility of secondary genetic findings (SFs) in under-represented populations in genomics research. SFs arise from deep DNA sequencing done for research or diagnostic purposes and may burden patients and their families despite their potential health importance. This study aims to evaluate the perspective of both groups regarding SFs and their choices in the return of results from genetic testing in the context of orofacial (...) clefts.Methods Using an online survey, we evaluated the experiences of 252 HCPs and 197 parents across participating cleft clinics in Ghana and Nigeria toward the return of SFs across several domains.Results Only 1.6% of the HCPs felt they had an expert understanding of when and how to incorporate genomic medicine into practice, while 50.0% agreed that all SFs should be returned to patients. About 95.4% of parents were willing to receive all the information from genetic testing (including SFs), while the majority cited physicians as their primary information source (64%).Conclusions Overall, parents and providers were aware that genetic testing could help in the clinical management of diseases. However, they cited a lack of knowledge about genomic medicine, uncertain clinical utility, and lack of available learning resources as barriers. The knowledge gained from this study will assist with developing guidelines and policies to guide providers on the return of SFs in sub-Saharan Africa and across the continent. (shrink)

Constructions marking information structure in French have been widely documented within the constructionist framework. C’est ‘it is’ clefts have been demonstrated to express the focus of the sentence. Nevertheless, it remains unclear how children are able to acquire clefts, and how they develop information structure categories. The aim of this study is to investigate the acquisition of clefts in French through the usage-based framework, to understand whether IS categories emerge gradually like other linguistic categories, and how children build IS categories. (...) For this, I analysed 256 c’est-clefts produced by three children between age 2 and 3. I show that most early clefts are produced by children with the chunk c’est moi associated with the concrete function of requesting to perform an action themselves. This chunk then becomes a frame with slot, extending the function to other human referents and discourse participants with the function of requesting adults to perform an action. Another large portion of early clefts seems to belong to a frame with slot c’est X whose function is to identify the agent who carried out an action. These findings suggest that the information structure category of focus emerges gradually. (shrink)

The ideology of ‘purity’, normalcy and hierarchy through food and its relations is a postcolonial, feminist, queer issue. In an increasingly intolerant Hindutva political climate in India, a politics of enforced vegetarianism-based-purity as a mark of authenticity and ideal national identity intersects with liberalisation of the economy and globalisation of tastes to produce complex hierarchies of taste and ideas of culinary belonging. Given that literary and other cultural products can play an influential role in issues of social change, my paper (...) critically investigates how queer contemporary anglophone Indian fiction reworks dominant attitudes towards abjection through consumption, queering the approach to disgust as a stable marker of unbelonging in the contexts of postcoloniality and the transnational. Specifically, I examine approaches to abjection through food and discuss transgression through food as a postcolonial re-reading of disgust-based politics and aesthetics in two novels: The Boyfriend (2003) by author and gay-activist R. Raj Rao, and A Life Apart (2010) by writer-reviewer Neel Mukherjee—both of whom are part of an emerging group of authors writing in English and explicitly dealing with male same-sex desire in the subcontinent and the diaspora. Using a transnational and intersectional queer feminist lens on disgust and queering through food, I discuss how by challenging the hidden codes of a disgust-based gastro-politics and aesthetics in culture, The Boyfriend and A Life Apart reveal new spaces of sovereignty and self-expression in the everyday. In the process, I show how they provide fresh positions of resistance and subjectivity that complicate narrow ideas of belonging—national, diasporic and bodily—the production of which becomes crucial in the context of carving out a transnational queer (gastro) aesthetics and politics. (shrink)

There is an active debate within the field of phonology concerning the cognitive status of substantive phonetic factors such as ease of articulation and perceptual distinctiveness. A new framework is proposed in which substance acts as a bias, or prior, on phonological learning. Two experiments tested this framework with a method in which participants are first provided highly impoverished evidence of a new phonological pattern, and then tested on how they extend this pattern to novel contexts and novel sounds. Participants (...) were found to generalize velar palatalization (e.g., the change from [k] as in keep to [t⌢∫S] as in cheap) in a way that accords with linguistic typology, and that is predicted by a cognitive bias in favor of changes that relate perceptually similar sounds. Velar palatalization was extended from the mid front vowel context (i.e., before [e] as in cape) to the high front vowel context (i.e., before [i] as in keep), but not vice versa. The key explanatory notion of perceptual similarity is quantified with a psychological model of categorization, and the substantively biased framework is formalized as a conditional random field. Implications of these results for the debate on substance, theories of phonological generalization, and the formalization of similarity are discussed. (shrink)

The article applies selected concepts from the writings of Julia Kristeva to the analysis of a novel by Doris Lessing entitled The Cleft. Published in 2007, The Cleft depicts the origin of sexual difference in the human species. Its emergence is fraught with anxiety and sexually specific violence, and invites comparison with the primal separation from the mother and the emancipation of the subject in process at the cost of relegating the maternal to the abject in the writings (...) of Julia Kristeva. Lessing creates an ahistorical community of females from which the male community eventually evolves. The growing awareness of sexual difference dovetails with the emotional and intellectual development, as the nascent human subject gradually enters linear time viewed from perspective by the narrator of the novel, a Roman senator who hoards ancient manuscripts with the story of Clefts and Squirts. The article juxtaposes the ideas of Lessing and Kristeva, who have both cut themselves off from feminism, and have both been inspired by psychoanalysis. Primarily, Lessing’s fictional imaginary can be adequately interpreted in light of Kristeva’s concept of abjection as an element that disturbs the system. My interpretation of abjection is indebted to Pamela Sue Anderson’s reading of Kristeva, notably her contention that violence as a response to sexual difference lies at the heart of collective identity. Finally, the imaginary used by Lessing and Kristeva is shown to have stemmed from the colonial imaginary like the concepts of Freud and Jung. (shrink)

O objetivo deste ensaio é refletir sobre o significado da expressão “arte do paladar”, enfocando os aspectos da nossa história evolutiva – uma história contemporaneamente biológica e cultural – os quais fizeram de nós os únicos “macacos” capazes de cozinhar o alimento, de produzi-lo de modo sistemático, de escolhê-lo em meio a uma vasta gama de alimentos, com base em diferentes critérios, de atribuir-lhe um valor simbólico e de celebrálo através da linguagem; razões pelas quais o homem pode reivindicar plenamente (...) a invenção dos sabores. Resultado de um longo processo de elaboração da natureza, a arte do paladar é, portanto, o resultado de todos os processos pelos quais transformamos um dos atos mais naturais, isto é, o ato de comer, em um artificial, cultural e intelectual, aplicando um conhecimento, um saber prático, para conceber, imaginar e elaborar novos objetos alimentares, novas sensações para o paladar, novas possibilidades de interação social. Palavras-chave: Arte de alimentos. Sabor. Cozinhar. Culinária. Linguagem. (shrink)