Patients have received experimental pharmaceuticals outside of clinical trials for decades. There are no industry-wide best practices, and many companies that have granted compassionate use, or ‘preapproval’, access to their investigational products have done so without fanfare and without divulging the process or grounds on which decisions were made. The number of compassionate use requests has increased over time. Driving the demand are new treatments for serious unmet medical needs; patient advocacy groups pressing for access to emerging treatments; internet platforms (...) enabling broad awareness of compelling cases or novel drugs and a lack of trust among some that the pharmaceutical industry and/or the FDA have patients’ best interests in mind. High-profile cases in the media have highlighted the gap between patient expectations for compassionate use and company utilisation of fair processes to adjudicate requests. With many pharmaceutical manufacturers, patient groups, healthcare providers and policy analysts unhappy with the inequities of the status quo, fairer and more ethical management of compassionate use requests was needed. This paper reports on a novel collaboration between a pharmaceutical company and an academic medical ethics department that led to the formation of the Compassionate Use Advisory Committee. Comprising medical experts, bioethicists and patient representatives, CompAC established an ethical framework for the allocation of a scarce investigational oncology agent to single patients requesting non-trial access. This is the first account of how the committee was formed and how it built an ethical framework and put it into practice. (shrink)

The earlier volume in this series dealt with two religions of Indian origin, namely, Buddhism and Jainism. The Indian religious scene, however, is characterized by not only religions which originated in India but also by religions which entered India from outside India and made their home here. Thus religious life in India has been enlivened throughout its history by the presence of religions of foreign origin on its soil almost from the very time they came into existence. This volume covers (...) three such religions—Zoraoastrianism, Judaism, and Islam. In the case of Zoraostianism, even its very beginnings are intertwined with India, as Zoroastrianism reformed a preexisting religion which had strong links to the Vedic heritage of India. This relationship took on a new dimension when a Zoroastrian community, fearing persecution in Persia after its Arab conquest, sought shelter in western India and ultimately went on to produce India’s pioneering nationalist in the figure of Dadabhai Naoroji ( 1825-1917), also known as the Grand Old Man of India. Jews found refuge in south India after the destruction of the Temple by the Romans in 70 C.E. and have remained a part of the Indian religious scene since then, some even returning to Israel after it was founded in 1948. Islam arrived in Kerala as soon as it was founded and one of the earliest mosques in the history of Islam is found in India. Islam differs from the previously mentioned religions inasmuch as it went on to gain political hegemony over parts of the country for considerable periods of time, which meant that its impact on the religious life of the subcontinent has been greater compared to the other religions. It has also meant that Islam has existed in a religiously plural environment in India for a longer period than elsewhere in the world so that not only has Islam left a mark on India, India has also left its mark on it. Indeed all the three religions covered in this volume share this dual feature, that they have profoundly influenced Indian religious life and have also in turn been profoundly influenced by their presence in India. (shrink)

The earlier volume in this series dealt with two religions of Indian origin, namely, Buddhism and Jainism. The Indian religious scene, however, is characterized by not only religions which originated in India but also by religions which entered India from outside India and made their home here. Thus religious life in India has been enlivened throughout its history by the presence of religions of foreign origin on its soil almost from the very time they came into existence. This volume covers (...) three such religions—Zoraoastrianism, Judaism, and Islam. In the case of Zoraostianism, even its very beginnings are intertwined with India, as Zoroastrianism reformed a preexisting religion which had strong links to the Vedic heritage of India. This relationship took on a new dimension when a Zoroastrian community, fearing persecution in Persia after its Arab conquest, sought shelter in western India and ultimately went on to produce India’s pioneering nationalist in the figure of Dadabhai Naoroji ( 1825-1917), also known as the Grand Old Man of India. Jews found refuge in south India after the destruction of the Temple by the Romans in 70 C.E. and have remained a part of the Indian religious scene since then, some even returning to Israel after it was founded in 1948. Islam arrived in Kerala as soon as it was founded and one of the earliest mosques in the history of Islam is found in India. Islam differs from the previously mentioned religions inasmuch as it went on to gain political hegemony over parts of the country for considerable periods of time, which meant that its impact on the religious life of the subcontinent has been greater compared to the other religions. It has also meant that Islam has existed in a religiously plural environment in India for a longer period than elsewhere in the world so that not only has Islam left a mark on India, India has also left its mark on it. Indeed all the three religions covered in this volume share this dual feature, that they have profoundly influenced Indian religious life and have also in turn been profoundly influenced by their presence in India. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work.This work is in the public domain in (...) the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work.As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Arthur C. Danto's essays not only critique bodies of work but reflect upon art's conceptual evolution as well, drawing for the reader a kind of "philosophical map" indicating how art and the criteria for judging it has changed over the twentieth century. In _Unnatural Wonders_ the renowned critic finds himself at a point when contemporary art has become wholly pluralistic, even chaotic-with one medium as good as another-and when the moment for the "next thing" has already passed. So the (...) theorist goes in search of contemporary art's most exhilarating achievements, work that bridges the gap between art and life, which, he argues, is now the definitive art of our time. Danto considers the work of such young artists as John Currin and Renee Cox and older living masters including Gerhard Richter and Sol LeWitt. He discusses artists of the New York School, like Philip Guston and Joan Mitchell, and international talents, such as the South African William Kentridge. Danto conducts a frank analysis of Matthew Barney's _The Cremaster Cycle_, Damien Hirst's skeletons and anatomical models, and Barbara Kruger's tchotchke-ready slogans; finds the ghost of Henry James in the work of Barnett Newman; and muses on recent Whitney Biennials and art influenced by 9/11. He argues that aesthetic considerations no longer play a central role in the experience and critique of art. Instead art addresses us in our humanity, as men and women who seek meaning in the "unnatural wonders" of art, a meaning that philosophy and religion are unable to provide. (shrink)

Arthur O. Lovejoy famously referred to thirteen pragmatisms. If he were called on to enumerate postmodernisms, no doubt he would increase this number tenfold.1 Fortunately I need not follow his lead for the task at hand, namely, to discuss whether the pragmatic tradition can narrow the divide between modernism and postmodernism on the topic of cosmopolitanism. To do so I will focus on specific sets of ideas that have been associated with these terms. So, for example, modernists have been (...) viewed as defenders of some form of universality, ethical or conceptual, and of a responsible, self-actuating, authentic subject. Postmodernists look toward particularity and alterity, and stress that notions of a unitary subject .. (shrink)

Suppose that \(\kappa \) is indestructibly supercompact and there is a measurable cardinal \(\lambda > \kappa \). It then follows that \(A_0 = \{\delta is a measurable cardinal and the Mitchell ordering of normal measures over \(\delta \) is nonlinear \(\}\) is unbounded in \(\kappa \). If the Mitchell ordering of normal measures over \(\lambda \) is also linear, then by reflection (and without any use of indestructibility), \(A_1= \{\delta is a measurable cardinal and the Mitchell ordering (...) of normal measures over \(\delta \) is linear \(\}\) is unbounded in \(\kappa \) as well. The large cardinal hypothesis on \(\lambda \) is necessary. We demonstrate this by constructing via forcing two models in which \(\kappa \) is supercompact and \(\kappa \) exhibits an indestructibility property slightly weaker than full indestructibility but sufficient to infer that \(A_0\) is unbounded in \(\kappa \) if \(\lambda > \kappa \) is measurable. In one of these models, for every measurable cardinal \(\delta \), the Mitchell ordering of normal measures over \(\delta \) is linear. In the other of these models, for every measurable cardinal \(\delta \), the Mitchell ordering of normal measures over \(\delta \) is nonlinear. (shrink)

We summarize the known methods of producing a non-supercompact strongly compact cardinal and describe some new variants. Our Main Theorem shows how to apply these methods to many cardinals simultaneously and exactly control which cardinals are supercompact and which are only strongly compact in a forcing extension. Depending upon the method, the surviving non-supercompact strongly compact cardinals can be strong cardinals, have trivial Mitchell rank or even contain a club disjoint from the set of measurable cardinals. These results improve (...) and unify Theorems 1 and 2 of [5], due to the first author. (shrink)

Art theory has consistently emphasised the importance of situational, cultural, institutional and historical factors in viewers’ experience of fine art. However, the link between this heavily context-dependent interpretation and the workings of the mind is often left unexamined. Drawing on relevance theory—a prominent, cogent and productive body of work in cognitive pragmatics—we here argue that fine art achieves its effects by prompting the use of cognitive processes that are more commonly employed in the interpretation of words and other stimuli presented (...) in a communicative context. We describe in particular how institutional factors effectively co-opt these processes for new ends, allowing viewers to achieve cognitive effects that they otherwise would not, and so provide cognitivist backing for an Institutional Theory of Art, such as that put forward by Arthur Danto. More generally, we situate and describe the Western fine art tradition as a phenomenon that is a consequence of both the cognitive processes involved in communication, and of cultural norms, practices and institutions. (shrink)

We determine exact consistency strengths for various failures of the Singular Cardinals Hypothesis (SCH) in the setting of the Zermelo-Fraenkel axiom system ZF without the Axiom of Choice (AC). By the new notion of parallel Prikry forcing that we introduce, we obtain surjective failures of SCH using only one measurable cardinal, including a surjective failure of Shelah's pcf theorem about the size of the power set of $\aleph _{\omega}$ . Using symmetric collapses to $\aleph _{\omega}$ , $\aleph _{\omega _{1}}$ , (...) or $\aleph _{\omega _{2}}$ , we show that injective failures at $\aleph _{\omega}$ , $\aleph _{\omega _{1}}$ , or $\aleph _{\omega _{2}}$ can have relatively mild consistency strengths in terms of Mitchell orders of measurable cardinals. Injective failures of both the aforementioned theorem of Shelah and Silver's theorem that GCH cannot first fail at a singular strong limit cardinal of uncountable cofinality are also obtained. Lower bounds are shown by core model techniques and methods due to Gitik and Mitchell. (shrink)

The focus of this article is J. Leslie Mitchell’s Spartacus (1933), his fictional representation of the slave rebellion in ancient Rome led by the eponymous gladiator. The article begins by examining Mitchell’s contribution to debates over the role of the revolutionary writer in Left Review in the mid-1930s and his place in the British Left in this era, before going on to survey the ways in which the figure of Spartacus and the German Spartacists are represented across (...) class='Hi'>Mitchell’s oeuvre. It then explores key source material utilized in the writing of the novel, as well as outlining comparisons between Mitchell’s representation of Spartacus and those of his fellow novelists Howard Fast and Arthur Koestler. Including close readings of Spartacus and informed by archival research and previously unpublished manuscript items, the article argues that at the same time as denouncing the cruelties of Roman rule, Spartacus also signals Mitchell’s passionate opposition to what he considered the violent histories of oppression suffered by the commons of the earth of all times, culminating in the capitalist crisis of Mitchell’s own period in the 1930s. Mitchell creates this effect of historical simultaneity by writing a work of myth-history – as opposed to historical realism or political propaganda – that employs the utopian legend of the Golden Age to inspire radical dissent against modern deprivation. (shrink)

This book analyzes the moral confusion of contemporary society, relating rival conceptions of morality with a wide variety of views about the nature and predicament of man. Mitchell argues that many secular thinkers possess a traditional "Christian" conscience which they find hard to defend in terms of an entirely secular world-view, but which is more in line with a Christian understanding of man.

ABSTRACT:The notion of stakeholder salience based on attributes (e.g., power, legitimacy, urgency) is applied in the family business setting. We argue that where principal institutions intersect (i.e., family and business); managerial perceptions of stakeholder salience will be different and more complex than where institutions are based on a single dominant logic. We propose that (1) whereas utilitarian power is more likely in the general business case, normative power is more typical in family business stakeholder salience; (2) whereas in a general (...) business context legitimacy is socially constructed; for family stakeholders, legitimacy is based on heredity; and (3) whereas temporality and criticality are somewhat independent in general-business urgency, they are linked in the family business case because of family ties and family-centered non-economic goals. We apply this theoretical framework to position and integrate the contributions to this special section ofBusiness Ethics Quarterlyon “Stakeholder Theory, Ethics, Corporate Social Responsibility, and Family Enterprise.”. (shrink)

ABSTRACT:The notion of stakeholder salience based on attributes (e.g., power, legitimacy, urgency) is applied in the family business setting. We argue that where principal institutions intersect (i.e., family and business); managerial perceptions of stakeholder salience will be different and more complex than where institutions are based on a single dominant logic. We propose that (1) whereas utilitarian power is more likely in the general business case, normative power is more typical in family business stakeholder salience; (2) whereas in a general (...) business context legitimacy is socially constructed; for family stakeholders, legitimacy is based on heredity; and (3) whereas temporality and criticality are somewhat independent in general-business urgency, they are linked in the family business case because of family ties and family-centered non-economic goals. We apply this theoretical framework to position and integrate the contributions to this special section ofBusiness Ethics Quarterlyon “Stakeholder Theory, Ethics, Corporate Social Responsibility, and Family Enterprise.”. (shrink)