Patients have received experimental pharmaceuticals outside of clinical trials for decades. There are no industry-wide best practices, and many companies that have granted compassionate use, or ‘preapproval’, access to their investigational products have done so without fanfare and without divulging the process or grounds on which decisions were made. The number of compassionate use requests has increased over time. Driving the demand are new treatments for serious unmet medical needs; patient advocacy groups pressing for access to emerging treatments; internet platforms (...) enabling broad awareness of compelling cases or novel drugs and a lack of trust among some that the pharmaceutical industry and/or the FDA have patients’ best interests in mind. High-profile cases in the media have highlighted the gap between patient expectations for compassionate use and company utilisation of fair processes to adjudicate requests. With many pharmaceutical manufacturers, patient groups, healthcare providers and policy analysts unhappy with the inequities of the status quo, fairer and more ethical management of compassionate use requests was needed. This paper reports on a novel collaboration between a pharmaceutical company and an academic medical ethics department that led to the formation of the Compassionate Use Advisory Committee. Comprising medical experts, bioethicists and patient representatives, CompAC established an ethical framework for the allocation of a scarce investigational oncology agent to single patients requesting non-trial access. This is the first account of how the committee was formed and how it built an ethical framework and put it into practice. (shrink)

In all of these discourses, she has sought to cultivate an awareness of how the self is situated and influenced, as well as the ways in which a self can influence others.In this volume, twelve scholars examine and display the influence of ...

This initial volume of the Collected Works of Edith Stein offers, for the first time in English, the unabridged biography of Edith Stein (Teresa Benedicta of the Cross), depicting her life as a child and young adult. Her text ends abruptly because the Nazi SS arrested, then deported, her to the Auschwitz concentration camp in 1942. Edith Stein is one of the most significant German women of the 20th century. At the age of twenty-five she became the (...) first assistant to Edmund Husserl, the founder of Phenomenology. She was much in demand as a writer and lecturer after her conversion from atheism to Catholicism. Later, as a Discalced Carmelite nun, she maintained her intellectual pursuits until she, like so many others, became a victim of the Nazi persecution that raged across Eastern Europe. By making this landmark work available in English, the Institute of Carmelite Studies provides an eye-witness account of persons and activities on the scene at the time when psychology and philosophy became separate disciplines. In addition to photographs and a map, this volume is enhanced with a preface, the foreword and afterword, notes, and a list of places associated with Edith Stein’s life. It is our aim that these, together with Edith Stein’s text, may help bring into relief the many background details of the rich autobiographical work she has left us. (shrink)

Paul Lewis and Walter Gulick summarize and evaluate Mark Micthell’s new book, Michael Polanyi: The Art of Knowing, and Mitchell responds to their comments in this symposium article.

Mitchell S. Green presents a systematic philosophical study of self-expression - a pervasive phenomenon of the everyday life of humans and other species, which has received scant attention in its own right. He explores the ways in which self-expression reveals our states of thought, feeling, and experience, and he defends striking new theses concerning a wide range of fascinating topics: our ability to perceive emotion in others, artistic expression, empathy, expressive language, meaning, facial expression, and speech acts. He draws (...) on insights from evolutionary game theory, ethology, the philosophy of language, social psychology, pragmatics, aesthetics, and neuroscience to present a stimulating and accessible interdisciplinary work. (shrink)

This study examines a moderated/mediated model of ethical leadership on follower job satisfaction and affective organizational commitment. We proposed that managers have the potential to be agents of virtue or vice within organizations. Specifically, through ethical leadership behavior we argued that managers can virtuously influence perceptions of ethical climate, which in turn will positively impact organizational members' flourishing as measured by job satisfaction and affective commitment to the organization. We also hypothesized that perceptions of interactional justice would moderate the ethical (...) leadership-to-climate relationship. Our results indicate that ethical leadership has both a direct and indirect influence on follower job satisfaction and affective commitment. The indirect effect of ethical leadership involves shaping perceptions of ethical climate, which in turn, engender greater job satisfaction and affective organizational commitment. Furthermore, when interactional justice is perceived to be high, this strengthens the ethical leadership-to-climate relationship. (shrink)

David Braddon-Mitchell and Frank Jackson’s popular introduction to philosophy of mind and cognition is now available in a fully revised and updated edition. Ensures that the most recent developments in the philosophy of mind and cognitive science are brought together into a coherent, accessible whole. Revisions respond to feedback from students and teachers and make the volume even more useful for courses. New material includes: a section on Descartes’ famous objection to materialism; extended treatment of connectionism; coverage of the (...) view that psychology is autonomous; fuller discussion of recent debates over phenomenal experience; and much more. (shrink)

The philosophy of mind and cognition has been transformed by recent advances in what is loosely called cognitive science. This book is a thoroughly up-to-date introduction to and account of that transformation, in which the many strands in contemporary cognitive science are brought together into a coherent philosophical picture of the mind. The book begins with discussions of the pre-history of contemporary philosophy of mind - dualism, behaviourism, and early versions of the identity theory of mind - and moves through (...) discussions of functionalism in autonomy of psychology, to topics such as eliminative materialism, individualism and the problems of content and representation. The synoptic nature of the discussion makes it ideal as the foundation of an undergraduate course in the philosophy of mind. (shrink)

In recent years the view that understanding a language requires knowing what its words and expressions mean has come under attack. One line of attack attempts to show that while knowledge can be undermined by Gettier-style counterexamples, language understanding cannot be. I consider this line of attack, particularly in the work of Pettit and Longworth, and show it to be unpersuasive. I stress, however, that maintaining a link between language understanding and knowledge does not itself vindicate a cognitivist view of (...) the former. (shrink)

The domain of phenomenological investigation delineated by the Husserlian term authentic empathy presents us with an immediate tension. On the one hand, authentic empathy is supposed to grant the subject access (in some sense that remains to be fully specified) to the Other’s experience. On the other hand, foundational phenomenological considerations pertaining to the apprehension of a foreign subjectivity determine that it is precisely a disjunction in subjective processes that is constitutive of the Other being other. In my approach to (...) this problem, I seek, within the context of a reading of Edith Stein’s work 'On the Problem of Empathy', to clarify the place of ascription in authentic empathy, and to render more explicit a certain notion of “contiguity” that I take to be informing Stein’s understanding of the co-givenness of the Other’s mental life. I go on to argue that a resolution to the problem of empathy lies in the idea that the respective lived experiences of self and Other are, as a matter of descriptive fact, phenomenally connected by a relation of resemblance, and that, consonantly, the essential structure of authentic empathy is characterised in its mature phases by an homological relation to picture consciousness. (shrink)

David Braddon-Mitchell and Frank Jackson’s popular introduction to philosophy of mind and cognition is now available in a fully revised and updated edition. Ensures that the most recent developments in the philosophy of mind and cognitive science are brought together into a coherent, accessible whole. Revisions respond to feedback from students and teachers and make the volume even more useful for courses. New material includes: a section on Descartes’ famous objection to materialism; extended treatment of connectionism; coverage of the (...) view that psychology is autonomous; fuller discussion of recent debates over phenomenal experience; and much more. (shrink)

Two perennial questions in aesthetics, among others, are the demarcation question, viz., what, if anything, distinguishes the aesthetic domain from the cognitive or moral domains, and the normative question, viz., what kind of normativity, if any, does the aesthetic domain involve. Although recent attempts to answer these questions can be found in contemporary literature, in this paper I examine the answers defended by the early phenomenologist Edith Landmann-Kalischer. I show that Landmann-Kalischer answers the demarcation question by blending together a (...) cognitivist account of aesthetic judgment with an objectivist account of beauty, and that she builds an account of aesthetic normativity on this cognitivist and objectivist basis. I contend that her subtle and unified account of aesthetic demarcation and normativity has advantages over other competing hedonist and Kantian views and, as such, merits further consideration in contemporary debates. (shrink)

Many philosophical naturalists eschew analysis in favor of discovering metaphysical truths from the a posteriori, contending that analysis does not lead to philosophical insight. A countercurrent to this approach seeks to reconcile a certain account of conceptual analysis with philosophical naturalism; prominent and influential proponents of this methodology include the late David Lewis, Frank Jackson, Michael Smith, Philip Pettit, and David Armstrong. Naturalistic analysis is a tool for locating in the scientifically given world objects and properties we quantify over in (...) everyday discourse. This collection gathers work from a range of prominent philosophers who are working within this tradition, offering important new work as well as critical evaluations of the methodology. Its centerpiece is an important posthumous paper by David Lewis, "Ramseyan Humility," published here for the first time. The contributors first address issues of philosophy of mind, semantics, and the new methodology's a priori character, then turn to matters of metaphysics, and finally consider problems regarding normativity. Conceptual Analysis and Philosophical Naturalism is one of the first efforts to apply this approach to such a wide range of philosophical issues. _Contributors: _David Braddon-Mitchell, Mark Colyvan, Frank Jackson, Justine Kingsbury, Fred Kroon, David Lewis, Dustin Locke, Kelby Mason, Jonathan McKeown-Green, Peter Menzies, Robert Nola, Daniel Nolan, Philip Pettit, Huw Price, Denis Robinson, Steve Stich, Daniel Stoljar The hardcover edition does not include a dust jacket. (shrink)

Edith Wyschogrod presents the first full-length study in English of the important contemporary French philosopher Emmanuel Levinas. It is a revision of the author’s earlier study and includes discussions of his recent writings as well as current scholarship. Dr. Wyschogrod’s extensive discussion of Levinas's relation to Judaism, especially his use of literature from the Torah and other religious writings, will be of interest to religious scholars. The author compares Levinas’s thought with that of his contemporaries, most notably Jacques Derrida (...) and Husserl. (shrink)

In recent years the view that understanding a language requires knowing what its words and expressions mean has come under attack. One line of attack attempts to show that while knowledge can be undermined by Gettier-style counterexamples, language understanding cannot be. I consider this line of attack, particularly in the work of Pettit and Longworth, and show it to be unpersuasive. I stress, however, that maintaining a link between language understanding and knowledge does not itself vindicate a cognitivist view of (...) the former. (shrink)

Illuminated by the writings of Edith Stein, this paper presents a model of empathy as a very particular intersubjective understanding. This is commonly a view absent from psychology literature. For Stein, empathy is the experience of experientially and directly knowing another person’s experience, as it unfolds in the present, together with the awareness of the ‘otherness’ of that experience. It can be conceptually distinguished, in terms of process and experience, from current models that propose that empathic understandings are ‘intellectual’ (...) experiences or sympathetic experiences. As such, she provides an additional or alternative aspect to understanding other people’s experiences. Our paper provides a summary of Stein’s key analytic claims about three key facets of empathy. Her views are discussed in the light of debates relevant for contemporary psychology and social cognition. (shrink)

Theory theory and simulation theory share the assumption that mental states are unobservable, such that mental state attribution requires an extra psychological step beyond perception. Phenomenologists deny this, contending that we can directly perceive people's mental states. Here I evaluate objections to theory theory and simulation theory as accounts of everyday social perception offered by Dan Zahavi and Shaun Gallagher. I agree that their phenomenological claims have bite at the personal level, distinguishing direct social perception from conscious theorizing and simulation. (...) Their appeals to phenomenology and other arguments do not, however, rule out theory theory or simulation theory as accounts of the sub-personal processes underlying social perception. While I here remain uncommitted about the plausibility of sub-personal theorizing and simulation, I argue that phenomenologists must do more in order to reject these accounts. (shrink)

I will discuss Stein’s first major philosophical work, On the Problem of Empathy. I’ll first present some of the background context to the composition of this work and then discuss some of the themes of the work that I find intriguing.

G. E. Moore observed that to assert, 'I went to the pictures last Tuesday but I don't believe that I did' would be 'absurd'. Over half a century later, such sayings continue to perplex philosophers. In the definitive treatment of the famous paradox, Green and Williams explain its history and relevance and present new essays by leading thinkers in the area.

A number of recent theories of quantum gravity lack a one-dimensional structure of ordered temporal instants. Instead, according to many of these views, our world is either best represented as a single three-dimensional object, or as a configuration space composed of such three-dimensional objects, none of which bear temporal relations to one another. Such theories will be empirically self-refuting unless they can accommodate the existence of conscious beings capable of representation. For if representation itself is impossible in a timeless world, (...) then no being in such a world could entertain the thought that a timeless theory is true, let alone believe such a theory or rationally believe it. This paper investigates the options for understanding representation in a three-dimensional, timeless, world. Ultimately it concludes that the only viable option is one according to which representation is taken to be deeply non-naturalistic. Ironically then we are left with two seemingly very unattractive options. Either a very naturalistic motivation—taking seriously a live view in fundamental physics—leads us to a very non-naturalistic view of the mental, or else views in the philosophy of mind partly dictate what is an acceptable theory in physics. (shrink)

Regulatory focus theory is proposed as offering an explanation for the influence of ethical leadership on organizational citizenship behaviors and employee commitments. The prevention focus mindset of an employee is argued to be the mechanism by which an ethical leader influences extra-role compliance behavior as well as normative commitment, whereas the promotion focus mindset of an employee is argued to be the mechanism by which an ethical leader influences extra-role voice behavior as well as affective commitment. Moreover, leader-member exchange is (...) proposed as a moderator of the relationship of ethical leadership to regulatory focus mindsets and employee behavior and commitments. Using the data collected in two waves from 250 working adults, we tested the proposed relationships with moderated mediation bootstrap procedures. The findings generally support the hypothesized relationships and point toward important implications for ethical leadership in work settings. (shrink)

The idea that there could be spatially extended mereological simples has recently been defended by a number of metaphysicians (Markosian 1998, 2004; Simons 2004; Parsons (2000) also takes the idea seriously). Peter Simons (2004) goes further, arguing not only that spatially extended mereological simples (henceforth just extended simples) are possible, but that it is more plausible that our world is composed of such simples, than that it is composed of either point-sized simples, or of atomless gunk. The difficulty for these (...) views lies in explaining why it is that the various sub-volumes of space occupied by such simples, are not occupied by proper parts of those simples. Intuitively at least, many of us find compelling the idea that spatially extended objects have proper parts at every sub-volume of the region they occupy. It seems that the defender of extended simples must reject a seemingly plausible claim, what Simons calls the geometric correspondence principle (GCP): that any (spatially) extended object has parts that correspond to the parts of the region that it occupies (Simons 2004: 371). We disagree. We think that GCP is a plausible principle. We also think it is plausible that our world is composed of extended simples. We reconcile these two notions by two means. On the one hand we pay closer attention to the physics of our world. On the other hand, we consider what happens when our concept of something—in this case space—contains elements not all of which are realized in anything, but instead key components are realized in different features of the world. (shrink)

Edith Stein lived an unconventional life. Born into a devout Jewish family, she drifted into atheism in her mid teens, took up the study of philosophy, studied with Edmund Husserl, the founder of phenomenology, became a pioneer in the women's movement in Germany, a military nurse in World War I, converted from atheism to Catholic Christianity, became a Carmelite nun, was murdered at Auschwitz-Birkenau in 1942, and canonized by Pope John Paul II.

Frege was the grandfather of analytical philosophy, Husserl the founder of the phenomenological school, two radically different philosophical movements. In 1903, say, how would they have appeared to any German student of philosophy who knew the work of both? Not, certainly, as two deeply opposed thinkers: rather as remarkably close in orientation, despite some divergence of interests. They may be compared with the Rhine and the Danube, which rise quite close to one another and for a time pursue roughly parallel (...) courses, only to diverge in utterly different directions and flow into different seas. Why, then, did this happen? What small ingredient into the thought of each was eventually magnified into so great an effect? (shrink)

Some theories of personal identity allow some variation in what it takes for a person to survive from context to context; and sometimes this is determined by the desires of person-stages or the practices of communities.This leads to problems for decision making in contexts where what is chosen will affect personal identity.‘Temporal Phase Pluralism’ solves such problems by allowing that there can be a plurality of persons constituted by a sequence of person stages. This illuminates difficult decision making problems when (...) persons have to choose between different life-altering choices. (shrink)

In this pathbreaking book Mitchell Aboulafia considers the development of the sense of self by critically analyzing the philosophies of George Herbert Mead--an American pragmatist who argues that self-consciousness results from social interaction through language and symbol--and of Jean-Paul Sartre, the existentialist who maintains that consciousness is free to create the self. Building on their work, Aboulafia provides an original analysis of consciousness and self-determination.

Edith Stein claims that communal experiences are not reducible to the collection of individual experiences directed to the same object or upon the same content. Based on this intuition she gives a phenomenological description of the intentional structure that is proper to communal experiences regarding to their content, mode, and subject. While expanding on her attempts to reassess Husserl’s description of intentionality in an original social-ontological framework, I will stress her precious distinction between individual consciousness and communal stream of (...) experience. I will argue that, if Stein defines the being of the community through its the communal stream of experience, the latter has to be interpreted through Husserl’s teleological concept of ideal multiplicity of experiences. Discussing Stein’s account both against the background of the methodology of Edmund Husserl’s phenomenology and contextualizing it within the social-ontological struggle that took place in Germany during the Great War, I will focus on her description of we-intentionality and aim to unearth its phenomenological core as well as its methodological limits. (shrink)

Researchers in the enactivist tradition have recently argued that social interaction can constitute social cognition, rather than simply serve as the context for social cognition. They contend that a focus on social interaction corrects the overemphasis on mechanisms inside the individual in the explanation of social cognition. I critically assess enactivism’s claims about the explanatory role of social interaction in social cognition. After sketching the enactivist approach to cognition in general and social cognition in particular, I identify problems with an (...) enactivist taxonomy of roles for social interaction in the explanation of social cognition (contextual, enabling, and constitutive). In particular, I show that this enactivist taxonomy does not clearly distinguish between enabling conditions and constitutive elements, which would make them in danger of committing the coupling-constitution fallacy found in some attempts to extend cognition. I explore resources enactivism has to more clearly demarcate constitutive parts of a cognitive system, but identify problems in applying them to some of the main cases of social cognition enactivists characterize as being constituted by social interaction. I offer the mechanistic approach to explanation as an alternative that captures much of what enactivists want to say about the relations between social and individual levels, but views social interactions from the perspective of embedded cognition rather than as being constitutive of social cognition. (shrink)

The domain of phenomenological investigation delineated by the Husserlian term authentic empathy presents us with an immediate tension. On the one hand, authentic empathy is supposed to grant the subject access (in some sense that remains to be fully specified) to the Other’s experience. On the other hand, foundational phenomenological considerations pertaining to the apprehension of a foreign subjectivity determine that it is precisely a disjunction in subjective processes that is constitutive of the Other being other. In my approach to (...) this problem, I seek, within the context of a reading of Edith Stein’s work On the Problem of Empathy, to clarify the place of ascription in authentic empathy, and to render more explicit a certain notion of “contiguity” that I take to be informing Stein’s understanding of the co-givenness of the Other’s mental life. I go on to argue that a resolution to the problem of empathy lies in the idea that the respective lived experiences of self and Other are, as a matter of descriptive fact, phenomenally connected by a relation of resemblance, and that, consonantly, the essential structure of authentic empathy is characterised in its mature phases by an homological relation to picture consciousness. (shrink)

Speech acts are a staple of everyday communicative life, but only became a topic of sustained investigation, at least in the English-speaking world, in the middle of the Twentieth Century.[1] Since that time “speech act theory” has been influential not only within philosophy, but also in linguistics, psychology, legal theory, artificial intelligence, literary theory and many other scholarly disciplines.[2] Recognition of the importance of speech acts has illuminated the ability of language to do other things than describe reality. In the (...) process the boundaries among the philosophy of language, the philosophy of action, the philosophy of mind and even ethics have become less sharp. In addition, an appreciation of speech acts has helped lay bare an implicit normative structure within linguistic practice, including even that part of this practice concerned with describing reality. Much recent research aims at an accurate characterization of this normative structure underlying linguistic practice. (shrink)

Vector-based models of word meaning have become increasingly popular in cognitive science. The appeal of these models lies in their ability to represent meaning simply by using distributional information under the assumption that words occurring within similar contexts are semantically similar. Despite their widespread use, vector-based models are typically directed at representing words in isolation, and methods for constructing representations for phrases or sentences have received little attention in the literature. This is in marked contrast to experimental evidence (e.g., in (...) sentential priming) suggesting that semantic similarity is more complex than simply a relation between isolated words. This article proposes a framework for representing the meaning of word combinations in vector space. Central to our approach is vector composition, which we operationalize in terms of additive and multiplicative functions. Under this framework, we introduce a wide range of composition models that we evaluate empirically on a phrase similarity task. (shrink)

This article argues that greater theoretical attention should be paid to the figure of the zombie in the fields of law, cultural studies and philosophy. Using The Walking Dead as a point of critical departure concepts of legal personhood are interrogated in relation to permanent vegetative states, bare life and the notion of the third person. Ultimately, the paper recommends a rejection of personhood; instead favouring a legal and philosophical engagement with humanity and embodiment. Personhood, it is suggested, creates a (...) barrier in law allowing individuals in certain contexts to be rendered non-persons and thus outside the scope of legal rights. An approach that rejects personhood in favour of embodiment would allow individuals to enjoy their rights without being subject to such discrimination. It is also suggested that the concept of the human, itself complicated by the figure of the zombie, allows for legal engagement with a greater number of putative rights claimants including admixed embryos, cyborgs and the zombie. (shrink)