We claim that adjustable parameters play a crucial role in building and applying simulation models. We analyze that role and illustrate our findings using examples from equations of state in thermodynamics. In building simulation models, two types of experiments, namely, simulation and classical experiments, interact in a feedback loop, in which model parameters are adjusted. A critical discussion of how adjustable parameters function shows that they are boon and bane of simulation. They help to enlarge the scope of simulation far (...) beyond what can be determined by theoretical knowledge, but at the same time undercut the epistemic value of simulation models. (shrink)

This article investigates the question why even the existence of “moral conscience” became regarded with serious doubts among radical eighteenth-century French philosophes La Mettrie, d’Holbach, Diderot, and Voltaire, from the vantage point of conceptual history. The philosophes’ stance of regarding moral conscience only as a name for certain acquired prejudices both fails to engage with the conception of moral conscience upheld by their theistic opponents and stands in a sharp contrast to the moral thought of Protestant reformation, which – less (...) than two centuries earlier – had elevated moral conscience to a position of an infallible moral authority. The article argues, however, that, in spite of the opposition between these two conceptions of conscience, they might be connected, and that the former might have even been a consequence of the latter. It will be shown that the pre-Reformation conception of moral conscience, crystallized in Aquinas, presents it being based on our natural attraction to “the human good”. However, as this conception was not created by medieval theologians, but was inherited from non-theistic ancient philosophy, in principle it would have been as compatible with the deistic and atheistic worldviews of the philosophes as the other ancient philosophical concepts, such as “the human good” and “human nature”, that the philosophes continued using in their original, teleological senses. Having presented a brief overview of the history of moral conscience, the article proceeds to show how the Protestant reformers removed the attraction to the human good from moral conscience while making its normative guidance infallible. The article will suggest that, due to the prevalence of this, exclusively theological, conception of moral conscience in the intellectual environment shaped by Protestantism, several British thinkers of the seventeenth century, including Hobbes, Locke, and Hume, who could not endorse the theological aspects of moral conscience, gradually reduced it into a mere acquired “sentiment”. As their philosophy was a major influence on the philosophes, the article concludes that the loss of a rational justification for moral conscience in the works of the British philosophers could have also been what motivated the philosophes to question moral conscience. (shrink)

This article sketches an idealized strategy for the identification of neural correlates of consciousness. The proposed strategy is based on a state space approach originating from the analysis of dynamical systems. The article then focuses on one constituent of consciousness, phenomenal awareness. Several rudimentary requirements for the identification of neural correlates of phenomenal awareness are suggested. These requirements are related to empirical data on selective attention, on completely intrinsic selection and on globally unconscious states. As an example, neuroscientific findings on (...) synchronized γ activity are categorized according to these requirements. (shrink)

Philosophical discussions on causal inference in medicine are stuck in dyadic camps, each defending one kind of evidence or method rather than another as best support for causal hypotheses. Whereas Evidence Based Medicine advocates the use of Randomised Controlled Trials and systematic reviews of RCTs as gold standard, philosophers of science emphasise the importance of mechanisms and their distinctive informational contribution to causal inference and assessment. Some have suggested the adoption of a pluralistic approach to causal inference, and an inductive (...) rather than hypothetico-deductive inferential paradigm. However, these proposals deliver no clear guidelines about how such plurality of evidence sources should jointly justify hypotheses of causal associations. We here develop such guidelines by first giving a philosophical analysis of the underpinnings of Hill’s viewpoints on causality. We then put forward an evidence-amalgamation framework adopting a Bayesian net approach to model causal inference in pharmacology for the assessment of harms. Our framework accommodates a number of intuitions already expressed in the literature concerning the EBM vs. pluralist debate on causal inference, evidence hierarchies, causal holism, relevance, and reliability. (shrink)

According to the objective Bayesian approach to inductive logic, premisses inductively entail a conclusion just when every probability function with maximal entropy, from all those that satisfy the premisses, satisfies the conclusion. When premisses and conclusion are constraints on probabilities of sentences of a first-order predicate language, however, it is by no means obvious how to determine these maximal entropy functions. This paper makes progress on the problem in the following ways. Firstly, we introduce the concept of a limit in (...) entropy and show that, if the set of probability functions satisfying the premisses contains a limit in entropy, then this limit point is unique and is the maximal entropy probability function. Next, we turn to the special case in which the premisses are categorical sentences of the logical language. We show that if the uniform probability function gives the premisses positive probability, then the maximal entropy function can be found by simply conditionalising this uniform prior on the premisses. We generalise our results to demonstrate agreement between the maximal entropy approach and Jeffrey conditionalisation in the case in which there is a single premiss that specifies the probability of a sentence of the language. We show that, after learning such a premiss, certain inferences are preserved, namely inferences to inductive tautologies. Finally, we consider potential pathologies of the approach: we explore the extent to which the maximal entropy approach is invariant under permutations of the constants of the language, and we discuss some cases in which there is no maximal entropy probability function. (shrink)

Narrative allegory is distinguished from mythology as reality from symbol; it is, in short, the proper intermedium between person and personification. Where it is too strongly individualized, it ceases to be allegory […]. In the community of scholars of intermedia research, the above quoted citation is commonly regarded as Coleridge’s coining of the term “intermedium” or “intermediality”. However, a short glance at the discursive strategy of his argument emphasizes that his notion of “intermedium” must be closely linked to the poetics (...) and aesthetics of 19th-century romanticism. For the romantic poet, the term of “intermedium” does not point to media relations or intermedia processes but to.. (shrink)

We study questionnaire responses to situations in which sacrificing one life may save many other lives. We demonstrate gender differences in moral judgments: males are more supportive of the sacrifice than females. We investigate a source of the endorsement of the sacrifice: antisocial preferences. First, we measure individual proneness to spiteful behavior, using an experimental game with monetary stakes. We demonstrate that spitefulness can be sizable—a fifth of our participants behave spitefully—but it is not associated with gender. Second, we find (...) that gender is consistently associated with responses even when we account for individual differences in the propensity to spitefulness. (shrink)

We claim that adjustable parameters play a crucial role in building and applying simulation models. We analyze that role and illustrate our findings using examples from equations of state in thermodynamics. In building simulation models, two types of experiments, namely, simulation and classical experiments, interact in a feedback loop, in which model parameters are adjusted. A critical discussion of how adjustable parameters function shows that they are boon and bane of simulation. They help to enlarge the scope of simulation far (...) beyond what can be determined by theoretical knowledge, but at the same time undercut the epistemic value of simulation models. (shrink)

As digital media becomes more central to the lives of adolescents, it also becomes increasingly relevant for their sexual communication. Sexting as an important image-based digital medium provides opportunities for self-determined digital communication, but also carries specific risks for boundary violations. Accordingly, sexting is understood either as an everyday, or as risky and deviant behavior among adolescents. In the affectedness of boundary violations gender plays an important role. However, it is still unclear to what extent digital sexual communication restores stereotypical (...) gender roles and restrictive sexuality norms or, alternatively, enables new spaces of possibility. In this sense, current research points to a desideratum regarding adolescents’ orientations toward sexting as a practice between spaces of possibility and boundary violations. This paper discusses the possibilities, but also the risks, of intimate digital communication among adolescents. The main question is, how adolescents themselves perceive sexting practices and how they position themselves between both spaces for possibility and for the exchange of unwanted sexual content. For this purpose, orientations toward normalities and gender of students are reconstructed. To answer these questions, twelve single-sex, group discussions were carried out with students aged 16 and 17 at five different secondary schools in northern Germany. A total of 20 boys and 22 girls took part. The group discussions were structured by a narrative generating guideline. The analysis draws its methodology from the Documentary Method, regarding implicit and explicit forms of knowledge and discourse. It results in a typology of three types with different orientations. The study shows, that most of the students consider sexting to be a risky practice; only one type shows normality in the use of sexting. At the same time, some of the young people are interested in experimenting with image-based intimate digital communication. Further, gender differences in use and affectedness are also documented. In this way, orientations toward gender stereotypes “favor” both the attribution of responsibility to girls, and overlook the responsibility of students who perpetrated the boundary violation. The orientations of adolescents should be taken more into account in research as well as in educational programs for the prevention of sexual violence. (shrink)

Augmented Reality (AR) is commonly defined as a digital layer of information viewed on top of the physical world through a smartphone, tablet or eyewear. Increasingly, this understanding of AR is shifting to a dynamic framework of ‘smart things’, including wearable technology, sensors and artificial intelligence (AI), with the ability to intercede in key moments and to deliver contextual and meaningful experiences. The things that come into context are the logical next steps in an evolutionary development towards computers that are (...) better able to show empathy in relation to people: even more human-oriented, anticipative and ubiquitous. Thus, this outsourcing of meaning to empathic technologies points to one of the fundamental questions concerning the relation of human and technology – the nature of the trust that users place in technology. (shrink)

This paper presents the contributions of Alcindo Flores Cabral, professor of Chemistry at the Faculdade de Agronomia Eliseu Maciel, nowadays part of the Universidade Federal de Pelotas, to chemistry teaching. It is a contribution almost unknown to the Brazilian chemical community, although recognized as valuable by several renowned chemists abroad, like W. Hückel, G. Charlot, F. Strong, E. Fessenden and others. Cabral’s innovative helical representation is presented in connection not only with contemporary representations, but also an incursion is made into (...) the first helical systems proposed, those of Hinrichs and of Baumhauer. Some comments are made not only on Cabral’s Classificação Natural dos Elementos, published in 1946, but also about other texts he wrote for an efficient chemistry teaching. (shrink)

Epistemic scoring rules are the en vogue tool for justifications of the probability norm and further norms of rational belief formation. They are different in kind and application from statistical scoring rules from which they arose. In the first part of the paper I argue that statistical scoring rules, properly understood, are in principle better suited to justify the probability norm than their epistemic brethren. Furthermore, I give a justification of the probability norm applying statistical scoring rules. In the second (...) part of the paper I give a variety of justifications of norms for rational belief formation employing statistical scoring rules. Furthermore, general properties of statistical scoring rules are investigated. Epistemic scoring rules feature as a useful technical tool for constructing statistical scoring rules. (shrink)

Firm managers make ethical decisions regarding the form and quality of disclosure. Disclosure can have long-term implications for performance, earnings manipulation, and even fraud. We investigate the impact of venture capital (VC) backing on the quality and informativeness of disclosure controls and procedures for newly public companies. We find that these controls and procedures are stronger, as evidenced by fewer material weaknesses in internal control under Section 302 of the Sarbanes–Oxley Act, when companies are VC-backed. Moreover, these disclosures are informative (...) and are more likely to be followed by subsequent financial statement restatements than are disclosures made by non-VC-backed IPO companies. (shrink)

Este artigo apresenta a contribuição de Alcindo Flores Cabral (1907-1982) - professor de química da Faculdade de Agronomia Eliseu Maciel, hoje incorporada à Universidade Federal de Pelotas - ao ensino de química, uma contribuição quase desconhecida pela própria comunidade química brasileira, embora reconhecida como relevante por diversos químicos estrangeiros importantes, como W. Hückel, G. Charlot, F. Strong, E. Fessenden e outros. A inovadora representação helicoidal de Cabral é apresentada não só em conexão com representações contemporâneas, mas também inclui-se uma incursão (...) pelos primeiros sistemas helicoidais propostos, os de Hinrichs e de Baumhauer. Apresentam-se alguns comentários não somente sobre a Classificação natural dos elementos, publicada em 1946, mas também sobre outros textos escritos para tornar mais eficaz o ensino de química. (shrink)

O presente trabalho examina os aspectos históricos da extração do óleo de canela-sassafrás (Ocotea pretiosa Mez), rico em safrol, no Alto e Médio Vale do Itajaí, a partir de 1940, por iniciativa de Otto Grimm, no município de Rio do Sul. Apresenta-se o tema no contexto da memória química em Santa Catarina, e discutem-se os procedimentos utilizados, e principalmente os motivos que levaram tal indústria incipiente a não se converter em uma indústria de química fina. Para tanto, são apresentados alguns (...) dados pertinentes à química do safrol, indicando que tal indústria poderia ter evoluído, bem como os aspectos econômicos e sociais que, ao lado da proibição do corte da canela-sassafrás, levaram em 1990 à extinção definitiva dessa "química fina que poderia ter sido". (shrink)

Dos diferentes fatores associados a uma mudança de paradigma e, portanto, a uma revolução química, o menos discutido é o que envolve os assim chamados experimentos exemplares, mudanças radicais na metodologia de trabalho e nos procedimentos empíricos da química, mudanças e modificações estas que, no caso de uma ciência natural empírica, podem ter como consequência dados experimentais antes inacessíveis, levando, por fim, a uma nova abordagem de conceitos, hipóteses e teorias e desencadeando uma "revolução" química, um novo paradigma. Muito mais (...) do que uma revolução química, dever-se-ia optar por uma gradativa evolução química. Escolhemos três dessas situações como "exemplares": a modificação no procedimento empírico da química pneumática, com o uso da cuba pneumática contendo mercúrio; a introdução de novos métodos de extração de compostos orgânicos naturais, com a substituição do método pirogênico pelo de extração com solventes; um novo entendimento de "análise química", com a substituição da comparação de amostras tidas como autênticas pela decomposição do analito. (shrink)

The chemist Max von Pettenkofer studied with Justus von Liebig, and after leaving Giessen in 1844 did not immediately find an academic position. During the period 1844/1845 he wrote a cycle of 16 Chemical Sonnets, but published them only in 1886. The Sonnets have with few exceptions a historiographical character. We present a translation of the Sonette into Portuguese as well as commentaries about their content and their philosophical significance. We also comment rather briefly on Pettenkofer’s career as an empirical (...) chemist and later as a somewhat heterodox hygienist. (shrink)

In this essay, we aim to provide an overview of the periodic table’s origins and history, and of the elements which conspired to make it chemistry’s most recognisable icon. We pay attention to Mendeleev’s role in the development of a system for organising the elements and chemical knowledge while facilitating the teaching of chemistry. We look at how the reception of the table in different chemical communities was dependent on the local scientific, cultural and political context, but argue that its (...) eventual universal acceptance is due to its unique ability to accommodate possessed knowledge while enabling novel predictions. Furthermore, we argue that its capacity to unify apparently disconnected phenomena under a simple framework facilitates our understanding of periodicity, making the table an icon of aesthetic value, and an object of philosophical inquiry. Finally, we briefly explore the table’s iconicity throughout its representations in pop art and science fiction. (shrink)

This essay is an examination of the relationship between phenomenology and analytic method in the philosophy of law. It proceeds by way of a case study, the requirement of compliance in Raz’s theory of mandatory norms. Proceeding in this way provides a degree of specificity that is otherwise neglected in the relevant literature on method. Drawing on insights from the philosophy of art and cognitive neuroscience, it is argued that the requirement of compliance is beset by a range of epistemological (...) difficulties. The implications of these difficulties are then reviewed for method and normativity in practical reason. A topology of normativity emerges nearer the end of the paper, followed by a brief examination of how certain normative categories must satisfy distinct burdens of proof. (shrink)

Baron d’Holbach was a critic of established religion, or a philosophe, in late 18 th -century France. His work is often perceived as less inventive than the work of other materialist philosophes, such as Helvétius and Diderot. However, I claim that d’Holbach makes an original, unjustly overlooked move in the criticism of religious moral teaching. According to the materialist philosophes, this teaching claims that true happiness is only possible in the afterlife. As an alternative, Helvétius and Diderot offer theories according (...) to which the experience of pleasure constitutes happiness, the end of all human desire. In contemporary terms, these theories would represent psychological hedonism. But, as Diderot himself admits, they have a problem in accounting for why people seem to naturally regard some pleasures as preferable to others. I argue that in response to this challenge, instead of accepting the psychological hedonism of his fellow materialists, d’Holbach shows how one can abstain from reducing happiness to pleasure and yet remain a materialist. (shrink)

Autonomy was an important political concept in ancient Greece. Kant made it the ground of morality: only acting motivated by autonomous reason is moral. But he admits that reason does not have a power to motivate us: desires can always override it. Thus it seems that human reason is not autonomous. The principle of autonomy, however, is an intrinsic part of Kant’s “Copernican Revolution” and his rationalism about the grounding of morality. Questioning the former would lead to fideism or to (...) skepticism while rejecting the latter to reductionism. Neither course is less problematic for grounding morality than the principle of autonomy is. I suggest that Aristotle can help us to see how this dilemma can be avoided. Unlike Kant and many others, he does not seek to ground morality beyond our experience. The Aristotelian understanding of human beings as capable of evaluating one another’s actions with the language of purposefulness can explain which actions are moral without falling into the dilemma implied by the Kantian principle of autonomy. (shrink)

W niniejszym artykule analizuję koncepcję Arystotelesa dotyczącą wymagań epistemicznych koniecznych do identyfikacji czynów moralnie dobrych. W Etyce Nikomachejskiej, Arystoteles zdaje się twierdzić, że jesteśmy w stanie rozpoznawać takie czyny, nie mając wiedzy o tym, dlaczego są one dobre. Inne twierdzenia zawarte w tych dziele, nie pozwalają jednak na bezkrytyczne przyjęcie tej tezy. Zdaniem Johna McDowella, Arystoteles uważał, iż dobro etyczne czynu jest zależne od kontekstu. Gdyby tak było, by rozpoznać dany czyn jako dobry, musielibyśmy wiedzieć jakie cechy danej sytuacji czynią (...) go dobrym. Bronię tezy, że nawet jeśli dobro czynu byłoby zależne od kontekstu, Arystoteles nie uważałby znajomości tego kontekstu za jedyny sposób rozpoznania czynu jako dobry. By tego dowieść, sięgam do dorobku współczesnej filozofii. Realizm wewnętrzny Hilarego Putnama pozwala wyjaśnić w jaki sposób podmiot rozpoznaje egzemplarze należące do danego rodzaju naturalnego, bez znajomości definicji tego rodzaju naturalnego. David Charles pokazuje, że Arystoteles podziela podobny pogląd, choć nie uważa, że podmiot musi zakładać, iż istnieje definicja danego rodzaju. Twierdzę, że ten aspekt teorii Arystotelesa może być zastosowany także do identyfikacji czynów moralnie dobrych. Jednostka może rozpoznawać dobre czyny jako czyny konieczne do prowadzenia cnotliwego życia. Nie musi wiedzieć dlaczego określone czyny są dobre. Wystarczy, że ma wizję dobrego życia, którą – jak twierdzi Arystoteles – może rozwinąć poprzez naśladowanie tych, którzy mają „oko doświadczenia”. (shrink)

Among the readers of Swedenborg, the Swedish thinker’s ‘theory of correspondences’ is often interpreted as treating empirical realities as only imperfect manifestations of spiritual realities. This interpretation that ascribes idealism to Swedenborg was originally proposed by Kant in the Dreams of a Spirit-Seer. Although Kant criticizes Swedenborg’s theory, he considers it no inferior to the theories of Leibniz and Wolf, which can entice a reader of Swedenborg to take Kant’s interpretation at face value: even if Kant did not agree with (...) Swedenborg, at least he took him to be on par with these ‘serious’ philosophers. However, this paper attempts to show that unless a reader of Swedenborg is willing to endorse Kant’s disdain towards ‘enthusiasm’, Swedenborg should not be interpreted as a Platonic idealist, because he devised his theory of correspondences precisely in order to avoid such idealism. As few scholars have recently pointed out, Swedenborg, like Kant, thinks that all our cognitive abilities operate in the limits of time and space, i.e. in the empirical world, but for Swedenborg, as opposed to Kant, this does not imply that we cannot acquire knowledge of the spiritual world. According to these scholars, Swedenborg thinks that such knowledge can only be acquired mystically, which would render him a Platonic idealist, just as Kant claimed. However, this paper claims that pace the aforementioned scholars, this is not the only or even the default way of coming to know the spiritual world according to Swedenborg. The paper argues that when positing that every empirical and spiritual reality ‘correspond’ with one another, Swedenborg uses the Latin word correspondere in a technical sense. In other words, he thinks that any human cognition is both spiritual in the sense of involving a logical relationship between extension and spirit, and empirical by occurring in time and space. Thus, by cognising something in the empirical world, we also cognise something in the spiritual world, even if we were not capable of knowing spiritual realities in themselves. This element of Swedenborg’s theory distances him from Platonic idealism. The paper concludes with a suggestion that Kant might have perceived the limitations of his interpretation of Swedenborg later on, as signalled by the fact that in the early 1780s, Kant extended his conception of Platonism to include all philosophy other than his own. However, taking this road would make Platonic idealism an uninformative concept for an interpreter of Swedenborg and apt to be replaced by the term ‘enthusiasm’–the concept that Kant used when describing those with whom he disagreed. (shrink)

Certain passages of Nicomachean Ethics seem to suggest a model of moral education that excludes those who have been misguided by their educators from being responsible for their character. I will argue, however, that this impression may result from misinterpreting the method of Aristotle’s moral educators. It is often thought, at least since Myles Burnyeat’s classic paper, ‘Aristotle on Learning to Be Good’1, that according to Aristotle, a moral educator should tell to moral students which actions are good so that (...) they could begin to practice performing them. I will show that this interpretation is both exegetically problematic, and the likely cause of the above, uncharitable impression. I will argue that it would be more justifiable to interpret Aristotle to be maintaining that the moral students should discover good actions themselves, though trial and error, and that the moral educator might only be needed to keep them away from acting too badly, as Howard Curzer has proposed2. Since in order to discover good actions on his own, a moral student needs to exercise moral discernment, he could be held responsible of the character that he will develop even if his moral educators were misguided him. I will suggest that Aristotle might think that what enables even morally misled people to become morally discerning learners is synesis–ability to identify good actions on the basis of other people’s opinions. (shrink)

Among the readers of Swedenborg, the Swedish thinker’s ‘theory of correspondences’ is often interpreted as treating empirical realities as only imperfect manifestations of spiritual realities. This interpretation that ascribes idealism to Swedenborg was originally proposed by Kant in the Dreams of a Spirit-Seer. Although Kant criticizes Swedenborg’s theory, he considers it no inferior to the theories of Leibniz and Wolf, which can entice a reader of Swedenborg to take Kant’s interpretation at face value: even if Kant did not agree with (...) Swedenborg, at least he took him to be on par with these ‘serious’ philosophers. However, this paper attempts to show that unless a reader of Swedenborg is willing to endorse Kant’s disdain towards ‘enthusiasm’, Swedenborg should not be interpreted as a Platonic idealist, because he devised his theory of correspondences precisely in order to avoid such idealism. As few scholars have recently pointed out, Swedenborg, like Kant, thinks that all our cognitive abilities operate in the limits of time and space, i.e. in the empirical world, but for Swedenborg, as opposed to Kant, this does not imply that we cannot acquire knowledge of the spiritual world. According to these scholars, Swedenborg thinks that such knowledge can only be acquired mystically, which would render him a Platonic idealist, just as Kant claimed. However, this paper claims that pace the aforementioned scholars, this is not the only or even the default way of coming to know the spiritual world according to Swedenborg. The paper argues that when positing that every empirical and spiritual reality ‘correspond’ with one another, Swedenborg uses the Latin word correspondere in a technical sense. In other words, he thinks that any human cognition is both spiritual in the sense of involving a logical relationship between extension and spirit, and empirical by occurring in time and space. Thus, by cognising something in the empirical world, we also cognise something in the spiritual world, even if we were not capable of knowing spiritual realities in themselves. This element of Swedenborg’s theory distances him from Platonic idealism. The paper concludes with a suggestion that Kant might have perceived the limitations of his interpretation of Swedenborg later on, as signalled by the fact that in the early 1780s, Kant extended his conception of Platonism to include all philosophy other than his own. However, taking this road would make Platonic idealism an uninformative concept for an interpreter of Swedenborg and apt to be replaced by the term ‘enthusiasm’–the concept that Kant used when describing those with whom he disagreed. (shrink)

Among the readers of Swedenborg, the Swedish thinker’s ‘theory of correspondences’ is often interpreted as treating empirical realities as only imperfect manifestations of spiritual realities. This interpretation that ascribes idealism to Swedenborg was originally proposed by Kant in the Dreams of a Spirit-Seer. Although Kant criticizes Swedenborg’s theory, he considers it no inferior to the theories of Leibniz and Wolf, which can entice a reader of Swedenborg to take Kant’s interpretation at face value: even if Kant did not agree with (...) Swedenborg, at least he took him to be on par with these ‘serious’ philosophers. However, this paper attempts to show that unless a reader of Swedenborg is willing to endorse Kant’s disdain towards ‘enthusiasm’, Swedenborg should not be interpreted as a Platonic idealist, because he devised his theory of correspondences precisely in order to avoid such idealism. As few scholars have recently pointed out, Swedenborg, like Kant, thinks that all our cognitive abilities operate in the limits of time and space, i.e. in the empirical world, but for Swedenborg, as opposed to Kant, this does not imply that we cannot acquire knowledge of the spiritual world. According to these scholars, Swedenborg thinks that such knowledge can only be acquired mystically, which would render him a Platonic idealist, just as Kant claimed. However, this paper claims that pace the aforementioned scholars, this is not the only or even the default way of coming to know the spiritual world according to Swedenborg. The paper argues that when positing that every empirical and spiritual reality ‘correspond’ with one another, Swedenborg uses the Latin word correspondere in a technical sense. In other words, he thinks that any human cognition is both spiritual in the sense of involving a logical relationship between extension and spirit, and empirical by occurring in time and space. Thus, by cognising something in the empirical world, we also cognise something in the spiritual world, even if we were not capable of knowing spiritual realities in themselves. This element of Swedenborg’s theory distances him from Platonic idealism. The paper concludes with a suggestion that Kant might have perceived the limitations of his interpretation of Swedenborg later on, as signalled by the fact that in the early 1780s, Kant extended his conception of Platonism to include all philosophy other than his own. However, taking this road would make Platonic idealism an uninformative concept for an interpreter of Swedenborg and apt to be replaced by the term ‘enthusiasm’–the concept that Kant used when describing those with whom he disagreed. (shrink)

This article argues that contrary to a received interpretation, Emanuel Swedenborg’s doctrine of correspondences, according to which each empirical reality has a corresponding spiritual reality, is closer to Spinozistic monism than Neoplatonic idealism. According to the former, there is only one substance: God, which we can cognize through its spir­itual and material aspects. According to the latter, the material world consists of substances that receive their form through participation in the ideas of the spiri­tual world. The article will show that (...) although some of Swedenborg’s claims can appear as expressing Neoplatonic idealism, his reading of the Bible as a guide for moral improvement, his rejection of the religious mysteries that cannot be rationally understood, his various examples of correspondences, his view that we can cognize God by studying the correspondences, and his definition of God as the only substance, make evident that he does not consider the spiritual realities ideas in the Neoplatonic sense. The article will interpret Swedenborg to think that the spiritual realities are learned concepts that enable us to describe and experience the world as having spiritual significance and thus acquire a fuller cognition of God. (shrink)

This paper examines a looming reproducibility crisis in the core of the hard sciences. Namely, it concentrates on molecular modeling and simulation (MMS), a family of methods that predict properties of substances through computing interactions on a molecular level and that is widely popular in physics, chemistry, materials science, and engineering. The paper argues that in order to make quantitative predictions, sophisticated models are needed which have to be evaluated with complex simulation procedures that amalgamate theoretical, technological, and social factors (...) – leading to problems with reproducibility. Thus, for methodological reasons, the predictive success causes a reproducibility problem. (shrink)

Background: Treating medication-refractory freezing of gait in Parkinson’s disease remains challenging despite several trials reporting improvements in motor symptoms using subthalamic nucleus or globus pallidus internus deep brain stimulation. Pedunculopontine nucleus region DBS has been used for medication-refractory FoG, with mixed findings. FoG, as a paroxysmal phenomenon, provides an ideal framework for the possibility of closed-loop DBS.Methods: In this clinical trial, five subjects with medication-refractory FoG underwent bilateral GPi DBS implantation to address levodopa-responsive PD symptoms with open-loop stimulation. Additionally, PPN (...) DBS leads were implanted for CL-DBS to treat FoG. The primary outcome of the study was a 40% improvement in medication-refractory FoG in 60% of subjects at 6 months when “on” PPN CL-DBS. Secondary outcomes included device feasibility to gauge the recruitment potential of this four-lead DBS approach for a potentially larger clinical trial. Safety was judged based on adverse events and explantation rate.Findings: The feasibility of this approach was demonstrated as we recruited five subjects with both “on” and “off” medication freezing. The safety for this population of patients receiving four DBS leads was suboptimal and associated with a high explantation rate of 40%. The primary clinical outcome in three of the five subjects was achieved at 6 months. However, the group analysis of the primary clinical outcome did not reveal any benefit.Interpretation: This study of a human PPN CL-DBS trial in medication-refractory FoG showed feasibility in recruitment, suboptimal safety, and a heterogeneous clinical effect in FoG outcomes. (shrink)

Over the past few years, the Virtual Organization (VO) paradigm has been emerging as an ideal solution to support collaboration among globally distributed entities (individuals and/or organizations). However, due to rapid technological and societal changes, there has also been an astonishing growth in technologies and services for mobile users. This has opened up new collaborative scenarios where the same participant can access the VO from different locations and mobility becomes a key issue for users and services. The nomadicity and mobility (...) introduces additional challenges for managing collaboration in VO environments. This paper focuses on the Identity Management challenge in a Mobile Dynamic VO environment, which is a VO that takes into account nomadicity and seamless mobility aspects as elaborated within the EU funded project Akogrimo (Access to Knowledge through the Grid in a mobile world). The resulting work is the design of the Akogrimo Identity Management system supporting the authentication and authorization process across the different administrative domains of the Mobile Dynamic VO. This design follows the service oriented approach and integrates the different perspectives: that of the network, that of the user and that of the service provider. Such an integration requires facing challenges; both from the architectural and technological viewpoints because different ‘worlds’ (i.e. network and service level) leverage different (and sometimes conflicting) approaches when addressing Identity Management. (shrink)