The Mona Lisa is probably the most celebrated example of ambiguous expression in art. Soranzo and Newberry demonstrated that a similar ambiguity can be perceived also in La Bella Principessa, another portrait credited to Leonardo da Vinci by many. The paper aims to show that an ambiguous expression can be perceived in a further painting attributed to Leonardo: The Lady with Dishevelled Hair, or La Scapigliata. An experiment was conducted whereby participants rated on a 7-point Likert scale the perceived (...) level of contentment of La Scapigliata and that of a comparable painting created by Andrea di Cione, alias Il Verrocchio. The two artworks were presented in random order to two groups of participants. One group could see the artworks from Close whilst the other group from Far from a Close or Far condition. Results show that the change of distance affected the perceived level of contentment of Leonardo’s figure but not that of Verrocchio’s. Specifically, whilst both artworks received similar ratings of contentment from the close-up condition, La Scapigliata was perceived to be more content from afar. It is concluded that La Scapigliata exhibits an ambiguous expression, and that this ambiguity is similar to the one observed in the Mona Lisa and La Bella Principessa. This result can be only partially interpreted within the spatial frequency hypothesis advanced by Livingstone and shows that a phenomenological account of Leonardo’s work might be more suited to capture the full extent of the phenomenon. Specifically, it is suggested that the principles of perceptual belongingness may need to be considered to fully capture the extent of the ambiguity depicted by Leonardo. (shrink)

Understanding the functional mechanisms underlying genetic signals associated with complex traits and common diseases, such as cancer, diabetes and Alzheimer's disease, is a formidable challenge. Many genetic signals discovered through genome‐wide association studies map to non‐protein coding sequences, where their molecular consequences are difficult to evaluate. This article summarizes concepts for the systematic interpretation of non‐coding genetic signals using genome annotation data sets in different cellular systems. We outline strategies for the global analysis of multiple association intervals and the in‐depth (...) molecular investigation of individual intervals. We highlight experimental techniques to validate candidate (potential causal) regulatory variants, with a focus on novel genome‐editing techniques including CRISPR/Cas9. These approaches are also applicable to low‐frequency and rare variants, which have become increasingly important in genomic studies of complex traits and diseases. There is a pressing need to translate genetic signals into biological mechanisms, leading to prognostic, diagnostic and therapeutic advances. (shrink)

This article serves as a step-by-step guide of a new application of Q-methodology to investigate people’s preferences for multivariate stimuli. Q-methodology has been widely applied in fields such as sociology, education and political sciences but, despite its numerous advantages, it has not yet gained much attention from experimental psychologists. This may be due to the fact that psychologists examining preferences, often adopt stimuli resulting from a combination of characteristics from multiple variables, and in repeated measure designs. At present, Q methodology (...) has not been adapted to accommodate. We therefore developed a novel analysis procedure allowing Q-methodology to handle these conditions. We propose a protocol requiring five analyses of a decision process to estimate: the preference of stimuli, the dominance of variables, the individual differences, the interaction between individual differences and preference, and the interaction between individual differences and dominance. The guide comes with a script developed in R to run the five analyses; furthermore, we provide a case study with a detailed description of the procedure and corresponding results. This guide is particularly beneficial to conduct and analyze experiments in any research on people’s preferences, such as experimental aesthetics, prototype testing, visual perception, etc. (shrink)

In 1993, Agostini and Proffitt showed that perceptual belongingness causes simultaneous lightness contrast to be seen in configurations in which the inducing elements are not adjacent to the target. The aim of the present research was to measure the strength of belongingness in determining the contrast phenomenon when the numbers of the inducing and induced elements and their relative positions are manipulated in Agostini-and-Proffitt-type configurations. In the first experiment, by using a forced choice paradigm, naïve observers indicated which gray disks (...) arranged to form the letter T in two rows appeared lighter/darker. In the second experiment, expert observers performed two nulling tasks: 1) the lightness of gray disk was adjusted until it was perceived equal to that of gray target aligned with white/black inducers; 2) the lightness of target organized with white/black inducers was adjusted to match the target organized with black/ white inducers. We found that also when there are few inducers, perceptual belongingness causes the contrast effect to propagate spatially on all the induced elements. Spatial position does not influence the induction effect. Low-level theories cannot account for these phenomena, but higher-level processes must be factored in to explain them. (shrink)

Thus we read these lines in the manuscripts and in the printed editions ; thus the lines were read in the Middle Ages and, perhaps, already in antiquity.

We have surveyed various recent European opinions on Germ-Line engineering. The majority express more or less severe reservations about any interventions on the human Germ-Line, including therapeutic ones. However, they are divided over the pragmatic, or categorical-ethical nature of the relevant arguments. This split reflects two competing views of technology. The ‘pessimistic’ one is deeply concerned by the slippery slope leading from bona fide therapeutic applications of genetic engineering to eugenic practices. It insists that, if anything can defend us against (...) these evils, it must be a set of strong, ethically-based prohibitions. The other, ‘optimist’ view is more confident in the discriminating powers of societal regulation. We argue for the latter view and suggest that the pragmatic arguments brought to this debate are less problematic than the ethical ones. (shrink)

В настоящей книге представлен анализ внутренней логики и социокультурного контекста существования Московского методологического кружка - одной из самых влиятельных мыслительно-практических контркультурных традиций советской эпохи.

La filosofía de la historia se ha debatido durante siglos en una estéril lucha entre idealistas y materialistas. El libro de Ignacio Ellacuría es un intento de superar esa dicotomía clásica. Tomando como punto de partida algunos conceptos fundamentales de la filosofía de Zubiri, Ellacuría cree posible asumir y a la vez criticar ambos extremos, desde una actitud más realista. De ahí el título del libro. Es importante destacar que la historia, para Ignacio Ellacuría, es el lugar de realización de (...) la ética. La historia no está hecha, se construye, es un proceso de creación de posibilidades humanas, y, en tanto que tal, una labor ética. La tesis de Zubiri de que el hombre tiene que hacerse cargo de la realidad, en Ellacuría se transforma en esta otra: el ser humano está obligado a encargarse de la realidad, y a cargar con ella. Este es el imperativo ético. Imperativo que, por otra parte, no sólo le obliga individualmente al hombre, en el reducto de la propia conciencia, al modo del idealismo, ni tampoco sólo en tanto que miembro de una clase social, como en el marxismo, sino como sujeto a la vez individual y específico, como miembro a la vez solitario y solidario de la especie humana. La obra póstuma de Ignacio Ellacuría constituye sin duda su más ingente trabajo intelectual en el campo de la filosofía, y representa, por su calidad y contenido, una pieza clave para comprender no solamente su producción estrictamente filosófica, sino también su pensamiento teológico y socio-político. (shrink)

Contemporary psychiatry maintains the myth that it is value neutral by appeal to modern medical science for both its diagnostic categories and its therapeutic interventions, leaving the impression that it relies on reason—that is to say, reason divorced from tradition—to master human nature. Such a practice has a certain way of characterizing and defining humanity's lapses from acceptable human behavior—a lapse from human being. The modern practice of psychiatry applies a particular notion (largely influenced by Enlightenment ideals) of scientific instrumentation (...) to the human person in order to diagnose the ailment and manufacture a corresponding treatment in keeping with a hidden conception of human biological flourishing. This covert vision is an impoverished (and possibly dangerous) one. As much as the practice of psychiatry is constrained by the goals of the dominant moral tradition of our day, it becomes a tool (or technique) for achieving the transient and partial ends of modern individualism. Given this truncated view of human nature and human end, modern psychiatry fails to attend comprehensively to the unity of a life, missing altogether the essential relevance of character formation, and thereby forfeiting excellence in human flourishing. (shrink)

Первое российское энциклопедическое издание, посвященное философии буддизма, является самым полным в отечественной литературе сводом знаний о буддийской философии. Его главная цель - описать философское кредо буддизма в контексте разнообразия школ.

The overgeneration argument attempts to show that accepting second-order validity as a sound formal counterpart of logical truth has the unacceptable consequence that the Continuum Hypothesis is either a logical truth or a logical falsehood. The argument was presented and vigorously defended in John Etchemendy’s The Concept of Logical Consequence and it has many proponents to this day. Yet it is nothing but a seductive fallacy. I demonstrate this by considering five versions of the argument; as I show, each is (...) either unsound or lacks a troubling conclusion. (shrink)

Brendel and Miller (2008) take the most distinctive commitment in their pragmatic approach to be treating ethical principles as having a hypothetical status. I am sympathetic to a pragmatic approac...

Background This pilot study evaluated the speaking book ‘What it means to be part of a clinical trial’. The book aims at empowering populations with information on their rights and responsibilities when enrolled in clinical research. Wide publication of the book—at significant cost—is anticipated. It is important that the book is evaluated within the communities for whom it is intended, and the necessary changes (if any) are made, before translation and large-scale publication takes place. Objective The objective of the study (...) was to measure the efficacy and ease of use of the book. Methods Participants were recruited from a catering company. Participants were questioned on their knowledge of clinical trials and were then given the book. Instructions for use of the book were given to one group (‘experimental’ group). The other group (‘control’ group) was not given any instructions. A week later, the investigators returned, repeated the knowledge questions and asked ‘ease of use’ questions. Results A two-way repeated measure of covariants showed a statistically significant positive increase in knowledge of clinical trials among the intervention group (p=0.02). Results for the control group displayed trends that were not statistically significant. Percentage analysis of ‘ease of use’ questions proved that the book is easy to use, although some changes would be beneficial. Conclusion This study revealed that the speaking book is easy to use. It significantly increased knowledge of clinical trials among the study sample if instructions on use of the book were provided. (shrink)

An interpretation of the work of Schleiermacher and Otto recently offered by Andrew Dole, according to which these two thinkers differed over the extent to which religion can be explained naturalistically, and over the sense in which the supernatural can be admitted, is examined and refuted. It is argued that there is no difference between the two thinkers on this issue. It is shown that Schleiermacher's claim that a supernatural event is at the same time a natural event does not (...) invite, but rather forecloses the possibility of, a naturalistic explanation of the event. It is further demonstrated that Otto, like Schleiermacher, denied the existence of supernatural events interpreted as events that infringe the laws of nature. (shrink)