Spectacular treatment disasters in recent years have made it clear that informal "let's-try-it-and-see" methods of testing new proposals are more risky now than ever before, and have led many to call for a halt to experimentation in clinical medicine. In this easy-tp-read, philosophical guide to human experimentation, William Silverman pleads for wider use of randomized clinical trials, citing many examples that show how careful trials can overturn preconceived or ill-conceived notions of a therapy's effectiveness and lead to a (...) clearer understanding of clinical anomalies. Because it gives careful guidance on setting up trials and avoiding conceptual pitfalls, this book will be of great interest to all epidemiologists and clinical statisticians, and to a wide varitey of clinicians, pharmacologists, and nurses. Since it requires no medical or statistical knowledge, it will also appeal to ethicists, lawyers, and the general public. (shrink)

Medicine is moving away from reliance on the proclamations of authorities to the use of numerical methods to estimate the size of effects of its interventions. But a rumbling note of uneasiness underlines present-day medical progress: the more we know, The more questions we encounter about what to do with the hard-won information. The essays in Where's the Evidence examine the dilemmas that have arisen as the result of medicine's unprecedented increase in technical powers. How do doctors draw the line (...) between "knowing" (the acquisition of new medical information) and doing" (the application of that new knowledge)? What are the long-term consequences of responding to the demand that physicians always do everything that can be done? Is medicine's primary aim to increase the length of life? Or is it to reduce the amount of pain and suffering? And who is empowered to choose when these ends are mutually exclusive? This engaging collection of essays will be of interest to professionals interested in the evidence-based medicine debate, including epidemiologists, neonatologists, those involved in clinical trials and health policy, medical ethicists, medical students, and trainees. (shrink)

Neonatal pediatrics has made stunning and completely unprecedented progress in recent years. Nonetheless, an increasing number of voices now ask, Where is this field of medicine going? Is it, dare one ask, even headed in the right direction? These are reasonable questions, but first we need to know where this subspecialty of pediatrics has been. The current phenomenon is all the more remarkable because it differs so completely from the past.

Game of Thrones is a popular, award-winning television series with an eight-season run on Home Box Office, based on the Song of Fire and Ice series of books by George R.R. Martin. It depicts a morally complex political situation in a fantasy environment that has some similarities to medieval Europe. In the midst of this setting, the series advocates a cynical attitude towards politics, social structures, and religion. Most notably, the series suggests that there is no such thing as political (...) legitimacy. This chapter identifies a pattern of cynicism throughout Game of Thrones but points towards the thoughts of John Locke and Thomas Aquinas as possible alternatives to the story’s cynicism. (shrink)

Providing the most thorough coverage available in one volume, this comprehensive, broadly based collection offers a wide variety of selections in four major genres, and also includes a section on film. Each of the five sections contains a detailed critical introduction to each form, brief biographies of the authors, and a clear, concise editorial apparatus. Updated and revised throughout, the new Fourth Edition adds essays by Margaret Mead, Russell Baker, Joan Didion, Annie Dillard, and Alice Walker; fiction by Nathaniel Hawthorne, (...) Ursula K. LeGuin, Anton Chekov, James Joyce, Katherine Mansfield, F. Scott Fitzgerald, William Faulkner, Alice Walker, Louise Erdrich, Donald Barthelme, and James McPherson; poems by John Donne, Robert Browning, Walt Whitman, Edwin Arlington Robinson, e.e. cummings, Langston Hughes, W.H. Auden, Philip Levine, and Louise Gluck; and plays by August Wilson, Marsha Norman, Wendy Wasserstein, and Vaclav Havel. The chapter devoted to film examines the relation of film to literature and gives the complete screenplay for Citizen Kane plus close analysis of a scene from the film. With its innovative structure, comprehensive coverage, and insightful and stimulating presentation of all kinds of literature, this is an anthology readers will turn to again and again. (shrink)

v. 1. Medieval and early classical science.--v. 2. Classical and contemporary science.

Brief thumbnail sketches capture group interest and show the relevance of ethical considerations in real life situations. Bill Bain has considerable experience of business and is currently a PhD student at the Management School of London University's Imperial College, 53 Prince's Gate, Exhibition Road, London SW7 2PG.

Objective To determine the attitudes of Egyptian patients regarding their participation in research and with the collection, storage and future use of blood samples for research purposes. Design Cross-sectional survey. Study population Adult Egyptian patients (n=600) at rural and urban hospitals and clinics. Results Less than half of the study population (44.3%) felt that informed consent forms should provide research participants the option to have their blood samples stored for future research. Of these participants, 39.9% thought that consent forms should (...) include the option that future research be restricted to the illness being studied. A slight majority (66.2%) would donate their samples for future genetic research. Respondents were more favourable towards having their blood samples exported to other Arab countries (62.0%) compared with countries in Europe (41.8%, p<0.001) and to the USA (37.2%, p<0.001). Conclusions This study shows that many individuals do not favour the donation of a blood sample for future research. Of those who do approve of such future research, many favour a consent model that includes an option restricting the future research to the illness being studied. Also, many Egyptians were hesitant to have their blood samples donated for genetic research or exported out of the Arab region to the USA and European countries. Further qualitative research should be performed to determine the underlying reasons for many of our results. (shrink)

Contemporary thinkers who address the problem of causal relations generally favor Hume’s analysis, although some periodically manifest interest in Aristotle’s exposition as an important and viable alternative. Few, however, find among the many philosophers who came between Aristotle and Hume any worthwhile contributor to the development of this problematic. Some might note, for example, Nicholas of Autrecourt as a medieval precursor of Hume, but this merely keeps the discussion fluctuating between the same two poles. This essay aims to call attention (...) to a different and intermediate view, not hitherto noted, that was proposed in the High Middle Ages by Thomas Aquinas. It argues that Aquinas made a significant advance beyond Aristotle in his analysis of antecedent causation, and thereby made possible the certification of some elements in Hume’s analysis, without subscribing to its more extreme results. In so doing, moreover, Aquinas adumbrated some problems in contemporary analytic discussions of the causal relationships between events, and consequently may shed light on their solution. (shrink)

This book is the first detailed reconstruction of the late work of John Rawls, who was perhaps the most influential philosopher of the twentieth century. Rawls's 1971 treatise, A Theory of Justice, stimulated an outpouring of commentary on 'justice-as-fairness,' his conception of justice for an ideal, self-contained, modern political society. Most of that commentary took Rawls to be defending welfare-state capitalism as found in Western Europe and the United States. Far less attention has been given to Rawls's 2001 book, Justice (...) as Fairness: A Restatement. In the Restatement, Rawls not only substantially reformulates the 'original position' argument for the two principles of justice-as-fairness but also repudiates capitalist regimes as possible embodiments. Edmundson further develops Rawls's non-ideal theory, which guides us when we find ourselves in a society that falls well short of justice. (shrink)

The use of mathematical models to support decision making is proliferating in both the public and private sectors. Advances in computer technology and greater opportunities to learn the appropriate techniques are extending modeling capabilities to more and more people. As powerful decision aids, models can be both beneficial or harmful. At present, few safeguards exist to prevent model builders or users from deliberately, carelessly, or recklessly manipulating data to further their own ends. Perhaps more importantly, few people understand or appreciate (...) that harm can be caused when builders or users fail to recognize the values and assumptions on which a model is based or fail to take into account all the groups who would be affected by a model's results. This volume provides a setting for a dialogue about ethics and shows the need to continue and define a vocabulary for exploring ethical concerns. It will become increasingly important for model builders and users to have a clear and strong code of ethics to guide them in making the ethical decisions they surely will have to face. (shrink)

A summary of basics for student and seminarian.

The problem of Galileo's logical methodology has long interested scholars. In this volume William A. Wallace offers a solution that is completely unexpected, yet backed by convincing documentary evidence. His analysis starts with an early notebook Galileo wrote at Pisa, appropriating a Jesuit professor's exposition of the Posterior Analystics of Aristotle, and ends with one of the last letters Galileo wrote, stating that in logic he has been a Peripatetic all his life. Wallace's detective work unearths the complete logic (...) course from which the notebook was excerpted, then proceeds to show how its terminology and methodology continue to surface in Galileo's later writings in which he founds his new sciences of the heavens and of local motion. The result is a tour de force that commends itself not only to Galileo's scholars and to logicians, philosophers, and historians, but to anyone interested in the epistemic roots of modern science. (shrink)

Philosophy, despite its typical attitude of detachment and abstraction, has for most of its long history been engaged with the practical and mundane-seeming question of whether there is a duty to obey the law. As Matthew Kramer has recently summarized: “For centuries, political and legal theorists have pondered whether each person is under a general obligation of obedience to the legal norms of the society wherein he or she lives. The obligation at issue in those theorists' discussions is usually taken (...) to be prima-facie, comprehensively applicable, universally borne, and content-independent.” This essay is a commentary on the current state of discussion of this perennial philosophical topic. (shrink)

Rights come in various types - human, moral, civil, political and legal - and claims about who has a right, and to what, are often contested. What are rights? Are they timeless and universal, or merely conventional? How are they related to other morally significant values, such as well-being, autonomy, and community? Can animals have rights? Or fetuses? Do we have a right to do as we please so long as we do not harm others? This is the only accessible (...) and readable introduction to the history, logic, moral implications, and political tendencies of the idea of rights. It is organized chronologically and discusses important events, such as the French Revolution. As an undergraduate text it is well-suited to introductions to political philosophy, moral philosophy, and ethics. It could also be used in courses on political theory in departments of political science and government, and in courses on legal theory in law schools. (shrink)

Darwin's greatest accomplishment was to show how life might be explained as the result of natural selection. But does Darwin's theory mean that life was unintended? William A. Dembski argues that it does not. In this book Dembski extends his theory of intelligent design. Building on his earlier work in The Design Inference (Cambridge, 1998), he defends that life must be the product of intelligent design. Critics of Dembski's work have argued that evolutionary algorithms show that life can be (...) explained apart from intelligence. But by employing powerful recent results from the No Free Lunch Theory, Dembski addresses and decisively refutes such claims. As the leading proponent of intelligent design, Dembski reveals a designer capable of originating the complexity and specificity found throughout the cosmos. Scientists and theologians alike will find this book of interest as it brings the question of creation firmly into the realm of scientific debate. (shrink)

The design inference uncovers intelligent causes by isolating their key trademark: specified events of small probability. Just about anything that happens is highly improbable, but when a highly improbable event is also specified undirected natural causes lose their explanatory power. Design inferences can be found in a range of scientific pursuits from forensic science to research into the origins of life to the search for extraterrestrial intelligence. This challenging and provocative 1998 book shows how incomplete undirected causes are for science (...) and breathes new life into classical design arguments. It will be read with particular interest by philosophers of science and religion, other philosophers concerned with epistemology and logic, probability and complexity theorists, and statisticians. (shrink)

The aim of this paper is to report some little-known aspects of sixteenth-century physics as these relate to the development of mechanics in the seventeenth century. The research herein reported grew out of a study on the mechanics of Domingo de Soto, a sixteenth-century Spanish scholastic,1 which has been concerned, in part, with examining critically Pierre Duhem's thesis that the English “Calculatores” of the fourteenth century were a primary source for Galileo's science.2 The conclusion to which this has come, thus (...) far, is that Duhem had important insights into the late medieval preparation for the modern science of mechanics, but that he left out many of the steps. And the steps are important, whether one holds for a continuity theory or a discontinuity theory vis-à-vis the connection between late medieval and early modern science. (shrink)

THE pervasive role of causality in the development of Galileo's science has been obscured largely by two factors. Philosophers who address the problem usually exhibit an anti-causal bias traceable to David Hume, and this disposes them to concentrate on passages in Galileo's writings that can be given a positivist interpretation. Historians are likewise selective in their treatment of his texts, for they tend to enforce sharp dichotomies between Galileo's earlier Latin compositions and his treatises in Italian, especially the two dialogues (...) of his later years for which he is justly famous. With this twofold reinforcement from philosophers and historians of science, one might think that the problem of causality in Galileo's science is whether or not the Italian physicist actually reasoned in causal terms such as those explained in Aristotle's Posterior Analytics. A large and influential school at the moment would say that this is the question, and that it is best answered in the negative: causal analysis played little or no role in the development of Galileo's science, and certainly less and less in his later years. Indeed, it was his rejection of Aristotle precisely on these grounds that merits for him the title, "Father of Modern Science," the canons of which science are almost diametrically opposite those of the science advocated by Greek peripatetics and medieval scholastics, before the onset of the modern era. (shrink)

How is a legitimate state possible? Obedience, coercion and intrusion are three ideas that seem inseparable from all government and seem to render state authority presumptively illegitimate. This book exposes three fallacies inspired by these ideas and in doing so challenges assumptions shared by liberals, libertarians, cultural conservatives, moderates and Marxists. In three clear and tightly argued essays William Edmundson dispels these fallacies and shows that living in a just state remains a worthy ideal. This is an important book (...) for all philosophers, political scientists and legal theorists as well as other readers interested in the views of Rawls, Dworkin and Nozick, many of whose central ideas are subjected to rigorous critique. (shrink)