Advocates of an ‘extended evolutionary synthesis’ have claimed that standard evolutionary theory fails to accommodate epigenetic inheritance. The opponents of the extended synthesis argue that the evidence for epigenetic inheritance causing adaptive evolution in nature is insufficient. We suggest that the ambiguity surrounding the conception of the gene represents a background semantic issue in the debate. Starting from Haig’s gene-selectionist framework and Griffiths and Neumann-Held’s notion of the evolutionary gene, we define senses of ‘gene’, ‘environment’, and ‘phenotype’ in a way (...) that makes them consistent with gene-centric evolutionary theory. We argue that the evolutionary gene, when being materialized, need not be restricted to nucleic acids but can encompass other heritable units such as epialleles. If the evolutionary gene is understood more broadly, and the notions of environment and phenotype are defined accordingly, current evolutionary theory does not require a major conceptual change in order to incorporate the mechanisms of epigenetic inheritance. _1_ Introduction _2_ The Gene-centric Evolutionary Theory and the ‘Evolutionary Gene’ _2.1_ The evolutionary gene _2.2_ Genes, phenotypes, and environments _3_ Epigenetic Inheritance and the Gene-Centred Framework _3.1_ Treating the gene as the sole heritable material? _3.2_ Epigenetics and phenotypic plasticity _4_ Conclusion. (shrink)

Heritability estimates obtained from genome-wide association studies are much lower than those of traditional quantitative methods. This phenomenon has been called the “missing heritability problem.” By analyzing and comparing GWAS and traditional quantitative methods, we first show that the estimates obtained from the latter involve some terms other than additive genetic variance, while the estimates from the former do not. Second, GWAS, when used to estimate heritability, do not take into account additive epigenetic factors transmitted across generations, while traditional quantitative (...) methods do. Given these two points we show that the missing heritability problem can largely be dissolved. (shrink)

Graphical AbstractThere are four major hypotheses (H1, H2, H3, and H4) as to the source of missing heritability. We propose that estimates obtained from GWAS underestimate heritability by not taking into account non-DNA (epigenetic) sources of heritability. Taking those factors into account (H4) should result in increased heritability estimates.

This paper is an original attempt to understand the foundations of economic reasoning. It endeavors to rigorously define the relationship between subjective interpretations and objective valuations of such interpretations in the context of theoretical economics. This analysis is substantially expanded through a dynamic approach, where the truth of a valuation results in an updated interpretation or changes in the agent's subjective belief regarding the effectiveness of the selected action as well as the objective reality of the effectiveness of all other (...) possible actions (i.e. consequence realization). Complications arise when the economic agent is presented with a set of actions that render ambiguous preference, or when the effectiveness of an action cannot be perceived upon its selection, thereby necessitating a different theory of choice and consequence realization. (shrink)

This work is developed to improve the current quality of e-commerce logistics services. From the perspective of multiple consumer psychology, based on e-commerce, consumer psychology, and other related theories, vegetable e-commerce B is selected as the research object. The commodity quality, accuracy, and timeliness of commodity distribution and other factors of e-commerce B are discussed through questionnaire survey. Then, according to customers’ opinions about “e-commerce B’s distribution and professional aspects that need to be improved,” the research is conducted. Finally, the (...) direction of follow-up optimization is proposed from four different perspectives of multiple consumption psychology. The research results show that more than 89% of the surveyed customers believe that e-commerce B does a good job in terms of commodity quality, accuracy, and timeliness of commodity distribution, and has a high level of logistics service. However, 26.34% of customers hope that e-commerce B can strengthen the protection of personal privacy, 24.97% hope that the platform can add “delay insurance” for goods, and 39.54% hope that the logistics information of purchased goods can be updated in real time. Therefore, e-commerce B needs to be optimized and improved continuously in the future development. Therefore, research on the optimization of logistics service quality of e-commerce is performed under multiple consumption psychology, which provides certain help for the rapid development of subsequent e-commerce. (shrink)

2. The mouth: Sexuality and metaphysics.

In this paper I take a critical look at Judith Jarvis Thomson famous violinist analogy for abortion. I argue that while the violinist example does show that a right to life does not entail a right to be given the means of life, the violinist cast is relevantly different from the pregnancy case. I also argue that Thomson's positive argument in favor of the permissibility of abortion fails because it is based on a false conception of bodily self-ownsership. Finally, I (...) offer an argument against abortion built not on the child's rights, but the mother's obligation to the vulnerable. (shrink)

With a focus on Confucian descriptions, this book carefully examines feeling, value and virtue and reveals the order of the heart by a phenomenological clarification of our personal and interpersonal experience.

This book is a comparative study of the fundamental metaphysical assumptions and their epistemological implications in Chinese and Western philosophy. The author uses a topical comparison methodology based on responses to a central topical issue to argue for commensurability in Chinese and Western metaphysics.

This book is a comparative study of the fundamental metaphysical assumptions and their epistemological implications in Chinese and Western philosophy. The author uses a topical comparison methodology based on responses to a central topical issue to argue for commensurability in Chinese and Western metaphysics.

本书是一本介绍道教与中国古代政治的书。研究的内容包括:道家政治伦理思想的发展概况及其理论基础;对于仁义礼法的道德批判等。.

本书考察了以理学家, 科技实践家, 医学研究者及人文学等为代表的典型人物的科技思想, 比较清晰地勾勒出金元科技思想史的发展脉络, 并对金元科技思想的历史演变及宗教特征进行了新的学术审视和反思. 本书分为上下两卷, 本册为上卷.

Lun Xun's collected anti-Confucianist writings.

The persistent challenge of formulating ontic structuralism in a rigorous manner, which prioritizes structures over the entities they contain, calls for a transformation of traditional logical frameworks. I argue that Univalent Foundations (UF), which feature the axiom that all isomorphic structures are identical, offer such a foundation and are more attractive than other proposed structuralist frameworks. Furthermore, I delve into the significance in the case of the hole argument and, very briefly, the nature of symmetries.

1. Die religiöse Krisis des deutschen Idealismus.--2. Idealismus und Erweckungsbewegung im Kampf und im Bund.