This provocative but persuasive book is essentially a radical attack upon the Humean conception of causality and the presentation and defense of a counter-theory, closer to everyday experience and pre-Humean traditional views. As formulated by empiricist philosophers, the Humean approach depends on two basic postulates. The philosophical analysis of any non-empirical concept must be a formal explication; any residue elements have to be accounted for in terms of their psychological origins. The world as experienced can be conceived adequately as a (...) logically independent system of things or flux of events, without the unwarranted assumption that individuals persist diachronically. As the grounds for undermining these assumptions, the authors develop a conception of causes as "powerful particulars," i.e., things which have both a nature and powers. So long as the nature remains unchanged the agent in question will continue to behave in this fashion with a natural necessity, stemming from the individual’s nature and specific powers. The opening chapter discusses the problem of conceptual and natural necessity—as distinct from logical necessity which alone is allowed by the Humean empiricists. Natural necessity is the mark of the relationship between real causes and their respective effects, whereas conceptual necessity characterizes the way our statements about such are themselves related. Later the irreducibility of natural necessity is emphasized and its differences from logical entailment spelled out. Chapter two takes up the subject of the "regularity theory and its allies." Characteristic of such are two claims: the empirical content of a causal-relationship statement is exhausted by the actual or hypothetical regularity between independent entities, and the necessity ordinarily attributed to causal production is an illusion, to be accounted for in various ways. Subsequent chapters are devoted to assaulting the pillars of the Humean notion either directly or indirectly through an illuminating and attractive account of their own theory of nature, causal powers, and natural necessity. The final chapter, entitled "Fields of Potential," indulges in speculation about the nature of ultimate entities on the basis of an extended generalization of the notion of the powerful individual, and concludes with a brief account of the historical antecedents of Faraday’s modern field theory and the metaphysical implications of a generalized field theory.—A.B.W. (shrink)

Renewed interest in the Presocratics of the last few decades has not ignored Heraclitus, and some new and fruitful lines of inquiry are now being pursued. This article on Heraclitus presents a unified Heraclitus who is a thoughtful critic of his predecessors, and keenly interested in the possibility of human understanding. This Heraclitus rejects the Milesian account of a single substance with systematic changes and transformations that guarantee the stability of the whole. He recognizes that his new views will be (...) difficult to understand, but provides hints and lessons to allow his hearer or reader to grasp his philosophical account. Parmenides of Elea, too, has not been ignored by the scholarly community—a number of new interpretations of Parmenides have appeared in the last decade. (shrink)

Understanding terrestrial carbon metabolism is critical because terrestrial ecosystems play a major role in the global carbon cycle. Furthermore, humans have severely disrupted the carbon cycle in ways that will alter the climate system and directly affect terrestrial metabolism. Changes in terrestrial metabolism may well be as important an indicator of global change as the changing temperature signal. Improving our understanding of the carbon cycle at various spatial and temporal scales will require the integration of multiple, complementary and independent methods (...) that are used by different research communities. Tools such as air sampling networks, inverse numerical methods, and satellite data allow us to study the strength and location of the global- and continental-scale carbon sources and sinks. Bottom-up studies provide estimates of carbon fluxes at finer spatial scales and examine the mechanisms that control fluxes at the ecosystem, landscape, and regional scales. Bottom-up approaches include comparative and process studies that provide the necessary mechanistic information to develop and validate terrestrial biospheric models. An iteration and reiteration of top-down and bottom-up approaches will be necessary to help constrain measurements at various scales. We propose a major international effort to coordinate and lead research programs of global scope of the carbon cycle. (shrink)

In this book I address a dichotomy that is as central as any in ontology - that between ordinary objects or substances and the various attributes (Le., properties, kinds, and relations) we associate with them. My aim is to arrive at the correct philosophical account of each member of the dichotomy. What I shall argue is that the various attempts to understand substances or attri butes in reductive terms fail. Talk about attributes, I shall try to show, is just that (...) - talk about attributes; and, likewise, talk about substances is just tha- talk about substances. The result is what many will find a strange combina tion of views - a Platonistic theory of attributes, where attributes are univer sals or multiply exemplifiable entities whose existence is independent of "the world of flux", and an Aristotelian theory of substance, where substances are basic unities not reducible to metaphysically more fundamental kinds of things. Part One is concerned with the ontology of attributes. After distinguishing three different patterns of metaphysical thinking about attributes, I examine, in turn, the phenomena of predication, resemblance, and higher order quanti fication. I argue that none of these phenomena by itself is sufficient to establish the inescapability of a Platonistic interpretation of attributes. Then, I discuss the phenomenon of abstract reference as it is exhibited in the use of abstract singular terms. (shrink)

The fructose 6-phosphate (Fru-6P) saturation curve for phosphofructokinase (PFK) from E. coli is sigmoidal in the presence of saturating MgATP levels, while the corresponding curve for B. stearothermophilus PFK is essentially hyperbolic. Sigmoidality can be due to apparent cooperativity arising from the kinetic mechanism of an enzyme. We have determined the kinetic mechanism of B. stearothermophilus PFK (BsPFK). BsPFK was found to obey a non rapid-equilibrium random mechanism similar to the one E. coli PFK (EcPFK) follows. Substrate inhibition by MgATP (...) was observed. We propose that substrates bind to BsPFK through two alternative pathways, one of which is slower. The substrate inhibition arises in part from reaction flux through the slower pathway. Although EcPFK and BsPFK obey similar kinetic mechanisms, they are inhibited differently by MgATP: EcPFK is profoundly inhibited, BsPFK only weakly. The structural basis for this difference could be closure of the active site via a conformational transition that occurs in EcPFK, but not BsPFK. To investigate the importance of this transition for MgATP inhibition of EcPFK, we have constructed a chimeric enzyme (ChiPFK) that contains the "rigid" ATP-binding domain of BsPFK grafted onto the remainder of the EcPFK subunit. Our results indicate that ChiPFK is locked in an "open" structure resembling the activated form of EcPFK. It is insensitive to heterotropic regulation. Nevertheless, ChiPFK exhibits residual cooperativity. Possible explanations for the cooperativity are discussed. The 6F loop is proposed to be important in PFK allosteric behavior. Residues along the loop are largely conserved between BsPFK and EcPFK, except for 161, which is a glutamate in BsPFK, and a glutamine in EcPFK. Using site-directed mutagenesis, Glu 161 of BsPFK has been changed to glutamine and alanine. Similarly, Gin 161 of EcPFK has been changed to glutamate, arginine and alanine. Of the five mutants, one, QA161, was particularly interesting. Though activated normally by GDP, it was completely insensitive to PEP inhibition. This indicates that the hydrogen-bonding ability of residue 161 is critical for PEP inhibition of EcPFK, and that GDP activation and PEP inhibition follow different structural pathways. (shrink)

Ion channels are transport proteins present in the lipid bilayers of biological membranes. They are involved in many physiological processes, such as the generation of nerve impulses, hormonal secretion, and heartbeat. Conformational changes in the ion channel-forming protein allow the opening or closing of pores to control the ionic flux through the cell membranes. The opening and closing of the ion channel have been classically treated as a random kinetic process, known as a Markov process. Here the time the (...) channel remains in a given state is assumed to be independent of the condition it had in the previous state. More recently, however, several studies have shown that this process is not random but a deterministic one, where both the open and closed dwell-times and the ionic current flowing through the channel are history-dependent. This property is called long memory or long-range correlation. However, there is still much controversy regarding how this memory originates, which region of the channel is responsible for this property, and which models could best reproduce the memory effect. In this article, we provide a review of what is, where it is, its possible origin, and the mathematical methods used to analyze the long-term memory present in the kinetic process of ion channels. (shrink)

Steve Awodey and A. W. Carus. The Turning Point and the Revolution: Philosophy of Mathematics in Logical Empiricism from Tractatus on Logical Syllogism.

ABSTRACTA lineage has been drawn between the immanent philosophy articulated by Gilles Deleuze and Félix Guattari and the work of Donna Haraway, most notably by the nomadic feminist and immanentist Rosi Braidotti. However, while containing certain parallels via the process nature of their ontologies, upon further inspection, such an equivocation is unwarranted on the grounds that it fails to remain nuanced in distinguishing the precise ‘mechanism’ or midwife that gives birth to the continued proliferation of the flux of becoming. (...) This disparity is exposed through the erection of a homology using Lacanian psychoanalysis that eases the passing from immanentism to Haraway by showing that the latter inscribes the obverse of L'Autre into the field of becoming unravelling privileged channels of desire. This results in an ingenuity that can never be pinned down by the signifier and, further, actively works to subvert it through ploy. (shrink)

The acclaimed American sociologist and cultural philosopher Philip Rieff gained great academic prestige with his thesis on the emergence of 'Psychological Man' in western culture and with his classic book, Freud: The Mind of the Moralist, published in 1959. In this work and the later The Triumph of the Therapeutic (1966) he not only offered a highly original interpretation of the work of Sigmund Freud, but critically evaluated the enormous influence of psychotherapeutic thinking on Western culture. However, Rieff's later work (...) on the theory of culture did not garner the same attention, and his most recent writings have received very little critical engagement. In Sociology and the Sacred, Antonius A.W. Zondervan sets out to remedy this neglect, arguing that Rieff's work is ripe for intellectual reconsideration. (shrink)

Thagard's theory of explanatory coherence (TEC) is a conceptual and computational framework that is used to show how new scientific theories can be judged to be superior to previous ones. In Structures in Science (SiS), Kuipers criticizes TEC as a model that does not faithfully reflect scientific practice. This article tries to explain the machinery behind TEC, and tries to indicate where TEC falls short (conceptually speaking) and where it can be improved. The main idea proposed in this article is (...) not to derive a coherence network from the input (à la TEC), but to construct a coherence network right from the input itself. (shrink)

The relation is developed between rotation generators of the Lorentz group and the magnetic fields of free-space electromagnetism. Using these classical relations, it is shown that in the quantum field theory there exists a longitudinal photomagneton, a quantized magnetic flux density operator which is directly proportional to the photon spin angular momentum. Commutation relations are given in the quantum field between the longitudinal photomagneton and the usual transverse magnetic components of quantized electromagnetism. The longitudinal component is phase free, but (...) the transverse components are phase dependent. All three components can magnetize material in general, but only the transverse components contribute to Planck's law. The photon therefore has three, not two, relativistically invariant degrees of polarization, an axial, longitudinal, polarization, and the usual right and left circular transverse polarizations. Since the longitudinal polarization is axial, it is a phase- free magnetic field. (shrink)

In this contribution, the author argues that there are in our European tradition two fundamental conceptions of politics since the French Revolution. We can call them the politics as the art of co-existence, and the politics of dénouement. Both conceptions also have a very different stance towards the traditional religions: for the first one mentioned freedom of religion is constitutive, for the second one religion must serve the state or can even be made redundant. Paradigmatic in this respect was the (...) communist treatment of religion as a relic of the past that will disappear when historic reason makes our society transparant . Here politics transforms in a quasi-eschatological political religion. In the twientieth century neo-marxist philosophers say farewell to this kind of politics and begin to rediscover religious inheritances and theological motives. Today two other positions towards religions are noticeable: the utilitaristic reductionist treatment of religion as a need , and ‘Enlightment fundamentalism’ which continues the rationalist communist conception of religion as a relic of the past. The author criticises both tendencies, and defends a ‘politics without dénouement’ which correspondents to a ‘religion without guarantee’. In closing the author argues that the recent populist politics either dream of a new alliance between religion and/or ‘culture’ and the state, or – in a strange inversion of the multicultural ideals of the nineties – promote a purely polemical identity against an ‘alien’ religion, i.c. Islam. Here the author claims that both tendencies fail to recognize the real nature of the new problems. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Motion and Mercutio in Romeo and JulietDaryl W. PalmerThere is nothing permanent that is not true, what can be true that is uncertaine? How can that be certaine, that stands upon uncertain grounds? 1It is by now a commonplace in modern scholarship that drama, particularly Tudor drama, poses questions, rehearses familiar debates, and even speculates about mere possibilities. 2 In 1954, Madeleine Doran spelled out some of the ways (...) in which debate "affected the structure of Elizabethan drama." 3 In turn, Joel B. Altman, having eloquently extended Doran's examination, concludes that "the plays functioned as media of intellectual and emotional exploration for minds that were accustomed to examine the many sides of a given theme, to entertain opposing ideals, and by so exercising the understanding, to move toward some fuller apprehension of truth that could be discerned only through the total action of the drama." 4 Altman points to Henry Medwall's Fulgens and Lucres (c. 1490) as an exemplar of this practice. Although the interlude instructs and entertains, "the center of interest has shifted from demonstration to inquiry. The action develops not from an abstract assertion, but from a specific question: who is the nobler man, Cornelius or Gaius?" 5 By the time William Shakespeare began to write his plays, inquiry was an essential part of dramatic construction. So Juliet asks, "What's in a name?" 6 Hamlet opens with the question: "Who's [End Page 540] there?" (1.1.1), and achieves a kind of apotheosis in the figure of its hero: "To be, or not to be, that is the question..." (3.1.55). Everyone recognizes these familiar questions, and we know (or think we know) how to describe the most viable answers. I want to suggest, however, that this familiarity has dulled our appreciation of the drama's interrogative range. As a way of resisting this tendency, I want to argue that Shakespeare's Romeo and Juliet takes up an ancient conversation about motion, a dialog that originates with the pre-Socratics. This is not to say that the play is ultimately about motion. It obviously engages a panoply of thematic materials. I have simply chosen, in this limited space, to concentrate on the way the playwright stages his questioning as a kind of fencing lesson. My goal is to produce neither a "reading" of the play nor an allegory of philosophy, but rather to recollect the ways in which Shakespeare's drama qualifies and extends an ancient interrogative tradition. In so doing, I follow Stanley Cavell who maintains "that Shakespeare could not be who he is—the burden of the name of the greatest writer in the language, the creature of the greatest ordering of English—unless his writing is engaging the depth of the philosophical preoccupations of his culture." 7Some of the most venerable documents of Western philosophy fix on the problem of motion. If we go back more than 2,300 years, we come upon Plato's Theaetetus, in which Socrates explains a "first principle" to the title character, namely that "the universe really is motion and nothing else." 8 A kind of history lesson in ontology and epistemology, this tentative explanation has its origins in Heraclitus or Empedocles or Protagoras or some combination of the aforementioned. Perhaps the most famous expression of this ideal comes from Heraclitus: "You cannot step twice into the same river, for other waters and yet others go ever flowing on." 9 More to the point is the following declaration from the same philosopher: "Everything flows and nothing abides; everything gives way and nothing stays fixed." 10 In this spirit, Protagoras declares, "All matter is in a state of flux." 11 Such precedents provide the backdrop for Socrates in the Theaetetus as he summarizes: "The point is that all these things are, as we were saying, in motion, but there is a quickness or slowness in their motion" (Thea, 156c). In this historical spirit, he identifies "a tradition from the ancients, who hid their meaning from the common herd in poetical figures, that Oceanus and Tethys, the source of all things, are flowing streams and nothing is at rest" (Thea, 180d–e).To... (shrink)

In this paper, I lay out a case for why those objects of aesthetic attention which are principally characterized as natural objects should be understood not statically, as existing in merely a three-dimensional fixed state, but as dynamic, as existing in a space-time context, complete with change, movement, and flux. After this, I explain why this is important, how the dynamic nature of natural objects raises a concern for aesthetically evaluating natural objects, and how that concern may be addressed.

In lieu of an abstract, here is a brief excerpt of the content:Motion and Mercutio in Romeo and JulietDaryl W. PalmerThere is nothing permanent that is not true, what can be true that is uncertaine? How can that be certaine, that stands upon uncertain grounds? 1It is by now a commonplace in modern scholarship that drama, particularly Tudor drama, poses questions, rehearses familiar debates, and even speculates about mere possibilities. 2 In 1954, Madeleine Doran spelled out some of the ways (...) in which debate "affected the structure of Elizabethan drama." 3 In turn, Joel B. Altman, having eloquently extended Doran's examination, concludes that "the plays functioned as media of intellectual and emotional exploration for minds that were accustomed to examine the many sides of a given theme, to entertain opposing ideals, and by so exercising the understanding, to move toward some fuller apprehension of truth that could be discerned only through the total action of the drama." 4 Altman points to Henry Medwall's Fulgens and Lucres (c. 1490) as an exemplar of this practice. Although the interlude instructs and entertains, "the center of interest has shifted from demonstration to inquiry. The action develops not from an abstract assertion, but from a specific question: who is the nobler man, Cornelius or Gaius?" 5 By the time William Shakespeare began to write his plays, inquiry was an essential part of dramatic construction. So Juliet asks, "What's in a name?" 6 Hamlet opens with the question: "Who's [End Page 540] there?" (1.1.1), and achieves a kind of apotheosis in the figure of its hero: "To be, or not to be, that is the question..." (3.1.55). Everyone recognizes these familiar questions, and we know (or think we know) how to describe the most viable answers. I want to suggest, however, that this familiarity has dulled our appreciation of the drama's interrogative range. As a way of resisting this tendency, I want to argue that Shakespeare's Romeo and Juliet takes up an ancient conversation about motion, a dialog that originates with the pre-Socratics. This is not to say that the play is ultimately about motion. It obviously engages a panoply of thematic materials. I have simply chosen, in this limited space, to concentrate on the way the playwright stages his questioning as a kind of fencing lesson. My goal is to produce neither a "reading" of the play nor an allegory of philosophy, but rather to recollect the ways in which Shakespeare's drama qualifies and extends an ancient interrogative tradition. In so doing, I follow Stanley Cavell who maintains "that Shakespeare could not be who he is—the burden of the name of the greatest writer in the language, the creature of the greatest ordering of English—unless his writing is engaging the depth of the philosophical preoccupations of his culture." 7Some of the most venerable documents of Western philosophy fix on the problem of motion. If we go back more than 2,300 years, we come upon Plato's Theaetetus, in which Socrates explains a "first principle" to the title character, namely that "the universe really is motion and nothing else." 8 A kind of history lesson in ontology and epistemology, this tentative explanation has its origins in Heraclitus or Empedocles or Protagoras or some combination of the aforementioned. Perhaps the most famous expression of this ideal comes from Heraclitus: "You cannot step twice into the same river, for other waters and yet others go ever flowing on." 9 More to the point is the following declaration from the same philosopher: "Everything flows and nothing abides; everything gives way and nothing stays fixed." 10 In this spirit, Protagoras declares, "All matter is in a state of flux." 11 Such precedents provide the backdrop for Socrates in the Theaetetus as he summarizes: "The point is that all these things are, as we were saying, in motion, but there is a quickness or slowness in their motion" (Thea, 156c). In this historical spirit, he identifies "a tradition from the ancients, who hid their meaning from the common herd in poetical figures, that Oceanus and Tethys, the source of all things, are flowing streams and nothing is at rest" (Thea, 180d–e).To... (shrink)

In a framework describing manifestly covariant relativistic evolution using a scalar time τ, consistency demands that τ-dependent fields be used. In recent work by the authors, general features of a classical parametrized theory of gravitation, paralleling general relativity where possible, were outlined. The existence of a preferred “time” coordinate τ changes the theory significantly. In particular, the Hamiltonian constraint for τ is removed From the Euler-Lagrange equations. Instead of the 5-dimensional stress-energy tensor, a tensor comprised of 4-momentum density mid (...) class='Hi'>flux density only serves as the source. Building on that foundation, in this paper we develop a linear approximate theory of parametrized gravitation in the spirit of the flat spacetime approach to general relativity. Using a modified form of Kraichnan's flat spacetime derivation of general relativity, we extend the linear theory to a family of nonlinear theories in which the flat metric and the gravitational field coalesce into a single effective curved metric. (shrink)

: In this paper, I lay out a case for why those objects of aesthetic attention which are principally characterized as natural objects should be understood not statically, as existing in merely a three-dimensional fixed state, but as dynamic, as existing in a space-time context, complete with change, movement, and flux. After this, I explain why this is important, how the dynamic nature of natural objects raises a concern for aesthetically evaluating natural objects, and how that concern may be (...) addressed. (shrink)

Friedrich Nietzsche is generally received as a clever critic of metaphysics who nevertheless remained hopelessly entangled in the metaphysical tradition he sought to challenge. As a consequence perhaps of Heidegger's influential designation of Nietzsche as the "last metaphysician of the West," scholars have for the most part treated Nietzsche's critique of metaphysics as provocative and entertaining, but ultimately unsuccessful. In his important study of 1987, Eric Blondel attempts to recuperate and defend Nietzsche's immanent critique of metaphysics. The key to Blondel's (...) interpretation is his attention to the body as the central focus of Nietzsche's philosophy. For Blondel as for Nietzsche, the body stands for the "other" of metaphysics: flux, appearance, becoming, excess, incontinence, and difference. Any attempt to fix or define or stabilize the body necessarily involves its relapse into the procrustean bed of metaphysics. The central question of Nietzsche's philosophy thus becomes, How can we speak of the body without thereby violating it? According to Blondel, Nietzsche realized that a discursive account of the body is both necessary--lest philosophy degenerate into an idle exercise--and yet impossible to articulate without recourse to the suffocating categories of metaphysics. (shrink)

This essay is a critical notice of Thomas Nagel’s The Last Word. Though the essay evidences broad sympathy with the spirit of Nagel’s book, its main burden is to query the letter of the book. Nagel’s defence of the view that there are certain beliefs and ways of thinking that are not from any point of view, or that are ‘objective’ in his own terms, is criticized on the grounds that it is too facile. It is also criticized for not (...) being pitted against a critique of beliefs and ways of thinking that are from some point of view, or that are ‘subjective’ in his terms. (shrink)

Ecologists are challenged by the need to bridge and synthesize different approaches and theories to obtain a coherent understanding of ecosystems in a changing world. Both food web theory and regime shift theory shine light on mechanisms that confer stability to ecosystems, but from different angles. Empirical food web models are developed to analyze how equilibria in real multi-trophic ecosystems are shaped by species interactions, and often include linear functional response terms for simple estimation of interaction strengths from observations. Models (...) of regime shifts focus on qualitative changes of equilibrium points in a slowly changing environment, and typically include non-linear functional response terms. Currently, it is unclear how the stability of an empirical food web model, expressed as the rate of system recovery after a small perturbation, relates to the vulnerability of the ecosystem to collapse. Here, we conduct structural sensitivity analyses of classical consumer-resource models in equilibrium along an environmental gradient. Specifically, we change non-proportional interaction terms into proportional ones, while maintaining the equilibrium biomass densities and material flux rates, to analyze how alternative model formulations shape the stability properties of the equilibria. The results reveal no consistent relationship between the stability of the original models and the proportionalized versions, even though they describe the same biomass values and material flows. We use these findings to critically discuss whether stability analysis of observed equilibria by empirical food web models can provide insight into regime shift dynamics, and highlight the challenge of bridging alternative modelling approaches in ecology and beyond. (shrink)

As earthquakes expose geological faults, so mental conflict reveals tendencies to rupture within the mind. Dissension is rife not only between people but also within them, for each of us is subject to a contrariety of desires, beliefs, motivations, aspirations. What image are we to form of ourselves that might best enable us to accept the reality of discord, or achieve the ideal of harmony? Greek philosophers offer us a variety of pictures and structures intended to capture the actual and (...) the possible either within a reason that fails to be resolute, or within a split soul that houses a play of forces. Reflection upon them alerts us to the elusiveness at once of mental reality, and of the understanding by which we hope to capture and transform it. Studying in turn the treatments of _Mental Conflict_ in Socrates, Plato, Aristotle and the Stoics, A.W. Price demonstrates how the arguments of the Greeks are still relevant to philosophical discussion today. (shrink)

As earthquakes expose geological faults, so mental conflict reveals tendencies to rupture within the mind. Dissension is rife not only between people but also within them, for each of us is subject to a contrariety of desires, beliefs, motivations, aspirations. What image are we to form of ourselves that might best enable us to accept the reality of discord, or achieve the ideal of harmony? Greek philosophers offer us a variety of pictures and structures intended to capture the actual and (...) the possible either within a reason that fails to be resolute, or within a split soul that houses a play of forces. Reflection upon them alerts us to the elusiveness at once of mental reality, and of the understanding by which we hope to capture and transform it. Studying in turn the treatments of _Mental Conflict_ in Socrates, Plato, Aristotle and the Stoics, A.W. Price demonstrates how the arguments of the Greeks are still relevant to philosophical discussion today. (shrink)