Is truth itself natural? This is an important question for both those working on truth and those working on naturalism. For theorists of truth, answering the question of whether truth is natural will tell us more about the nature of truth (or lack of it), and the relations between truth and other properties of interest. For those working on naturalism, answering this question is of paramount importance to those who wish to have truth as part of the natural order. In (...) this paper, we focus primarily on the kinds of theories of truth that occupy the central positions in current debates about truth, namely correspondence theories, deflationary theories, epistemic theories, and pluralist theories, and aim to discern the extent to which truth is a natural property on each view. (shrink)

The heme‐containing cytochromes P‐450 are a ubiquitous family of monooxygenase isozymes responsible for the oxidative metabolism of a wide variety of endogenous as well as exogenous compounds. Many of the compounds metabolized by this enzyme system are effectively detoxified and converted to derivatives more easily eliminated from the organism. However, some compounds can be activated to reactive species capable of eliciting a cascade of toxic lesions, including cancer. Since its discovery nearly 30 years ago, the cytochrome P‐450 enzyme system has (...) received a great deal of attention, particularly in the areas of their mechanisms of metabolism, range of substrate specificity, the purification and characterization of the multiple isozymes and, more recently, the regulation of expression of specific forms. This review will discuss current notions concerning the expression of at least one cytochrome P‐450 isozyme and future directions that should lead to a more complete understanding of cytochrome P‐450 gene expression in general, particularly as it impacts upon biochemical pharmacology. (shrink)

Noam Chomsky and other linguists and psychologists have suggested that human linguistic behavior is somehow governed by a mental representation of a transformational grammar. Challenges to this controversial claim have often been met by invoking an explicitly computational perspective: It makes perfect sense to suppose that a grammar could be represented in the memory of a computational device and that this grammar could govern the device's use of a language. This paper urges, however, that the claim that humans are such (...) a device is unsupported and that it seems unlikely that linguists and psychologists really want to claim any such thing. Evidence for the linguists' original claim is drawn from three main sources: the explanation of language comprehension and other linguistic abilities; evidence for formal properties of the rules of the grammar; and the explanation of language acquisition. It is argued in this paper that none of these sources provides support for the view that the grammar governs language processing in something like the way a program governs the operation of a programmed machine. The computational approach, on the contrary, suggests ways in which linguistic abilities can be explained without the attribution of any explicit representation of rules governing linguistic behavior. (shrink)

As the usual regulatory framework did not fit well during the last Ebola outbreak, innovative thinking still needed. In the absence of an outbreak, randomised controlled trials of clinical efficacy in humans cannot be done, while during an outbreak such trials will continue to face significant practical, philosophical, and ethical challenges. This article argues that researchers should also test the safety and effectiveness of novel vaccines in wild apes by employing a pluralistic approach to evidence. There are three reasons to (...) test vaccines in wild populations of apes: i) protect apes; ii) reduce Ebola transmission from wild animals to humans; and iii) accelerate vaccine development and licensing for humans. Data obtained from studies of vaccines among wild apes and chimpanzees may even be considered sufficient for licensing new vaccines for humans. This strategy will serve to benefit both wild apes and humans. (shrink)

Salient landmarks enhance route learning. We hypothesised that semantically salient nostalgic landmarks would improve route learning compared to non-nostalgic landmarks. In two experiments, participants learned a route through a computer-generated maze using directional arrows and wall-mounted pictures. On the test trial, the arrows were removed, and participants completed the maze using only the pictures. In the nostalgia condition, pictures were of popular music artists and TV characters from 5 to 10 years ago. In the control condition, they were recent pictures (...) of these same artists and characters. In Experiment 1, in the test trial, participants in the nostalgia condition completed the maze faster than controls. Experiment 2 conceptually replicated these findings and extended them by exploring boundary conditions. Participants had to learn two mazes sequentially. In Maze 1, we placed nostalgic/control landmarks only at non-decision points (whereas we placed them at decision points in Experiment 1). In Maze 2, we placed nostalgic/control landmarks at decision points during acquisition but removed them in the test trial (whereas they were present in the test trial in Experiment 1). In both mazes, participants in the nostalgia (compared to control) condition completed the test trial faster. (shrink)

Four different kinds of grammars that can define crossing dependencies in human language are compared here: (i) context sensitive rewrite grammars with rules that depend on context, (ii) matching grammars with constraints that filter the generative structure of the language, (iii) copying grammars which can copy structures of unbounded size, and (iv) generating grammars in which crossing dependencies are generated from a finite lexical basis. Context sensitive rewrite grammars are syntactically, semantically and computationally unattractive. Generating grammars have a collection of (...) nice properties that ensure they define only “mildly context sensitive” languages, and Joshi has proposed that human languages have those properties too. But for certain distinctive kinds of crossing dependencies in human languages, copying or matching analyses predominate. Some results relevant to the viability of mildly context sensitive analyses and some open questions are reviewed. (shrink)

By formalizing recent syntactic theories for natural languages Stabler shows how their complexity can be handled without guesswork or oversimplification. By formalizing recent syntactic theories for natural languages in the tradition of Chomsky's Barriers, Stabler shows how their complexity can be handled without guesswork or oversimplification. He introduces logical representations of these theories together with special deductive techniques for exploring their consequences that will provide linguists with a valuable tool for deriving and testing theoretical predictions and for experimenting with alternative (...) formulations of grammatical principles. Stabler's novel approach allows results to be deduced with straightforward calculations and provides a systematic framework for tackling the problem of how speakers can infer the properties of an utterance from principles of the grammar. The special treatment of equality, induction principles, and inclusion of a general method for collecting structures from proofs means that sophisticated linguistic arguments can be carried out in detail, giving a rich perspective to issues in linguistic theory and parsing. (shrink)

At Epistles 2.2.87–9 Horace introduces an argument against writing poetry based on the unpleasant mutual admiration required in poetic society with an anecdote about an orator and a jurisconsult: †frater erat Romae† consulti rhetor, ut alter alterius sermone meros audiret honores, Gracchus ut hic illi, foret huic ut Mucius ille.

While researchers have examined the types of ethical issues that arise in long-term care, few studies have explored long-term care nurses’ experiences of moral distress and fewer still have examined responses to initial moral distress. Using an interpretive description approach, 15 nurses working in long-term care settings within one city in Canada were interviewed about their responses to experiences of initial moral distress, resources or supports they identified as helpful or potentially helpful in dealing with these situations, and factors that (...) hindered nurses in their responses. Using a thematic analysis process, three major themes were identified from the nurses’ experiences: (i) the context of the situation matters; (ii) the value of coming together as a team; and (iii) looking for outside direction. The work of responding to initial moral distress was more fruitful if opportunities existed to discuss conflicts with other team members and if managers supported nurses in moving their concerns forward through meetings or conversations with the team, physician, or family. Access to objective others and opportunities for education about ethics were also identified as important for dealing with value conflicts. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Notes and Discussions AGOSTINO NIFO'S EARLY VIEWS ON IMMORTALITY Various historians of Renaissance philosophy have taken some notice of the prolific author and important philosopher of the late 15th and early 16th centuries, Agostino Nifo (1470-1538), x but no one has yet studied his writings in a methodical and exhaustive fashion. 2 He not only published philosophical works in logic, physics, psychology and metaphysics, but he also authored treatises (...) on humanist topics? Recent scholars have tended to concentrate their attention on his psychological doctrines, no doubt because he was one of the major opponents of Pietro Pomponazzi (1462-1525) during the immortality controversy.4 Nifo published his De Immortalitate Animae in 1518 as a reply to the De lmmortalitate Ardmae, On the year of Nifo)s birth, see Bruno Nardi, Saggi sull'aristotelismo padovano dal secolo xav al xvl ('Florence, 1958), p. 284, n. 8. There is contemporary evidence that he died on January 18, 1538. See Bartolommeo Capasso, "Le cronache de li antiqui ri del regno di Napoli di D. Gaspare Fuscolill0," Archivio storico per le province napoletane, I (1876), p. 538. The standard bio-bibliography still remains Pasquale Tuozzi, "Agostino Nifo 9 le sue opere," Atti e memorie della R. Accademia di Scienze, Lettere ed Arti in Padova, Nuova scrie, XX (Padua, 1904), pp. 63-86. But see also Giuseppr Tommasino, Tra umanisti e filosoft (Maddaloni, 1921), Porte I, pp. 123-147; and Edward P. Mahoney, "A Note on Agostino Nifo," Philological Quarterly (forthcoming). z See Franeeseo Fiorentino, Pietro Pomponazzi; Studi storici su la scuola bolognese e padovana del secolo xvI (Florence, 1868); Carlo Giacon, La seconda scolastica: 1 grandi commentatori di San Tommaso (Milan, 1944); Etienne Gilson, "L'affaire de l'immortalit6 de l'fime ~t Venise at* d6but du xvIe si~ele," in Umanesirno europeo e uraanesimo veneziano, ed. Vittore Branea (Florence, 1963), pp. 31-61; Miehele Giorgiantonio, "Un nostro filosofo dimentieato dcl '400 (Luea Prassicio e Agostino Nifo)," Sophia, XVI (1948), pp. 212-214 and 303-312; Bruno Nardi, Saggi sulraristotelismo padovano dal secolo x]v al xvI (Florence, 1958); idem, Sigieri di Brabante nel pensiero del Rinascimento Italiano (Rome, 1945); Giovanni di NapoH, L'immortalitd delranima nel Rinascimento ('Turin, 1963); John Herman Randall, Jr., The School of Padua and the Emergence of Modern Science (Padua, 1961); Wilhelm Risse, Die Logik der Neuzeit, I (Stuttgart, 1964); Eugenio Garin, La cultura [ilosofica del Rinascimento Italiano (Florence, 1961); idem, Storia della filosofia italiana, II (Turin, 1966). See Nifo's De Armorum Literarumque Comparatione Commentariolus (Naples, 1526); De Pulchro et Amore (Rome, 1531); De Re Aulica (Naples, 1534); and Prima Pars Opusculorum (Venice, 1535). The second of these works has been studied by Jules Houdoy, La beaut~ des femmes dans la litt#rature et darts rart du xII" au xvIe si~cle; Analyse du livre de A. Niphus du Beau et de l'amour (Paris, 1876). 4 For recent discussion of the immortality controversy, see Etienne Gilson, "Autour de Pomponazzi, ProbMmatique de l'immortalit~ de l'~me en Italic au d~but du xvIe si~.cle," Archives d'histoire doctrinale et litt~raire du moyen dge, Ann6e 1961, pp. 163-179; Giovanni di Napoli, op. cit., especially pp. 227-338; Paul Oskar Kristeller, Eight Philosophers of the Italian Renaissance (Stanford, 1964), pp. 72-90; Bruno Nardi, Studi su Pietro Pomponazzi (Florence, 1965); Martin Pine, "Pomponazzi and the Problem of 'Double Truth'," Journal ot the History of Ideas, XXIX (1968), pp. 163-176; Harold Shulsky, "Paduan Epistemology and the Doctrine of the One Mind," lournal of the History of Philosophy, VI (1968), pp. 341-361. [451] 452 HISTORY OF PHILOSOPHY (1516) of Pomponazzi, who had argued that personal immortality cannot be philosophically demonstrated, s But while these scholars correctly point out that Nifo abandoned an Averroist interpretation of Aristotle concerning the unity of the intellect and the immortality of the soul for the position which they assume to be Thomistic, they are not precise as to just when Nile made the shift.6 They have not observed that in his first two printed works, namely, the commentary on Averroes' Destructio Destructionum (1497) and the early commentary on the De Anima (1503), Nifo explicitly accepts Averroes as the... (shrink)

Historical studies may become classics for the wrong reasons, as did Henry Thode's Francis of Assisi or Michelet's Joan of Arc, which we now regard as cultural icons in their own right, emblems of specific elements of the cultures of the era in which they were written. We do not, however, read them for the insight they provide into their declared subjects, nor are their conclusions those of current scholarship. Other studies become classics for the right reasons. The year 1999 (...) marks the eightieth anniversary of the publication of Johan Huizinga's Herfsttij der Middeleeuwen: Studie over levens- en gedachtenvormen der veertiende en vijftiende eeuw in Frankrijk en de Nederlanden, “The Autumn [or Harvest, or Waning, or Decline, or Evening] of the Middle Ages: A Study of the Forms of Life and Thought in the Fourteenth and Fifteenth Centuries in France and the Netherlands [or the Low Countries, or the Burgundian Low Countries].”. (shrink)

This article seeks in the Platonic philosophers of late antiquity insights applicable to a new discipline, the philosophy of Pagan religion. An impor¬tant element of any such discipline would be a method of mythological hermeneutics that could be applied cross-culturally. The article draws par¬ticular elements of this method from Sallust and Olympiodorus. Sallust’s five modes of the interpretation of myth (theological, physical, psychical, material and mixed) are discussed, with one of them, the theological, singled out for its applicability to all (...) myths and because it interprets myth in reference exclusively to the nature of the Gods and their relationship to a model of the cosmos in its totality. The other modes of interpretation, while useful in particular contexts, are not uniformly applicable to all myths, interpret the myths as concerning things other than the Gods themselves, and interpret the myths with reference to particular sectors of the cosmos. Accordingly, it is from Sallust’s theological mode of interpre¬tation that the new method draws its inspiration. From Olympiodorus the method derives strategies for interpreting basic narrative attributes that myths share with all stories. Thus temporal sequence is interpreted as an ascent, from our perspective, from less perfect to more perfect manifestations of the powers of the Gods. Passivity, conflict, and transitive relations in general between the Gods are interpreted as expressing attributes of the cosmos to the constitution of which the Gods dedicate their energies, rather than as placing constraint upon the Gods themselves. The article concludes with a series of broad principles meant to guide the new method. (shrink)

Completing the systematic henadological interpretation of Proсlus’ Platonic Theology begun in The Intelligible Gods in the Platonic Theology of Proclus (“Méthexis” 21, 2008, pp. 131-143) and The Second Intelligible Triad and the Intelligible-Intellective Gods (“Méthexis” 23, 2010, pp. 137-157), the present article concerns the conditions of the emergence of fully mediated, diacritical multiplicity out of the polycentric henadic manifold. The product of the activity of the intellective Gods (that is, the product of the intellective activity of Gods as such), in (...) resolving the contradiction between existential uniqueness and universalizable potencies in the divine natures, also grounds the human exercise of philosophical cognition in the founding self-analysis of divine individuals. (shrink)

Is truth itself natural? This is an important question for both those working on truth and those working on naturalism. For theorists of truth, answering the question of whether truth is natural will tell us more about the nature of truth (or lack of it), and the relations between truth and other properties of interest. For those working on naturalism who wish to have truth as part of the natural order, answering this question is of paramount importance. In this chapter, (...) we focus primarily on the kinds of theory of truth that occupy the central positions in current debates about truth, namely correspondence theories, deflationary theories, epistemic theories, and pluralist theories, and aim to discern the extent to which truth is a natural property on each view. (shrink)

Minimalist grammars (MGs) and multiple context-free grammars (MCFGs) are weakly equivalent in the sense that they define the same languages, a large mildly context-sensitive class that properly includes context-free languages. But in addition, for each MG, there is an MCFG which is strongly equivalent in the sense that it defines the same language with isomorphic derivations. However, the structure-building rules of MGs but not MCFGs are defined in a way that generalizes across categories. Consequently, MGs can be exponentially more succinct (...) than their MCFG equivalents, and this difference shows in parsing models too. An incremental, top-down beam parser for MGs is defined here, sound and complete for all MGs, and hence also capable of parsing all MCFG languages. But since the parser represents its grammar transparently, the relative succinctness of MGs is again evident. Although the determinants of MG structure are narrowly and discretely defined, probabilistic influences from a much broader domain can influence even the earliest analytic steps, allowing frequency and context effects to come early and from almost anywhere, as expected in incremental models. (shrink)

Saul Kripke has proposed an argument to show that there is a serious problem with many computational accounts of physical systems and with functionalist theories in the philosophy of mind. The problem with computational accounts is roughly that they provide no noncircular way to maintain that any particular function with an infinite domain is realized by any physical system, and functionalism has the similar problem because of the character of the functional systems that are supposed to be realized by organisms. (...) This paper shows that the standard account of what it is for a physical system to compute a function can avoid Kripke's criticisms without being reduced to circularity; a very minor and natural elaboration of the standard account suffices to save both functionalist theories and computational accounts generally. (shrink)

This essay is a reflection on how ethical violations continue to have an impact across generations within families of vulnerable populations that have experienced significant breaches in biomedical research. The focus is on the surviving family members of the United States Public Health Service Syphilis Study at Tuskegee (USPHS). Emphasis will be on responsible ethical practices in research and the use of an unique approach narrative storytelling to address the needs of family descendents who have been impacted by the USPHS (...) Syphilis Study. (shrink)

Linguists rely on intuitive conceptions of structure when comparing expressions and languages. In an algebraic presentation of a language, some natural notions of similarity can be rigorously defined (e.g. among elements of a language, equivalence w.r.t. isomorphisms of the language; and among languages, equivalence w.r.t. isomorphisms of symmetry groups), but it tums out that slightly more complex and nonstandard notions are needed to capture the kinds of comparisons linguists want to make. This paper identihes some of the important notions of (...) structural similarity, with attention to similarity claims that are prominent in the current linguistic tradition of transformational grammar. @ 2002 Elsevier Science B.V. All rights reserved. (shrink)

Plotinus’ famous treatise against the Gnostics (33), together with contemporary and thematically related treatises on Intelligible Beauty (31), on Number (34), and on Free Will and the Will of the One (39), can be seen as providing the essential components of a Plotinian defense of polytheism against conceptual moves that, while associated for him primarily with Gnostic sectarians overlapping with Platonic philosophical circles, will become typical of monotheism in its era of hegemony. When Plotinus’ Gnostics ‘contract’ divinity into a single (...) God, they not only devalue the cosmos for its multiplicity and diversity, but also multiply intelligible principles unreasonably. This is because they have foreclosed the distinction, which is to become increasingly explicit in the later antique Platonists, between the intelligible and that which is given existentially, the domain belonging to Plotinus’ indeterminate multiplicity of ‘intelligible Gods’, as opposed to the dialectically determinate number of intelligible principles. Plotinus is prescient in recognizing that incipient monotheism threatens to erase the distinction between philosophy and theology, and between both of these and psychology, the final outcome of which can only be solipsism or nihilism. The defense of polytheism is seen in this fashion to be essential to the preservation of the space for philosophical discourse. (shrink)