Gene discovery reveals new biology, expands the utility of marker‐assisted selection, and enables targeted mutagenesis. Still, such discoveries can take over a decade. We present a general strategy, “Agile Genetics,” that uses nested, structured populations to overcome common limits on gene resolution. Extensive simulation work on realistic genetic architectures shows that, at population sizes of >5000 samples, single gene‐resolution can be achieved using bulk segregant pools. At this scale, read depth and technical replication become major drivers of resolution. Emerging enrichment (...) methods to address coverage are on the horizon; we describe one possibility – iterative depth sequencing (ID‐seq). In addition, graph‐based pangenomics in experimental populations will continue to maximize accuracy and improve interpretation. Based on this merger of agronomic scale with molecular and bioinformatic innovation, we predict a new age of rapid gene discovery. (shrink)

Longing is a universal human experience, born of the inevitable gulf between dream and reality, what we need and what we have. While the experience of longing may arise from loss or the awareness of a void in one’s life, it may also become a powerful engine of spiritual growth, prompting one to draw closer to the hidden yet present “Other.” Across the range of Jewish teachings, longing takes center stage in one’s spiritual life. From the Bible through current frontiers (...) in Jewish belief and practice, God is both known and unknown, immediate and remote, present and in constant eclipse. This book captures the sense of longing in Jewish tradition by creating a dialogue between the author’s own struggles with an estranged father and a wide range of traditional and contemporary sources. Focusing on the story of the Hebrew prophet Elisha, the book takes the reader through a journey of abandonment, creative destruction, and ultimately repair and healing, engaging with currents in biblical theology, rabbinic thought, Kabbalah, and contemporary Jewish philosophy. Written in a familiar yet probing style, this book is an accessible introduction to Jewish thought and spirituality as well as a thoughtful companion for more experienced students. (shrink)

This book addresses concerns about educational and moral standards in a world increasingly characterised by nihilism. On the one hand there is widespread anxiety that standards are falling; on the other, new machinery of accountability and inspection to show that they are not. The authors in this book state that we cannot avoid nihilism if we are simply _laissez-faire_ about values, neither can we reduce them to standards of performance, nor must we return to traditional values. They state that we (...) need to create a new set of values based on a critical assessment of contemporary practice in the light of a number of philosophical texts that address the question of nihilism, including the work of Nietzsche. (shrink)

Although the counterfactual comparative account of harm, according to which someone is harmed when things go worse for her than they otherwise would have, is intuitively plausible, it has recently come under attack. There are five serious objections in the literature: some philosophers argue that the counterfactual account makes it hard to see how we could harm someone in the course of benefitting that person; others argue that Parfit’s non-identity problem is particularly problematic; another objection claims that the account forces (...) us to see many harms where there is just one; a fourth objection is based on the claim that the counterfactual account makes mysterious the distinction between harms and mere failures-to-benefit; and a final problem arises from cases of pre-emption, in which the nearest possible world in which the harmful event does not occur is a world in which some other harmful event occurs. This paper argues that, properly understood, harm essentially involves a counterfactual comparison, and that these comparisons are sensitive to context in the manner typical of counterfactual conditionals, and that, augmented with two plausible distinctions, this account has the resources to provide satisfying responses to each of the objections that have been raised against it. (shrink)

At the center of the literature on conditionals lies the division between indicative and subjunctive conditionals, and Ernest Adams’ famous minimal pair: If Oswald didn’t shoot Kennedy, someone else did. If Oswald hadn’t shot Kennedy, someone else would have. While a lot of attention is paid to figuring out what these different kinds of conditionals mean, significantly less attention has been paid to the question of why their grammatical differences give rise to their semantic differences. In this paper, I articulate (...) and defend an answer to this question that illuminates and unifies the meanings of both kinds of conditionals. The basic idea is that epistemic and metaphysical possibilities differ with respect to their interaction with time, such that there can be present epistemic possibilities with different pasts, while present metaphysical possibilities share the same past. The interpretation of conditionals is subject to a pragmatic constraint that rules out interpretations in which their consequents are directly settled by information used to build their domains. The past + future morphology on subjunctives, but not indicatives, is what allows them to receive a metaphysical interpretation in light of this pragmatic constraint. The resulting theory predicts several surprising features of indicatives and subjunctives, which I argue are correct. (shrink)

In previous work, we presented evidence suggesting that ordinary people do not conceive of subjective experiences as having phenomenal qualities. We then argued that these findings undermine a common justification given for the reality of the hard problem of consciousness. In a thought-provoking article, Talbot has challenged our argument. In this article, we respond to his criticism.

Mainstream teleosemantics is the view that mental representation should be understood in terms of biological functions, which, in turn, should be understood in terms of selection processes. One of the traditional criticisms of teleosemantics is the problem of novel contents: how can teleosemantics explain our ability to represent properties that are evolutionarily novel? In response, some have argued that by generalizing the notion of a selection process to include phenomena such as operant conditioning, and the neural selection that underlies it, (...) we can resolve this problem. Here, we do four things: we develop this suggestion in a rigorous way through a simple example, we draw on recent neurobiological research to support its empirical plausibility, we defend the move from a host of objections in the literature, and we sketch how the picture can be extended to help us think about more complex “conceptual” representations and not just perceptual ones. (shrink)

The 'postmodern condition,' in which instrumentalism finally usurps all other considerations, has produced a kind of intellectual paralysis in the world of education. The authors of this book show how such postmodernist thinkers as Derrida, Foucault, and Lyotard illuminate puzzling aspects of education, arguing that educational theory is currently at an impasse. They postulate that we need these new and disturbing ideas in order to "think again" fruitfully and creatively about education.

This article presents a distinct sense of ‘mechanism’, which I call the functional sense of mechanism. According to this sense, mechanisms serve functions, and this fact places substantive restrictions on the kinds of system activities ‘for which’ there can be a mechanism. On this view, there are no mechanisms for pathology; pathologies result from disrupting mechanisms for functions. Second, on this sense, natural selection is probably not a mechanism for evolution because it does not serve a function. After distinguishing this (...) sense fromsimilar explications of ‘mechanism’, I argue that it is ubiquitous in biology and has valuable epistemic benefits. (shrink)

I distinguish two forms of pluralism about biological functions, between-discipline pluralism and within-discipline pluralism. Between-discipline pluralism holds that different theories of function are appropriate for different subdisciplines of biology and psychology. I provide reasons for rejecting this view. Instead, I recommend within-discipline pluralism, which emphasizes the plurality of function concepts at play within any given subdiscipline of biology and psychology.

Theories of function are conventionally divided up into historical and ahistorical ones. Proponents of ahistorical theories often cite the ahistoricity of their accounts as a major virtue. Here, I argue that none of the mainstream “ahistorical” accounts are actually ahistorical. All of them embed, implicitly or explicitly, an appeal to history. In Boorse’s goal-contribution account, history is latent in the idea of statistical-typicality. In the propensity theory, history is implicit in the idea of a species’ natural habitat. In the causal (...) role theory, history is required for making sense of dysfunction. I elaborate some consequences for the functions debate. (shrink)

A common misunderstanding of the selected effects theory of function is that natural selection operating over an evolutionary time scale is the only functionbestowing process in the natural world. This construal of the selected effects theory conflicts with the existence and ubiquity of neurobiological functions that are evolutionary novel, such as structures underlying reading ability. This conflict has suggested to some that, while the selected effects theory may be relevant to some areas of evolutionary biology, its relevance to neuroscience is (...) marginal. This line of reasoning, however, neglects the fact that synapses, entire neurons, and potentially groups of neurons can undergo a type of selection analogous to natural selection operating over an evolutionary time scale. In the following, I argue that neural selection should be construed, by the selected effect theorist, as a distinct type of function-bestowing process in addition to natural selection. After explicating a generalized selected effects theory of function and distinguishing it from similar attempts to extend the selected effects theory, I do four things. First, I show how it allows one to identify neural selection as a distinct function-bestowing process, in contrast to other forms of neural structure formation such as neural construction. Second, I defend the view from one major criticism, and in so doing I clarify the content of the view. Third, I examine drug addiction to show the potential relevance of neural selection to neuroscientific and psychological research. Finally, I endorse a modest pluralism of function concepts within biology. (shrink)

Mechanisms, in the prominent biological sense of the term, are historical entities. That is, whether or not something is a mechanism for something depends on its history. Put differently, while your spontaneously-generated molecule-for-molecule double has a heart, and its heart pumps blood around its body, its heart does not have a mechanism for pumping, since it does not have the right history. My argument for this claim is that mechanisms have proper functions; proper functions are historical entities; so, mechanisms are (...) historical entities, too. This thesis runs against the mainstream new mechanist way of thinking about mechanisms, where mechanisms are generally thought of in an ahistorical way. After arguing for this thesis, I draw out some consequences for philosophy of science and metaphysics. (shrink)

One of the most striking features of speculative theology (kalaam) as it developed within the Ash'arite tradition of Islam is its denial of causal power to creatures. Much like Malebranche in the seventeenth century, the Ash'arites saw this denial as a natural extension of monotheism and were led as a result to embrace an occasionalist account of causality. According to their analysis, causal power is identical with creative power, and since God is the sole and sovereign creator, God is the (...) only causal agent. To assert anything else is to compromise monotheism. This position, of course, was in direct opposition to the prevailing accounts of causality within the philosophical tradition of Islam at the time. The philosophers (falaasifa) had by and large taken over accounts of causality from Aristotle and the Neoplatonists and adapted them in accordance with their own set of concerns. In such accounts, while God stands as the first cause, secondary causationis unambiguously affirmed, even if variously understood. Thus, as they offered a sophisticated account of causal action in direct opposition to the occasionalist thesis, thefalaasifa posed something of challenge to the theologians. (shrink)

The book is an argument about the moral foundations of foreign policy. It argues that the traditional idea of liberal equality can be interpreted so as to give moral guidance to policy leaders in understanding what they ought to seek internationally.

Although the thesis that the moral better than relation is transitive seems obviously true, there is a growing literature according to which Parfit’s repugnant conclusion and related puzzles reveal that this thesis is false or problematic. This paper begins by presenting several such puzzles and explaining how they can be used in arguments for the intransitivity of better than. It then proposes and defends a plausible alternative picture of the behavior of better than that both resolves the repugnant conclusion and (...) preserves transitivity. On the threshold-based model of lexicality defended here, hedonic episodes whose intensity is above a certain point are lexically greater than those whose intensity is below it. The final sections argue that this model is independently plausible and can be defended from several important objections. (shrink)

Philosophers who study the problem of biological function often begin their deliberations by reflecting on the functions of parts of animals, or the behavior of animals. Applying theories of biological function to unconventional or borderline cases can help us to better evaluate and refine those theories. This is the case when we consider whether parts of transposable elements —bits of “selfish” DNA that move about within a host genome—have functions of their own, that is, whether the parts of TEs have (...) the function of helping the TE move about within the genome. Here I argue that whether or not the parts of TEs have functions depends crucially on whether collections of TEs form “populations,” by which I mean, here, a group of individuals of the same type that impact one another’s chances of persistence or multiplication, by impacting one another’s access to a shared resource. I think there is suggestive, but not conclusive, evidence that some TEs have functions of their own. Considering the problem of TE functionality, then, has value both for philosophy and for biology. (shrink)

Despite the voluminous literature on biological functions produced over the last 40 years, few philosophers have studied the concept of function as it is used in neuroscience. Recently, Craver (forthcoming; also see Craver 2001) defended the causal role theory against the selected effects theory as the most appropriate theory of function for neuroscience. The following argues that though neuroscientists do study causal role functions, the scope of that theory is not as universal as claimed. Despite the strong prima facie superiority (...) of the causal role theory, the selected effects theory (when properly developed) can handle many cases from neuroscience with equal facility. It argues this by presenting a new theory of function that generalizes the notion of a ‘selection process’ to include processes such as neural selection, antibody selection, and some forms of learning—that is, to include structures that have been differentially retained as well as those that have been differentially reproduced. This view, called the generalized selected effects theory of function, will be defended from criticism and distinguished from similar views in the literature. (shrink)

I argue that in Plato's _Sophist, the account of true and false statement which emerges within the discussion of not being and falsehood neither entails nor outwardly suggests any of the traditional characterizations of a correspondence "theory" of truth. On the contrary, what emerges is a minimalistic "conception" of truth which requires neither positing the existence of facts nor formulating an explanatory definition of truth. I make comparisons with Aristotle's discussion of truth in the _Categories and _De Interpretatione, and I (...) offer reasons why one should not expect to find the emergence of a "theory" of truth in the _Sophist. (shrink)

According to operator theories, "if" denotes a two-place operator. According to restrictor theories, "if" doesn't contribute an operator of its own but instead merely restricts the domain of some co-occurring quantifier. The standard arguments (Lewis 1975, Kratzer 1986) for restrictor theories have it that operator theories (but not restrictor theories) struggle to predict the truth conditions of quantified conditionals like -/- (1) a. If John didn't work at home, he usually worked in his office. b. If John didn't work at (...) home, he must have worked in his office. -/- Gillies (2010) offers a context-shifty conditional operator theory that predicts the right truth conditions for epistemically modalized conditionals like (1b), thus undercutting one standard argument for restrictor theories. I explore how we might generalize Gillies' theory to adverbially quantified conditionals like (1a) and deontic conditionals, and argue that a natural generalization of Gillies' theory -- following his strategy for handling epistemically modalized conditionals -- won't work for these other conditionals because a crucial assumption that epistemic modal bases are closed (used to neutralize the epistemic quantification contributed by "if") doesn't have plausible analogs in these other domains. (shrink)

Several prominent ethical philosophers have attempted to demonstrate that there exist instances or types of value that are of crucial moral significance but which cannot legitimately be compared with one another. Bernard Williams and Michael Stocker, for example, argue that it can sometimes be rational to regret having chosen the all-things-considered better of two alternatives, and that this sense of regret entails that the goodness of the worse option is not made up for by and is therefore incommensurable with that (...) of the better. Joseph Raz and others have made similar points. In this paper, I propose a theory of value that is monistic in that it countenances just one sort of morally crucial value, but pluralistic in that several distinct properties bearer this value. I then explain how this view avoids incommensurable values without doing violence to the core intuitions that seemed to necessitate them, and how it fits into a larger conception of morality, right conduct, and moral psychology. (shrink)

What would the global history of philosophy look like if it were told not as a story of ideas but as a series of job descriptions—ones that might have been used to fill the position of philosopher at different times and places over the past 2,500 years? The Philosopher does just that, providing a new way of looking at the history of philosophy by bringing to life six kinds of figures who have occupied the role of philosopher in a wide (...) range of societies around the world over the millennia—the Natural Philosopher, the Sage, the Gadfly, the Ascetic, the Mandarin, and the Courtier. The result is at once an unconventional introduction to the global history of philosophy and an original exploration of what philosophy has been—and perhaps could be again. By uncovering forgotten or neglected philosophical job descriptions, the book reveals that philosophy is a universal activity, much broader—and more gender inclusive—than we normally think today. In doing so, The Philosopher challenges us to reconsider our idea of what philosophers can do and what counts as philosophy. (shrink)

This chapter focuses on attributions of phenomenal consciousness, leaving to the side interesting questions about how people attribute other types of consciousness. While researchers are not in perfect agreement about how the concept of phenomenal consciousness should be understood, the standard line is that a creature is phenomenally conscious just in case it has phenomenally conscious mental states, and that a mental state is phenomenally conscious just in case it has phenomenal qualities. The chapter explores whether lay people employ the (...) concept of phenomenal consciousness. It begins by looking at the evidence for an affirmative answer to this question, focusing on Joshua Knobe and Jesse Prinz's article, Intuitions About Consciousness: Experimental Studies. The chapter explains the evidence for a negative answer to the target question, focusing on Justin Sytsma and Edouard machery's article, Two Conceptions of Subjective Experience. (shrink)

This historical compendium investigates scientific methods conceived between the Renaissance and the nineteenth century. Beginning with attacks on Scholasticism and the rist of the New Science, the authors explain the roles of both major andminor figures in describing scientific methods. Although the chapters are interrelated and contain explicit comparisons, each chapter is a complete study in itself. The authors' emphasis on writing for the non-specialist and their liberal use of primary sources make this an outstanding textbook.

As historian Henning Schmidgen notes, the scientific study of the nervous system would have been “unthinkable” without the industrialization of communication in the 1830s. Historians have investigated extensively the way nerve physiologists have borrowed concepts and tools from the field of communications, particularly regarding the nineteenth-century work of figures like Helmholtz and in the American Cold War Era. The following focuses specifically on the interwar research of the Cambridge physiologist Edgar Douglas Adrian, and on the technology that led to his (...) Nobel-Prize-winning research, the thermionic vacuum tube. Many countries used the vacuum tube during the war for the purpose of amplifying and intercepting coded messages. These events provided a context for Adrian's evolving understanding of the nerve fiber in the 1920s. In particular, they provide the background for Adrian's transition around 1926 to describing the nerve impulse in terms of “information,” “messages,” “signals,” or even “codes,” and for translating the basic principles of the nerve, such as the all-or-none principle and adaptation, into such an “informational” context. The following also places Adrian's research in the broader context of the changing relationship between science and technology, and between physics and physiology, in the first few decades of the twentieth century. (shrink)

The idea that God, understood as the most perfect being, must create the best possible world is often underacknowledged by contemporary theologians and philosophers of religion. This book clearly demonstrates the rationale for what Justin Daeley calls Theistic Optimism and interacts with the existing literature in order to highlight its limitations. While locating Theistic Optimism in the thought of Gottfried Leibniz, Daeley argues that Theistic Optimism is consistent with divine freedom, aseity, gratitude, and our typical modal intuitions. By offering (...) plausible solutions to each of the criticisms levelled against Theistic Optimism, he also provides a vigorous and original defence against the charge that it deviates from the Christian tradition. Engaging with both the Christian tradition and contemporary theologians and philosophers, Why God Must Do What is Best positions the idea of Theistic Optimism firmly within the language of contemporary philosophy of religion. (shrink)

The management process affects the level of ethical performance in organizational life. As one part of this process, managers establish priorities which give direction to an organization. In business firms, management typically stresses the attainment of profits and other related economic and technical factors. Since little explicit recognition is given to ethics, the resulting climate makes it easy to ignore ethical factors. Changing this situation by making ethics a significant part of the corporate culture is difficult and requires a combination (...) of management communication and management example. However, managers who choose to emphasize ethics and who skillfully articulate their importance can improve the integration of ethics into the day-to-day operating decisions of the firm. (shrink)

The first use of the term "information" to describe the content of nervous impulse occurs 20 years prior to Shannon`s (1948) work, in Edgar Adrian`s The Basis of Sensation (1928). Although, at least throughout the 1920s and early 30s, the term "information" does not appear in Adrian`s scientific writings to describe the content of nervous impulse, the notion that the structure of nervous impulse constitutes a type of message subject to certain constraints plays an important role in all of his (...) writings throughout the period. The appearance of the concept of information in Adrian`s work raises at least two important questions: (i) what were the relevant factors that motivated Adrian`s use of the concept of information? (ii) What concept of information does Adrian appeal to, and how can it be situated in relation to contemporary philosophical accounts of the notion of information in biology? The first question involves an account of the application of communications technology in neurobiology as well as the historical and scientific background of Adrian`s major scientific achievement, which was the recording of the action potential of a single sensory neuron. The response to the second question involves an explication of Adrian`s concept of information and an evaluation of how it may be situated in relation to more contemporary philosophical explications of a semantic concept of information. I suggest that Adrian`s concept of information places limitations on the sorts of systems that are referred to as information carriers by causal and functional accounts of information. (shrink)

I contend that Descartes’s view of mind-body union is not a Platonic view in which the soul uses the body as its vehicle, but hylomorphic in that mind and body form a single unit. I argue that Descartes’s view is most like Ockham’s, and therefore Descartes is entitled to maintain a hylomorphic theory to the same extent that Ockham is. I argue further that the soul is the substantial form of human being, and that mind and body are incomplete substances (...) that are substantially united to form the human substance. Finally, I address Descartes’s claim that the whole soul has its principle seat in the pineal gland, and conclude that this does not imply a Platonic view as one might suspect. This hylomorphic interpretation avoids the problem of mind-body interaction, which might be seen as preventing the possibility of the soul’s immortality, because an explanation of the behavior of one entity is required instead of an explanation of the interaction between two, apparently incompatible, entities. (shrink)

Why is pain the opposite of pleasure? Several theories of pleasure and pain have substantial difficulty explaining this basic feature. Theories according to which pleasure and pain are individual sensations or features of sensations have particular difficulty, since it is difficult to understand how pairs of sensations could be opposites. Some philosophers argue that the pain is the opposite of pleasure because pain and pleasure are fundamentally a matter of desire and aversion, and desire and aversion are clear opposites. I (...) argue that the structure of desire and aversion does not correspond to that of pleasure and pain. I propose that pleasure and pain are opposites because pleasure is good and pain is bad, and good and bad are clear opposites. I show that this view explains the structure of opposition of pleasure and pain, and I answer several objections. (shrink)

I develop a distinction between two types of psychological hedonism. Inferential hedonism (or “I-hedonism”) holds that each person only has ultimate desires regarding his or her own hedonic states (pleasure and pain). Reinforcement hedonism (or “R–hedonism”) holds that each person's ultimate desires, whatever their contents are, are differentially reinforced in that person’s cognitive system only by virtue of their association with hedonic states. I’ll argue that accepting R-hedonism and rejecting I-hedonism provides a conciliatory position on the traditional altruism debate, and (...) that it coheres well with the neuroscientist Anthony Dickinson’s theory about the evolutionary function of hedonic states, the “hedonic interface theory.” Finally, I’ll defend R-hedonism from potential objections. (shrink)

Arnauld raised the concern that Descartes’s real distinction argument proved too much, because it seemed to lead us back to the Platonic view according to which the mind uses the body as its vehicle. Descartes responds by pointing out that he argued against this account of mind-body union in the Sixth Meditation. Descartes believes he did not prove too much, because he offers an argument against this view whose premises and conclusion are consistent with the real distinction argument. In this (...) paper, the union argument is reconstructed and evaluated in order to see if, through his rejection of the Platonic view, Descartes adequately addresses Arnauld’s concern. In the end, Descartes adequately addresses this concern only if God’s veracity provides a secure foundation for a crucial inference. Finally, these considerations show a way for those committed to the real distinction of mind and body to avoid the problem of their interaction. (shrink)